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Essentials of Noncoding RNA in Neuroscience

Essentials of Noncoding RNA in Neuroscience
Ontogenetics, Plasticity of the Vertebrate Brain

by Davide De Pietri Tonelli

  • Publisher : Academic Press
  • Release : 2017-06-14
  • Pages : 338
  • ISBN : 0128498994
  • Language : En, Es, Fr & De
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Essentials of Noncoding RNA in Neuroscience: Ontogenetics, Plasticity of the Vertebrate Brain focuses on the role of miRNAs in neurogenesis, gliogenesis, neuronal network formation, and the cell biology of forebrain development. The important role miRNAs play in neuronal maturation, neocortex function, and in some neurodevelopmental disorders is discussed, as are the computational challenges and methods used in the identification of miRNA targets. This book is a valuable reference for neuroscientists who wish to better understand the role of miRNAs in complex processes. It is of strong interest to those working to develop enabling technologies to detect and monitor miRNA expression and function, and to evaluate its roles in neural progenitor proliferation/differentiation, neuronal plasticity, and learning and memory. Discusses the unique features of neural miRNAs Details functional investigation of miRNA actions and current experimental approaches Includes extensive coverage of miRNA biology, developmental and postnatal neurogenesis, and computational challenges for miRNA target identification Contains thorough discussion of the transcriptional control of miRNA expression in forebrain development and in specific neuronal subtypes, as well as miRNA function in neurogenesis, neuronal network maturation, plasticity, gliogenesis, and dysfunction Provides an overview of miRNA roles in neurodevelopmental disorders and their possible role in the evolution of the neocortex

MicroRNA in Regenerative Medicine

MicroRNA in Regenerative Medicine
A Book

by Chandan K. Sen

  • Publisher : Elsevier
  • Release : 2014-11-26
  • Pages : 1288
  • ISBN : 0124058582
  • Language : En, Es, Fr & De
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This work encapsulates the uses of miRNA across stem cells, developmental biology, tissue injury and tissue regeneration. In particular contributors provide focused coverage of methodologies, intervention and tissue engineering. Regulating virtually all biological processes, the genome’s 1048 encoded microRNAs appear to hold considerable promise for the potential repair and regeneration of tissues and organs in future therapies. In this work, 50 experts address key topics of this fast-emerging field. Concisely summarizing and evaluating key findings emerging from fundamental research into translational application, they point to the current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA across repair and regeneration, and special coverage of methodologies and interventions as they point towards organ and tissue engineering Multi-colour text layout with 150 colour figures to illustrate important findings Take home messages encapsulate key lessons throughout text Short chapters offer focused discussion and clear ‘voice’

Essentials of Surgical Pediatric Pathology with DVD-ROM

Essentials of Surgical Pediatric Pathology with DVD-ROM
A Book

by Marta C. Cohen,Irene Scheimberg

  • Publisher : Cambridge University Press
  • Release : 2015-02-05
  • Pages : 524
  • ISBN : 1107430801
  • Language : En, Es, Fr & De
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Highly illustrated, practical yet comprehensive bench manual for general pathologists encountering pediatric cases, and pediatric pathology trainees.

Essentials of Abnormal Psychology

Essentials of Abnormal Psychology
A Book

by V. Mark Durand,David H. Barlow

  • Publisher : Nelson Education
  • Release : 2015
  • Pages : 736
  • ISBN : 130554479X
  • Language : En, Es, Fr & De
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Revised to reflect DSM-5, this briefer version of Durand and Barlow’s widely taught text fully describes abnormal psychology through the authors’ standard-setting integrative approach--the most modern, scientifically valid method for studying the subject. Through this approach, students learn that psychological disorders are rarely caused by a single influence, but rooted in the interaction among multiple factors: biological, psychological, cultural, social, familial, and even political. A conversational writing style, consistent pedagogy, and real case profiles--95 percent from the authors’ own case files--provide a realistic context for the scientific findings of the book. In addition, these features ensure that readers never lose sight of the fact that real people are behind the DSM-5 criteria, the theories, and the research. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Elements of Molecular Neurobiology

Elements of Molecular Neurobiology
A Book

by C. U. M. Smith

  • Publisher : John Wiley & Sons
  • Release : 2003-06-13
  • Pages : 630
  • ISBN : 047085717X
  • Language : En, Es, Fr & De
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This edition of the popular text incorporates recent advances in neurobiology enabled by modern molecular biology techniques. Understanding how the brain works from a molecular level allows research to better understand behaviours, cognition, and neuropathologies. Since the appearance six years ago of the second edition, much more has been learned about the molecular biology of development and its relations with early evolution. This "evodevo" (as it has come to be known) framework also has a great deal of bearing on our understanding of neuropathologies as dysfunction of early onset genes can cause neurodegeneration in later life. Advances in our understanding of the genomes and proteomes of a number of organisms also greatly influence our understanding of neurobiology. * Well known and widely used as a text throughout the UK, good reviews from students and lecturers. * Good complement to Fundementals of Psychopharmacology by Brian Leonard. This book will be of particular interest to biomedical undergraduates undertaking a neuroscience unit, neuroscience postgraduates, physiologists, pharmacologists. It is also a useful basic reference for university libraries. Maurice Elphick, Queen Mary, University of London "I do like this book and it is the recommended textbook for my course in Molecular Neuroscience. The major strength of the book is the overall simplicity of the format both in terms of layout and diagrams."

AGO-Driven Non-Coding RNAs

AGO-Driven Non-Coding RNAs
Codes to Decode the Therapeutics of Diseases

by Bibekanand Mallick

  • Publisher : Academic Press
  • Release : 2019-01-20
  • Pages : 387
  • ISBN : 0128156708
  • Language : En, Es, Fr & De
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The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

Personalized Epigenetics

Personalized Epigenetics
A Book

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2015-04-28
  • Pages : 610
  • ISBN : 0128004363
  • Language : En, Es, Fr & De
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine

'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine
A Book

by Nosheen Masood,Saima Shakil Malik

  • Publisher : Springer Nature
  • Release : 2020-03-20
  • Pages : 499
  • ISBN : 9811510679
  • Language : En, Es, Fr & De
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This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Current Advances in Amyotrophic Lateral Sclerosis

Current Advances in Amyotrophic Lateral Sclerosis
A Book

by Alvaro Estévez

  • Publisher : BoD – Books on Demand
  • Release : 2013-09-11
  • Pages : 266
  • ISBN : 9535111957
  • Language : En, Es, Fr & De
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Our understanding of the pathology of amyotrophic lateral sclerosis is a continuously changing field. New hypotheses are generated with each new discovery; they are abandoned to be reanalyzed after some time under the light of new observations. This book present a series of reviews from experts in different aspects of the disease focus on these hypotheses. There are also a few review chapters providing clear examples of these new observations that make the field to reanalyze previous conclusions.

Gene Expression and Regulation in Mammalian Cells

Gene Expression and Regulation in Mammalian Cells
Transcription From General Aspects

by Fumiaki Uchiumi

  • Publisher : BoD – Books on Demand
  • Release : 2018-02-21
  • Pages : 334
  • ISBN : 9535138553
  • Language : En, Es, Fr & De
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"Central dogma" was presented by Dr. Francis Crick 60 years ago. The information of nucleotide sequences on DNAs is transcribed into RNAs by RNA polymerases. We learned the mechanisms of how transcription determines function of proteins and behaviour of cells and even how it brings appearances of organisms. This book is intended for scientists and medical researchers especially who are interested in the relationships between transcription and human diseases. This volume consists of an introductory chapter and 14 chapters, divided into 4 parts. Each chapter is written by experts in the basic scientific field. A collection of articles presented by active and laboratory-based investigators provides recent advances and progresses in the field of transcriptional regulation in mammalian cells.

Molecular Cell Biology

Molecular Cell Biology
A Book

by Harvey F. Lodish,Berk Lodish (Zipursky, Matsudaria, Baltimore, Darnell),Arnold Berk,James E. Darnell,S. Lawrence Zipursky,David Baltimore,Paul Matsudaira

  • Publisher : Scientific American Library
  • Release : 2000
  • Pages : 1084
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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With its acclaimed author team, cutting-edge content, emphasis on medical relevance, and coverage based on landmark experiments, "Molecular Cell Biology" has justly earned an impeccable reputation as an authoritative and exciting text. The new Sixth Edition features two new coauthors, expanded coverage of immunology and development, and new media tools for students and instructors.

Translating MicroRNAs to the Clinic

Translating MicroRNAs to the Clinic
A Book

by Jeffrey Laurence

  • Publisher : Academic Press
  • Release : 2016-09-17
  • Pages : 392
  • ISBN : 0128005548
  • Language : En, Es, Fr & De
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Translating microRNA to the Clinic reviews the possibilities of current methodological tools and experimental approaches used by leading translational researchers. The book features the uses of micro ribonucleic acid as deployed in cancer targeting in biomarkers, diabetes, cardiovascular disease, and neurodegeneration, among many others. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field, promoting a cross-disciplinary communication between the sub-specialities of medicine, but in common with other books on the topic. In addition, the book emphasizes recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply microRNA from lab to clinic“/li> Extensive pedagogical updates aiming to improve the education of translational researchers in this field Transdisciplinary approach aims to support cross-fertilization between different sub-specialties of medicine

Viruses: Essential Agents of Life

Viruses: Essential Agents of Life
A Book

by Günther Witzany

  • Publisher : Springer Science & Business Media
  • Release : 2012-11-13
  • Pages : 428
  • ISBN : 940074899X
  • Language : En, Es, Fr & De
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A renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.

Essentials of Cerebellum and Cerebellar Disorders

Essentials of Cerebellum and Cerebellar Disorders
A Primer For Graduate Students

by Donna L. Gruol,Noriyuki Koibuchi,Mario Manto,Marco Molinari,Jeremy D. Schmahmann,Ying Shen

  • Publisher : Springer
  • Release : 2016-11-22
  • Pages : 656
  • ISBN : 3319245511
  • Language : En, Es, Fr & De
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Essentials of the Cerebellum and Cerebellar Disorders is the first book of its kind written specifically for graduate students and clinicians. It is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. This monograph makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from ataxia clinics and cerebellar laboratories throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

Biomedical Sciences

Biomedical Sciences
Essential Laboratory Medicine

by Raymond Iles,Suzanne Docherty

  • Publisher : John Wiley & Sons
  • Release : 2011-11-29
  • Pages : 440
  • ISBN : 1119962412
  • Language : En, Es, Fr & De
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Biomedical Sciences is an indispensable, all encompassing core textbook for first/ second year biomedical science students that will support them throughout their undergraduate career. The book includes the key components of the IBMS accredited degree programmes, plus sections on actual practice in UK hospital laboratories (including the compilation of a reflective portfolio). The book is visually exciting, and written in an interesting and accessible manner while maintaining scientific rigour. Highlighted boxes within the text link the theory to actual clinical laboratory practice for example, the histopathology chapter includes a photographically illustrated flow chart of the progress of a specimen through the histopathology lab, so that students can actually see how the specimen reception/inking/cut-up/cassette/block/section/stain system works, with an emphasis on the safety procedures that ensure specimens are not confused).

Handbook of Behavior, Food and Nutrition

Handbook of Behavior, Food and Nutrition
A Book

by Victor R. Preedy,Ronald Ross Watson,Colin R. Martin

  • Publisher : Springer Science & Business Media
  • Release : 2011-04-15
  • Pages : 2094
  • ISBN : 9780387922713
  • Language : En, Es, Fr & De
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This book disseminates current information pertaining to the modulatory effects of foods and other food substances on behavior and neurological pathways and, importantly, vice versa. This ranges from the neuroendocrine control of eating to the effects of life-threatening disease on eating behavior. The importance of this contribution to the scientific literature lies in the fact that food and eating are an essential component of cultural heritage but the effects of perturbations in the food/cognitive axis can be profound. The complex interrelationship between neuropsychological processing, diet, and behavioral outcome is explored within the context of the most contemporary psychobiological research in the area. This comprehensive psychobiology- and pathology-themed text examines the broad spectrum of diet, behavioral, and neuropsychological interactions from normative function to occurrences of severe and enduring psychopathological processes.

Bioinformatics

Bioinformatics
Updated Features and Applications

by Ibrokhim Y. Abdurakhmonov

  • Publisher : BoD – Books on Demand
  • Release : 2016-07-27
  • Pages : 268
  • ISBN : 953512546X
  • Language : En, Es, Fr & De
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An interdisciplinary bioinformatics science aims to develop methodology and analysis tools to explore large-volume of biological data using conventional and modern computer science, statistics, and mathematics, as well as pattern recognition, reconstruction, machine learning, simulation and iterative approaches, molecular modeling, folding, networking, and artificial intelligence. Written by international team of life scientists, this Bioinformatics book provides some updates on bioinformatics methods, resources, approaches, and genome analysis tools useful for molecular sciences, medicine and drug designs, as well as plant sciences and agriculture. I trust chapters of this book should provide advanced knowledge for university students, life science researchers, and interested readers on some latest developments in the bioinformatics field.

Environmental Epigenetics

Environmental Epigenetics
A Book

by L. Joseph Su,Tung-chin Chiang

  • Publisher : Springer
  • Release : 2015-05-18
  • Pages : 321
  • ISBN : 1447166787
  • Language : En, Es, Fr & De
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This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Autism

Autism
Paradigms, Recent Research and Clinical Applications

by Michael Fitzgerald,Jane Yip

  • Publisher : BoD – Books on Demand
  • Release : 2017-04-12
  • Pages : 344
  • ISBN : 953513079X
  • Language : En, Es, Fr & De
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This book opens with a discussion of neurodiversity and an elaboration of the diagnosis of autism. It then examines factors correlating with autism, including sex bias, month of birth, migration and impact of infant feeding. The next section is on the impact of autism. The neurobiology and genetic section deals with epigenetics and intracellular pathways associated with etiology. The development and behaviour section deals with proprioceptive profiles and joint attention in autism. The final section focuses on interventions including mindfulness, animal assisted activity, social/cultural perspective on autism intervention and physical activity. The book is relevant to all professionals and researchers working with persons with autism, including psychiatrists/psychologists, speech and language therapists, occupational therapists, teachers, nurses and care workers.

Avery's Neonatology

Avery's Neonatology
Pathophysiology & Management of the Newborn

by Mhairi G. MacDonald,Mary M. K. Seshia,Martha D. Mullett

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2005
  • Pages : 1748
  • ISBN : 9780781746434
  • Language : En, Es, Fr & De
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Revised and updated by a new editorial team, the Sixth Edition of this text will remain the leading reference on the clinical care of the newborn. It provides complete, authoritative information on the biology of the newborn and the pathophysiology and management of diseases during the neonatal period. This edition has five new chapters on the role of telemedicine in neonatology, the impact of labor and delivery on the fetus, fetal determinants of adult disease, breast feeding, and control of breathing and apnea. Also included is a full-color insert illustrating key signs and symptoms, selected imaging techniques, and dermatologic conditions.