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Dyneins

Dyneins
The Biology of Dynein Motors

by Stephen M. King

  • Publisher : Academic Press
  • Release : 2017-11-22
  • Pages : 684
  • ISBN : 0128097027
  • Language : En, Es, Fr & De
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Dyneins: The Biology of Dynein Motors, Second Edition, offers a broad view of dyneins from structure, composition and organization, to biology of dynein function in both cytoplasm and cilia. As the second book in a pair on this topic, these works provide an overview of dyneins, from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics and the consequences of defects for human biology, disease and development. This second edition is extensively revised, with coverage expanded from 24 to 42 chapters. Much of the expanded coverage occurs in Volume Two on dynein dysfunction and disease, such as the role of dynein and cancer, while Volume One covers the history and evolution of dyneins, dyneins in ciliary biology and cytoplasmic dynein biology. Presents a broad-based, up-to date view of the biology of dynein motors Discusses approaches from genetics, molecular biology, biochemistry and biophysics Includes a companion website with movies of dynamic cell behavior Covers the topic in comprehensive chapters written by world experts

Dyneins

Dyneins
Dynein Mechanics, Dysfunction, and Disease

by Stephen M. King

  • Publisher : Academic Press
  • Release : 2017-11-28
  • Pages : 530
  • ISBN : 0128097019
  • Language : En, Es, Fr & De
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Dyneins: Structure, Biology and Disease, Second Edition, offers a broad view of dyneins mechanics, dysfunction, and disease, providing an overview of dyneins from structure and function, to dysfunction and disease. Since the first edition, enormous strides have been taken in understanding dynein structure, its organization in the axoneme, single molecule motor mechanics, and the consequences of defects for human biology, disease, and development. To account for these enormous strides, the second edition is extensively revised. Additionally, the coverage has expanded from 24 to 42 chapters, and is now housed in two volumes. Much of the expanded coverage occurs in Volume 2 which focuses on dynein dysfunction and disease, such as the role of dynein and cancer. Volume 1 covers the history and evolution of dyneins, dyneins in ciliary biology, and cytoplasmic dynein biology, while Volume 2 covers the structure and mechanics of dynein motors and dynein dysfunction and disease. Presents a broad-based and up-to date view of dynein mechanics, dysfunction, and disease Contains approaches from genetics, molecular biology, biochemistry, and biophysics discussed Provides companion website with movies of dynamic cell behavior Includes extensive chapters written by leading, global experts

Dyneins

Dyneins
Structure, Biology and Disease

by Stephen M. King,King M. Stephen

  • Publisher : Academic Press
  • Release : 2011
  • Pages : 639
  • ISBN : 0123820049
  • Language : En, Es, Fr & De
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With an accompanying Web site showing more than 100 streaming videos of cell dynamic behavior for best comprehension of material, "Dyneins" is the only reference covering the structure, biology, and application of dynein research to human disease. From bench to bedside, this book offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics, and medicine.

Dyneins—Advances in Research and Application: 2012 Edition

Dyneins—Advances in Research and Application: 2012 Edition
ScholarlyPaper

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-26
  • Pages : 27
  • ISBN : 1481626094
  • Language : En, Es, Fr & De
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Dyneins—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Dyneins in a compact format. The editors have built Dyneins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dyneins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dyneins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of Dynein (Second Edition)

Handbook of Dynein (Second Edition)
A Book

by Keiko Hirose

  • Publisher : CRC Press
  • Release : 2019-05-28
  • Pages : 420
  • ISBN : 0429667434
  • Language : En, Es, Fr & De
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Dyneins are molecular motors that are involved in various cellular processes, such as cilia and flagella motility, vesicular transport, and mitosis. Since the first edition of this book was published in 2012, there has been a significant breakthrough: the crystal structures of the motor domains of cytoplasmic dynein have been solved and the previously unknown details of this huge and complex molecule have been unveiled. This new edition contains 14 chapters written by researchers in the US, Europe, and Asia, including 3 new chapters that incorporate new fields. The other chapters have also been substantially updated. Compared with the earlier edition, this book focuses more on the motile mechanisms of dynein, especially by biophysical methods such as cryo-EM, X-ray crystallography, and single-molecule nanometry. It is a major handbook for frontline researchers as well as for advanced students studying cell biology, molecular biology, biochemistry, biophysics, and structural biology.

Handbook of Dynein

Handbook of Dynein
A Book

by Keiko Hirose,Linda A. Amos

  • Publisher : CRC Press
  • Release : 2012-02-22
  • Pages : 350
  • ISBN : 981430333X
  • Language : En, Es, Fr & De
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This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students. Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.

Assembly, Structure and Regulation of Dyneins in Cilia

Assembly, Structure and Regulation of Dyneins in Cilia
A Book

by Panteleimon Rompolas

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 470
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Handbook of Dynein

Handbook of Dynein
A Book

by Keiko Hirose,Linda A. Amos

  • Publisher : CRC Press
  • Release : 2012-02-22
  • Pages : 350
  • ISBN : 9814303348
  • Language : En, Es, Fr & De
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This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students. Besides comprehensive cover of structural information gained by electron microscopy, electron cryo-tomography, X-ray crystallography, and nuclear magnetic resonance, this book provides detailed descriptions of mechanistic experiments by single-molecule nanometry. The reports include in vitro studies of the motility of reconstituted complexes and in vivo studies of organisms expressing mutant dyneins. The recent technical improvements described, which have played an important part in recent advances, include the expression and preparation of recombinant dynein heavy chains or individual subdomains.

Dyneins

Dyneins
Structure, Biology and Disease

by Stephen M. King

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biochemical Analyses of Axonemal Dyneins from a Wild-type Tetrahymena and a Mutant Tetrahymena Lacking Outer Dynein Arms

Biochemical Analyses of Axonemal Dyneins from a Wild-type Tetrahymena and a Mutant Tetrahymena Lacking Outer Dynein Arms
A Book

by Xuejun Kong

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 94
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Single Molecule Biology

Single Molecule Biology
A Book

by Alexander E. Knight

  • Publisher : Academic Press
  • Release : 2009-02-26
  • Pages : 368
  • ISBN : 9780080921235
  • Language : En, Es, Fr & De
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Single molecule techniques, including single molecule fluorescence, optical tweezers, and scanning probe microscopy, allow for the manipulation and measurement of single biological molecules within a live cell or in culture. These approaches, amongst the most exciting tools available in biology today, offer powerful new ways to elucidate biological function, both in terms of revealing mechanisms of action on a molecular level as well as tracking the behaviour of molecules in living cells. This book provides the first complete and authoritative treatment of this rapidly emerging field, explicitly from a biological perspective. The contents are organized by biological system or molecule. Each chapter discusses insights that have been revealed about their mechanism, structure or function by single molecule techniques. Among the topics covered are enzymes, motor proteins, membrane channels, DNA, ribozymes, cytoskeletal proteins, and other key molecules of current interest. An introduction by the editor provides a concise review of key principles and an historical overview. The last section discusses applications in molecular diagnostics and drug discovery. * Organized by biological system or molecule. * Each chapter discusses insights into mechanism of action, structure, and function * Covers enzymes, motor proteins, membrane channels, DNA, ribozymes, etc. * Includes an introduction to key principles and an historical overview. * Discusses applications in molecular diagnostics and drug discovery. * Provides an expert's perspective on future developments.

Axonemal Dyneins and Force Generation by Neurons in Drosophila Melanogaster Ear

Axonemal Dyneins and Force Generation by Neurons in Drosophila Melanogaster Ear
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 88
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Analogous to vertebrate hair cells, the mechanosensory cilia of Drosophila auditory neurons are motile and serve dual, transducing and actuating roles. Structurally, the latter cilia resemble non-motile primary cilia, raising the question of how they generate motility. Two axonemal dynein motors are described in this thesis that are expressed in the fly's auditory neurons and differently contribute to cilium motility: Whereas one dynein is required to generate motility, the other dynein regulates this motility by interacting with transient receptor potential ion channels of the vanilloid su...

Cilia: Motors and Regulation

Cilia: Motors and Regulation
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2009-12-01
  • Pages : 400
  • ISBN : 9780080961071
  • Language : En, Es, Fr & De
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Along with its companion volume on axonemal dynein-mediated motility, this book provides researchers with a comprehensive and up-to-date source of methods for the analysis cilia and flagella, focusing primarily on approaches that have been devised or significantly extended since the last volume of Methods in Cell Biology on this topic (volume 47, 1995). Edited by Stephen M. King and Gregory J. Pazour, the newest installment of this highly acclaimed serial will serve as an essential addition to the study of cilia and flagella. * Covers protocols for cilia and flagella across systems and species * Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time * Relevant to clinicians interested in respiratory disease, male infertility, and other syndromes who need to learn biochemical, molecular, and genetic approaches to studying cilia, flagella, and related structures

Inborn Errors of Development

Inborn Errors of Development
The Molecular Basis of Clinical Disorders of Morphogenesis

by Charles J. Epstein,Robert P. Erickson,Anthony Joseph Wynshaw-Boris

  • Publisher : Oxford University Press, USA
  • Release : 2004
  • Pages : 1082
  • ISBN : 019514502X
  • Language : En, Es, Fr & De
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In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.

The Chlamydomonas Sourcebook: Cell Motility and Behavior

The Chlamydomonas Sourcebook: Cell Motility and Behavior
A Book

by George Witman

  • Publisher : Academic Press
  • Release : 2009-03-07
  • Pages : 512
  • ISBN : 9780080919577
  • Language : En, Es, Fr & De
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This volume reviews virtually everything that is known about cell motility and behavior in Chlamydomonas. World experts in each area focus on mitosis and cytokinesis; flagellar assembly and motility; intraflagellar transport, and more will use this reference as a guide for understanding human diseases of the cilium. The volume is richly illustrated and is supplemented by a Website containing both classic and previously unpublished videos of cell motility in Chlamydomonas. Because Chlamydomonas has been the premier model for investigating the function and behavior of cilia and flagella, the chapters summarize the current state of knowledge in these areas as it applies to all ciliated organisms. Thus, this volume will be an essential source for all students and researchers interested in cell motility. This volume is part of a 3-Volume Set (ISBN: 978-0-12-370873-1) and is also sold individually. Includes a table listing the known proteins (with NCBI accession numbers) for each structure discussed, and the known mutations that affect each structure and process Essential reference to a model species for the study of mechanisms of motility in free living cells Includes methods for Chlamydomonas motility research Companion Website with videos illustrates the marvels of the Chlamydomonas flagella in action

Metabolic Pumps and Intracellular Homeostasis, Hormones and Cell Function, Intercellular Communication, Cell Motility and Contractility, Part B

Metabolic Pumps and Intracellular Homeostasis, Hormones and Cell Function, Intercellular Communication, Cell Motility and Contractility, Part B
A Book

by Edward Bittar

  • Publisher : Academic Press
  • Release : 1992-01-22
  • Pages : 256
  • ISBN : 1559383100
  • Language : En, Es, Fr & De
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Volumes 5A and 5B of Fundamentals of Medical Cell Biology are a treatment of several key subjects, including cellular signaling. One profitable way to tackle both volumes is to read them with care but without endeavouring to master most of the details. Then should follow a more plodding study, chapter by chapter. Such a strategy is also urged in respect of the preceding volumes. Although each chapter is only as detailed as space permits, it should in the case of the student serve as an incentive to the study of the original papers.

Proteomics of Spermatogenesis

Proteomics of Spermatogenesis
A Book

by G. S. Gupta

  • Publisher : Springer Science & Business Media
  • Release : 2006-07-02
  • Pages : 855
  • ISBN : 0387276556
  • Language : En, Es, Fr & De
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Recent developments of experimental techniques in cellular and molecular biology have made it possible to understand the molecular biology of male gametogenesis in greater detail. This book focuses on the description of specialized proteins, which are dominantly and/or specifically expressed in germ cells and localized in spermatozoa. There is an urgent need to classify proteins of spermatogenic cells with a view of their functions, and their applications in the regulation of fertility and in understanding infertility. The understanding of structural properties of male germ cell specific proteins can offer vulnerable points for targeted intervention in testis without generalized effects on stages of spermatogenesis. Besides targeted action in male germ cells, sperm specific proteins and polypeptides may also offer potential application in the development of a contraceptive vaccine.

Lewin's CELLS

Lewin's CELLS
A Book

by Lynne Cassimeris,George Plopper,Vishwanath R. Lingappa

  • Publisher : Jones & Bartlett Publishers
  • Release : 2011-03-25
  • Pages : 1053
  • ISBN : 1449641148
  • Language : En, Es, Fr & De
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Completely revised and updated to incorporate the latest data in the field, Lewin's CELLS, Second Edition is the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.

Encyclopedia of Cell Biology

Encyclopedia of Cell Biology
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2015-08-07
  • Pages : 3008
  • ISBN : 0123947960
  • Language : En, Es, Fr & De
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The Encyclopedia of Cell Biology offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Computational Modeling in Biological Fluid Dynamics

Computational Modeling in Biological Fluid Dynamics
A Book

by Lisa J. Fauci,Shay Gueron

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 247
  • ISBN : 1461301513
  • Language : En, Es, Fr & De
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This IMA Volume in Mathematics and its Applications COMPUTATIONAL MODELING IN BIOLOGICAL FLUID DYNAMICS is based on the proceedings of a very successful workshop with the same title. The workshop was an integral part of the September 1998 to June 1999 IMA program on "MATHEMATICS IN BIOLOGY." I would like to thank the organizing committee: Lisa J. Fauci of Tulane University and Shay Gueron of Technion - Israel Institute of Technology for their excellent work as organizers of the meeting and for editing the proceedings. I also take this opportunity to thank the National Science Founda tion (NSF), whose financial support of the IMA made the Mathematics in Biology program possible. Willard Miller, Jr., Professor and Director Institute for Mathematics and its Applications University of Minnesota 400 Lind Hall, 207 Church St. SE Minneapolis, MN 55455-0436 612-624-6066, FAX 612-626-7370 miller@ima.umn.edu World Wide Web: http://www.ima.umn.edu v PREFACE A unifying theme in biological fluid dynamics is the interaction of moving, elastic boundaries with a surrounding fluid. A complex dynami cal system describes the motion of red blood cells through the circulatory system, the movement of spermatazoa in the reproductive tract, cilia of microorganisms, or a heart pumping blood. The revolution in computa tional technology has allowed tremendous progress in the study of these previously intractable fluid-structure interaction problems.