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Drug Repurposing in Cancer Therapy

Drug Repurposing in Cancer Therapy
Approaches and Applications

by Kenneth K.W. To,William C.S. Cho

  • Publisher : Academic Press
  • Release : 2020-07-29
  • Pages : 458
  • ISBN : 0128199032
  • Language : En, Es, Fr & De
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Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Multiple Myeloma as an Example of Drug Repurposing for Cancer Treatment

Multiple Myeloma as an Example of Drug Repurposing for Cancer Treatment
Matura Paper

by Charlotte Driessen

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Repurposing

Drug Repurposing
Hypothesis, Molecular Aspects and Therapeutic Applications

by Farid A. Badria

  • Publisher : BoD – Books on Demand
  • Release : 2020-12-02
  • Pages : 234
  • ISBN : 1839685204
  • Language : En, Es, Fr & De
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Drug repurposing or drug repositioning is a new approach to presenting new indications for common commercial and clinically approved existing drugs. For example, chloroquine, an old antimalarial drug, showed promising results for treating COVID-19, interfering with MDR in several types of cancer, and chemosensitizing human leukemic cells.This book focuses on the hypothesis, risk/benefits, and economic impacts of drug repurposing on drug discovery in dermatology, infectious diseases, neurological disorders, cancer, and orphan diseases. It brings together up-to-date research to provide readers with an informative, illustrative, and easy-to-read book useful for students, clinicians, and the pharmaceutical industry.

Cracking Cancer Toolkit

Cracking Cancer Toolkit
Using Repurposed Drugs for Cancer Treatment

by Jeffrey Dach

  • Publisher : Unknown Publisher
  • Release : 2020-10
  • Pages : 584
  • ISBN : 9781732421011
  • Language : En, Es, Fr & De
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After three family members were stricken with aggressive cancer, I realized I had to get up to speed on the jargon of cancer research, and devise my own cancer toolkit of repurposed drugs and supplements if I wanted my loved ones to survive. This book is a record of that journey as we explore "Cancer as a Metabolic Disease" and the repurposed drugs and supplements targeting metabolic pathways for eradication of cancer stem cells. The problem is not about finding the one elusive anti-cancer drug or botanical substance. The problem is that we have too many anti-cancer substances to choose from. How do we narrow down the list and use them in an effective combination? Hopefully, this book will give you the information needed to select a few key repurposed drugs and supplements to target Cancer Stem Cells and the important metabolic pathways in a synergistic manner, resulting in the desired curative efficacy. -Jeffrey Dach, MDExcerpt from Foreword by Carol Petersen, RPh, CNP: Dr. Jeffrey Dach found himself face to face with serious cancer challenges to family members. His training in radiology gave him a platform to launch his investigation and he worked tirelessly to find information that could change a deadly outcome. His searches cover 5 years of study. He investigated practitioners and scientists who might have insights. In the end, his family members had successful outcomes. He has decided to share the information he accumulated. "Cracking Cancer Toolbox" is not a protocol nor recipe for success for any particular cancer. It is however, a gateway to learning much more about cancer than the average oncologist will relate to their patients. Knowledge is power. Reading this book and keeping it as a reference will open doors to learning new theories and potential therapies. Many therapies already exist but have been unused because of strict adherence to the narrative. Dr. Dach presents us with the gift of translation. His writing is clear and understandable. We don't have to have a PhD or medical degree to grasp concepts that come cloaked in medical jargon. This compilation of cancer information is a great work. He sends it into the world so many more can benefit. - Carol Petersen, RPh, CNPExcerpt from Foreword by Akbar Khan, MD: And now we have Dr. Jeffrey Dach's book, Cracking Cancer Toolkit, which explains the metabolic theory of cancer and other novel theories in a comprehensible writing style, understandable to the non-medical reader. Given how common cancer is today, this book is a valuable addition to any home library. Indeed, the knowledge you gain may save your life, or the life of a friend or family member. - Akbar Khan, MD About the Author: Jeffrey Dach, MD is a practicing physician, originally board certified in Diagnostic and Interventional Radiology. In 2005, Dr Dach retired from radiology and resumed outpatient clinical medicine in a small office in Davie, Florida. He is the author of Heart Book, Bioidentical Hormones 101 and Natural Medicine 101. He is co-author of Stop the Thyroid Madness Vol.2. Dr. Dach lives in Hollywood, Florida, and is married, with three adult married children, and three grandchildren. His web sites are www.jeffreydachmd.com and www.crackingcancertoolkit.com.

Drug Repositioning: Current Advances and Future Perspectives

Drug Repositioning: Current Advances and Future Perspectives
A Book

by Yuhei Nishimura,Hideaki Hara

  • Publisher : Frontiers Media SA
  • Release : 2019-01-11
  • Pages : 329
  • ISBN : 288945696X
  • Language : En, Es, Fr & De
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Drug repositioning is the process of identifying new indications for existing drugs. At present, the conventional de novo drug discovery process requires an average of about 14 years and US$2.5 billion to approve and launch a drug. Drug repositioning can reduce the time and cost of this process because it takes advantage of drugs already in clinical use for other indications or drugs that have cleared phase I safety trials but have failed to show efficacy in the intended diseases. Historically, drug repositioning has been realized through serendipitous clinical observations or improved understanding of disease mechanisms. However, recent technological advances have enabled a more systematic approach to drug repositioning. This eBook collects 16 articles from 112 authors, providing readers with current advances and future perspectives of drug repositioning.

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
A Book

by Claudiu Supuran,Simone Carradori

  • Publisher : Academic Press
  • Release : 2020-09-15
  • Pages : 228
  • ISBN : 0128209283
  • Language : En, Es, Fr & De
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pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Genetic Engineering & Biotechnology News

Genetic Engineering & Biotechnology News
GEN.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Oxidative Stress

Oxidative Stress
Human Diseases and Medicine

by Canhua Huang,Yuanyuan Zhang

  • Publisher : Springer Nature
  • Release : 2021-05-27
  • Pages : 323
  • ISBN : 981160522X
  • Language : En, Es, Fr & De
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This book offers a systematic review of the cutting-edge knowledge in stress medicine. Cellular redox imbalance, resulting from overproduction of reactive oxide species (ROS), leads to oxidative stress and subsequent occurrence and development of many diseases, such as cancer, diabetes, pain, etc. In addition, ROS can induce post-translational modification of proteins and play roles through redox signaling pathways. In this book, the authors attempt to re-define the key concepts in oxidative stress, such as oxidative eustress and oxidative distress, revisit the pivotal signaling of oxidative stress in human diseases, and discuss the debate in current anti-oxidant strategies, such as natural products and drug repurposing. This book serves as a reference to graduate students and researchers in this growing field.

Prostate Cancer Metabolism

Prostate Cancer Metabolism
From Biochemistry to Therapeutics

by Tomas Koltai,Stephan J. Reshkin,Fatima Baltazar,Larry Fliegel

  • Publisher : Academic Press
  • Release : 2021-07-01
  • Pages : 200
  • ISBN : 032390551X
  • Language : En, Es, Fr & De
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Prostate Cancer Metabolism: From Biochemistry to Therapeutics shows the peculiarities of prostate cancer metabolism, emphasizing the targetable aspects – that have not been considered in conventional treatment protocols. The book specifically addresses treatment of the castration-resistant stage of prostate cancer proposing many repurposed drugs and nutraceuticals to complement, not replace, standard therapies. The large body of evidence supporting these concepts makes them deserving of further research and well-designed clinical trials. It discusses lipid, cholesterol, glutamine, and glucose metabolisms and their impact on prostate cancer. Additionally, it explains how current established drugs can be repurposed to improve treatment outcomes. The concepts set out in the book, that deal with cancer at the cellular/molecular level, help identify new avenues of research and treatments to pursue that do not affect well-being whilst offer consistent benefits. Since most practicing physicians have not studied basic biochemistry since medical school, each chapter begins with a brief review of the topic to facilitate an understanding of the metabolically-oriented approach to targeting prostate cancer. Conventional treatments are not discussed here since they are covered in textbooks and specialized updates that abound in the medical literature. It is a valuable resource for cancer researchers, oncologists, clinicians and members of biomedical field who want to learn more about prostate cancer metabolism and how to apply recent findings in the field to bedside. Explains the basic aspects of prostate cancer metabolism, including its biochemistry which has a pivotal role in clinical practice Discusses new drugs and nutraceuticals with a metabolism-centered approach Offers practical bedside approach in combination with molecular and biochemical fundamentals to help readers identify and provide the best treatment to their patients

Drug Repositioning

Drug Repositioning
Bringing New Life to Shelved Assets and Existing Drugs

by Michael J. Barratt,Donald E. Frail

  • Publisher : John Wiley & Sons
  • Release : 2012-05-29
  • Pages : 477
  • ISBN : 0470878274
  • Language : En, Es, Fr & De
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With Viagra the most famous example, drug repositioning has been growing in importance for pharmaceutical companies seeking to reinvigorate development pipelines. This book provides a broad overview of drug repositioning including the business reasons and unique opportunities and challenges. Its coverage also presents a number of current and emerging technologies that are being applied, along with relevant case studies, as well as neglected diseases to consider. Pharmaceutical researchers will learn how to use drug repositioning techniques to increase the lifespan and applications of their drugs, and also decrease both costs and development time.

Resistance to Targeted Therapies Against Adult Brain Cancers

Resistance to Targeted Therapies Against Adult Brain Cancers
A Book

by Amanda Tivnan

  • Publisher : Springer
  • Release : 2016-11-26
  • Pages : 260
  • ISBN : 3319465058
  • Language : En, Es, Fr & De
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This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.

Current Applications for Overcoming Resistance to Targeted Therapies

Current Applications for Overcoming Resistance to Targeted Therapies
A Book

by Myron R. Szewczuk,Bessi Qorri,Manpreet Sambi

  • Publisher : Springer
  • Release : 2019-07-15
  • Pages : 320
  • ISBN : 303021477X
  • Language : En, Es, Fr & De
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Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.

The Unfolded Protein Response in Cancer

The Unfolded Protein Response in Cancer
A Book

by Robert Clarke

  • Publisher : Springer
  • Release : 2019-03-01
  • Pages : 220
  • ISBN : 303005067X
  • Language : En, Es, Fr & De
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This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
A Book

by John B. Taylor,D. J. Triggle

  • Publisher : Elsevier Science Ltd
  • Release : 2007
  • Pages : 7200
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Cardiovascular and Pulmonary Physical Therapy, Third Edition

Cardiovascular and Pulmonary Physical Therapy, Third Edition
A Book

by William DeTurk,Lawerence Cahalin

  • Publisher : McGraw Hill Professional
  • Release : 2018-01-12
  • Pages : 800
  • ISBN : 1259837963
  • Language : En, Es, Fr & De
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A comprehensive, up-to-date textbook spanning the entire scope of cardiovascular and pulmonary practice A Doody’s Core Title for 2019! Cardiovascular and Pulmonary Physical Therapy, Third Edition reflects the broadest possible spectrum of cardiovascular and pulmonary practice and draws upon the expertise of a carefully selected team of world-renowned contributors. This internationally acclaimed text reviews must-know background knowledge, thoroughly explains exercise principles, cites the best evidence, and integrates the American Physical Therapy Association’s approved practice patterns into the chapter content. Learn how to apply principles to practice in any setting with: • The Guide to Physical Therapy Practice integrated throughout, with an entire chapter devoted to its history and use • Preferred practice patterns for cardiovascular and pulmonary physical therapy form the core of eight chapters are used as springboards to describe interventions and outcomes • Case studies in practice pattern chapters allow you to experience the proper application of the practice patterns • The patient-client management model is used in the case studies with appropriate test, measures, and interventions selected from the practice patterns and applied to the patient • “International Perspectives” provide a way to gain insight into the global practice of physical therapy • Evidence-based and peer reviewed published material is included to help you develop specific intervention regimens • Online access to case-based exercises, video clips illustrating technical psychomotor skills, and demonstrations of cardiac and pulmonary physical exams

Pacific Symposium on Biocomputing

Pacific Symposium on Biocomputing
A Book

by Russ B. Altman,A. Keith Dunker,Lawrence Hunter,Tiffany Murray,Marylyn D. Ritchie

  • Publisher : World Scientific Publishing Company Incorporated
  • Release : 2013-11-19
  • Pages : 426
  • ISBN : 9789814596343
  • Language : En, Es, Fr & De
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Cancer panomics: Computational methods and infrastructure for integrative analysis of cancer high-throughput "OMICS" data. Session introduction / Soren Brunak ... [et al.] -- Tumor haplotype assembly algorithms for cancer genomics / Derek Aguiar, Wendy S.W. Wong, Sorin Istrail -- Extracting significant sample-specific cancer mutations using their protein interactions / Liviu Badea -- The stream algorithm: Computationally efficient ridge-regression via Bayesian model averaging, and applications to pharmacogenomic prediction of cancer cell line sensitivity / Elias Chaibub Neto ... [et al.] -- Sharing information to reconstruct patient-specific pathways in heterogeneous diseases / Anthony Gitter ... [et al.] -- Detecting statistical interaction between somatic mutational events and germline variation from next-generation sequence data / Hao Hu, Chad D. Huff -- Systematic assessment of analytical methods for drug sensitivity prediction from cancer cell line data / In Sock Jang ... [et al.] -- Integrative analysis of two cell lines derived from a non-small-lung cancer patient - A panomics approach / Oleg Mayba ... [et al.] -- An integrated approach to blood-based cancer diagnosis and biomarker discovery / Martin Renqiang Min ... [et al.] -- Multiplex meta-analysis of medulloblastoma expression studies with external controls / Alexander A. Morgan ... [et al.] -- Computational approaches to drug repurposing and pharmacology. Session introduction / S. Joshua Swamidass ... [et al.] -- Challenges in secondary analysis of high throughput screening data / Aurora S. Blucher, Shannon K. McWeeney -- Drug intervention response predictions with paradigm (DIRPP) identifies drug resistant cancer cell lines and pathway mechanisms of resistance / Douglas Brubaker ... [et al.] -- Anti-infectious drug repurposing using an integrated chemical genomics and structural systems biology approach / Clara Ng ... [et al.] -- Drug-target interaction prediction by integrating chemical, genomic, functional and pharmacological data / Fan Yang, Jinbo Xu, Jianyang Zeng -- Prediction of off-target drug effects through data fusion / Emmanuel R. Yera, Ann E. Cleves, Ajay N. Jain -- Exploring the pharmacogenomics knowledge base (PharmGKB) for repositioning breast cancer drugs by leveraging web ontology language (OWL) and cheminformatics approaches / Qian Zhu ... [et al.] -- Detecting and characterizing pleiotropy: New methods for uncovering the connection between the complexity of genomic architecture and multiple phenotypes. Session introduction / Anna L. Tyler, Dana C. Crawford, Sarah A. Pendergrass -- Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene / Christian Darabos, Samantha H. Harmon, Jason H. Moore -- Environment-wide association study (EWAS) for type 2 diabetes in the Marshfield personalized medicine research project biobank / Molly A. Hall ... [et al.] -- Dissection of complex gene expression using the combined analysis of pleiotropy and epistasis / Vivek M. Philip, Anna L. Tyler, Gregory W. Carter -- Personalized medicine: From genotypes and molecular phenotypes towards therapy. Session introduction / Jennifer Listgarten ... [et al.] -- PATH-SCAN: A reporting tool for identifying clinically actionable variants / Roxana Daneshjou ... [et al.] -- Imputation-based assessment of next generation rare exome variant arrays / Alicia R. Martin ... [et al.] -- Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients/ Matthew Oetjens ... [et al.] -- Robust reverse engineering of dynamic gene networks under sample size heterogeneity / Ankur P. Parikh, Wei Wu, Eric P. Xing -- Variant priorization and analysis incorporating problematic regions of the genome / Anil Patwardhan ... [et al.] -- Bags of words models of epitope sets: HIV viral load regression with counting grids / Alessandro Perina, Pietro Lovato, Nebojsa Jojic -- Joint association discovery and diagnosis of Alzheimer's disease by supervised heterogeneous multiview learning / Shandian Zhe ... [et al.] -- Text and data mining for biomedical discover. Session introduction / Graciela H. Gonzalez ... [et al.] -- Vector quantization kernels for the classification of protein sequences and structures / Wyatt T. Clark, Predrag Radivojac -- Combining Heterogenous data for prediction of disease related and pharmacogenes / Christopher S. Funk, Lawrence E. Hunter, K. Bretonnel Cohen -- A novel profile biomarker diagnosis for mass spectral proteomics / Henry Han -- Towards pathway curation through literature mining - A case study using PharmGKB / Ravikumar K.E., Kavishwar B. Wagholikar, Hongfang Liu -- Sparse generalized functional linear model for predicting remission status of depression patients / Yashu Liu ... [et al.] -- Development of a data-mining algorithm to identify ages at reproductive milestones in electronic medical records / Jennifer Malinowski, Eric Farber-Eger, Dana C. Crawford -- An efficient algorithm to integrate network and attribute data for gene function prediction / Shankar Vembu, Quaid Morris -- Matrix factorization-based data fusion for gene function prediction in Baker's yeast and slime mold / Marinka Zitnik, Blaz Zupan -- Workshops. Applications of bioinformatics to non-coding RNAs in the era of next-generation sequencing / Chao Cheng, Jason Moore, Casey Greene -- Building the next generation of quantitative biologists / Kristine A. Pattin ... [et al.] -- Uncovering the etiology of autism spectrum disorders: Genomics, bioinformatics, environment, data collection and exploration, and future possibilities / Sarah A. Pendergrass, Santhosh Girirajan, Scott Selleck

Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms

Developmental Epilepsy: From Clinical Medicine To Neurobiological Mechanisms
A Book

by Stafstrom Carl E,Velisek Libor

  • Publisher : World Scientific
  • Release : 2019-06-24
  • Pages : 436
  • ISBN : 9813277742
  • Language : En, Es, Fr & De
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This is a collection of chapters from renowned authors focused on the contemporary issues in developmental epilepsy, from both clinical and basic science perspectives. Developmental epilepsy (or epilepsy syndromes), while receiving much more attention than 20 years ago, is still not well understood. This lag in research is reflected in the challenges of treating developmental epilepsy. The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy.The book is introduced by a chapter on brain development to provide a background for understanding when and how seizures and epilepsy can emerge. Recent clinical research indicates strong relationship between childhood epilepsy and developmental cognitive impairment. This connection can be studied in experimental animals and can uncover developmental mechanisms common to both conditions. Targeting those mechanisms might reveal disease-modifying treatments. Febrile seizures are very common in the pediatric population and their impact on further epilepsy development is explored. The link between immunity, inflammation and epileptogenesis in the developing brain is explored. Many developmental epilepsies arise from brain malformations or neuronal migration deficits; some juvenile epilepsies have a clear genetic basis while the etiology of others is less certain. Recently, the involvement of the mTOR pathway in certain childhood epilepsy syndromes was recognized, prompting the repurposing of drugs used in cancer treatment for therapy of these specific epilepsy syndromes. Steroid hormones have significant hormonal effects on neurotransmitter receptors and function, and therefore have an impact on childhood epilepsy; sex steroids may have long term organizational effects on brain structure and epilepsy development. Stress, even early in development, may affect the developing brain and lead to behavioral changes as well as increased susceptibility to seizures.

An Innovative Approach to Understanding and Treating Cancer: Targeting pH

An Innovative Approach to Understanding and Treating Cancer: Targeting pH
From Etiopathogenesis to New Therapeutic Avenues

by Tomas Koltai,Stephan J. Reshkin,Salvador Harguindey

  • Publisher : Academic Press
  • Release : 2020-01-16
  • Pages : 574
  • ISBN : 0128190604
  • Language : En, Es, Fr & De
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An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

Bioinformatics and Biomedical Engineering

Bioinformatics and Biomedical Engineering
7th International Work-Conference, IWBBIO 2019, Granada, Spain, May 8-10, 2019, Proceedings

by Ignacio Rojas,Olga Valenzuela,Fernando Rojas,Francisco Ortuño

  • Publisher : Springer
  • Release : 2019-06-13
  • Pages : 527
  • ISBN : 3030179389
  • Language : En, Es, Fr & De
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The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019. The total of 97 papers presented in the proceedings, was carefully reviewed and selected from 301 submissions. The papers are organized in topical sections as follows: Part I: High-throughput genomics: bioinformatics tools and medical applications; omics data acquisition, processing, and analysis; bioinformatics approaches for analyzing cancer sequencing data; next generation sequencing and sequence analysis; structural bioinformatics and function; telemedicine for smart homes and remote monitoring; clustering and analysis of biological sequences with optimization algorithms; and computational approaches for drug repurposing and personalized medicine. Part II: Bioinformatics for healthcare and diseases; computational genomics/proteomics; computational systems for modelling biological processes; biomedical engineering; biomedical image analysis; and biomedicine and e-health.

Drug Delivery Strategies for the Treatment of Advanced Lung Cancer and Various Lung Metastases

Drug Delivery Strategies for the Treatment of Advanced Lung Cancer and Various Lung Metastases
A Book

by Elizabeth Bielski

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 248
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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We describe the development mitochondrial-targeted dendrimer nanocarriers (DNCs) as a platform for the repurposing of chemotherapeutics, the development of siRNA/TPP-DNC complexes (TPP-dendriplexes) as a platform for pulmonary delivery of siRNAs, the development of asymmetric dendrimers with a chemotherapeutic and varying surface functionalities to enhance tumor targeting and penetration, and address the impact of local pulmonary administration of tumor associated macrophage (TAM)-targeting immunotherapy. Overall, we conclude that all these strategies described above have the potential capability to address issues resulting from MDR and for the treatment of primary and secondary lung tumors.