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Drug-Induced Liver Injury

Drug-Induced Liver Injury
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-07-13
  • Pages : 288
  • ISBN : 0128173173
  • Language : En, Es, Fr & De
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Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Drug-Induced Liver Disease

Drug-Induced Liver Disease
A Book

by Neil Kaplowitz,Laurie D. DeLeve

  • Publisher : Academic Press
  • Release : 2013-04-18
  • Pages : 776
  • ISBN : 0123878187
  • Language : En, Es, Fr & De
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This field has shown tremendous growth in recent years, primarily due to the recognition that drug-induced liver disease is the most common cause of liver failure and one of the major contributors to the withdrawal of drugs developed by the pharmaceutical industry. Drug-Induced Liver Disease, 3rd edition is a comprehensive reference that covers mechanisms of injury, diagnosis and management, major hepatotoxins, regulatory perspectives and much more. Written by highly respected authorities, this new edition is an updated and definitive reference for clinicians and scientists in academia, the pharmaceutical industry and government settings. This book contains 4 new chapters on key topics in the area and provides a current and extensive review of the latest developments concerning the toxicology, pharmacology, genetics and immunology of drug-induced liver disease. A multi-authored reference work written by leading clinical, academic and industry experts in drug-induced liver disease Contains four new chapters on key areas in the field, including one on worldwide drug-induced liver injury networks Each chapter has been updated to address the latest research and findings in the field and 16 new chapter authors have been added to this new edition Includes coverage of the basic, clinical and practical aspects of drug-induced liver disease to provide the single most comprehensive reference on the subject

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease,

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease,
A Book

by Nicholaos Pyrsopoulos

  • Publisher : Elsevier Health Sciences
  • Release : 2013-10-17
  • Pages : 298
  • ISBN : 0323261078
  • Language : En, Es, Fr & De
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Dr. Pyrsopolous has created a comprehensive review on the most important and timely topics in drug heptatotoxicity. He has arraanged for there to be a full span of very basic articles that discuss drug metabolism, hepatotoxicity, and drug-induced acute liver failure as well as other important articles devoted to clinical manifestations and treatment of drug induced hepatotoxicity; Pathological manifestations of drug induced hepatotoxicity; Drug induced cholestasis; Lipid lowering agents induced hepatotoxicity; Herbal ,complementary and alternative medicine induced liver injury; Antiretroviral and anti - HCV DAA related hepatotoxicity; Antibiotic related hepatotoxicity; Acetaminophen related hepatoxicity; NSAIDS induced hepatoxocity; Chemotherapy induced hepatotoxicity; Anti epileptic induced hepatotoxicity; and steatohepatitis induced by drugs.

Drug-Induced Hepatotoxicity

Drug-Induced Hepatotoxicity
A Book

by Ross Cameron,George Feuer,Felix de la Iglesia

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 681
  • ISBN : 3642610137
  • Language : En, Es, Fr & De
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The advances in science and medicine we are now experiencing are unprec edented and exciting. Life expectancy is prolonged, and quality of life is much improved. We learn of fabulous new discoveries made at the bench or the bedside every week. Many diseases have been totally eliminated, others can be significantly improved by new therapeutic formulations. Much of the success can be attributed to a better understanding of disease processes and the specific targeting of new and more effective medications. As is the case in many areas of successful human endeavour, there can be a downside. In the case of drugs and chemicals it is their adverse effects which are of concern. Of course, every effort is made to devise medications that are safe, and the need to elucidate and understand mechanisms are crucial, yet adverse effects remain a problem. They can be unpredictable and diverse. Drugs have been shown to induce virtually the whole gamut of human liver pathology from acute fulminant hepatitis to chronic active hepatitis to cirrho sis and even malignancy. Hence the possibility of adverse drug effects must be considered in the differential diagnosis of many patients with liver disease. This is well recognized and is very important; indeed, removal of the offending agent can often lead to reversal of the adverse effect. This is an area of hepatology where we can really make a difference.

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease, E-Book

Drug Hepatotoxicity, An Issue of Clinics in Liver Disease, E-Book
A Book

by Vinod Rustgi

  • Publisher : Elsevier Health Sciences
  • Release : 2016-11-16
  • Pages : 276
  • ISBN : 0323496628
  • Language : En, Es, Fr & De
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Dr. Rustgi has assembled the leading experts in the management of Heptatitis B to present the current treatment and clinical course for diagnosis and management of the disease. Articles are devoted to: Drug metabolism in the liver; Mechanism of Liver Damage including the RUCAM scale; Drug-induced acute liver failure; Epidemiology and genetic risk factors; Adverse drug reactions: type A (intrinsic or pharmacological) or type B (idiosyncratic); Pathology of injury including phenotypes; The clinical course of drug-induced liver disease; Environmental factors of drug hepatotoxicity; Newer agents in drug hepatotoxicity; Drug hepatotoxicity: herbal products; Drug hepatotoxicity: models including “human on a chip and zebrafish; Acute and chronic liver failure from drugs: impact on the kidney; and Management of acute hepatotoxicity including medical agents and liver support systems. Readers will come away with the cutting edge science behind the latest innovations in the treatment of Hepatitis B.

Drug-induced Liver Disease

Drug-induced Liver Disease
A Book

by Hyman J. Zimmerman

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 79
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Hepatotoxicity,An Issue of Clinics in Liver Disease, E-Book

Drug Hepatotoxicity,An Issue of Clinics in Liver Disease, E-Book
A Book

by Pierre Gholam

  • Publisher : Elsevier Health Sciences
  • Release : 2019-12-03
  • Pages : 240
  • ISBN : 0323708587
  • Language : En, Es, Fr & De
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In collaboration with Consulting Editor, Dr. Norman Gitlin, Dr. Pierre Gholam has put together topics that provide a current clinical update on the treatment and management of patients with drug-induced liver injury (DILI). Expert authors have contributed clinical review articles on the following topics: Epidemiology, Predisposing Factors and Outcomes; Genetic Predisposition to DILI; Causality Assessment Frequent Offenders and Patterns of Injury; Quantitative Systems Toxicology Approaches to Understand and Predict DILI; Liver Histology: Diagnostic and Prognostic Features; Acute Liver Failure Secondary to DILI; DILI in Persons with Pre-existing Chronic Liver Disease; DILI in the Setting of Statin Use; DILI in the Setting of Analgesic Use; DILI Secondary to Herbals and Dietary Supplements; and DILI Reporting and Resources for the Clinician. Readers will come away with the information they need to improve outcomes in patients with DILI.

Drug-induced Liver Disease

Drug-induced Liver Disease
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 191
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug-Induced Liver Disease

Drug-Induced Liver Disease
A Book

by Neil Kaplowitz

  • Publisher : CRC Press
  • Release : 2002-10-16
  • Pages : 784
  • ISBN : 0203909127
  • Language : En, Es, Fr & De
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Featuring more than 4100 references, Drug-Induced Liver Disease will be an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines.

Drug-induced Liver Disease

Drug-induced Liver Disease
A Book

by Geoffrey C. Farrell

  • Publisher : W.B. Saunders Company
  • Release : 1994-01-01
  • Pages : 673
  • ISBN : 9780443043680
  • Language : En, Es, Fr & De
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Liver disease induced by drugs poses many challenging problems to all who have to deal with them. This book should help the reader to understand, diagnose, treat and ultimately prevent, hepatic drug reactions. The book brings together all that is currently known about drug-induced liver disease in a format which is explanatory as well as comprehensive.

Drug Hepatoxicity

Drug Hepatoxicity
An Issue of Clinics in Liver Disease

by William M. Lee

  • Publisher : Saunders
  • Release : 2007-08-01
  • Pages : 683
  • ISBN : 9781416050506
  • Language : En, Es, Fr & De
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Drug hepatotoxicity is one of the current hot topics in hepatology and internal medicine for that matter. In the last 5 years, two drugs have been withdrawn for significant liver injury causing death or need for transplantation; additionally, others have not been approved and several have had black box warning labels placed due to concerns that the risk is small but significant for harmful outcomes. The present volume is intended to review our current understanding of the principles underlying our understanding of the problems associated with drug-related liver injury: what the pathogenetic mechanism are, how the condition is diagnosed, what drugs are associated with drug-induced liver injury and how these conditions present. The reader should be well-advised that there are few absolutes in this area and a lot of opinion but as we know more, we can be more careful about using drugs in our everyday practice of the best of 21st century medicine. This is a volume for anyone who regularly prescribes drugs for his/her patients and who is concerned enough to wish to avoid pitfalls in doing so.

Drug-induced Liver Disease

Drug-induced Liver Disease
A Book

by James H. Lewis

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 11
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecules, Systems and Signaling in Liver Injury

Molecules, Systems and Signaling in Liver Injury
A Book

by Wen-Xing Ding,Xiao-Ming Yin

  • Publisher : Springer
  • Release : 2017-08-02
  • Pages : 290
  • ISBN : 3319581066
  • Language : En, Es, Fr & De
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This essential volume presents comprehensive information on cell death and autophagy in liver diseases, including the role and molecular signaling pathways of cell death in alcohol and non-alcoholic fatty liver disease, bile acids, hepatitis C virus and drug-induced liver injury. The book starts with a discussion of lipotoxicity in non-parenchymal cells, followed by a discussion of cell death and autophagy in cholangiocytes, hepatic stellate cells and Kupffer cells in hepatic biliary diseases, fibrosis and liver inflammation. The book also covers Bcl-2 family proteins, beta-catenin and HMGB1 signaling in regulating cell death in the liver as well as mitochondria, ER stress and gut microbiota on liver injury. The Cell Death in Biology and Diseases series has recruited world experts ranging from basic scientists to clinicians on cell death in liver diseases. Likewise the contributors of this volume are leaders in their fields with worldwide expertise and perspective. Molecul es, Systems and Signaling in Liver Injury is an essential companion to Hepatocytes and Non-Parenchymal Cells and Diseases. It is beneficial for both clinicians and basic scientists and is relevant to those working on drug discovery for preventing and treating liver diseases by targeting cell death and autophagy pathways.

Drug-Induced Liver Disease, Second Edition

Drug-Induced Liver Disease, Second Edition
A Book

by Neil Kaplowitz,Laurie D. DeLeve

  • Publisher : CRC Press
  • Release : 2007-07-10
  • Pages : 816
  • ISBN : 9780849398964
  • Language : En, Es, Fr & De
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Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable reference for gastroenterologists, hepatologists, family physicians, internists, pathologists, pharmacists, pharmacologists, and clinical toxicologists, and graduate and medical school students in these disciplines. This book supplies an in-depth discussion of drug-induced hepatoxicology, covering mechanisms, histopathology, management, risk factors, and patterns of drug and toxin-induced disease. It includes contributions international experts.

Acute Liver Failure, an Issue of Clinics in Liver Disease

Acute Liver Failure, an Issue of Clinics in Liver Disease
A Book

by Nikolaos T. Pyrsopoulos

  • Publisher : Elsevier
  • Release : 2018-04-03
  • Pages : 14
  • ISBN : 9780323583602
  • Language : En, Es, Fr & De
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Dr. Pyrsopoulos has assembled the top authors in the field to provide current reviews on acute liver failure, to be the first time this topic is addressed in one volume. Topics are devoted to Classification and Epidemiologic Aspects of Acute Liver Failure; Acute Liver Failure: Mechanisms of disease and multi-systemic involvement; The Pathology of Acute Liver Failure; Liver Regeneration in the Acute Liver Failure Patient; Viral Hepatitis and Acute Liver Failure: Still a Problem; Drug- induced Liver Injury and Acute Liver Failure; Acetaminophen and Acute Liver Failure; Non-Viral Or Drug-Induced Etiologies of Acute Liver Failure; The Clinical Spectrum and Manifestations of Acute Liver Failure; Non ICU Management of Acute Liver Failure; Management of Acute Liver Failure in the ICU Setting; Prognostic Models of Acute Liver Failure; The Role of Liver Transplantation in Acute Liver Failure; and Future Approaches and Therapeutic Modalities for Acute Liver Failure. Readers will come away with a current point of view about how to approach and manage the patient with acute liver failure.

Fact Sheet, Drug-induced Liver Injury Database (LiverTox)

Fact Sheet, Drug-induced Liver Injury Database (LiverTox)
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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LiverTox provides comprehensive information about liver injury caused by prescription and nonprescription drugs, herbals and dietary supplements. LiverTox provides guidance to healthcare providers on the diagnosis and management of this important cause of liver disease. LiverTox also provides a central repository of information in support of clinical and basic research on the prevention and control of drug-induced liver injury.

Hepatotoxicity

Hepatotoxicity
The Adverse Effects of Drugs and Other Chemicals on the Liver

by Hyman J. Zimmerman

  • Publisher : Lippincott Williams & Wilkins
  • Release : 1999
  • Pages : 789
  • ISBN : 9780781719520
  • Language : En, Es, Fr & De
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Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Liver Disease

Liver Disease
A Clinical Casebook

by Stanley Martin Cohen,Perica Davitkov

  • Publisher : Springer
  • Release : 2018-12-18
  • Pages : 311
  • ISBN : 331998506X
  • Language : En, Es, Fr & De
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This clinical casebook provides a concise yet comprehensive state-of-the-art review of liver disease. Presented in a case-based format, each case features a scenario centered on a different variant of liver disease, with sections on case history, diagnosis/assessment, treatment, outcomes, alternative approaches, and clinical pearls. Diseases covered include drug-induced liver injury, acute hepatitis, chronic hepatitis, NAFLD, and cholangitis. Scenarios such as liver disease in pregnancy, elevated liver function tests, and liver transplants are also presented in the casebook. Written by experts in the field, Liver Disease: A Clinical Casebook is a valuable resource for clinicians and practitioners who treat patients with liver disease.

Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury

Investigation of the Mechanism of Idiosyncratic Drug-induced Liver Injury
A Book

by Imir G. Metushi

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Development of a Spheroid Model to Investigate Drug-induced Liver Injury

Development of a Spheroid Model to Investigate Drug-induced Liver Injury
A Book

by H. Gaskell

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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