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Pharmacological Advances in Natural Product Drug Discovery

Pharmacological Advances in Natural Product Drug Discovery
A Book

by Guanhua Du

  • Publisher : Academic Press
  • Release : 2020-03
  • Pages : 312
  • ISBN : 0128201851
  • Language : En, Es, Fr & De
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Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more. Includes the authority and expertise of leading contributors in natural product pharmacology Provides the latest pharmacological research progresses of eight medicinal compounds from natural products Presents a thorough discussion on the compatibility of traditional medicines

Innovation in the Pharmaceutical Industry

Innovation in the Pharmaceutical Industry
The Process of Drug Discovery and Development

by Takuji Hara

  • Publisher : Edward Elgar Publishing
  • Release : 2003
  • Pages : 271
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Innovation in the Pharmaceutical Industry traces the discovery and development of drugs in Japan and the UK both historically and sociologically. It includes sixteen case studies of major pharmaceutical developments in the twentieth century, encompassing, amongst others, beta-blockers, beta-stimulants, inhaled steroids and histamine H2-antagonists.The book illustrates that the four stages of drug development - namely compound, application, organisational authorisation and market - are interactively shaped by heterogeneous actors and institutions. The book also identifies three different types of pharmaceutical development - paradigmatic innovation, application innovation and modification-based innovation, all with distinguishable features in the drug development process. Finally, several historical, structural and cultural factors influencing the shaping of medicines are revealed by the comparison between British and Japanese drug innovation.Addressing a number of practical implications for the promotion of the pharmaceutical industry, this book will be of enormous interest to students, researchers and academics specialising in science and technology, and the management of technology and innovation. Practitioners, managers, and policy planners within the pharmaceutical industry will also deem this book invaluable.

Comprehensive Analysis of Parasite Biology

Comprehensive Analysis of Parasite Biology
From Metabolism to Drug Discovery

by Sylke M?ller,Rachel Cerdan,Ovidiu Radulescu,Paul M. Selzer

  • Publisher : John Wiley & Sons
  • Release : 2016-10-17
  • Pages : 576
  • ISBN : 3527339043
  • Language : En, Es, Fr & De
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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

Drug Discovery and Development - Present and Future

Drug Discovery and Development - Present and Future
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Epigenetic Drug Discovery

Epigenetic Drug Discovery
A Book

by Wolfgang Sippl,Manfred Jung

  • Publisher : John Wiley & Sons
  • Release : 2019-03-25
  • Pages : 504
  • ISBN : 3527343148
  • Language : En, Es, Fr & De
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This broad view of epigenetic approaches in drug discovery combines methods and strategies with individual targets, including new and largely unexplored ones such as sirtuins and methyl-lysine reader proteins. Presented in three parts - Introduction to Epigenetics, General Aspects and Methodologies, and Epigenetic Target Classes - it covers everything any drug researcher would need in order to know about targeting epigenetic mechanisms of disease. Epigenetic Drug Discovery is an important resource for medicinal chemists, pharmaceutical researchers, biochemists, molecular biologists, and molecular geneticists.

Application of a Human Tumor Colony Forming Assay to New Drug Screening

Application of a Human Tumor Colony Forming Assay to New Drug Screening
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 519
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Discovery

Drug Discovery
A History

by Walter Sneader

  • Publisher : John Wiley & Sons
  • Release : 2005-10-31
  • Pages : 472
  • ISBN : 0470015527
  • Language : En, Es, Fr & De
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Written by a leading authority with an excellent reputation and ability for writing a good narrative, Drug Discovery: A History is a far cry from simply a list of chemical structures. This lively new text considers the origins, development and history of medicines that generate high media interest and have a huge social and economic impact on society. Set within a wide historical, social and cultural context, it provides expanded coverage of pre-twentieth century drugs, the huge advances made in the twentieth century and the latest developments in drug research. Hallmark features: Up-to-the-minute information in drug research Vignettes of special and unusual information, and anecdotes Discusses drug prototypes from all sources More comprehensive than other volumes on history of drug discovery From the reviews: "...an excellent bibliographic resource for those interested in the background papers that serve as the foundation for discovery of specific drug entities." JOURNAL OF MEDICAL CHEMISTRY, June 2006 "...a very comprehensive overview of drug development. It should be on the shelf on any aspiring pharmacist, medicinal chemist, or person interested in the history of therapeutic agents." JOURNAL OF CHEMICAL EDUCATION, February 2006 "...a very readable and closely researched book..." CHEMISTRY & INDUSTRY, October 2005

Ectoparasites

Ectoparasites
Drug Discovery Against Moving Targets

by Charles Q. Meng,Ann E. Sluder

  • Publisher : John Wiley & Sons
  • Release : 2018-10-22
  • Pages : 376
  • ISBN : 3527341684
  • Language : En, Es, Fr & De
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This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.

Structure-based Drug Discovery

Structure-based Drug Discovery
An Overview

by R. E. Hubbard

  • Publisher : Royal Society of Chemistry
  • Release : 2006-01-01
  • Pages : 261
  • ISBN : 0854043519
  • Language : En, Es, Fr & De
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A collection of methods to determine and analyse the 3-D structure of biomolecules. These methods have been enhanced to improve the speed and quality of drug discovery.

Drug Discovery and Development

Drug Discovery and Development
Technology in Transition

by H. P. Rang,Daniel Vasella

  • Publisher : Churchill Livingstone
  • Release : 2006
  • Pages : 346
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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'Drug Discovery and Development' describes the huge complexities involved in bringing a drug to market and how new molecular understanding and techniques can make the process more targeted and successful.

Analogue-based Drug Discovery

Analogue-based Drug Discovery
A Book

by IUPAC,János Fischer,C. Robin Ganellin

  • Publisher : John Wiley & Sons
  • Release : 2006-12-13
  • Pages : 606
  • ISBN : 3527607498
  • Language : En, Es, Fr & De
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The first authoritative overview of past and current strategies for successful drug development by analog generation, this unique resource spans all important drug classes and all major therapeutic fields, including histamine antagonists, ACE inhibitors, beta blockers, opioids, quinolone antibiotics, steroids and anticancer platinum compounds. Of the 19 analog classes presented in detail, 9 are described by the scientists who discoverd them. The book includes a table of the most successful drug analogs as based on the IMS ranking and compares them in terms of chemical structure, mode of action and patentability.

Analogue-based Drug Discovery II

Analogue-based Drug Discovery II
A Book

by János Fischer,C. Robin Ganellin

  • Publisher : John Wiley & Sons
  • Release : 2010-08-24
  • Pages : 564
  • ISBN : 9783527632121
  • Language : En, Es, Fr & De
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Born out of a project of the IUPAC's committee on Medicinal Chemistry and Drug Development, this reference addresses past and current strategies for successful drug analog development, extending the previously published volume by nine new analog classes and eight case studies. Like its precursor, this volume also contains a general section discussing universally applicable strategies for analog discovery and development. Spanning a wide range of therapeutic fields and chemical classes, the two volumes together constitute the first systematic approach to drug analog development. Of interest to virtually every researcher working in drug discovery and pharmaceutical chemistry.

Carbohydrate-based Drug Discovery, 2 Volume Set

Carbohydrate-based Drug Discovery, 2 Volume Set
A Book

by Chi-Huey Wong

  • Publisher : John Wiley & Sons
  • Release : 2003-10-17
  • Pages : 980
  • ISBN : 9783527306329
  • Language : En, Es, Fr & De
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To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Computational Medicinal Chemistry for Drug Discovery

Computational Medicinal Chemistry for Drug Discovery
A Book

by Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare

  • Publisher : CRC Press
  • Release : 2003-12-17
  • Pages : 1169
  • ISBN : 9780203913390
  • Language : En, Es, Fr & De
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Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computa

Botanical Leads for Drug Discovery

Botanical Leads for Drug Discovery
A Book

by Bikarma Singh

  • Publisher : Springer Nature
  • Release : 2020-10-05
  • Pages : 468
  • ISBN : 9811559171
  • Language : En, Es, Fr & De
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Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Computational and Structural Approaches to Drug Discovery

Computational and Structural Approaches to Drug Discovery
Ligand-protein Interactions

by Robert M. Stroud,Janet Finer-Moore

  • Publisher : Royal Society of Chemistry
  • Release : 2008
  • Pages : 382
  • ISBN : 0854043659
  • Language : En, Es, Fr & De
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This insightful book represents the experience and understanding of the global experts in the field and spotlights both the structural and medicinal chemistry aspects of drug design. The need to 'encode' the physiological factors of pharmacology, a key area, is explored.

Drug Discovery and Clinical Research

Drug Discovery and Clinical Research
A Book

by SK Gupta

  • Publisher : JP Medical Ltd
  • Release : 2011-06-01
  • Pages : 668
  • ISBN : 9350252724
  • Language : En, Es, Fr & De
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The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same time, it has become challenging for all stakeholders to keep abreast with the explosion in information. The race for the finish-line leaves very little time for the researchers to update themselves and keep tabs on the latest developments in the industry. To meet these challenges, this book entitled Drug Discovery and Clinical Research has been compiled. All chapters have been written by stalwarts of the field who have their finger on the pulse of the industry. The aim of the book is to provide succinctly within one cover, an update on all aspects of this wide area. Although each of the chapter dealt here starting from drug discovery and development, clinical development, bioethics, medical devices, pharmacovigilance, data management, safety monitoring, patient recruitment, etc. are topics for full-fledged book in themselves, an effort has been made via this book to provide a bird’s eye view to readers and help them to keep abreast with the latest development despite constraints of time. It is hoped that the book will contribute to the growth of readers, which should translate into drug discovery and clinical research industry’s growth.

Translational Medicine

Translational Medicine
Molecular Pharmacology and Drug Discovery

by Robert A. Meyers

  • Publisher : John Wiley & Sons
  • Release : 2018-07-16
  • Pages : 1064
  • ISBN : 3527336591
  • Language : En, Es, Fr & De
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This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.

Drug Discovery Handbook

Drug Discovery Handbook
A Book

by Shayne C. Gad

  • Publisher : Wiley-Interscience
  • Release : 2005-07-11
  • Pages : 1471
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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THE FIRST COMPREHENSIVE GUIDE TO THE METHODS AND TECHNIQUES OF DRUG DISCOVERY The Drug Discovery Handbook gives professionals a tool to facilitate drug discovery by bringing together, for the first time in one resource, a compendium of methods and techniques that need to be considered when developing new drugs. This comprehensive, practical guide presents an explanation of the latest techniques and methods in drug discovery, including: Genomics, proteomics, high-throughput screening, and systems biology Summaries of how these techniques and methods are used to discover new central nervous system agents, antiviral agents, respiratory drugs, oncology drugs, and more Specific approaches to drug discovery, including problems that are encountered, solutions to these problems, and limitations of various methods and techniques The thorough coverage and practical, scientifically valid problem-solving approach of Drug Discovery Handbook will serve as an invaluable aid in the complex task of developing new drugs.

Basic Principles of Drug Discovery and Development

Basic Principles of Drug Discovery and Development
A Book

by Benjamin Blass

  • Publisher : Elsevier
  • Release : 2015-04-24
  • Pages : 580
  • ISBN : 012411525X
  • Language : En, Es, Fr & De
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Basic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property." Provides a clear explanation of how the pharmaceutical industry works Explains the complete drug discovery process, from obtaining a lead, to testing the bioactivity, to producing the drug, and protecting the intellectual propertyIdeal for anyone interested in learning about the drug discovery process and those contemplating careers in the industry Explains the transition process from academia or other industries