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Freeze-Drying of Pharmaceutical and Food Products

Freeze-Drying of Pharmaceutical and Food Products
A Book

by Tse-Chao Hua,Bao-Lin Liu,Haimei Zhang

  • Publisher : Elsevier
  • Release : 2010-07-30
  • Pages : 280
  • ISBN : 1845697472
  • Language : En, Es, Fr & De
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Freeze-drying is an important preservation technique for heat-sensitive pharmaceuticals and foods. Products are first frozen, then dried in a vacuum at low temperature by sublimation and desorption, rather than by the application of heat. The resulting items can be stored at room temperature for long periods. This informative text addresses both principles and practice in this area. The first chapter introduces freeze-drying. The authors then review the fundamentals of the technique, heat-mass transfer analyses, modelling of the drying process and the equipment employed. Further chapters focus on freeze-drying of food, freeze-drying of pharmaceuticals and the protective agents and additives applied. The final chapter covers the important subjects of disinfection, sterilization and process validation. Freeze-drying of pharmaceutical and food products is an essential reference for food, pharmaceutical and refrigeration engineers and scientists with an interest in preservation techniques. It will also be of use to students in these fields. Addresses the principles and practices used in this important preservation technique Explains the fundamentals of heat-mass transfer analysis, modelling and the equipment used Discusses the importance of disinfection, sterilization and process validation

Freeze Drying of Pharmaceutical Products

Freeze Drying of Pharmaceutical Products
A Book

by Davide Fissore,Roberto Pisano,Antonello Barresi

  • Publisher : CRC Press
  • Release : 2019-10-24
  • Pages : 192
  • ISBN : 042966673X
  • Language : En, Es, Fr & De
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Freeze Drying of Pharmaceutical Products provides an overview of the most recent and cutting-edge developments and technologies in the field, focusing on formulation developments and process monitoring and considering new technologies for process development. This book contains case studies from freeze dryer manufacturers and pharmaceutical companies for readers in industry and academia. It was contributed to by lyophilization experts to create a detailed analysis of the subject matter, organically presenting recent advancements in freeze-drying research and technology. It discusses formulation design, process optimization and control, new PAT-monitoring tools, multivariate image analysis, process scale-down and development using small-scale freeze-dryers, use of CFD for equipment design, and development of continuous processes. This book is for industry professionals, including chemical engineers and pharmaceutical scientists.

Freeze-drying of Pharmaceuticals and Biopharmaceuticals

Freeze-drying of Pharmaceuticals and Biopharmaceuticals
A Book

by Felix Franks,Tony Auffret

  • Publisher : Royal Society of Chemistry
  • Release : 2008
  • Pages : 206
  • ISBN : 0854041516
  • Language : En, Es, Fr & De
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Aimed at product and process developers in the biopharmaceutical industry and academia, this is the first book to describe freeze-drying, as related to the pharmaceutical industry.

Freeze-Drying

Freeze-Drying
A Book

by Georg-Wilhelm Oetjen,Peter Haseley

  • Publisher : John Wiley & Sons
  • Release : 2008-01-08
  • Pages : 407
  • ISBN : 3527612491
  • Language : En, Es, Fr & De
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Many modern pharmaceutical and biological products, e.g. blood derivatives, vaccines, cytostatic drugs, antibiotics, bacteria cultures but also consumer goods such as soluble coffee are freeze-dried to transform perishable substances into a form that can be stored and reconstituted to their almost original state without loss of quality. The book describes the up-to-date fundamentals of freeze-drying, not just presenting the process in all its seven steps theoretically, but explaining it with many practical examples. Many years of experience in freeze-drying allow the authors to supply valuable criteria for the selection of laboratory, pilot and production plants, discussing the advantages, drawbacks and limitations of different plant designs. In this second, completely revised edition, process and plant automation are introduced in a separate section and methods to transfer pilot plant qualifications and process data to production are presented. The guidelines for process and plant evaluation and qualifications have been updated and enlarged. Trouble shooting is concentrated in a section of its own and literature has been updated with 100 new quotations to include references as recent as 2002, and 100 new tables and figures have been added.

Freeze-Drying/Lyophilization Of Pharmaceutical & Biological Products, Second Edition, Revised and Expanded

Freeze-Drying/Lyophilization Of Pharmaceutical & Biological Products, Second Edition, Revised and Expanded
A Book

by Louis Rey,Joan C. May

  • Publisher : CRC Press
  • Release : 2004-01-21
  • Pages : 600
  • ISBN : 0203021320
  • Language : En, Es, Fr & De
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Thoroughly acquainting the reader with freeze-drying fundamentals, Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products, Second Edition carves practical guidelines from the very latest theoretical research, technologies, and industrial procedures. It delineates the best execution of steps from closure preparation and regulatory control of products to equipment sterilization and process validation. With 13 new chapters providing state-of-the-art information, the book unveils innovations currently advancing the field, including LYOGUARD® packaging for bulk freeze-drying and the irradiation of pharmaceutical and biological products.

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products

Freeze-Drying/Lyophilization of Pharmaceutical and Biological Products
A Book

by Louis Rey

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 584
  • ISBN : 1439825769
  • Language : En, Es, Fr & De
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Freeze-drying, or lyophilization, is a well established technology used in the preservation of numerous pharmaceutical and biological products. This highly effective dehydration method involves the removal of water from frozen materials via the direct sublimation of ice. In recent years, this process has met with many changes, as have the regulatio

Freeze Drying and Advanced Food Technology

Freeze Drying and Advanced Food Technology
A Book

by Samuel A. Goldblith,Louis Rey,W. W. Rothmayr

  • Publisher : Unknown Publisher
  • Release : 1975
  • Pages : 730
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Freeze Drying Or Lyophilization

Freeze Drying Or Lyophilization
An Engineering Perspective

by Muhammad Waseem Akbar

  • Publisher : Unknown Publisher
  • Release : 2020-12-31
  • Pages : 86
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Book DescriptionFreeze drying has many applications in the Food and Pharmaceutical industry. This book is an authentic and supreme emblem of quality that covers the basic concepts related to the lyophilization process. Review of almost all the relevant books and scientific journals is made to make the book error-free. Specifically, this book focusses on the freeze-drying process and their operating parameters for the agricultural products. I want to especially thanks to Prof. Dr Yongbin Han, Department of Agricultural Products Processing and Storage Engineering, School of Food Science and Technology, Nanjing Agricultural University, China; to help me to complete this book.Key Features: -Introduction to Freeze Drying Technique-Defining of all related Process Parameters and Variables-Recent Researches in the Freeze-Drying Field-Chemistry of Agricultural Products and their Thermal Properties-Disadvantages of Freeze-Drying Technique-Different Mathematical Models proposed by different Researchers and their ComponentsWhat will you learn?After reviewing this book, you will be able to understand the freeze-drying technique and all related terminologies. Raw material treatment, it's freezing, primary and secondary drying; all these operations should be carried out under critical considerations to dry the product efficiently. Product quality is the ultimate goal in this process and it can best achieve using freeze-drying. Thermal properties and the nature of the raw material may change the operating parameters for each of the product. But specifically, this book focuses on the freeze-drying process for agricultural products.Who is this Book for?This book is for: -Food Engineers -Freeze-drying researchers-Chemical Engineers (Those who are serving food industries as lab chemist, QC officers, and R&D officers) -Food nutritionists -Food professionals (Those who are working in food industries in freeze-drying related departments as quality officers, lab supervisors, product development officers, product audit chemists, and vicinities) -Food production compliance staff Table of Contents -Abstract-Introduction to Freeze Drying-Chemistry of Agricultural Products-Freeze Drying Stages-Freeze Drying Process Parameters -Thermal Properties of food-Disadvantages of Freeze-Drying Process-Components of Freeze Dryer-Mathematical Modeling-Conclusion-Nomenclature-ReferencesAbout this AuthorMuhammad Waseem Akbar is a food engineer by education. He is expert in nutritional, health and processing courses. Drying is a preservation technique. He has a special interest in the freeze-drying technique. This is one of the most emerging drying technique and has the potential to produce quality products with an extended shelf life for years. The author has written multiple books in the food science and engineering domain.

Water Properties of Food, Pharmaceutical, and Biological Materials

Water Properties of Food, Pharmaceutical, and Biological Materials
A Book

by Maria del Pilar Buera,Jorge Welti-Chanes,Peter J. Lillford,Horacio R. Corti

  • Publisher : CRC Press
  • Release : 2006-01-13
  • Pages : 792
  • ISBN : 1420001183
  • Language : En, Es, Fr & De
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Unique and informative, Water Properties of Food, Pharmaceutical, and Biological Materials is based on lectures and papers given by leading international researchers at the 9th International Symposium of the Properties of Water in Foods (ISOPOW 9) that took place in September 2004. Each chapter presents an authoritative account of the latest research on the physical and chemical properties of water in relation to the stability of food, pharmaceutical, and biological materials. The first part of the text focuses on presentations given by invited speakers, whereas the second part is dedicated to oral presentations and discussions. Topics include the role of water in structural and functional properties, preserving biomolecule functionality in restricted water environments, and micro- and nano- techniques used for assessing water-solid interactions in food and drug development. This book is an invaluable resource that synthesizes cutting-edge information with innovative viewpoints from internationally esteemed researchers who participated in ISOPOW 2004.

Food Technology in Australia

Food Technology in Australia
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmaceutical Lyophilization

Pharmaceutical Lyophilization
Physical Stability Issues and Application of Ternary State Diagram

by Chitra Telang

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 440
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Advances in Heat and Mass Transfer in Biological Systems

Advances in Heat and Mass Transfer in Biological Systems
Presented at 1994 International Mechanical Engineering Congress and Exposition, Chicago, Illinois, November 6-11, 1994

by Linda J. Hayes,Robert B. Roemer

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 159
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Agriculture and Agro-industries Journal

Agriculture and Agro-industries Journal
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1975
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings of the ... Annual Washington State University Institute of Dairying

Proceedings of the ... Annual Washington State University Institute of Dairying
A Book

by Washington State University. Institute of Dairying

  • Publisher : Unknown Publisher
  • Release : 1962
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Volatile Retention Kinetics and Microstructure of Microwave Freeze-dried Model Foods

Volatile Retention Kinetics and Microstructure of Microwave Freeze-dried Model Foods
A Book

by Su-Der Chen

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 308
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modern Drying Technology, Volume 3

Modern Drying Technology, Volume 3
Product Quality and Formulation

by Evangelos Tsotsas,Arun S. Mujumdar

  • Publisher : John Wiley & Sons
  • Release : 2011-08-29
  • Pages : 430
  • ISBN : 3527315586
  • Language : En, Es, Fr & De
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The five-volume series provides a comprehensive overview of all important aspects of drying technology like computational tools at different scales (Volume 1), modern experimental and analytical techniques (Volume 2), product quality and formulation (Volume 3), energy savings (Volume 4) and process intensification (Volume 5). Based on high-level cutting-edge results contributed by internationally recognized experts in the various treated fields, this book series is the ultimate reference in the area of industrial drying. Located at the intersection of the two main approaches in modern chemical engineering, product engineering and process systems engineering, the series aims at bringing theory into practice in order to improve the quality of high-value dried products, save energy, and cut the costs of drying processes. Volume 3 discusses how desired properties of foods, biomaterials, active pharmaceutical ingredients, and fragile aerogels can be preserved during drying, and how spray drying and spray fluidized bed processes can be used for particle formation and formulation. Methods for monitoring product quality, such as process analytical technology, and modeling tools, such as Monte Carlo simulations, discrete particle modeling and neural networks, are presented with real examples from industry and academia. Other Volumes and Sets: Volume 1 - Modern Drying Technology, Computational Tools at Different Scales Volume 1: Diverse model types for the drying of products and the design of drying processes (short-cut methods, homogenized, pore network, and continuous thermo-mechanical approaches) are treated, along with computational fluid dynamics, population balances, and process systems simulation tools. Emphasis is put on scale transitions. Volume 2 - Modern Drying Technology: Experimental Techniques Volume 2: Comprises experimental methods used in various industries and in research in order to design and control drying processes, measure moisture and moisture distributions, characterize particulate material and the internal micro-structure of dried products, and investigate the behavior of particle systems in drying equipment. Key topics include acoustic levitation, near-infrared spectral imaging, magnetic resonance imaging, X-ray tomography, and positron emission tracking. Volume 4 - Modern Drying Technology: Energy Savings Volume 4: Deals with the reduction of energy demand in various drying processes and areas, highlighting the following topics: Energy analysis of dryers, efficient solid-liquid separation techniques, osmotic dehydration, heat pump assisted drying, zeolite usage, solar drying, drying and heat treatment for solid wood and other biomass sources, and sludge thermal processing. Volume 5 - Process Intensification Volume 5: Dedicated to process intensification by more efficient distribution and flow of the drying medium, foaming, controlled freezing, and the application of superheated steam, infrared radiation, microwaves, power ultrasound and pulsed electric fields. Process efficiency is treated in conjunction with the quality of sensitive products, such as foods, for a variety of hybrid and combined drying processes. Available in print as 5 Volume Set or as individual volumes. Buy the Set and SAVE 30%! Also available in electronic formats.

The Chemical Engineer

The Chemical Engineer
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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International Food Ingredients Directory

International Food Ingredients Directory
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Technological Change, Its Impact on Industry in Metropolitan Chicago

Technological Change, Its Impact on Industry in Metropolitan Chicago
A Report

by Corplan Associates

  • Publisher : Unknown Publisher
  • Release : 1964
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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How Products are Made

How Products are Made
An Illustrated Guide to Product Manufacturing

by Kyung-Sun Lim

  • Publisher : Gale / Cengage Learning
  • Release : 1994
  • Pages : 304
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Provides information on a variety of products, discussing background, history, raw materials, design, and the manufacturing process