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Epigenetics of Exercise and Sports

Epigenetics of Exercise and Sports
Concepts, Methods, and Current Research

by Stuart Raleigh

  • Publisher : Academic Press
  • Release : 2021-07-13
  • Pages : 320
  • ISBN : 0128209372
  • Language : En, Es, Fr & De
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Epigenetics of Exercise and Sports: Concepts, Methods, and Current Research explains fundamental epigenetic processes and how these are altered by exercise and sports. After a brief review of fundamental epigenetic biology, this all-new volume in the Translational Epigenetics series offers step-by-step instruction in how epigenetic factors are investigated for their influence over exercise related traits of human physiology, disease, and injury. The current state of knowledge in the field and recent findings are discussed in-depth, illuminating how exercise and sports performance may epigenetically modify our physiology, disease and injury risks, and how this knowledge can be applied in personalized exercise approaches, diagnostics, and treatment. This book also explores the shortcomings of explaining exercise related phenomena using only genomics and traditional biochemical techniques, setting the scene for a paradigm shift in exercise biology. In addition, over a dozen international specialists contribute chapters on exercise and sports epigenetics, and their influence over metabolism, obesity, aging, immunity, and neurological disease, as well as the epigenetic impacts of concussions and sports doping. A concluding chapter discusses ongoing themes in the field and outlooks for future research. Thoroughly examines fundamental concepts in exercise and sports epigenetics, methods for new research, and known impacts for human physiology, disease, and clinical outcomes Discusses exercise and sports epigenetics in relation to metabolism, obesity, aging, immunity, and neurological disease, concussion, and sports doping, among other topics Includes preliminary information on exercise epigenetics and covid-19 infection Features chapter contributions from international experts in the field

Sports, Exercise, and Nutritional Genomics

Sports, Exercise, and Nutritional Genomics
Current Status and Future Directions

by Debmalya Barh,Ildus I. Ahmetov

  • Publisher : Academic Press
  • Release : 2019-08-25
  • Pages : 606
  • ISBN : 0128163402
  • Language : En, Es, Fr & De
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Sports, Exercise, and Nutritional Genomics: Current Status and Future Directions is the first reference volume to offer a holistic examination of omics-driven advances across different aspects of exercise and sports physiology, biochemistry, sports medicine, psychology, anthropology, and sports nutrition; and highlighting the opportunities towards advance personalized training and athlete health management. More than 70 international experts from 14 countries have discussed key exercise and sport-related themes through the prism of genomics, epigenomics, transcriptomics, proteomics, metabolomics, telomere biology, talent in sport, individual differences in response to regular physical activity, that in the future may empower coaches, sports physicians, fitness experts, genetic counselors, and translational scientists to employ various omics data and approaches in improving health and physical performance of people participating in sports and exercise activities. Contributors address current knowledge of genetic influence on athletic performance, individual responses to exercise training, as well as the genetics of musculoskeletal phenotypes, exercise-related injuries, flexibility, and neurodegenerative disorders in athletes. Finally, performance-related and psychological traits associated with epigenetic, transcriptomic and metagenomic biomarkers are also considered, along with nutritional and pharmacogenomic aids in sports medicine and personalized nutrition. Effectively synthesizes key themes across molecular aspects of exercise and sports sciences Provides a knowledge base for future translation of omics solutions to talent identification, individualized training, and nutrition Features contributions from international experts (researchers and clinicians) in the subject area

Medical Epigenetics

Medical Epigenetics
A Book

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2016-06-21
  • Pages : 924
  • ISBN : 0128032405
  • Language : En, Es, Fr & De
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Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Routledge Handbook of Sport and Exercise Systems Genetics

Routledge Handbook of Sport and Exercise Systems Genetics
A Book

by J. Timothy Lightfoot,Monica J. Hubal,Stephen M. Roth

  • Publisher : Routledge
  • Release : 2019-03-14
  • Pages : 514
  • ISBN : 135138015X
  • Language : En, Es, Fr & De
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Technological advances over the last two decades have placed genetic research at the forefront of sport and exercise science. It provides potential answers to some of contemporary sport and exercise’s defining issues and throws up some of the area’s most challenging ethical questions, but to date, it has rested on a fragmented and disparate literature base. The Routledge Handbook of Sport and Exercise Systems Genetics constitutes the most authoritative and comprehensive reference in this critical area of study, consolidating knowledge and providing a framework for interpreting future research findings. Taking an approach which covers single gene variations, through genomics, epigenetics, and proteomics, to environmental and dietary influences on genetic mechanisms, the book is divided into seven sections. It examines state-of-the-art genetic methods, applies its approach to physical activity, exercise endurance, muscle strength, and sports performance, and discusses the ethical considerations associated with genetic research in sport and exercise. Made up of contributions from some of the world’s leading sport and exercise scientists and including chapters on important topical issues such as gene doping, gender testing, predicting sport performance and injury risk, and using genetic information to inform physical activity and health debates, the handbook is a vital addition to the sport and exercise literature. It is an important reference for any upper-level student, researcher, or practitioner working in the genetics of sport and exercise or exercise physiology, and crucial reading for any social scientist interested in the ethics of sport.

Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise

Genetic and Epigenetic Modulation of Cell Functions by Physical Exercise
A Book

by Italia Di Liegro

  • Publisher : MDPI
  • Release : 2020-05-12
  • Pages : 170
  • ISBN : 3039284800
  • Language : En, Es, Fr & De
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From an evolutionary perspective, our species has relied upon physical activity for most of its history to survive and has had to escape from predators, to scavenge for food, and to use physique to work or build necessary means for everyday life. Physical activity has been part of our evolution and progress since the very beginning and, consequently, our entire body has been programmed to be active physically. In the last 20 years, scientific research has increasingly shown that our ancient survival principle has beneficial effects not only on the cells and organs involved in physical activities but on the metabolism of the entire organism, influencing the homeostasis and integration of all bodily functions, likely stimulating the production of hormones and other regulatory molecules, with each affecting vital signalling pathways. Most of the web of factors involved in molecular signalling upon exercise are suspected to be centrally controlled by the brain, which has been reported to be deeply modified by physical activity. Such complexity requires a multifaceted approach to shed light on the molecular interactions that occur between physical activity and its outcome at a cellular level.

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics
A Book

by Shuai Li,John Hopper

  • Publisher : Academic Press
  • Release : 2021-08-31
  • Pages : 374
  • ISBN : 0128209526
  • Language : En, Es, Fr & De
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Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

Genome Stability

Genome Stability
From Virus to Human Application

by Igor Kovalchuk,Olga Kovalchuk

  • Publisher : Academic Press
  • Release : 2021-07-17
  • Pages : 760
  • ISBN : 0323856802
  • Language : En, Es, Fr & De
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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Sport and Exercise Science

Sport and Exercise Science
A Book

by Matjaz Merc

  • Publisher : BoD – Books on Demand
  • Release : 2018-02-07
  • Pages : 124
  • ISBN : 9535137948
  • Language : En, Es, Fr & De
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Professional and semiprofessional sports as well as excessive amateur exercise inevitably lead to some degree of musculoskeletal injury once in a sportsman's career. Some injuries are represented as chronic injuries, which can result in irreversible long-term tissue changes and deformities. The subject of this book is to represent the up-to-date knowledge about etiology, pathogenesis, diagnosis, management, and prevention of chronic injuries or sport-related long-term changes in locomotor system.

Exercise, Sport, and Bioanalytical Chemistry

Exercise, Sport, and Bioanalytical Chemistry
Principles and Practice

by Anthony C Hackney

  • Publisher : Elsevier
  • Release : 2016-03-14
  • Pages : 136
  • ISBN : 0128096918
  • Language : En, Es, Fr & De
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A new volume in the Emerging Issues in Analytical Chemistry series, Exercise, Sport, and Bioanalytical Chemistry: Principles and Practice focuses on the basic and applied aspects of energy metabolism in humans. Concise and scientific, yet intelligible to the nonscientist, the book consists of two parts. Part I, Introduction: Basics and Background, provides the biochemistry necessary to understand the rest of the book and describes analytical processes and results as an aid to grasping the science. Part II, Applications: Knowledge into Practice, explores measurement techniques for metabolism, energy expenditure of various activities, techniques that enhance expenditure, metabolic adaptation, foods and drugs that enhance expenditure, and the role of bioanalytical chemistry in future research in exercise and sport. Discussion of the benefits of exercise and practices for improving the capacity to perform exercise is illustrated by many useful and entertaining examples. This volume allows readers to come away with a grasp of the scientific concepts, how they are manifested in research techniques, and how the results of research can be applied in the real world of public health and personal development. The Emerging Issues in Analytical Chemistry series is published in partnership with RTI International and edited by Brian F. Thomas. Please be sure to check out our other featured volumes: Thomas, Brian F. and ElSohly, Mahmoud. The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations, 9780128046463, December 2015. Tanna, Sangeeta and Lawson, Graham. Analytical Chemistry for Assessing Medication Adherence, 9780128054635, April 2016. Rao, Vikram, Knight, Rob, and Stoner, Brian. Sustainable Shale Oil and Gas: Analytical Chemistry, Biochemistry, and Geochemistry Methods, 9780128103890, forthcoming September 2016. Farsalinos, Konstantinos, et al. Analytical Assessment of e-Cigarettes: From Contents to Chemical and Particle Exposure Profiles, 9780128112410, forthcoming November 2016. Provides readers with the fundamental biochemistry and some elements of the physiology behind physical activity/exercise and describes the analytical techniques used to elucidate the science Written in clear, concise, compelling prose that is neither simplistic to scientists nor too sophisticated for a large, diverse global audience A one-page Close-Up in each chapter illustrates key topics to catch, engage, entertain, and create a novel synthesis of thought

Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics
A Book

by José Luis García-Giménez

  • Publisher : Academic Press
  • Release : 2015-12-07
  • Pages : 696
  • ISBN : 0128019212
  • Language : En, Es, Fr & De
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Epigenetic Biomarkers and Diagnostics comprises 31 chapters contributed by leading active researchers in basic and clinical epigenetics. The book begins with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. It goes on to discuss classical methods and next generation sequencing-based technologies to discover and analyze epigenetic biomarkers. The book concludes with an account of DNA methylation, post-translational modifications and noncoding RNAs as the most promising biomarkers for cancer (i.e. breast, lung, colon, etc.), metabolic disorders (i.e. diabetes and obesity), autoimmune diseases, infertility, allergy, infectious diseases, and neurological disorders. The book describes the challenging aspects of research in epigenetics, and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and tested biomarkers to be used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies

Optimal Mobility and Function across the Lifespan

Optimal Mobility and Function across the Lifespan
A Book

by Ronald F. Zernicke,David Arthur Hart

  • Publisher : Frontiers Media SA
  • Release : 2021-03-12
  • Pages : 129
  • ISBN : 2889665933
  • Language : En, Es, Fr & De
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Stress: Genetics, Epigenetics and Genomics

Stress: Genetics, Epigenetics and Genomics
Volume 4: Handbook of Stress

by George Fink

  • Publisher : Academic Press
  • Release : 2020-10-24
  • Pages : 344
  • ISBN : 0128131578
  • Language : En, Es, Fr & De
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This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Sports, Society, and Technology

Sports, Society, and Technology
Bodies, Practices, and Knowledge Production

by Jennifer J. Sterling,Mary G. McDonald

  • Publisher : Springer Nature
  • Release : 2019-11-12
  • Pages : 282
  • ISBN : 9813291273
  • Language : En, Es, Fr & De
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Sports, Society, and Technology: Bodies, Practices, and Knowledge Production addresses the complex entanglements of science, technology, and sporting cultures. The collection explores themes around human and non-human actants, knowledge formations and processes, and the materiality and multiplicity of bodies through an engagement with the interdisciplinary fields of Sport Studies and Science and Technology Studies. Representing a range of methodological, theoretical, and disciplinary approaches, contributors interrogate the social, cultural, political, and historical intersections of an ever-expanding techno-scientific sporting landscape – from true bounce and brain trauma to exercise physiology, metrics, and esports, and from feminist technoscience, whey protein, and epigenetics to sickle cell screening and testosterone regulation.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
Translational Epigenetics

by Alexey Moskalev,Alexander M. Vaiserman

  • Publisher : Academic Press
  • Release : 2017-11-17
  • Pages : 544
  • ISBN : 012811083X
  • Language : En, Es, Fr & De
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Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Routledge International Handbook of Sport Psychology

Routledge International Handbook of Sport Psychology
A Book

by Robert J. Schinke,Kerry R. McGannon,Brett Smith

  • Publisher : Routledge
  • Release : 2016-02-05
  • Pages : 614
  • ISBN : 1317692322
  • Language : En, Es, Fr & De
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Contemporary sport psychology is a rapidly developing and theoretically rich discipline, and a sophisticated and challenging profession. The Routledge International Handbook of Sport Psychology offers a comprehensive and authoritative guide to contemporary sport psychology in all its aspects. Written by a team of world-leading researchers and practitioners from five continents, including both established scholars and the best emerging talents, the book traces the contours of the discipline of sport psychology, introducing fundamental theory, discussing key issues in applied practice, and exploring the most important themes, topics and debates across the sport psychology curriculum. Uniquely, the book presents comparative studies of the history and contemporary practice of sport psychology in ten countries, including the US, UK, China, Japan, Brazil, Russia and Israel, helping the reader to understand the cultural and contextual factors that shape international practice in sport psychology. As well as covering in depth the core pillars of sport psychology, from motivation and cognition to group dynamics, the book also includes a full section on cultural sport psychology, a vital but under-explored sub-discipline that is having a profound influence on contemporary theory and practice. With 56 chapters and unparalleled range, depth and currency, the Routledge Handbook of International Sport Psychology is an essential addition to any library with a serious holding in sport psychology.

The Role of Diet in One-carbon Metabolism and Epigenetics - a Metabolic Syndrome Perspective

The Role of Diet in One-carbon Metabolism and Epigenetics - a Metabolic Syndrome Perspective
PhD Thesis

by Mads Vendelbo Lind

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 225
  • ISBN : 9788793476585
  • Language : En, Es, Fr & De
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Sports Cardiology, An Issue of Cardiology Clinics, E-Book

Sports Cardiology, An Issue of Cardiology Clinics, E-Book
A Book

by Aaron Baggish,Andre La Gerche

  • Publisher : Elsevier Health Sciences
  • Release : 2016-10-03
  • Pages : 145
  • ISBN : 0323476996
  • Language : En, Es, Fr & De
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This issue of Cardiology Clinics on Sports Cardiology, edited by Drs. Aaron Baggish and Andre La Gerche, will cover a variety of aspects related to cardiovascular health and complications related to athletic activity. Topics covered in this issue include, but are not limited to, molecular aspects of exercise-induced cardiac remodeling; sudden cardiac death; atrial fibrillation in endurance athletes; congenital heart disease in athletes; exercise prescription for the athlete with cardiomyopathy; and advanced exercise testing for the sports cardiologist.

Sport, Exercise and Performance Psychology

Sport, Exercise and Performance Psychology
Research Directions To Advance the Field

by Anonim

  • Publisher : Oxford University Press
  • Release : 2021-09-03
  • Pages : 304
  • ISBN : 0197512518
  • Language : En, Es, Fr & De
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This book presents the most pressing questions to advance the field of sport, exercise, and performance psychology. Organized around performance and learning, health and wellbeing, and cultural and professional considerations, expert contributors in the field summarize the state-of-the-art literature, including tables with five must-read papers in each chapter. The book then presents the 125 critical research questions that must be addressed to move the field forward. As the main source of research questions for senior scholars, graduate masters and doctoral students, and advanced undergraduate students working on research projects, this book is the ultimate guide to addressing theoretical, methodological, and applied research in the field.

Epigenetics, Energy Balance, and Cancer

Epigenetics, Energy Balance, and Cancer
A Book

by Nathan A. Berger

  • Publisher : Springer
  • Release : 2016-09-23
  • Pages : 271
  • ISBN : 3319416103
  • Language : En, Es, Fr & De
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This volume of Energy Balance and Cancer provides state-of-the-art descriptions of the rapidly evolving science of epigenetics and how it may explain mechanisms by which alterations in energy balance such as obesity and physical activity may impact cancer. In addition to chapters explaining the processes mediating epigenetic regulation, the volume contains a series of chapters explaining how environmental influences including early life events, nutrition, exercise and microbiota may induce epigenetic changes that can affect carcinogenesis. The following chapters describe epigenetic relations of energy balance to cancer in distinct organ systems including esophagus, colon, prostate and breast. Epigenetics, Energy Balance and Cancer provides a valuable resource for students, research investigators and clinicians seeking to better understand these processes as well as a basis for novel translational and transdisciplinary approaches to further elucidate these processes and develop preventive and therapeutic strategies.

Nutrition, Exercise and Epigenetics: Ageing Interventions

Nutrition, Exercise and Epigenetics: Ageing Interventions
A Book

by Byung Pal Yu

  • Publisher : Springer
  • Release : 2015-02-11
  • Pages : 278
  • ISBN : 3319148303
  • Language : En, Es, Fr & De
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This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.