Download Fibroblast Growth Factor 23 Ebook PDF

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23
A Book

by Christian Faul,Kenneth White,Orlando Gutierrez

  • Publisher : Elsevier
  • Release : 2021-04-06
  • Pages : 376
  • ISBN : 0128180374
  • Language : En, Es, Fr & De
GET BOOK

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

The Role of Fibroblast Growth Factor-23 in Chronic Kidney Disease-mineral and Bone Disorder

The Role of Fibroblast Growth Factor-23 in Chronic Kidney Disease-mineral and Bone Disorder
A Book

by Majd A. I. Mirza

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 83
  • ISBN : 9789155478834
  • Language : En, Es, Fr & De
GET BOOK

SP287SERUM FIBROBLAST GROWTH FACTOR-23 (FGF-23), SOLUBLE KLOTHO (SKLOTHO) AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE (REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE).

SP287SERUM FIBROBLAST GROWTH FACTOR-23 (FGF-23), SOLUBLE KLOTHO (SKLOTHO) AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE (REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE).
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Fibroblast Growth Factor-23 and Klotho in Bone/mineral and Parathyroid Disorders

Fibroblast Growth Factor-23 and Klotho in Bone/mineral and Parathyroid Disorders
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 72
  • ISBN : 9789155475901
  • Language : En, Es, Fr & De
GET BOOK

Identification of Novel Regulators of Fibroblast Growth Factor 23 (FGF23) Production

Identification of Novel Regulators of Fibroblast Growth Factor 23 (FGF23) Production
The Role of High-fat Diet and AMP-activated Protein Kinase (AMPK) [kumulative Dissertation]

by Philipp Glosse

  • Publisher : Unknown Publisher
  • Release : 2020*
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

FGF23; Klotho; kidney; calcium; phosphate; Orai1; inflammation; energy deficiency.

High Fibroblast Growth Factor 23 Levels Associated With Low Hemoglobin Levels in Patients With Chronic Kidney Disease Stages 3 and 4

High Fibroblast Growth Factor 23 Levels Associated With Low Hemoglobin Levels in Patients With Chronic Kidney Disease Stages 3 and 4
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Abstract : Abstract: In chronic kidney disease (CKD), decreased erythropoietin production, low serum active vitamin D levels, and high renin-angiotensin-aldosterone activities had been regarded as major causes of renal anemia. At present, no clinical data are available to elucidate the association between renal anemia and fibroblast growth factor 23 (FGF23) levels in CKD. This study aimed to access whether FGF23 is involved in the pathogenesis of renal anemia. This cross-sectional observational study included 53 stable outpatients with CKD stages 3 and 4. Our primary predictor was serum FGF23 levels and outcome was hemoglobin levels. Measurements contained hemoglobin, FGF23, 25-hydroxyvitamin D, intact parathyroid hormone, plasma renin, serum aldosterone, HbA1C levels, lipid and iron profiles, and serum and urine electrolytes. Mean age of our patients was 66.4 ± 12.8 (SD) years, mean estimated glomerular filtration rate 33.5 ± 13.9 mL/min/1.73 m 2, median FGF23 level 200 (25th–75th percentile, 124–303) pg/mL, vitamin D level 19.5 (25th–75th percentile, 14.0–25.9) ng/mL, and hemoglobin level 12.7 (25th–75th percentile, 10.7–13.75) g/dL. Even after adjusting multiple variables, lower hemoglobin levels correlated significantly with FGF23 levels that were higher than the median value (>200 pg/mL). Moreover, after adjusting for aldosterone, but not 25-hydroxyvitamin D, it decreased the association with FGF23 that higher than median level and hemoglobin levels. We also observed a significant decrease of hemoglobin level in the higher FGF23 group who had a diabetes history. High FGF23 levels were observed to be associated with low hemoglobin levels, which may be partially mediated through the effects of serum aldosterone levels in our patients with CKD stages 3 and 4. Furthermore, we also presumed that diabetes itself may have an impact on the loop among FGF23, hemoglobin, and aldosterone levels in these CKD patients.

SP377EFFECTS OF LOWER PHOSPHATE DIETS ON FIBROBLAST GROWTH FACTOR-23 IN PATIENTS WITH CHRONIC KIDNEY DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.

SP377EFFECTS OF LOWER PHOSPHATE DIETS ON FIBROBLAST GROWTH FACTOR-23 IN PATIENTS WITH CHRONIC KIDNEY DISEASE: SYSTEMATIC REVIEW AND META-ANALYSIS.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease
A Book

by Reinhold G. Erben,L. Darryl Quarles

  • Publisher : Frontiers Media SA
  • Release : 2019-04-05
  • Pages : 329
  • ISBN : 2889458059
  • Language : En, Es, Fr & De
GET BOOK

αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology of diseases such as chronic kidney disease, left ventricular hypertrophy, myocardial infarction, hypertension, and disorders characterized by impaired bone mineralization. The 11 articles compiled in this Research Topic consist of three Original Research articles and 8 Reviews or Mini Reviews, and are an excellent source of information about the state of the art in the FGF23/αKlotho field, covering almost all aspects of FGF23/αKlotho biology.

FP317PROTEINURIA DECREASES IN THE ACTIVITY OF FIBROBLAST GROWTH FACTOR 23 AND REDUCED FGF23 ACTIVITY IS ASSOCIATED WITH RENAL PROGRESSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: RESULT FROM KNOW-CKD STUDY.

FP317PROTEINURIA DECREASES IN THE ACTIVITY OF FIBROBLAST GROWTH FACTOR 23 AND REDUCED FGF23 ACTIVITY IS ASSOCIATED WITH RENAL PROGRESSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE: RESULT FROM KNOW-CKD STUDY.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Index Medicus

Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

SP332CIRCULATING FIBROBLAST GROWTH FACTOR-23 LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF ANEMIA DEVELOPMENT IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE.

SP332CIRCULATING FIBROBLAST GROWTH FACTOR-23 LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF ANEMIA DEVELOPMENT IN PATIENTS WITH NON-DIALYSIS CHRONIC KIDNEY DISEASE.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Fibroblast Growth Factors

Fibroblast Growth Factors
A Book

by Xiaokun Li

  • Publisher : Academic Press
  • Release : 2018-06-20
  • Pages : 576
  • ISBN : 0128161434
  • Language : En, Es, Fr & De
GET BOOK

Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs. Focuses on the growth engineering aspects of FGF-based drug development and its clinical applications Presents useful information on the history of FGFs, along with basic research and growth engineering technology Provides detailed, practical research methods and results obtained on FGFs Considers the successes and problems in engineering technology Offers up-to-date, comprehensive coverage from the world’s leading research group

Endocrine FGFs and Klothos

Endocrine FGFs and Klothos
A Book

by Makoto Kuro-o

  • Publisher : Springer Science & Business Media
  • Release : 2012-03-06
  • Pages : 210
  • ISBN : 1461408873
  • Language : En, Es, Fr & De
GET BOOK

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

FP387IRON DEFICIENCY, ERYTHROPOIETIN, AND FIBROBLAST GROWTH FACTOR 23 IN THE GENERAL POPULATION.

FP387IRON DEFICIENCY, ERYTHROPOIETIN, AND FIBROBLAST GROWTH FACTOR 23 IN THE GENERAL POPULATION.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

FP618THE ASSOCIATION OF FIBROBLAST GROWTH FACTOR - 23 AND BONE TURNOVER MARKERS ON HEMODIALYSIS PATIENTS.

FP618THE ASSOCIATION OF FIBROBLAST GROWTH FACTOR - 23 AND BONE TURNOVER MARKERS ON HEMODIALYSIS PATIENTS.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

FP545THE CLINICAL IMPACT OF FIBROBLAST GROWTH FACTOR 23 AND SCLEROSTIN ON VASCULAR CALCIFICATION IN PREVALENT HEMODIALYSIS PATIENTS.

FP545THE CLINICAL IMPACT OF FIBROBLAST GROWTH FACTOR 23 AND SCLEROSTIN ON VASCULAR CALCIFICATION IN PREVALENT HEMODIALYSIS PATIENTS.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

The Fibroblast Growth Factor Family

The Fibroblast Growth Factor Family
A Book

by Andrew Baird,Michael Klagsbrun,New York Academy of Sciences

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 515
  • ISBN : 9780897666909
  • Language : En, Es, Fr & De
GET BOOK

Annals of Clinical Biochemistry

Annals of Clinical Biochemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Vitamin D

Vitamin D
A Book

by Sol Epstein

  • Publisher : Endocrinology and Metabolism C
  • Release : 2010
  • Pages : 479
  • ISBN : 9781437718171
  • Language : En, Es, Fr & De
GET BOOK

This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feedback loops were identified between vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in autoimmune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders, and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.

RENAL DYSFUNCTION AND FGF-23 IN PATIENTS WITH RECENT SMALL SUBCORTICAL STROKE: A PROSPECTIVE COHORT STUDY.

RENAL DYSFUNCTION AND FGF-23 IN PATIENTS WITH RECENT SMALL SUBCORTICAL STROKE: A PROSPECTIVE COHORT STUDY.
A Book

by Thomas Gattringer

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Background Cerebral small vessel disease (CSVD) may be part of a multisystemic small vessel disorder also affecting the kidneys, but most previous data on this topic was retrospective and used limited renal parameters. In this prospective study of stroke patients with CSVD-related recent small subcortical infarction (RSSI), we hypothesized that markers of renal dysfunction were associated with the burden of CSVD on baseline MRI and its progression at follow-up MRI.MethodsWe prospectively investigated 101 patients (mean age: 60u00b111 years, 73% men) with MRI-confirmed RSSI who underwent follow-ups until 15 months poststroke. Renal parameters assessed included eGFR, Albumin-Creatinine Ratio and fibroblast growth factor-23 (FGF-23, an early marker of renal dysfunction). Chronic kidney disease (CKD) was defined according to current guidelines. Baseline CSVD burden and progression were assessed on brain MRI. ResultsRSSI patients with CKD (n=24, 24%) had more severe WMH at baseline (Fazekas 2-3 in 58% vs. 36%, p=0.04), other MRI markers of chronic CSVD did not differ compared to patients without CKD. CKD did not predict CSVD progression at 15 months. However, patients in the highest FGF-23 quartile more frequently showed CSVD progression (50% vs. 21%, OR 3.89, p=0.03) and showed increased rates of recurrent vascular events in the observation period (53% vs. 19%, OR 4.93, p=0.003). ConclusionsAlthough the severity of WMH was associated with CKD, conventional parameters of renal dysfunction did not predict progression of CSVD. However, our data suggest FGF-23 as a new biomarker of CSVD progression and recurrence of vascular events in RSSI patients, which warrants further studies.