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Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces

Fractal Analysis of the Binding and Dissociation Kinetics for Different Analytes on Biosensor Surfaces
A Book

by Ajit Sadana,Neeti Sadana

  • Publisher : Elsevier
  • Release : 2007-12-20
  • Pages : 372
  • ISBN : 9780080555010
  • Language : En, Es, Fr & De
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Biosensors are finding increasing applications in different areas. Over the last few years the areas where biosensors may be used effectively has increased dramatically. This book like the previous four books on analyte-receptor binding and dissociation kinetics by this author addresses the often neglected area. The kinetics of binding and dissociation in solution to appropriate receptors immobilized on biosensor surfaces occurs under diffusional limitations on structured surfaces. The receptors immobilized on the biosensor surface contribute to the degree of heterogeneity on the sensor chip surface. The fractal analysis examples presented throughout the book provide a convenient means to make quantitative the degree of heterogeneity present on the sensor surface, and relates it to the binding and dissociation rate coefficients. The fractal dimension is a quantitative measure of the degree of heterogeneity present on the biosensor surface. The book emphasizes medially-oriented examples. The detection of disease-related analytes is also emphasized. The intent being that if intractable and insidious diseases are detected earlier, they will be controlled better, eventually leading to a better prognosis. Chapter 3 is a new chapter that emphasizes enhancing the relevant biosensor performance parameters such as sensitivity, stability, selectivity, response time, etc. As usual, as done in previous books by this author, the last chapter provides an update of the economics involved in biosensors, and the difficulties encounters in starting-up a biosensor company. - Modelling of binding and dissociation kinetics of analyte-receptor reactions on biosensor surfaces: provides physical insights into these reactions occurring on biosensor surfaces. Very few researchers even attempt to analyze the kinetics of these types of reactions. - Fractal analysis used to model the binding and dissociation kinetics: original and unique approach. - Economic analysis provided in the last chapter: helps balance the book; besides providing much-needed information not available in the open literature. - Emphasis on improving biosensor performance parameters: helps make biosensors better. - Empahsis on medically-related analytes: helps in prognosis of diseases.

Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals

Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals
A Book

by Ajit Sadana

  • Publisher : Elsevier
  • Release : 2006-08-08
  • Pages : 384
  • ISBN : 9780080463698
  • Language : En, Es, Fr & De
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The application of biosensors is expanding in different areas. These are portable and convenient devices that permit the rapid, accurate, and reliable detection of analytes of interest present either in the atmosphere or in aqueous or in liquid phases. The detection of glucose levels in blood for the effective management of diabetes is one. Though different biosensors have been designed for an increasing number of applications, the kinetics of binding (and dissociation) of analytes by the receptors on the biosensor surfaces has not been given enough attention in the open literature. This is a very important area of investigation since it significantly impacts biosensor performance parameters such as stability, sensitivity, selectivity, response time, regenerability, etc. Binding and Dissociation Kinetics for Different Biosensor Applications Using Fractals addresses this critical need besides helping to correct or demonstrate the need to modify the present software available with commercial biosensors that determines the kinetics of analyte-receptor reactions on biosensor surfaces. * first book to provide detailed kinetic analysis of the binding and dissociation reactions that are occuring on the biosensor surface * addresses the area of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces * provides physical insights into reactions occuring on biosensor surfaces

Fractal Binding and Dissociation Kinetics for Different Biosensor Applications

Fractal Binding and Dissociation Kinetics for Different Biosensor Applications
A Book

by Ajit Sadana

  • Publisher : Elsevier
  • Release : 2005-07-06
  • Pages : 650
  • ISBN : 9780080458915
  • Language : En, Es, Fr & De
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Biosensors are portable and convenient devices that permit the rapid and reliable analysis of substances. They are increasingly used in healthcare, drug design, environmental monitoring and the detection of biological, chemical, and toxic agents. Fractal Binding and Dissociation Kinetics for Different Biosensor Applications focuses on two areas of expanding biosensor development that include (a) the detection of biological and chemical pathogens in the atmosphere, and (b) biomedical applications, especially in healthcare. The author provides numerous examples of practical uses, particularly biomedical applications and the detection of biological or chemical pathogens. This book also contains valuable information dedicated to the economics of biosensors. After reading this book, the reader will gain invaluable insight into how biosensors work and how they may be used more effectively. * No other book provides a detailed kinetic analysis of the binding and dissociation reactions occurring on the biosensor surfaces * Packed with examples of practical uses of biosensors * Includes chapters dedicated to the economics of biosensors

Biosensors: Kinetics of Binding and Dissociation Using Fractals

Biosensors: Kinetics of Binding and Dissociation Using Fractals
A Book

by Ajit Sadana

  • Publisher : Elsevier
  • Release : 2003-12-17
  • Pages : 418
  • ISBN : 9780080528137
  • Language : En, Es, Fr & De
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This title brings to the attention of researchers in the industry, and in academia, the application of fractals to help in modeling the analyte/receptor binding and dissociation kinetics on biosensor surfaces. The work builds on that done in Engineering Biosensors: Kinetics and Design Applications, published by Academic Press in 2002. In particular, more examples are provided of where biosensors may be effectively used. This sequel is extremely timely, given the anticipation that the applications and reliance on biosensors will increase due to the advances in miniaturization, (wireless) communications, and the development of new materials (especially biological and chemical). Other applications of biosensors on the increase can be found in: the protection of civilian structures and infrastructures; protection from possible biological and chemical threats; health care; energy; food safety; and the environment to name a few. Covers all areas of applications of biosensors No other book on biosensors describes the kinetics of binding Provides numerous examples of where biosensors may be used

A Fractal Analysis of Binding and Dissociation Kinetics for Analytes Related to Various Human Diseases on Biosensor Surfaces

A Fractal Analysis of Binding and Dissociation Kinetics for Analytes Related to Various Human Diseases on Biosensor Surfaces
A Book

by Atul M. Doke

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 228
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces

A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces
A Book

by Ajit Sadana,Neeti Sadana,Richa Sadana

  • Publisher : Elsevier
  • Release : 2018-07-31
  • Pages : 337
  • ISBN : 0444638822
  • Language : En, Es, Fr & De
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A Fractal Analysis of Chemical Kinetics with Applications to Biological and Biosensor Interfaces analyzes the kinetics of binding and dissociation of different analytes by different biosensor techniques, demonstrating and then comparing each. Emphasis is placed on newer instrumentation techniques, such as SPRi (surface plasmon resonance imaging), and classical techniques, such as SPR (surface plasmon resonance), and finally, DNA biosensors and nanobiosensors. In addition, a final capstone chapter includes biosensor economics. These topics are all covered in one comprehensive book in a way that cannot be found elsewhere. Analyzes the kinetics of binding on biosensor surfaces Presents and compares different biosensor techniques Provides insights into the binding and dissociation mechanisms of analytes on biosensor surfaces Links the heterogeneity of biosensor surfaces to dissociation rate coefficients

A Fractal Analysis of the Binding and Dissociation Kinetics of Analyte-receptor Systems on Biosensor Surfaces

A Fractal Analysis of the Binding and Dissociation Kinetics of Analyte-receptor Systems on Biosensor Surfaces
A Book

by Ifejesu Eni-olorunda

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 186
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: The ability to detect and accurately measure the concentration of certain substances or species is useful in monitoring the activity of substances which may be harmful when present beyond a certain threshold usually in analyte-receptor systems. Biosensors are analytical devices which are capable of detecting the presence of target species in such systems, typically, in small concentrations. Some fields of application where this is highly relevant include drug detection in pharmacology, toxic chemical detection, food industry, biotechnology, and the healthcare field. Most of these sensing devices are commercially available and possess certain characteristics responsible for their operation efficiency. Several kinetic theories have been postulated in an attempt to describe the nature of interactions that occur on biosensor surfaces and also predict kinetic parameters associated with these interactions. The fractal kinetic theory provides novel physical insight into the kinetics of analyte-receptor reactions occurring on biosensor surfaces. It has been used in analyses presented in this thesis to evaluate important kinetic parameters such as the binding and dissociation rate coefficients, fractal dimensions and affinity values. Examples are presented on modern improvements to biosensor technology with special attention to applications within the bio-medical field and certain protein-protein reactions in the human body. Knowledge of these parameters in science can be instrumental in implementing biosensor design modifications that can improve key performance characteristics such as stability, specificity/selectivity, and response time.

Engineering Biosensors

Engineering Biosensors
Kinetics and Design Applications

by Ajit Sadana

  • Publisher : Academic Press
  • Release : 2001-10-04
  • Pages : 404
  • ISBN : 0080523633
  • Language : En, Es, Fr & De
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Biosensors are becoming increasingly important bioanalytical tools in the pharmaceutical, biotechnology, food, and other consumer oriented industries. The technology, though well developed in Europe, is slowly developing and has begun to generate interest in the United States only over the past couple of years. Research is now being directed toward the development of biosensors that are versatile, economical, and simple to use. Engineering Biosensors is a comprehensive introduction to biosensors that includes numerous illustrations to further explain the main concepts and practical examples from existing literature. It describes what biosensors are, where they are used, and how their performance is affected by existing surface characteristics. A better understanding of biosensors, as provided by this book, will greatly assist in the design of new as well as the improvement of existing biosensors. Readers are also provided with invaluable and hard-to-find data on the economics of the biosensor market to assist them in better understanding the market and where it is heading.

Handbook of Biosensors and Biosensor Kinetics

Handbook of Biosensors and Biosensor Kinetics
A Book

by Ajit Sadana,Neeti Sadana

  • Publisher : Elsevier
  • Release : 2010-08-26
  • Pages : 536
  • ISBN : 9780080932859
  • Language : En, Es, Fr & De
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Biosensors are essential to an ever-expanding range of applications, including healthcare; drug design; detection of biological, chemical, and toxic agents; environmental monitoring; biotechnology; aviation; physics; oceanography; and the protection of civilian and engineering infrastructures. This book, like the previous five books on biosensors by this author (and one by the co-author), addresses the neglected areas of analyte-receptor binding and dissociation kinetics occurring on biosensor surfaces. Topics are covered in a comprehensive fashion, with homogeneous presentation for the benefit of the reader. The contributors address the economic aspects of biosensors and incorporate coverage of biosensor fabrication and nanobiosensors, among other topics. The comments, comparison, and discussion presented provides a better perspective of where the field of biosensors is heading. Serves as a comprehensive resource on biosensor analysis Examines timely topics such as biosensor fabrication and nanobiosensors Covers economic aspects and medical applications (e.g., the role of analytes in controlling diabetes)

Biomarkers and Biosensors

Biomarkers and Biosensors
Detection and Binding to Biosensor Surfaces and Biomarkers Applications

by Ajit Sadana,Neeti Sadana

  • Publisher : Newnes
  • Release : 2014-12-08
  • Pages : 702
  • ISBN : 0444537953
  • Language : En, Es, Fr & De
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Biomarkers and Biosensors offers thorough coverage of biomarker/biosensor interaction, current research trends, and future developments in applications of drug discovery. This book is useful to researchers in this field as well as clinicians interested in new developments in early detection and diagnosis of disease or the mode of operation of biomarkers. Biomarkers and Biosensors also emphasizes kinetics, and clearly delineates how this influences the biomarker market. Offers thorough coverage of the kinetics of biomarker interaction with the biosensor surface Provides evidence-based approach to evaluate effectiveness Provides pharmaceutical chemists the possibilities and methodology in assessing the effectiveness of new drugs Provides the information needed for the selection of the best biomarker for a specific application

Biosensors: Kinetics of Binding and Dissociation Using Fractals

Biosensors: Kinetics of Binding and Dissociation Using Fractals
A Book

by Ajit Sadana

  • Publisher : Elsevier
  • Release : 2003-12-31
  • Pages : 401
  • ISBN : 9780444515124
  • Language : En, Es, Fr & De
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Effect of Reynolds number on fractal binding kinetics on a surface-based biosensor -- DNA fractal binding and dissociation kinetics -- Fractal analysis of binding and dissociation interactions of estrogen receptors to ligands on biosensor surfaces -- A fractal analysis of analyte-estrogen receptor binding and dissociation kinetics using biosensors : environmental effects -- A fractal analysis of analyte-estrogen receptor binding and dissociation kinetics using biosensors : biomedical effects -- Fractal analysis of binding interactions of nuclear estrogen receptors occurring on biosensor surfaces -- A kinetic study of analyte-receptor binding and dissociation for biosensor applications : a fractal analysis for cholera toxin and peptide-protein interactions / -- The temporal nature of the binding and dissociation rate coefficients and the affinity values for biosensor kinetics -- Fractal analysis of analyte-receptor binding and dissociation, and dissociation alone for biosensor applicati ...

Dekker Encyclopedia of Nanoscience and Nanotechnology

Dekker Encyclopedia of Nanoscience and Nanotechnology
A Book

by James A. Schwarz,Cristian I. Contescu,Karol Putyera

  • Publisher : CRC Press
  • Release : 2004
  • Pages : 4014
  • ISBN : 9780824750480
  • Language : En, Es, Fr & De
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Encyclopedia of Surface and Colloid Science

Encyclopedia of Surface and Colloid Science
A Book

by P. Somasundaran

  • Publisher : CRC Press
  • Release : 2006
  • Pages : 6675
  • ISBN : 9780849396076
  • Language : En, Es, Fr & De
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Proceedings of IEEE Sensors ...

Proceedings of IEEE Sensors ...
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chemical Engineering Progress

Chemical Engineering Progress
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recognition Receptors in Biosensors

Recognition Receptors in Biosensors
A Book

by Mohammed Zourob

  • Publisher : Springer Science & Business Media
  • Release : 2010-01-08
  • Pages : 863
  • ISBN : 9781441909190
  • Language : En, Es, Fr & De
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Recognition receptors play a key role in the successful implementation of chemical and biosensors. Molecular recognition refers to non-covalent speci?c binding between molecules, one of which is typically a macromolecule or a molecular assembly, and the other is the target molecule (ligand or analyte). Biomolecular recognition is typically driven by many weak interactions such as hydrogen bo- ing, metal coordination, hydrophobic forces, van der Waals forces, pi-pi interactions and electrostatic interaction (due to permanent charges, dipoles, and quadrupoles) the polarization of charge distributions by the interaction partner leading to ind- tion and dispersion forces, and Pauli-exclusion-principle-derived inter-atomic repulsion, and a strong, “attractive” force arising largely from the entropy of the solvent and termed the hydrophobic effect. In recent years, there has been much progress in understanding the forces that drive the formation of such complexes, and how these forces are relate to the physical properties of the interacting molecules and their environment allows rational design of molecules and materials that interact in speci?c and desired ways. This book presents a signi?cant and up-to-date review of the various recognition elements, their immobilization, characterization techniques by a panel of dist- guished scientists. This work is a comprehensive approach to the recognition receptors area presenting a thorough knowledge of the subject and an effective integration of these receptors on sensor surfaces in order to appropriately convey the state-of the-art fundamentals and applications of the most innovative approaches.

Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Spatially Resolved Characterization of Local Phenomena in Materials and Nanostructures: Volume 738

Spatially Resolved Characterization of Local Phenomena in Materials and Nanostructures: Volume 738
A Book

by Javier Piqueras,Fredy R. Zypman,Dawn A. Bonnell,Andrew P. Shreve

  • Publisher : Mrs Proceedings
  • Release : 2003-03-27
  • Pages : 425
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A primary driver of progress in nanoscience and technology is the continuing advances in the ability to measure structure, and particularly properties, at spatially localized scales. From the point of view of characterization, it is worth mentioning advances in the interpretation of processes in semiconductors, the ability to observe and manipulate metal, carbon and silicon nanowires and nanodots, and studies in molecular self-assembly. The papers in this book fall into two categories - those addressing classes of characterization techniques that emphasize how the combination of theoretical, experimental, and instrumentational developments lead to new capabilities in nanoscale characterization, and those focused on the use of various spatially localized approaches on a single phenomenon or materials issue. Topics include: characterization with electron optics; novel measurements of nanoscale properties; size-dependent behavior of nanoparticles; biological systems at the nanoscale; processing and properties of nanowires and heterostructures; and local phenomena in materials and microstructures.

Indium Tin Oxide-polyaniline Biosensor

Indium Tin Oxide-polyaniline Biosensor
Fabrication and Performance Analysis

by Zarini Muhammad-Tahir

  • Publisher : ProQuest
  • Release : 2006
  • Pages : 228
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles and Practice of Immunoassay

Principles and Practice of Immunoassay
A Book

by Christopher P. Price,David J. Newman

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 667
  • ISBN : 9780333625040
  • Language : En, Es, Fr & De
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The aims of this new edition are the same as the first edition, ie: to link the fundamental aspects of immunoassay together with the principles of the major techniques in use today. The highly acclaimed first edition was recommended as 'an excellent comprehensive source of background knowledge ... and a constant source of reference'. This new edition again covers the basic principles before going on to describe all the latest developments in this rapidly developing field. Completely new chapters such as Alternative Binding Particles, Microfabricated optical, and Microfabricated electrochemical immunoassay, together with the complete updating of all the techniques bring the reader/researcher up to date with all immunoassays. Upwards of a dozen or so contributors, expert in their field, have contributed to individual chapters. Finally the editors consider what the prospects are for immunoassay techniques in the future.