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Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease
A Book

by Gary D. Lopaschuk,Naranjan S. Dhalla

  • Publisher : Springer
  • Release : 2014-08-22
  • Pages : 295
  • ISBN : 1493912275
  • Language : En, Es, Fr & De
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Cardiac Energy Metabolism in Heart Failure

Cardiac Energy Metabolism in Heart Failure
From Concepts to Therapies

by Society for Heart and Vascular Metabolism

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Special Issue

Special Issue
Myocardial Energy Metabolism in Heart Failure

by William C. Stanley

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cardiac Energy Metabolism in Heart Failure and Metabolic Disease

Cardiac Energy Metabolism in Heart Failure and Metabolic Disease
A Book

by William C. Stanley

  • Publisher : Academic Press
  • Release : 2016-01-12
  • Pages : 384
  • ISBN : 9780128004302
  • Language : En, Es, Fr & De
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Cardiac Energy Metabolism in Heart Failure and Metabolic Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease
A Book

by Thomas Pulinilkunnil,Petra Kienesberger,Jeevan Nagendran

  • Publisher : Frontiers Media SA
  • Release : 2019-08-08
  • Pages : 89
  • ISBN : 2889459381
  • Language : En, Es, Fr & De
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The Sinatra Solution

The Sinatra Solution
Metabolic Cardiology: Easyread Large Bold Edition

by Stephen T. Sinatra, M.D.

  • Publisher : ReadHowYouWant.com
  • Release : 2009-04-24
  • Pages : 512
  • ISBN : 1442975016
  • Language : En, Es, Fr & De
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Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

Metabolic Efficiency in Remodeled Failing Hearts

Metabolic Efficiency in Remodeled Failing Hearts
A Book

by Waleed Gameel Tawfeek Masoud

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 280
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Heart failure is a serious cardiovascular disease that develops following a variety of insults to the heart including hypertrophy and myocardial infarction. While it is clear that heart failure is associated with changes in cardiac energy metabolism, it remains unclear if, and how, such changes might contribute to left ventricular (LV) contractile dysfunction. Two distinct hypotheses have been advanced to link changes in energy metabolism with heart failure: 1) there is a state of energetic crisis / starvation, where rates of energy metabolism decrease and thereby cause LV failure, or 2) there is inefficiency in energy utilization where more energy is required to produce external work. Inefficiency may be due to mismatched rates of glycolysis and glucose oxidation that leads to intracellular proton accumulation resulting in Na+ and Ca2+ overload. Recently, drug-induced modulation of rates of carbohydrate and fat metabolism has been proposed as a new approach for the treatment of LV dysfunction and heart failure. Such metabolic modulation can also be achieved experimentally by the use of genetically-modified experimental animals. This thesis compared the metabolic profile of remodeled post-infarction mouse hearts with normal hearts, studied the response of these hearts to ex vivo ischemia reperfusion (IR) and the ability of metabolic modulation to limit the deterioration of metabolic efficiency and LV dysfunction following myocardial infarction. Using coronary artery ligation, we created a mouse model of post-infarction remodeled heart failure that we verified using in vivo echocardiographic examination. Using ex vivo heart perfusion in the isolated working mode, we provided evidence that CAL hearts are metabolically inefficient rather than energy starved and that mismatched glucose metabolism is a possible contributor to metabolic inefficiency. Using malonyl CoA decarboxylase deficient (MCD-KO) mice that are known to have better matching of glucose metabolism, we confirmed that this metabolic intervention improved glucose matching, metabolic efficiency and limited functional deterioration in CAL hearts. We also studied the response of CAL hearts to ex vivo IR. We showed that CAL hearts have better functional recovery and limited functional deterioration following IR in comparison to SHAM hearts. This was associated with reduced ischemic glycogenolysis, lack of acceleration in fatty acid oxidation during reperfusion and increased triacylglycerol accumulation in reperfused CAL hearts. We provided evidence that mitochondrial mass, Ca2+ handling proteins and AMPK activity are unchanged and are unlikely to contribute to the observed response of CAL hearts to IR. This thesis also studied the potential for further protection of CAL hearts after IR via pharmacologic improvement of the match of glucose oxidation using dichloroacetate (DCA). We showed that in presence of lactate, DCA did not stimulate glucose oxidation, improve functional recovery or improve the match of glucose metabolism. We also showed that in absence of lactate, DCA was able to stimulate glucose oxidation but this was not enough to improve the matching of glucose metabolism. This thesis also discussed differences between mouse and rat heart metabolism that may explain the lack of response to DCA in mouse hearts. Similarly, we studied the possible improvement of metabolic efficiency in CAL hearts via acute ex vivo MCD inhibition but this acute intervention was not sufficient to produce benefit.

The Sinatra Solution

The Sinatra Solution
Metabolic Cardiology: Easyread Super Large 24pt Edition

by Stephen T. Sinatra, M.D.

  • Publisher : ReadHowYouWant.com
  • Release : 2009-04-24
  • Pages : 520
  • ISBN : 1442975261
  • Language : En, Es, Fr & De
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Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

The Sinatra Solution

The Sinatra Solution
Metabolic Cardiology: Easyread Super Large 18pt Edition

by Stephen T. Sinatra, M.D.

  • Publisher : ReadHowYouWant.com
  • Release : 2009-04-24
  • Pages : 320
  • ISBN : 1442975253
  • Language : En, Es, Fr & De
GET BOOK

Board-certified cardiologist Dr. Stephen T. Sinatra discusses the importance of energy metabolism on cardiovascular health and the positive impact these three energy-supplying nutrients have on the cardiovascular system. He guides you through the basics of energy metabolism and cardiac bioenergetics, and clearly explains the role of coenzyme Q10, L-carnitine, and D-ribose in the body and specifically how they affect your heart health. He also provides concise and informative examples of case histories and scientific studies that are testament to the important contribution the supplemental use of these energy-supplying nutrients make in the lives of people with heart disease every day.

Energy Metabolism in Heart Failure

Energy Metabolism in Heart Failure
A Book

by HOWARD J. EISEN

  • Publisher : Academic Press
  • Release : 2018-06-01
  • Pages : 256
  • ISBN : 0128046414
  • Language : En, Es, Fr & De
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Energy Metabolism in Heart Failure

Metabolisme Energetique Cardiaque Et Maladie Coronaire Du Patient Diabetique

Metabolisme Energetique Cardiaque Et Maladie Coronaire Du Patient Diabetique
Diabete--Montpellier 2001 : Symposium Satellite Biopharma, 28 Mars 2001

by Association de langue française pour l'étude du diabète et des maladies métaboliques,Biopharma

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 1
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Role of Cardiac Energy Metabolism During Stress in Hypertrophic and Dilated Cardiomyopathy

The Role of Cardiac Energy Metabolism During Stress in Hypertrophic and Dilated Cardiomyopathy
A Book

by Sairia Dass

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Both hypertrophic (HCM) and dilated cardiomyopathy (DCM), though differing in their etiologies, share features of impaired resting energetics. The aim of this thesis was to determine if cardiac high energy phosphate metabolism, measured as the phosphocreatine (PCr)/ ATP ratio using 31Phosphorus magnetic resonance spectroscopy (31p MRS), is further impaired during exercise in these pathologies. This would provide a possible explanation for the high incidence of exercise related death in HCM and DCM as well as the blunted inotropic response to exercise in DCM. Furthermore, this thesis investigates the role of stress perfusion and stress tissue oxygenation in HCM (as these are hypothesized to exacerbate the primary defect in energetics) and exercise training in DCM (which is hypothesized to improve function though the mechanisms are uncertain). This work developed a novel protocol for measuring 31p MRS in a clinically acceptable time frame. The traditional acquisition is at least 20 minutes (as much as 40 minutes in subjects with lower pulse rates). This is a particularly long time to allow for exercise in the magnet particularly in the symptomatic DCM cohort. Hence this work meticulously developed a shorter 8 minute protocol. Its validity, reproducibility and application to exercise were confirmed. The post processing of the MRS data was further improved for calculating blood contamination and tested with both simulated and patient data, including normal, hypertrophied and thinned myocardium. Applying this new method, this thesis is the first to report a further decrease in exercise energetics in HCM. The relationship between perfusion, tissue de-oxygenation and energetic compromise during exercise was then explored in HCM. Athletes, with physiological hypertrophy, were used as an additional control group in these experiments. These results demonstrated a strikingly blunted oxygenation response of the HCM heart to stress even in the pre-hypertrophy HCM mutation carriers. However, as a group, the data did not show a correlation between the blunted oxygenation response and the percentage change in PCr/ATP during exercise. None-the-Iess, these results can potentially be useful for distinguishing between hypertrophy in the athletes and pathological hypertrophy in HCM and for distinguishing HCM mutation carriers' pre hypertrophy and the normal heart. In the DCM cohort, this thesis explored the impact of exercise training on cardiac metabolism and function. The results showed no change in cardiac energetics and left ventricular ejection fraction during 8 minutes of exercise. In addition, an eight week home exercise programme did not alter resting or exercise cardiac PCrjATP, but improved cardiac function during rest and exercise, and increased exercise tolerance and quality of life scores. In conclusion, this thesis reports further insights into cardiac exercise energetics in HCM and DCM and its relationship to perfusion and oxygenation in HCM and to exercise training in DCM. Therapies that decrease the energy cost of cardiac work during exercise may prove beneficial targets to explore further in these conditions.

The Role of Energy Metabolism Defects in Cardiomyopathy

The Role of Energy Metabolism Defects in Cardiomyopathy
From Inborn Errors to Ischemia

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 2
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Inotropic Stimulation and Myocardial Energetics

Inotropic Stimulation and Myocardial Energetics
A Book

by H. Just,C. Holubarsch,H. Scholz

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-14
  • Pages : 273
  • ISBN : 3662079089
  • Language : En, Es, Fr & De
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Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.

A Symposium: From Increased Energy Metabolism to Cardiac Hypertrophy and Failure: Mediators and Molecular Mechanisms

A Symposium: From Increased Energy Metabolism to Cardiac Hypertrophy and Failure: Mediators and Molecular Mechanisms
Based on a Symposium Held September 25-27, 1998, in Baden-Baden, Germany

by Symposium from Increased Energy Metabolism to Cardiac Hypertrophy and Failure - Mediators and Molecular Mechanisms. 1998, Baden-Baden

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 98
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Scientist's Guide to Cardiac Metabolism

The Scientist's Guide to Cardiac Metabolism
A Book

by Michael Schwarzer,Torsten Doenst

  • Publisher : Academic Press
  • Release : 2015-11-04
  • Pages : 240
  • ISBN : 0128026146
  • Language : En, Es, Fr & De
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The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

From Increased Energy Metabolism to Cardiac Hypertrophy and Failure

From Increased Energy Metabolism to Cardiac Hypertrophy and Failure
Mediators and Molecular Mechanisms

by Heinrich Taegtmeyer,Guenther J. Dietze

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Inotropic Stimulation and Myocardial Energetics

Inotropic Stimulation and Myocardial Energetics
A Book

by H. Just,C. Holubarsch,H. Scholz

  • Publisher : Unknown Publisher
  • Release : 2014-01-15
  • Pages : 284
  • ISBN : 9783662079096
  • Language : En, Es, Fr & De
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Myocardial High-energy Phosphate Metabolism and Creatine Kinase Alterations in Hearts with Congestive Heart Failure

Myocardial High-energy Phosphate Metabolism and Creatine Kinase Alterations in Hearts with Congestive Heart Failure
A Book

by Yun Ye

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 328
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Heart Metabolism in Failure

Heart Metabolism in Failure
A Book

by R.A. Altschuld,R.A. Haworth

  • Publisher : Elsevier
  • Release : 1998-09-21
  • Pages : 379
  • ISBN : 9780080877181
  • Language : En, Es, Fr & De
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Heart failure continues to be a major public health problem in the United States with close to half a million new cases diagnosed each year. Moreover, deaths from heart failure are on the increase, in part because of advances in the treatment of other fatal diseases, and in part from the prevalence of lifestyles indifferent to the risk factors for heart disease. This is not to say that no progress has been made in the treatment of heart failure. While for many years treatment was confined to the management of the symptoms, in recent years with the advent of ACE inhibitor and ß blacker therapies, real improvements in cardiac function and life expectancy have been achieved (Volume 4B, Leier). On a more basic level, enormous advances have been made in describing many of the changes in structure and function of the heart and the parallel neurohumoral and circulatory adaptations that occur during the onset of failure. These advances have been made not only by using various animal models of heart failure, but also using fresh failing human heart tissue, which has become readily available for experimental investigation since the advent of cardiac transplantation. Understanding the significance of many of these changes that occur during the transition to failure and the role they play in the etiology of failure is, however, a much more difficult task. These are exciting times in heart failure research. It is as though many of the pieces of the jigsaw puzzle are available but the puzzle has yet to be assembled. The objective of these volumes is to bring together some advances that have been made in recent years in defining one aspect of the failing heart, that is, the role of altered metabolism, in order to facilitate assembly of the puzzle.