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Epigenetics of the Immune System

Epigenetics of the Immune System
A Book

by Dieter Kabelitz,Jaydeep Bhat

  • Publisher : Academic Press
  • Release : 2020-06-04
  • Pages : 384
  • ISBN : 0128179651
  • Language : En, Es, Fr & De
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Epigenetics of the Immune System focuses on different aspects of epigenetics and immunology, providing readers with the fundamental mechanisms relating to epigenetics and the immune system. This book provides in-depth information on immune cells as a toolbox in deciphering systematically regulated mechanisms using "omics" and computational biology approaches. In addition, the book presents the translational importance of epigenetics and the immune system in our understanding of pathophysiology in diseases and its therapeutic applications. Provides an overview of most important immune mechanisms, the current status of epigenetics, and how both of them are brought together Presents key principles of immune mechanisms in epigenetics, presenting current findings and key principles Features in-depth chapter contributions from a wide range of international researchers and specialists in immunology, translational medicine and epigenetics Merges two very large areas, covering the unique interrelatedness of epigenetics and immunology

Epigenetics in Psychiatry - Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy

Epigenetics in Psychiatry - Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy
A Book

by Nicole Katherin Moschny

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Samour & King's Pediatric Nutrition in Clinical Care

Samour & King's Pediatric Nutrition in Clinical Care
A Book

by Susan H Konek,Patricia J Becker

  • Publisher : Jones & Bartlett Learning
  • Release : 2019-03-15
  • Pages : 700
  • ISBN : 1284146391
  • Language : En, Es, Fr & De
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Samour & King's Pediatric Nutrition in Clinical Care, Fifth Edition provides comprehensive coverage of the nutritional aspects of pediatric clinical care. A widely trusted resource for more than twenty years, this text combines coverage of nutrition assessment and care with detailed coverage of normal growth, relevant disease states, and medical nutrition therapy.

Epigenetic Regulation and Epigenomics

Epigenetic Regulation and Epigenomics
A Book

by Robert A. Meyers

  • Publisher : John Wiley & Sons
  • Release : 2012-05-29
  • Pages : 1254
  • ISBN : 3527326820
  • Language : En, Es, Fr & De
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Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Epigenetic Inheritance and Evolution

Epigenetic Inheritance and Evolution
The Lamarckian Dimension

by Eva Jablonka,Marion J. Lamb,Senior Lecturer in Biology Birkbeck College Marion J Lamb

  • Publisher : Oxford University Press, USA
  • Release : 1995
  • Pages : 346
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Does the inheritance of acquired characteristics play a significant role in evolution? In this book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original, provocative exploration of the nature and origin of hereditary variations. Starting with a historical account of Lamarck's ideas and the reasons they have fallen in disrepute, the authors go on to challenge the prevailing assumption that all heritable variation is random and the result of variation in DNA base sequences. They also detail recent breakthroughs in our understanding of the molecular mechanisms underlying inheritance--including several pathways not envisioned by classical population genetics--and argue that these advances need to be more fully incorporated into mainstream evolutionary theory. Throughout, the book offers a new look at the evidence for and against the hereditability of environmentally induced changes, and addresses timely questions about the importance of non-Mendelian inheritance. A glossary and extensive list of references round out the book. Urging a reconsideration of the present DNA-centric view prevalent in the field, Epigentic Inheritance and Evolution will make fascinating and important reading for students and researchers in evolution, genetics, ecology, molecular biology, developmental biology, and the history and philosophy of science.

Autism Spectrum Disorders (ASD) - Searching for the Biological Basis for Behavioral Symptoms and New Therapeutic Targets

Autism Spectrum Disorders (ASD) - Searching for the Biological Basis for Behavioral Symptoms and New Therapeutic Targets

by Benjamin Gesundheit,Joshua Rosenzweig,Yehuda Shoenfeld

  • Publisher : Frontiers Media SA
  • Release : 2017-03-07
  • Pages : 329
  • ISBN : 2889451127
  • Language : En, Es, Fr & De
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Autism Spectrum Disorder (ASD) is currently diagnosed based on a series of behavioral tests. The challenge for researchers is to try to uncover the biological basis for these typical behaviors in order to improve diagnosis and identify potential targets for treatment. A multidisciplinary approach is necessary in order to move forward. This includes analysis of the current animal models for ASD and their suitability, reviewing immunological, immunogenetic and epigenetic research, reassessing clinical diagnostic tools, and surveying radiological, pathological, and serological records for clues. This volume includes research from some of the leading researchers on ASD. We are hopeful that it will stimulate further dialogue and research in this challenging field.

The Epigenetics of Autoimmunity

The Epigenetics of Autoimmunity
A Book

by Rongxin Zhang

  • Publisher : Academic Press
  • Release : 2018-04-25
  • Pages : 432
  • ISBN : 0128099283
  • Language : En, Es, Fr & De
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The Epigenetics of Autoimmunity covers a topic directly related to translational epigenetics. Via epigenetic mechanisms, a number of internal and external environmental risk factors, including smoking, nutrition, viral infection and the exposure to chemicals, could exert their influence on the pathogenesis of autoimmune diseases. Such factors could impact the epigenetic mechanisms, which, in turn, build relationship with the regulation of gene expression, and eventually triggering immunologic events that result in instability of immune system. Since epigenetic aberrations are known to play a key role in a long list of human diseases, the translational significance of autoimmunity epigenetics is very high. To bridge the gap between environmental and genetic factors, over the past few years, great progress has been made in identifying detailed epigenetic mechanisms for autoimmune diseases. Furthermore, with rapid advances in technological development, high-throughput screening approaches and other novel technologies support the systematic investigations and facilitate the epigenetic identification. This book covers autoimmunity epigenetics from a disease-oriented perspective and several chapters are presented that provide advances in wide-spread disorders or diseases such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), multiple sclerosis (MS), type 1 diabetes (T1DM), systemic sclerosis (SSc), primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (AITDs). These emerging epigenetic studies provide new insights into autoimmune diseases, raising great expectations among researchers and clinicians. This seminal book on this topic comprehensively covers the most recent advances in this exciting and rapidly developing new science. They might reveal not only new clinical biomarkers for diagnosis and disease progression, but also novel targets for potential epigenetic therapeutic treatment. Provides the accurate and cutting-edge information on autoimmunity epigenetics Wide coverage appeals to those interested in fundamental epigenetics and inheritance to those with more clinical interests Critical reviews of the mean of deriving and analysing autoimmunity epigenetics information as well as its translational potential Up-to-date coverage of emerging topics in autoimmunity epigenetics

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development

Transcriptional and Epigenetic Mechanisms Regulating Normal and Aberrant Blood Cell Development
A Book

by Constanze Bonifer,Peter N. Cockerill

  • Publisher : Springer Science & Business Media
  • Release : 2014-03-12
  • Pages : 416
  • ISBN : 3642451985
  • Language : En, Es, Fr & De
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During vertebrate hematopoiesis many specialized cell types are formed with vastly different functions such as B cells, T cells, granulocytes, macrophages, erythrocytes and megakaryocytes. To tightly control the enormous proliferative potential of developing blood cells, an intricately balanced signaling and transcription network has evolved that ensures that the different cell types are formed at the right time and in the right numbers. Intricate regulatory mechanisms ensure that blood cells function properly and have a determined life span. Moreover, in the adaptive immune system, long-lived memory cells have evolved that ensure that when pathogens have been seen once they will never cause a problem again. In this book we will therefore make a journey from asking how more primitive organisms use the epigenetic regulatory machinery to balance growth with differentiation control towards digging deep into what controls the function of specialized cells of the human immune system. We will first discover that flies make blood but exist without blood vessels, why fish make blood cells in the kidney and which precise genetic circuitries are required for these developmental pathways. We will then learn the regulatory principles that drive the differentiation of mature blood cells from stem cells and what controls their function in mammals. In the process, we will find out what unites hematopoietic stem cells and endothelial cells. Finally, we will shed light on the molecular mechanisms that either alter hematopoietic cell differentiation or lead to the development of cells with impaired function.

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation
A Book

by Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 692
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

A Model of Epigenetic, Pleiotropic, and Dominant Regulation of the Metastatic Phenotype

A Model of Epigenetic, Pleiotropic, and Dominant Regulation of the Metastatic Phenotype
A Book

by Suzi Safarians

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 316
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Annual Report

Annual Report
July 1, 2008-June 30, 2009

by University of California, Los Angeles. Molecular Biology Institute

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 220
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Patho-Epigenetics of Disease

Patho-Epigenetics of Disease
A Book

by Janos Minarovits,Hans Helmut Niller

  • Publisher : Springer Science & Business Media
  • Release : 2012-06-14
  • Pages : 466
  • ISBN : 1461433452
  • Language : En, Es, Fr & De
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In multicellular organisms the establishment, maintenance, and programmed alterations of cell-type specific gene expression patterns are regulated by epigenetic mechanisms. Thus, epigenetic alterations (DNA methylation, DNA associated Polycomb-Trithorax protein complexes, histone modifications) ensure the unique transcriptional activity and phenotypic diversity of diploid cells that carry identical or nearly identical DNA sequences. Because DNA methyltransferase I (DNMT1) associates with replication foci during S phase and prefers hemimethylated DNA as a substrate, DNMT1 ensures the clonal propagation of cytosine methylation patterns (maintenance methylation). Thus, DNA methylation may provide a memory function by helping progeny cells to “remember” their proper cellular identity. An alternative system of epigenetic memory, the Polycomb and Trithorax groups of protein complexes, that may operate both independently from and in concert with DNA methylation, ensures the heritable regulation of gene expression via modification of histone tails. The complex interplay of epigenetic regulatory mechanisms permits both the dynamic modulation of gene expression and the faithful transmission of gene expression patterns to each progeny cell upon division. These carefully orchestrated processes can go wrong, however, resulting in epigenetic reprogramming of the cells that may manifest in pathological changes, as it was first realized during the studies of epigenetic alterations in malignant tumors. By now it became a well established fact that not only genetic changes, but also the disruption of epigenetic regulation can result in carcinogenesis and tumor progression. Scientists working in other fields soon followed the pioneering work of cancer researchers, and revealed that epigenetic dysregulation forms the basis of a wide spectrum of human diseases.

The Epigenetics of Autoimmune Diseases

The Epigenetics of Autoimmune Diseases
A Book

by Moncef Zouali

  • Publisher : John Wiley & Sons
  • Release : 2009-04-01
  • Pages : 472
  • ISBN : 9780470743560
  • Language : En, Es, Fr & De
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The role of epigenetic mechanisms in autoimmune disease is only now starting to become clear. Understanding these mechanisms, their effect on cellular function and the role of environmental factors is vital to determining how to manage these often debilitating and fatal diseases. Drawing on the research of leading experts, this book provides a valuable insight into this important new area of autoimmunity research and a clear, up-to-date view on the major advances in the field. Specific coverage includes: How highly developed epigenetic mechanisms are involved in several aspects of normal immune regulation, in addition to maintaining immune tolerance to self-determinants. Specific epigenetic aspects of human autoimmune diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, systemic sclerosis, autoimmune diabetes, thyroid autoimmunity, inflammatory bowel disease and autoimmune hepatitis. How understanding epigenetic mechanisms can lead to therapeutic strategies based on manipulation of this previously unexploited facet of immune regulation. Discussion of the novel approaches that are being investigated to prevent or treat autoimmune diseases. This book is an essential resource for those actively involved in the field. It is also of interest to basic researchers interested in understanding the origin of autoimmunity and clinical specialists interested in gaining in-depth understanding of the pathogenesis of autoimmune diseases and their treatment.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America
A Book

by National Academy of Sciences (U.S.)

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biogerontology

Biogerontology
Mechanisms and Interventions, Volume 1100

by Suresh I. S. Rattan,Serif Akman

  • Publisher : Wiley-Blackwell
  • Release : 2007-05-07
  • Pages : 565
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biological aging and interventionary strategies are investigated with the eventual goal of extending healthy human lifespan and minimizing the incidence of diseases associated with aging. Biogerontologists, evolutionary biologists, biodemographers, scientists in related basic research, clinicians, and dieticians came together in Istanbul, Turkey, to share their research and discuss the latest developments in this rapidly advancing field. This volume presents chapters representative of the highlights of the meeting, including contributions in the following areas: (1) biological and nonbiological factors affecting lifespan and the quality of life; (2) ethical and social issues related to lifespan and health-span extension; (3) novel areas of understanding aging -- physiological, cellular, and molecular aspects; (4) new technologies to understand and modulate aging; (5) the latest successful approaches in the prevention and treatment of age-related diseases; and (6) aging intervention, prevention, and modulation by genes, natural and synthetic molecules, and lifestyle modifications. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

The Genie in Your Genes

The Genie in Your Genes
Epigenetic Medicine and the New Biology of Intention

by Dawson Church

  • Publisher : Elite Books
  • Release : 2009
  • Pages : 395
  • ISBN : 1604150211
  • Language : En, Es, Fr & De
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"Epigenetics--control of genes from outside the cell--is a brand new branch of science that promises a revolution in health and happiness. We used to think that our DNA determines much of our behavior as well as our physical characteristics. No more. Exciting new scientific research shows that many genes are being turned on and off -- every day -- by your beliefs, feelings, and attitudes. Every thought you think ripples throughout your body, affecting your immune system, brain, and hormone system."--p. [4] of cover.

Epigenetics for Beginners and Intermediate (2 Books in 1)

Epigenetics for Beginners and Intermediate (2 Books in 1)
How Epigenetics Can Potentially Revolutionize Our Understanding of the Structure and Behavior of Biological Life on Earth + Exploration DNA

by Frank Brown

  • Publisher : Unknown Publisher
  • Release : 2020-04-27
  • Pages : 330
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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You Are About To Develop A Comprehensive Understanding Of The Concept Of Epigenetics, Its Place In Modern Day Medicine, And Health Optimization And Why It Is Literally Changing How We Approach The Treatment Of Various Health Problems! Modern research has now confirmed that the behavior of your genes doesn't always depend on their DNA sequence, but also on factors referred to epigenetics, and that changes in these factors can play a critical role in disease, life structures, behavior and all aspects of life. And that's not all; research also shows that therapies based on these factors have proven effective in reversing some conditions, boosting the immune system, optimizing psychology and human adaptation. Epigenetics have thus taken the center stage in understanding human biology at a deeper level, life, and evolution. But what are epigenetics, and how to they work? How does the environment affect them, and how is this "remembered" in the body? How does epigenetic therapy work? What does it treat? Isn't it risky? What is the relationship between epigenetics and the human psychology? How can we benefit from the discovery and understanding of epigenetics? If you have these and other related questions, this 2 in 1 book is for you so keep reading. Here is a bit of what you'll learn from this 2 in 1 book: What epigenetics are, why they're important and how they work How epigenetics relate with our experiences How cells divide, and how genes control the growth and division of cells The difference between the DNA, gene and chromosomes The existing evidence of epigenetic changes, including in transgenerational epigenetic inheritance The ins and outs of epigenetics mechanisms The types of epigenetic therapies available today, including their risks, benefits and research on them The effect of epigenetic control in transcriptional regulation in pluripotency and early differentiation, DNA methylation and Demethylation, nucleosome remodeling and chromatin looping How epigenetics work at the molecular level and the effect of DNA damage in epigenetic change The functions of epigenetics, and how they boost mindfulness training, healthy eating and exercise How epigenetic therapy and modifications affects diabetic retinopathy, emotional disorders, cardiac dysfunction, cancer and schizophrenia, mesothelioma and many more How epigenetic modifications are used in understanding plant and animal evolution How epigenetic mechanisms are used in understanding human adaptation, boosting memory formation, growth and reinforcing infant neurobehavior. The role of epigenetic mechanisms in maternal care The role of environmental chemicals in epigenetics How epigenetics are involved in neurodegenerative diseases, drug formation, human development, the development of Hox genes and many more. The role of environmental exposures in pathophysiology of IPF Modulation of epigenetic marks by environmental exposures How epigenetic regulation affects the immune system ...And so much more! Whether you are a beginner or an intermediate in epigenetics, you will find this book educative, as you learn the A-Z of factors that are quickly changing our understanding of the structure of life. Don't wait.... Scroll up and click Buy Now with 1-Click or Buy Now to get started!

Proceedings of the Seventh International Symposium on Reproduction in Domestic Ruminants, Wellington, New Zealand, August 2006

Proceedings of the Seventh International Symposium on Reproduction in Domestic Ruminants, Wellington, New Zealand, August 2006
A Book

by J. L. Juengel

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 579
  • ISBN : 9781904761471
  • Language : En, Es, Fr & De
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The Year in Immunology

The Year in Immunology
A Book

by Noel R. Rose

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human Epigenetics: How Science Works

Human Epigenetics: How Science Works
A Book

by Carsten Carlberg,Ferdinand Molnár

  • Publisher : Springer Nature
  • Release : 2019-09-24
  • Pages : 153
  • ISBN : 3030229076
  • Language : En, Es, Fr & De
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The view “It’s all in our genes and we cannot change it” developed in the past 150 years since Gregor Mendel’s experiments with flowering pea plants. However, there is a special form of genetics, referred to as epigenetics, which does not involve any change of our genes but regulates how and when they are used. In the cell nucleus our genes are packed into chromatin, which is a complex of histone proteins and genomic DNA, representing the molecular basis of epigenetics. Our environment and lifestyle decisions influence the epigenetics of our cells and organs, i.e. epigenetics changes dynamically throughout our whole life. Thus, we have the chance to change our epigenetics in a positive as well as negative way and present the onset of diseases, such a type 2 diabetes or cancer. This textbook provides a molecular explanation how our genome is connected with environmental signals. It outlines that epigenetic programming is a learning process that results in epigenetic memory in each of the cells of our body. The central importance of epigenetics during embryogenesis and cellular differentiation as well as in the process of aging and the risk for the development of cancer are discussed. Moreover, the role of the epigenome as a molecular storage of cellular events not only in the brain but also in metabolic organs and in the immune system is described. The book represents an updated but simplified version of our textbook “Human Epigenomics” (ISBN 978-981-10-7614-8). The first five chapters explain the molecular basis of epigenetics, while the following seven chapters provide examples for the impact of epigenetics in human health and disease.