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Early Vascular Aging (EVA)

Early Vascular Aging (EVA)
New Directions in Cardiovascular Protection

by Peter M Nilsson,Michael Hecht Olsen,Stephane Laurent

  • Publisher : Academic Press
  • Release : 2015-08-06
  • Pages : 376
  • ISBN : 0128016760
  • Language : En, Es, Fr & De
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Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of increased rigidity of the great vessels, its causes, and further consequences. Information provided is accompanied by online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures. Introduces the latest information on early vascular aging (EVA), complete with summaries of recent evidence and guidelines for relevant risk factor control Ideal reference for the study of vascular aging, pulse wave velocity, arteriosclerosis, EVA, arterial stiffness, vascular, PWV biomarkers, and cardiovascular disease Contains all the relevant information available from different fields of knowledge (from basic biology to epidemiology) in regard to EVA Provides evidence that leads to a new target for interventions, early vascular aging (EVA) in subjects with early onset increased arterial stiffness Includes online access to a supplemental website with video clips of anatomic specimens, cardiac imaging, and surgical procedures

ASSOCIATION OF CARDIOVASCULAR RISK FACTORS AND EARLY VASCULAR AGEING IN TYROLEAN ADOLESCENTS - EVA TYROL STUDY.

ASSOCIATION OF CARDIOVASCULAR RISK FACTORS AND EARLY VASCULAR AGEING IN TYROLEAN ADOLESCENTS - EVA TYROL STUDY.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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BACKGROUND AND AIM Atherosclerosis is the most common cause of cardiovascular disease (CVD) and has its origin early in life. The prevalence of classic CVD risk factors like smoking, overweight, hypertension and unfavorable blood lipids in childhood and adolescence is associated with an increased risk for CVD in adulthood. Therefore this study aims to assess vascular changes and predictors for early vascular ageing (EVA) in a large cohort of healthy Tyrolean adolescents.METHODS Volunteering Tyrolean schools and companies were invited to take part in this regional cohort study. Common risk factors for CVD like smoking, activity, and diet were assessed as well as anthropometric data (BMI, blood pressure) and blood lipids. Vascular changes were evaluated by measuring intima-media-thickness of the common carotid artery (cIMT) by high resolution ultrasound as a marker for subclinical atherosclerosis.RESULTS 1573 (691 male, 882 female) adolescents with a mean age of 16 years were included in this analysis. 1556 participants had ultrasound measurement of cIMT. In a multivariable linear regression analysis male sex, BMI, daily physical activity and systolic blood pressure showed a positive relation to mean cIMT. Maximum cIMT was predicted by sex, BMI and systolic blood pressure. CONCLUSION Risk factors for atherosclerosis are present in Tyrolean adolescents and are associated with early vascular aging. The positive association between physical activity and mean cIMT may be explained by a non-atherosclerotic adaptation process. Maximum cIMT as a marker for first atherosclerotic lesions is not affected by physical activity.

Vascular Aging: Facts and Factors

Vascular Aging: Facts and Factors
A Book

by Elisabet Vila,Francesc Jiménez-Altayó,Paula Dantas

  • Publisher : Frontiers E-books
  • Release : 2021
  • Pages : 129
  • ISBN : 2889190528
  • Language : En, Es, Fr & De
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The increasing mean age of the population in developed countries has turned out to be an economic and social problem. Cardiovascular disease has long been considered to be age related in terms of their onset and progression. As such, we can say that the increase in life expectancy goes in parallel with increased incidence of cardiovascular disease. With age, a number of changes occur in the vasculature altering the homeostasis of the irrigated organs promoting target organ damage. While different adaptive mechanisms to protect vessels against mild stress have been described, the aging process induces a progressive failure of protective mechanisms, leading to vascular changes and higher susceptibility to cardiovascular diseases. Indeed, vascular aging is exacerbated by coexisting cardiovascular risk factors, such as hypertension, metabolic syndrome and diabetes. Compelling evidence indicates that diminished endothelial relaxation and increase, decrease, or no change in contractile responses to several agonists is associated with aging. There is an increase of vasoconstrictor factors expression and a decrease of vasodilators. Morphologic changes include lumen diameter enlargement, wall thickening and alterations of matrix substances as increased collagen or decreased elastin deposition, ultimately leading to greater arterial stiffening (reduced compliance). Importantly, arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Cellular and molecular mechanisms have also been documented. Senescence at the cellular level involves alterations in Ca2+ signaling and down regulation of anti-aging proteins. Both endothelial and smooth muscle cells change their number, morphology, function and their regenerative ability. Aging is also associated with a gradual loss of antioxidant defense mechanisms, a proinflammatory shift in the cytokine expression profile and a production of reactive oxygen species such as superoxide (O2-) that promotes the breakdown of nitric oxide. Nitric oxide and O2- interact to form peroxynitrite known to nitrosylate proteins affecting their physiological function. However, vascular wall proteins may also suffer from other potentially deleterious modifications as glycation (Maillard reaction) and glyco-oxidative reactions with increasing age, which could be linked to the age-associated changes in vascular function. Various strategies have shown benefit in preventing, delaying or attenuating vascular aging. For instance, a healthy lifestyle including low fat diet and/or exercise have a favorable effect. Nevertheless, it yet remains to be fully demonstrated whether vascular aging can be pharmacologically prevented. This Research Topic is intended to bring together research efforts to understand the causes and consequences of vascular aging and propose new therapeutic strategies for the management of vascular senescence.

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases
A Book

by Michel E. Safar,Michael F. O'Rourke,Edward D. Frohlich

  • Publisher : Springer
  • Release : 2014-07-30
  • Pages : 567
  • ISBN : 1447151984
  • Language : En, Es, Fr & De
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In cardiovascular prevention, there is classically a small number of cardiovascular risk factors to treat, such as hypertension, diabetes, hyperlipidemia and smoking excess, which are widely detected and treated. Recently, it has been widely recognized that new mechanical factors should be detected and treated and involves specifically pulsatile arterial hemodynamic (PAH) parameters such as: arterial stiffness, pulse pressure, and, to a lesser extent, augmentation index and pulse pressure amplification. The pedagogic aspect of this new CV specialty involves 3 principal parts: a. –Basic concepts and pathophysiological mechanisms of PAHb. –Clinical aspects and end-organ damage in PAHc. – Clinical pharmacology and therapeutics of PAH This book represents the first that spans basic science and clinical management of this new CV subspecialty. Much has been learned regarding the management of these patients in recent years and this book presents extensive data on the techniques needed to maximize outcomes.​

Manual of Hypertension of the European Society of Hypertension, Third Edition

Manual of Hypertension of the European Society of Hypertension, Third Edition
A Book

by Giuseppe Mancia,Guido Grassi,Konstantinos Tsioufis,Anna Dominiczak,Enrico Agabiti Rosei

  • Publisher : CRC Press
  • Release : 2019-06-06
  • Pages : 650
  • ISBN : 0429581440
  • Language : En, Es, Fr & De
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The Manual of Hypertension of the European Society of Hypertension reflects emerging concepts that have the potential to impact diagnostic and therapeutic approaches to hypertension. Updating all material, this new edition also delves into a number of areas that have received heightened interest in recent years or have become a matter of debate due to the controversial interpretation of the available data. FEATURES Reflects emerging concepts impacting diagnostic and therapeutic approaches Explores background, history, epidemiology, and risk factors Describes pharmacological, nonpharmacological, and medical treatments Examines hypertension in special populations and treatment

Promoting Healthy and Active Ageing

Promoting Healthy and Active Ageing
A Multidisciplinary Approach

by Telmo Pereira

  • Publisher : Routledge
  • Release : 2021-10-29
  • Pages : 192
  • ISBN : 1000454460
  • Language : En, Es, Fr & De
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This book demonstrates the efficacy of a multidisciplinary intervention strategy for promoting active and healthy ageing, with the assistance of dedicated technological resources. Taking an applied approach, this book promotes active and healthy ageing through the implementation of an intervention model based on the comprehensive geriatric approach (AGA). The proposed AGA model, entitled AGA@4life, is based on a holistic and multidisciplinary individual assessment protocol, with the consequent design and implementation of intervention strategies tailored to each individual, aimed at preventing frailty and functional, cognitive and social decline of the elderly. Intervention actions focus on personalized exercise programs, nutrition education, cognitive stimulation, co-morbidity monitoring, therapeutic counselling, and overall promotion of well-being. This book will be of interest to researchers, professionals, and students working in ageing and health, gerontology, and preventative and holistic approaches to well-being.

Issues in Cardiovascular Medicine: 2013 Edition

Issues in Cardiovascular Medicine: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-05-01
  • Pages : 1187
  • ISBN : 1490108890
  • Language : En, Es, Fr & De
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Issues in Cardiovascular Medicine / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Cardiovascular Toxicology. The editors have built Issues in Cardiovascular Medicine: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Toxicology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cardiovascular Medicine: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hemodynamics—Advances in Research and Application: 2012 Edition

Hemodynamics—Advances in Research and Application: 2012 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-26
  • Pages : 539
  • ISBN : 1464992797
  • Language : En, Es, Fr & De
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Hemodynamics—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Hemodynamics. The editors have built Hemodynamics—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hemodynamics in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hemodynamics—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Oxford Textbook of Children's Sport and Exercise Medicine

Oxford Textbook of Children's Sport and Exercise Medicine
A Book

by Neil Armstrong,Willem van Mechelen

  • Publisher : Oxford University Press
  • Release : 2017-05-05
  • Pages : 720
  • ISBN : 019252044X
  • Language : En, Es, Fr & De
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Now consisting of fifty innovative chapters authored by internationally recognised scientists and clinicians, the extensively revised third edition of the Oxford Textbook of Children's Sport and Exercise Medicine is the fundamental reference work on paediatric exercise medicine and sport science. Using a scientific evidence-based approach and new insights into understanding the exercising child and adolescent, this title covers a complex and rapidly evolving field. Designed to inform, challenge and support all involved in the study and treatment of the exercising child and adolescent, the Oxford Textbook of Children's Sport and Exercise Medicine presents complex scientific and medical material in an accessible and understandable manner. With extensive sections on Exercise Science, Exercise Medicine, Sport Science and Sport Medicine, chapters comprehensively cover training, physical activity in relation to health issues, the physiology of the young athlete and injury using the research and practical experience of a renowned author team. Fully illustrated and extensively revised, new topics and fully updated material complement the state-of-the-art approach of previous editions. With an increased focus on molecular exercise physiology, close to 75% of the content found in this edition is new material, reflecting the many advances and developments across this discipline.

Arterial Disorders

Arterial Disorders
Definition, Clinical Manifestations, Mechanisms and Therapeutic Approaches

by Adel Berbari,Giuseppe Mancia

  • Publisher : Springer
  • Release : 2015-03-19
  • Pages : 431
  • ISBN : 3319145568
  • Language : En, Es, Fr & De
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As our knowledge about arterial disease is greatly expanding, the aim of this book is to explore all aspects of arterial pathology, including classification, clinical manifestations, pathogenesis, and therapeutic options. The discussion of pathophysiologic mechanisms of arterial disease is wide ranging, encompassing hemodynamic, metabolic, humoral, inflammatory, genetic and environmental factors. Particular emphasis is placed on recent concepts, such as: the role of age-associated arterial alterations in the initiation and progression of cardiovascular diseases in older persons, the importance of mineral metabolism-bone vascular interactions, the clinical and prognostic significance of the renal resistive index, retinal circulation, toxemia of pregnancy as an arterial disease, and the role of pulmonary/vascular interaction in pulmonary hypertension and cross-talk of macrocirculation and microcirculation in target organ involvement. Evaluation procedures are carefully explained, and the full range of currently available therapeutic options, including lifestyle modifications and pharmacologic approaches, are described and appraised. ​

Biomarkers of Human Aging

Biomarkers of Human Aging
A Book

by Alexey Moskalev

  • Publisher : Springer Nature
  • Release : 2019-09-13
  • Pages : 421
  • ISBN : 3030249700
  • Language : En, Es, Fr & De
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This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Hypertension in Children and Adolescents

Hypertension in Children and Adolescents
New Perspectives

by Empar Lurbe,Elke Wühl

  • Publisher : Springer
  • Release : 2019-07-29
  • Pages : 277
  • ISBN : 3030181677
  • Language : En, Es, Fr & De
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This book is devoted to hypertension in children and adolescents, a clinical issue that – thanks to the strides made in several areas of pathophysiological and clinical research – has received growing interest in cardiovascular medicine over the last several years. Given the increasing prevalence of hypertension in children and adolescents, this book represents an important and useful tool to address what has become a significant public health issue. It covers a diverse range of topics, from advances in the definition of hypertension and the identification of new risk factors, to current treatment strategies. The book also presents an overview of the latest findings, including the clinical significance of isolated systolic hypertension (ISH) in youth, the importance of out-of-office and central blood pressure measurement, new methods for assessing vascular phenotypes, and clustering of CV risk factors. Gathering contributions by international experts and pursuing a practice-oriented approach, the book offers a valuable tool for cardiologists, pediatricians and nephrologists, as well as general practitioners.

Vascular Dementia

Vascular Dementia
A Book

by John Meyer,Gaiane Rauch,Helmut Lechner,Carlo Loeb

  • Publisher : Wiley-Blackwell
  • Release : 2001-01-17
  • Pages : 310
  • ISBN : 9780879934255
  • Language : En, Es, Fr & De
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Vascular dementia (VAD) accounts for one-third of all dementias in today''s aging population, second only to Alzheimer's disease (DAT). Fortunately, current imaging techniques allow clinicians to view specific lesions in the brain, classify them by etiology and anatomical location, and assess changes using serial imaging, while at the same time correlating those changes with signs and symptoms of VAD or DAT. In 17 chapters, this book summarizes new concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of VAD and DAT, and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter.

Proceedings of 24th Annual Cardiologists Conference 2018

Proceedings of 24th Annual Cardiologists Conference 2018
International Journal of Cardiovascular Research : Volume 7

by ConferenceSeries

  • Publisher : ConferenceSeries
  • Release : 2021
  • Pages : 135
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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June 11-13, 2018 Barcelona, Spain Key topics : Cardiologists, Clinical Cardiology, Heart Diseases, Hypertension, Electrocardiography, Diabetes & Heart, Cardio-Oncology, Pediatric & Geriatric Cardiology, Interventional Cardiology, Nuclear Cardiology, Sports Cardiology, Cardiac Surgery, Cardiac Nursing, Cardiac Regeneration, Case Reports on Cardiology, Devices / CRT / ICD / Surgery, Entrepreneurs Investment Meet, Cardiologists Training and Education, Women & Heart Disease.

Cardiovascular Risk Factors

Cardiovascular Risk Factors
A Book

by Armen Yuri Gasparyan

  • Publisher : BoD – Books on Demand
  • Release : 2012-03-14
  • Pages : 506
  • ISBN : 9535102400
  • Language : En, Es, Fr & De
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Cardiovascular risk factors contribute to the development of cardiovascular disease from early life. It is thus crucial to implement preventive strategies addressing the burden of cardiovascular disease as early as possible. A multidisciplinary approach to the risk estimation and prevention of vascular events should be adopted at each level of health care, starting from the setting of perinatology. Recent decades have been marked with major advances in this field, with the emergence of a variety of new inflammatory and immune-mediated markers of heightened cardiovascular risk in particular. The current book reflects some of the emerging concepts in cardiovascular pathophysiology and the shifting paradigm of cardiovascular risk estimation. It comprehensively covers primary and secondary preventive measures targeted at different age and gender groups. Attention is paid to inflammatory and metabolic markers of vascular damage and to the assessment of vascular function by noninvasive standardized ultrasound techniques. This is a must-read book for all health professionals and researchers tackling the issue of cardiovascular burden at individual and community level. It can also serve as a didactic source for postgraduate medical students.

Arterial Stiffness

Arterial Stiffness
Implications and Interventions

by Bradley S. Fleenor,Adam J. Berrones

  • Publisher : Springer
  • Release : 2015-11-26
  • Pages : 61
  • ISBN : 3319248448
  • Language : En, Es, Fr & De
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Arterial stiffness is an emerging risk factor with important implications for cardiovascular disease risk. Herein, we concisely summarize the physiological and pathophysiological aspects of arterial stiffening, and highlight the importance of increased arterial stiffness for future cardiovascular events. Factors contributing to increased arterial stiffness such as advancing age, obesity, race, sex differences and cardiorespiratory fitness are examined while elucidating the potential underlying mechanisms for each scenario. To conclude, we discuss novel interventions to prevent and/or reverse the arterial stiffening process in order to reduce cardiovascular risk. This book also: Overviews the cellular and molecular mechanisms of arterial stiffness Discusses the implications of arterial stiffness in target organ damage

Geriatric Urology, An Issue of Clinics in Geriatric Medicine,

Geriatric Urology, An Issue of Clinics in Geriatric Medicine,
A Book

by Tomas Lindor Griebling

  • Publisher : Elsevier Health Sciences
  • Release : 2016-01-07
  • Pages : 685
  • ISBN : 0323393357
  • Language : En, Es, Fr & De
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This issue of Clinics in Geriatric Medicine is devoted to Geriatric Urology. Guest Editor Tomas L. Griebling, MD, MPH has assembled a group of expert authors to review the following topics: Non-Surgical Treatment of Urinary Incontinence in Elderly Women; Outcomes of Surgery for Stress Urinary Incontinence in Older Women; Evaluation and Management of Pelvic Organ Prolapse in Elderly Women; Underactive Bladder in Older Adults; Translational Research and Voiding Dysfunction in Older Adults; Functional Brain Imaging and Voiding Dysfunction in Older Adults; The Role of Urodynamics in Elderly Patients; Associations Between Voiding Symptoms and Sexual Health in Older Adults; Asymptomatic Bacteriuria and Urinary Tract Infections in Older Adults; Comorbidity and Surgical Risk in Older Urologic Patients; Small Renal Masses in Older Adults; Prostate Cancer in Elderly Men: Active Surveillance and Other Considerations; Late Onset Hypogonadism and Testosterone Replacement in Elderly Men; and Contemporary Chemotherapy for Urologic Malignancies in Geriatric Patients.

Geriatric Urology

Geriatric Urology
A Book

by Tomas Lindor Griebling

  • Publisher : Elsevier Health Sciences
  • Release : 2015-08-28
  • Pages : 685
  • ISBN : 0323393349
  • Language : En, Es, Fr & De
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This issue of Clinics in Geriatric Medicine is devoted to Geriatric Urology.? Guest Editor Tomas L. Griebling, MD, MPH has assembled a group of expert authors to review the following topics: Non-Surgical Treatment of Urinary Incontinence in Elderly Women; Outcomes of Surgery for Stress Urinary Incontinence in Older Women; Evaluation and Management of Pelvic Organ Prolapse in Elderly Women; Underactive Bladder in Older Adults; Translational Research and Voiding Dysfunction in Older Adults; Functional Brain Imaging and Voiding Dysfunction in Older Adults; The Role of Urodynamics in Elderly Patients; Associations Between Voiding Symptoms and Sexual Health in Older Adults; Asymptomatic Bacteriuria and Urinary Tract Infections in Older Adults; Comorbidity and Surgical Risk in Older Urologic Patients; Small Renal Masses in Older Adults; Prostate Cancer in Elderly Men: Active Surveillance and Other Considerations; Late Onset Hypogonadism and Testosterone Replacement in Elderly Men; and Contemporary Chemotherapy for Urologic Malignancies in Geriatric Patients.

Textbook of Diabetes

Textbook of Diabetes
A Book

by Richard I. G. Holt,Clive Cockram,Allan Flyvbjerg,Barry J. Goldstein

  • Publisher : John Wiley & Sons
  • Release : 2016-12-06
  • Pages : 1104
  • ISBN : 1118924878
  • Language : En, Es, Fr & De
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Now in its fifth edition, the Textbook of Diabetes has established itself as the modern, well-illustrated, international guide to diabetes. Sensibly organized and easy to navigate, with exceptional illustrations, the Textbook hosts an unrivalled blend of clinical and scientific content. Highly-experienced editors from across the globe assemble an outstanding set of international contributors who provide insight on new developments in diabetes care and information on the latest treatment modalities used around the world. The fifth edition features an array of brand new chapters, on topics including: Ischaemic Heart Disease Glucagon in Islet Regulation Microbiome and Diabetes Diabetes and Non-Alcoholic Fatty Liver Disease Diabetes and Cancer End of Life Care in Diabetes as well as a new section on Psychosocial aspects of diabetes. In addition, all existing chapters are fully revised with the very latest developments, including the most recent guidelines from the ADA, EASD, DUK and NICE. Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates Via the companion website, readers can access a host of additional online materials such as: 200 interactive MCQ's to allow readers to self-assess their clinical knowledge every figure from the book, available to download into presentations fully searchable chapter pdfs Once again, Textbook of Diabetes provides endocrinologists and diabetologists with a fresh, comprehensive and multi-media clinical resource to consult time and time again.

Prehypertension and Cardiometabolic Syndrome

Prehypertension and Cardiometabolic Syndrome
A Book

by Reuven Zimlichman,Stevo Julius,Giuseppe Mancia

  • Publisher : Springer
  • Release : 2018-12-06
  • Pages : 689
  • ISBN : 331975310X
  • Language : En, Es, Fr & De
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This book sheds new light on the management of patients with borderline cardiovascular risk factors in order to prevent their progression to end organ damage. The book stimulates discussion of this poorly understood condition and lays the groundwork for developing recommendations and guidelines. While the diagnostic and therapeutic approach to full-blown diabetes, hypertension, dyslipidemia and obesity is well defined, there is still a lack of clear understanding and guidelines as far as patients with borderline conditions – especially when multiple – are concerned. Moreover, end-organ damage depends on several factors, including genetic factors, making it difficult to predict its extent. As such, the gradual transition from a healthy subject to one with functional hemodynamic changes, and then one with structurally asymptomatic changes and lastly to overt disease needs further investigation. In order to address these knowledge gaps, the book covers a broad variety of topics, making it a valuable tool for identifying which asymptomatic subjects could profit from being appropriately screened and at what stage. Furthermore it offers insights into better treating these patients to prevent their progression to overt disease. The book appeals to cardiologists, primary care physicians and all those healthcare professional looking to optimize the management of these complex and often undiagnosed cases.