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Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems
A Book

by Naoya Ogata,Sung W. Kim,Jan Feijen,Teruo Okano

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 381
  • ISBN : 4431658831
  • Language : En, Es, Fr & De
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First of all, I would like to share the great pleasure of the successful five-day symposium with every participant in the 5th Iketani Conference which was held in Kagoshima from April1S (Tuesday) to 22 (Saturday), 1995. Outstanding speakers enthusiastically presented their up-to-the-minute results. Relatively little time was allotted for each presentation to ensure asdnuch time· as possible for intensive discussions on the particular topics that had just been p~esented: I was delighted to see that the lectures were of high quality, and the discu,ssionswere lively, exciting, and productive in a congenial atmosphere. We also had 92 papers in the poster ·session, in which young (and relatively young) scientists made every effort to present the novel results of their research in advanced biomaterials and drug delivery systems (DDS). I believe some of the research is most promising and will become noteworthy in the twenty-first century. It was a privilege for me to deliver a lecture at the special session of the symposium. In my introductory remarks, I pointed out five key terms in multifaceted biomaterials research: materials design, concept or methodology, devices, properties demanded, and fundamentals. I am confident that innovative progress in device manufacturing for end-use, e.g., artificial organs, vascular grafts, and DDS, can be brought about only through properly designed advanced materials that exhibit the desired functionality at the interface with any living body.

Engineering Drug Delivery Systems

Engineering Drug Delivery Systems
A Book

by Ali Seyfoddin,Seyedehsara Masoomi Dezfooli,Carol Ann Greene

  • Publisher : Woodhead Publishing
  • Release : 2019-11-15
  • Pages : 250
  • ISBN : 0081025491
  • Language : En, Es, Fr & De
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Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology. This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry. Examines the properties and synthesis of biomaterials for successful drug delivery Discusses the important connection between drug delivery and tissue engineering Includes techniques and approaches applicable to a wide range of users Reviews innovative technologies in drug delivery systems such as 3-D printed devices for drug delivery

Engineering Polymer Systems for Improved Drug Delivery

Engineering Polymer Systems for Improved Drug Delivery
A Book

by Rebecca A. Bader,David A. Putnam

  • Publisher : John Wiley & Sons
  • Release : 2014-01-17
  • Pages : 496
  • ISBN : 1118747801
  • Language : En, Es, Fr & De
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Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.

Engineering of Biomaterials for Drug Delivery Systems

Engineering of Biomaterials for Drug Delivery Systems
Beyond Polyethylene Glycol

by Anilkumar Parambath

  • Publisher : Woodhead Publishing
  • Release : 2018-02-01
  • Pages : 404
  • ISBN : 0081017510
  • Language : En, Es, Fr & De
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Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Engineering of Biomaterials for Drug Delivery Systems

Engineering of Biomaterials for Drug Delivery Systems
Beyond Polyethylene Glycol

by Anilkumar Parambath

  • Publisher : Woodhead Publishing Limited
  • Release : 2018-01-27
  • Pages : 404
  • ISBN : 9780081017500
  • Language : En, Es, Fr & De
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Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field. Provides a self-contained work for the field of biomaterials for drug delivery Summarizes the current knowledge on PEGylation and strategies for bypassing it Presents research on an important, though under-represented issue in biomaterials Written by a world-class team of research scientists, engineers and clinicians

Drug Delivery

Drug Delivery
Materials Design and Clinical Perspective

by Eric P. Holowka,Sujata K. Bhatia

  • Publisher : Springer
  • Release : 2014-11-22
  • Pages : 355
  • ISBN : 1493919989
  • Language : En, Es, Fr & De
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Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the potential to alleviate these shortcomings. However, the synergy of these disciplines also presents problems in which nascent technology lacks the necessary evaluation within its intended clinical environment. Given the growing potential for materials science to address a number of unanswered therapeutic needs, it remains even more pressing to validate emerging drug delivery technologies in actual clinical environments. Drug Delivery: Materials Design and Clinical Perspective addresses the core fundamentals of drug delivery using material science and engineering principles, and then applies this knowledge using prominent examples from both the scientific literature and clinical practice. Each chapter focuses on a specific drug delivery technology, such as controlled-release materials, thin-film materials, or smart materials. Within each chapter, an initial section on “Engineering Concepts” reviews the relevant fundamental principles that guide rational design. The following section on “Materials Design” discusses how the design process applies engineering concepts for use in physiological systems. A third section on “Implementation” discusses current approaches in the literature which have demonstrated effective drug delivery in controlled environments. Finally, each chapter contains several sections on “Clinical Applications” which describe the validity of materials approaches from a clinical perspective; these sections review the safety and efficacy of drug delivery systems for specific, compelling medical applications. The book thereby bridges materials science with clinical medicine, and provides the reader with a bench-to-bedside view of novel drug delivery systems. · Provides a comprehensive description of drug delivery systems from a materials perspective · Includes a wide-ranging discussion of clinical applications of drug delivery systems · Presents separate chapters on controlled release materials, thin film materials, self-microemulsifying materials, smart materials, etc. · Covers fundamental engineering principles, rational materials design, implementation testing, and clinical applications for each material type

Collagen-Based Drug Delivery Systems for Tissue Engineering

Collagen-Based Drug Delivery Systems for Tissue Engineering
A Book

by Mădălina Georgiana Albu

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Collagen-Based Drug Delivery Systems for Tissue Engineering.

Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering

Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering
A Book

by Laurent Simon

  • Publisher : John Wiley & Sons
  • Release : 2012-11-27
  • Pages : 384
  • ISBN : 1118396480
  • Language : En, Es, Fr & De
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Enables readers to apply process dynamics and control theory to solve bioprocess and drug delivery problems The control of biological and drug delivery systems is critical to the health of millions of people worldwide. As a result, researchers in systems biology and drug delivery rely on process dynamics and control theory to build our knowledge of cell behavior and to develop more effective therapeutics, controlled release devices, and drug administration protocols to manage disease. Written by a leading expert and educator in the field, this text helps readers develop a deep understanding of process dynamics and control theory in order to analyze and solve a broad range of problems in bioprocess and drug delivery systems. For example, readers will learn how stability criteria can be used to gain new insights into the regulation of biological pathways and lung mechanics. They'll also learn how the concept of a time constant is used to capture the dynamics of diffusive processes. Readers will also master such topics as external disturbances, transfer functions, and input/output models with the support of the author's clear explanations, as well as: Detailed examples from the biological sciences and novel drug delivery technologies 160 end-of-chapter problems with step-by-step solutions Demonstrations of how computational software such as MATLAB and Mathematica solve complex drug delivery problems Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering is written primarily for undergraduate chemical and biomedical engineering students; however, it is also recommended for students and researchers in pharmaceutical engineering, process control, and systems biology. All readers will gain a new perspective on process dynamics and control theory that will enable them to develop new and better technologies and therapeutics to treat human disease.

Biodegradable Systems in Tissue Engineering and Regenerative Medicine

Biodegradable Systems in Tissue Engineering and Regenerative Medicine
A Book

by Rui L. Reis,Julio San Román

  • Publisher : CRC Press
  • Release : 2004-11-29
  • Pages : 592
  • ISBN : 0203491238
  • Language : En, Es, Fr & De
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Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health

Materials for Biomedical Engineering: Nanomaterials-based Drug Delivery

Materials for Biomedical Engineering: Nanomaterials-based Drug Delivery
A Book

by Alina-Maria Holban,Alexandru Grumezescu

  • Publisher : Elsevier
  • Release : 2019-03-20
  • Pages : 534
  • ISBN : 0128169141
  • Language : En, Es, Fr & De
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Materials for Biomedical Engineering: Nanomaterials-Based Drug Delivery highlights the progress made in the field of nanostructures bioactive materials and their impact on efficient drug delivery towards personalized medicine. Drug delivery is a well investigated and challenging bio-medical field, with promising perspectives in medicine and engineering. This book brings together the latest research findings regarding nanostructured materials and their potential in designing highly efficient and personalized drug delivery systems. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of nanostructures in drug delivery systems Includes novel opportunities and ideas for developing or improving technologies in composites by companies, biomedical industries, and in related sectors Features at least 50% of references from the last 2-3 years

Fundamentals of Drug Delivery

Fundamentals of Drug Delivery
A Book

by Heather A. E. Benson,Michael S. Roberts,Adrian C. Williams,Xiaowen Liang

  • Publisher : John Wiley & Sons
  • Release : 2021-10-26
  • Pages : 592
  • ISBN : 1119769604
  • Language : En, Es, Fr & De
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A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Advanced Drug Delivery

Advanced Drug Delivery
A Book

by Ashim Mitra,Chi H. Lee,Kun Cheng

  • Publisher : John Wiley & Sons
  • Release : 2013-08-26
  • Pages : 530
  • ISBN : 1118662849
  • Language : En, Es, Fr & De
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Provides both fundamentals and new and emerging applications Advanced Drug Delivery brings readers fully up to datewith the state of the science, presenting the basics, formulationstrategies, and therapeutic applications of advanced drug delivery.The book demonstrates how core concepts of pharmaceutical sciences,chemistry, and molecular biology can be combined and applied inorder to spark novel ideas to design and develop advanced drugdelivery systems for the treatment of a broad range of humandiseases. Advanced Drug Delivery features contributions from aninternational team of pharmaceutical scientists. Chapters reflect athorough review and analysis of the literature as well as theauthors' firsthand experience developing drug delivery systems. Thebook is divided into four parts: Part I, Introduction and Basics of Advanced DrugDelivery, explores physiological barriers, stability,transporters, and biomaterials in drug delivery Part II, Strategies for Advanced Drug Delivery, offerstested and proven strategies for advanced delivery of both smallmolecules and macromolecules Part III, Translational Research of Advanced DrugDelivery, focuses on regulatory considerations andtranslational applications of advanced drug delivery systems forthe treatment of cardiovascular diseases, cancer, sexuallytransmitted diseases, ophthalmic diseases, and brain diseases Part IV, Future Applications of Advanced Drug Delivery inEmerging Research Areas, examines stem cell research,cell-based therapeutics, tissue engineering, and molecularimaging Each chapter provides objectives and assessment questions tohelp readers grasp key concepts and assess their knowledge as theyprogress through the book. Advanced Drug Delivery is recommended for graduates andupper-level undergraduates in the pharmaceutical sciences who needa solid foundation in the basics. It is also recommended forpharmaceutical professionals who want to take advantage of new andemerging applications in advanced drug delivery systems.

Drug Delivery

Drug Delivery
Engineering Principles for Drug Therapy

by W. Mark Saltzman

  • Publisher : Oxford University Press
  • Release : 2001-03-15
  • Pages : 384
  • ISBN : 0199879753
  • Language : En, Es, Fr & De
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Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.

Long-Acting Drug Delivery Systems

Long-Acting Drug Delivery Systems
Pharmaceutical, Clinical, and Regulatory Aspects

by Eneko Larraneta,Thakur Raghu Raj Singh,Ryan F. Donnelly

  • Publisher : Woodhead Publishing
  • Release : 2021-09-24
  • Pages : 392
  • ISBN : 0128217596
  • Language : En, Es, Fr & De
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Long-Acting Drug Delivery Systems: Pharmaceutical, Clinical, and Regulatory Aspects offers a comprehensive overview of the technical, clinical, regulatory and industrial perspectives on these drug delivery systems. The book follows a sequential order, beginning with the current technical state-of-the-field and moving on to more clinical, industrial and regulatory topics. Opening chapters describe the current needs and potential applications of implantable and long-acting therapeutic approaches. The book goes on to describe established and novel long-acting systems, with a focus on the materials used to prepare these systems and their biocompatibility. Importantly, applied topics such as scale-up manufacturing, products under clinical trials and regulatory aspects are covered, offering the reader a holistic view of this rapidly growing field. Brings together technical, clinical, regulatory and industrial perspectives for a complete overview of long acting and implantable drug delivery systems Provides up-to-date coverage of established and novel long-acting and implantable drug delivery systems, both in development and actively in use Appeals to a broad readership, including materials scientists, pharmaceutical scientists, biomedical engineers, clinicians and regulatory experts

Nanostructures for Drug Delivery

Nanostructures for Drug Delivery
A Book

by Ecaterina Andronescu,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-03-24
  • Pages : 1024
  • ISBN : 0323461492
  • Language : En, Es, Fr & De
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Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial

Biomaterials Fabrication and Processing Handbook

Biomaterials Fabrication and Processing Handbook
A Book

by Paul K. Chu,Xuanyong Liu

  • Publisher : CRC Press
  • Release : 2008-03-27
  • Pages : 720
  • ISBN : 9780849379741
  • Language : En, Es, Fr & De
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Focusing on a lucrative and increasingly important area of biomedicine, the Biomaterials Fabrication and Processing Handbook brings together various biomaterials production and processing aspects, including tissue engineering scaffold materials, drug delivery systems, nanobiomaterials, and biosensors. With contributions from renowned international experts and extensive reference lists in each chapter, the volume provides detailed, practical information to produce and use biomaterials. The different facets of biomaterials technology are split into four sections in the book— Part I The development of new materials and devices capable of interacting specifically with biological tissues and the preparation of scaffolds using materials with appropriate composition and structure Part II The necessary materials to create a drug delivery system capable of controlled release and the incorporation of drug reservoirs into implantable devices for sustained controlled release Part III The significant role nanotechnology plays in the biomedical and biotechnology fields Part IV More biomaterials, including synthetic and natural degradable polymeric biomaterials, electroactive polymers as smart materials, and biomaterials for gastrointestinal and cartilage repair and reconstruction

Controlled Drug Delivery Systems

Controlled Drug Delivery Systems
Towards New Frontiers in Patient Care

by Filippo Rossi,Giuseppe Perale,Maurizio Masi

  • Publisher : Springer
  • Release : 2016-01-19
  • Pages : 100
  • ISBN : 3319022881
  • Language : En, Es, Fr & De
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This book offers a state-of-the-art overview of controlled drug delivery systems, covering the most important innovative applications. The principles of controlled drug release and the mechanisms involved in controlled release are clearly explained. The various existing polymeric drug delivery systems are reviewed, and new frontiers in material design are examined in detail, covering a wide range of polymer modification techniques. The concluding chapter is a case study focusing on use of a drug-eluting stent. The book is designed to provide the reader with a complete understanding of the mechanisms and design of controlled drug delivery systems, and to this end includes numerous step-by-step tutorials. It illustrates how chemical engineers can advance medical care by designing polymeric delivery systems that achieve either temporal or spatial control of drug delivery and thus ensure more effective therapy that eliminates the potential for both under- and overdosing.

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery
A Book

by Juergen Siepmann,Ronald A. Siegel,Michael J. Rathbone

  • Publisher : Springer Science & Business Media
  • Release : 2011-12-14
  • Pages : 592
  • ISBN : 1461408806
  • Language : En, Es, Fr & De
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Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Natural Polymer Drug Delivery Systems

Natural Polymer Drug Delivery Systems
Nanoparticles, Plants, and Algae

by Saurabh Bhatia

  • Publisher : Springer
  • Release : 2016-09-23
  • Pages : 225
  • ISBN : 3319411292
  • Language : En, Es, Fr & De
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This book describes 200 bio-polymers, including the most recent and advanced nanotechnology applications. The applications of various bio-medical and other future potential uses are covered and examined in depth. Systematic discussion of current leading natural polymers is also included.

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems
Recent Trends and Clinical Evidences

by Yashwant Pathak,Nazrul Islam

  • Publisher : CRC Press
  • Release : 2021-10-17
  • Pages : 692
  • ISBN : 1000450767
  • Language : En, Es, Fr & De
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Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems