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Engineering Drug Delivery Systems

Engineering Drug Delivery Systems
A Book

by Ali Seyfoddin,Seyedehsara Masoomi Dezfooli,Carol Ann Greene

  • Publisher : Woodhead Publishing
  • Release : 2019-11-15
  • Pages : 250
  • ISBN : 0081025491
  • Language : En, Es, Fr & De
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Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology. This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry. Examines the properties and synthesis of biomaterials for successful drug delivery Discusses the important connection between drug delivery and tissue engineering Includes techniques and approaches applicable to a wide range of users Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery

Drug Delivery Systems

Drug Delivery Systems
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-10-23
  • Pages : 792
  • ISBN : 0128145080
  • Language : En, Es, Fr & De
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Drug Delivery Systems examines the current state of the field within pharmaceutical science and concisely explains the history of drug delivery systems, including key developments. The book translates the physicochemical properties of drugs into drug delivery systems administered via various routes, such as oral, parenteral, transdermal and inhalational. Regulatory and product development topics are also explored. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of drug delivery systems within the pharmaceutical sciences industry and research, as well as in chemical engineering. Each chapter delves into a particular aspect of this fundamental field to cover the principles, methodologies and technologies employed by pharmaceutical scientists. This book provides a comprehensive examination that is suitable for researchers and advanced students working in pharmaceuticals, cosmetics, biotechnologies, and related industries. Provides up-to-date information on how to translate the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as oral, parenteral, transdermal and inhalational Contains extensive references and further reading for course and self-study

Design of Controlled Release Drug Delivery Systems

Design of Controlled Release Drug Delivery Systems
A Book

by Xiaoling Li

  • Publisher : McGraw Hill Professional
  • Release : 2005-11-24
  • Pages : 435
  • ISBN : 0071588833
  • Language : En, Es, Fr & De
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The goal of every drug delivery system is to deliver the precise amount of a drug at a pre-programmed rate to the desired location in order to achieve the drug level necessary for the treatment. An essential guide for biomedical engineers and pharmaceutical designers, this resource combines physicochemical principles with physiological processes to facilitate the design of systems that will deliver medication at the time and place it is most needed.

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems
A Book

by Naoya Ogata,Sung W. Kim,Jan Feijen,Teruo Okano

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 381
  • ISBN : 4431658831
  • Language : En, Es, Fr & De
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First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering

Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering
A Book

by Laurent Simon

  • Publisher : John Wiley & Sons
  • Release : 2012-12-10
  • Pages : 384
  • ISBN : 1118396464
  • Language : En, Es, Fr & De
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Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

Drug Delivery

Drug Delivery
Engineering Principles for Drug Therapy

by W. Mark Saltzman

  • Publisher : Oxford University Press
  • Release : 2001-03-15
  • Pages : 384
  • ISBN : 0199879753
  • Language : En, Es, Fr & De
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Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery
A Book

by Rebecca A. Bader,David A. Putnam

  • Publisher : John Wiley & Sons
  • Release : 2014-01-17
  • Pages : 496
  • ISBN : 1118747801
  • Language : En, Es, Fr & De
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Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Tissue Engineering And Novel Delivery Systems

Tissue Engineering And Novel Delivery Systems
A Book

by Michael J. Yaszemski,Debra J. Trantolo,Kai-Uwe Lewandrowski,Vasif Hasirci,David E. Altobelli,Donald L. Wise

  • Publisher : CRC Press
  • Release : 2003-11-04
  • Pages : 620
  • ISBN : 9780203913338
  • Language : En, Es, Fr & De
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Essential to anyone working in the field, this reference focuses on rencent advancements in tissue construction, repair and regeneration examining developments in gene and drug therapy, the evolution of tissue-engineered products, and new technologies for the design of functional tissues and organ systems.

Engineering Improvements for Epicardial Drug Delivery Systems

Engineering Improvements for Epicardial Drug Delivery Systems
A Book

by Shahrin Islam

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 80
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cardiovascular diseases continue have a large disease burden despite advancements in technology, therapeutic modalities, and prevention efforts. For various cardiovascular pathologies, epicardial drug delivery systems have shown promise. Our group has developed a replenishable epicardial drug delivery device called Therepi that allows for repeat administrations of therapeutics without necessitating multiple invasive surgeries. The purpose of this thesis is to improve upon the Therepi device and utilize the platform to study the effects of specific therapeutics on cardiac function in a preclinical small animal myocardial infarction (MI) model. I first show that the fibrous capsule that forms around the polycarbonate membrane interface of the first iteration Therepi device post-implantation can impede transport of therapeutics from the device to the heart. Then, I utilize a modified version of Therepi without the polycarbonate membrane to study the effects of repeat administrations of FSTL1, a promising protein with great therapeutic potential, on cardiac function post-MI. Results from this study indicate that removal of the polycarbonate membrane reduces the formation of a fibrous capsule and that repeat administrations of FSTL1 improve cardiac function after MI. Following this, I utilize a computational macroscale model of Therepi to study the effect of important design parameters such as loading conditions, biomaterial geometry and orientation relative to the cardiac fibers on drug delivery to the myocardium. The simulations highlight the significance of the cardiac fiber anisotropy as a crucial factor in governing drug distribution on the epicardial surface and limiting factor for penetration into the myocardium. The multiscale model can be useful for rapid iteration of different device concepts and determination which designs for epicardial drug delivery may be optimal and most promising for the ultimate therapeutic goal. In the future, the findings from this thesis will be further investigated to develop an improved version of Therepi that allows for better device-tissue adhesion, conformability, and transport. The effects of repeat administrations of FSTL1 from the Therepi device will be elucidated further to mechanistically understand how cardiac function is improved through this strategy.

Drug Delivery Aspects

Drug Delivery Aspects
Volume 4: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Academic Press
  • Release : 2020-03-27
  • Pages : 266
  • ISBN : 0128218509
  • Language : En, Es, Fr & De
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Drug Delivery Aspects reviews additional features of drug delivery systems, along with the standard formulation development, like preclinical testing, conversion into solid dosage forms, roles of excipients and polymers used on stability and sterile processing. There is a focus on formulation engineering and related large scale (GMP) manufacturing, regulatory, and functional aspects of drug delivery systems. A detailed discussion on biologics and vaccines gives insights to readers on new developments in this direction. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses engineering and large-scale manufacturing of nanocarriers Considers preclinical, regulatory and ethical guidelines on nanoparticles Contains in-depth discussions on delivery of biologics, vaccines and sterilisation Industrial view on solid dispersions, milling techniques

Drug Delivery

Drug Delivery
Materials Design and Clinical Perspective

by Eric P. Holowka,Sujata K. Bhatia

  • Publisher : Springer
  • Release : 2014-11-22
  • Pages : 355
  • ISBN : 1493919989
  • Language : En, Es, Fr & De
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Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
A Book

by Emmanuel C. Opara

  • Publisher : CRC Press
  • Release : 2020-02-28
  • Pages : 351
  • ISBN : 0429582757
  • Language : En, Es, Fr & De
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This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
A Book

by Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak

  • Publisher : CRC Press
  • Release : 2007-03-30
  • Pages : 376
  • ISBN : 9781420008449
  • Language : En, Es, Fr & De
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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Drug Delivery Systems

Drug Delivery Systems
A Book

by Kewal K. Jain

  • Publisher : Springer Science & Business Media
  • Release : 2008-03-07
  • Pages : 251
  • ISBN : 1588298914
  • Language : En, Es, Fr & De
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In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering
A Book

by Ashutosh Tiwari,Atul Tiwari

  • Publisher : John Wiley & Sons
  • Release : 2013-02-19
  • Pages : 576
  • ISBN : 1118644743
  • Language : En, Es, Fr & De
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This groundbreaking, multidisciplinary work is one of the first books to cover Nanotheragnostics, the new developmental edge of nanomedicine. Through a collection of authoritative chapters, the book reports on nanoscopic therapeutic systems that incorporate therapeutic agents, molecular targeting, and diagnostic imaging capabilities. An invaluable reference for researchers in materials science, bioengineering, pharmacy, biotechnology, and nanotechnology, this volume features four main parts on biomedical nanomaterials, advanced nanomedicine, nanotheragnostics, and nanoscaffolds technology.

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
Strategies, Technologies, and Applications

by Yoon Yeo

  • Publisher : John Wiley & Sons
  • Release : 2013-02-25
  • Pages : 324
  • ISBN : 1118570510
  • Language : En, Es, Fr & De
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Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Towards New Frontiers in Patient Care

by Filippo Rossi,Giuseppe Perale,Maurizio Masi

  • Publisher : Springer
  • Release : 2016-01-19
  • Pages : 100
  • ISBN : 3319022881
  • Language : En, Es, Fr & De
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This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering

Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering
A Book

by Lisa C. du Toit,Pradeep Kumar,Yahya E. Choonara,Viness Pillay

  • Publisher : Elsevier
  • Release : 2020-03-08
  • Pages : 316
  • ISBN : 0128184728
  • Language : En, Es, Fr & De
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Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient Explores the current generation of nanostructured 3D printed medical devices Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals

Liposome-Based Drug Delivery Systems

Liposome-Based Drug Delivery Systems
A Book

by Wan-Liang Lu,Xiang-Rong Qi

  • Publisher : Springer
  • Release : 2019-02-13
  • Pages : 400
  • ISBN : 9783662493182
  • Language : En, Es, Fr & De
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This volume mainly describes the protocols for fabrication of liposomal drug delivery system, and consists of three parts, namely, the advances in liposome-based drug delivery system, the general protocols for fabrication of drug-loading liposomes, and the protocols for preparation of functionalized liposome-based drug delivery system. It unearths the formulation of drug-loading liposomes, describes the detailed operation of liposomal formulation, and demonstrates their potential applications. This handbook is targeted at scientists, research students, and young investigators in pharmaceutical enterprises.