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Functionalized Nanomaterials for the Management of Microbial Infection

Functionalized Nanomaterials for the Management of Microbial Infection
A Strategy to Address Microbial Drug Resistance

by Rabah Boukherroub,Sabine Szunerits,Djamel Drider

  • Publisher : William Andrew
  • Release : 2016-12-14
  • Pages : 338
  • ISBN : 032341737X
  • Language : En, Es, Fr & De
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Functionalized Nanomaterials for the Management of Microbial Infection: A Strategy to Address Microbial Drug Resistance introduces the reader to the newly developing use of nanotechnology to combat microbial drug resistance. Excessive use of antibiotics and antimicrobial agents has produced an inexorable rise in antibiotic resistance in bacterial pathogens. The use of nanotechnology is currently the most promising strategy to overcome microbial drug resistance. This book shows how, due to their small size, nanoparticles can surmount existing drug resistance mechanisms, including decreased uptake and increased efflux of the drug from the microbial cell, biofilm formation, and intracellular bacteria. In particular, chapters cover the use of nanoparticles to raise intracellular antimicrobial levels, thus directly targeting sites of infection and packaging multiple antimicrobial agents onto a single nanoparticle. Provides the information users need to integrate antibacterial nanoparticles into future treatments Gives readers with backgrounds in nanotechnology, chemistry, and materials science an understanding of the main issues concerning microbial drug resistance and its challenges Includes real-life case studies that illustrates how functionalized nanomaterials are used to manage microbial infection

Nanostructures for Antimicrobial Therapy

Nanostructures for Antimicrobial Therapy
A Book

by Anton Ficai,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-05-29
  • Pages : 722
  • ISBN : 0323461514
  • Language : En, Es, Fr & De
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Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues. Shows how nanoantibiotics can be used to more effectively treat disease Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases

Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases
A Book

by Mahendra Rai,Kateryna Kon

  • Publisher : Academic Press
  • Release : 2015-05-23
  • Pages : 344
  • ISBN : 0128014717
  • Language : En, Es, Fr & De
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Nanotechnology in Diagnosis, Treatment and Prophylaxis of Infectious Diseases delivers comprehensive coverage of the application of nanotechnology to pressing problems in infectious disease. This text equips readers with cutting-edge knowledge of promising developments and future prospects in nanotechnology, paying special attention to microbes that are now resistant to conventional antibiotics, a concerning problem in modern medicine. Readers will find a thorough discussion of this new approach to infectious disease treatment, including the reasons nanotechnology presents a promising avenue for the diagnosis, treatment, and prophylaxis of infectious diseases. Provides a comprehensive overview of the use of nanotechnology in the treatment and diagnosis of infectious diseases Covers all common types of infective agents, including bacteria, viruses, fungi, and protozoa, along with their vectors, ticks, mosquitoes, flies, etc. Delivers commentary from an international researcher base, providing insights across differing economic statuses Includes a foundation of basic nanotechnological concepts to aid in designing new strategies to combat several pathogenic diseases and cancer Illustrates the high antimicrobial potential of nanoparticles, ultimately demonstrating how they are a promising alternative class that can be successfully used in fighting a myriad of infections

Antibiotic Materials in Healthcare

Antibiotic Materials in Healthcare
A Book

by Varaprasad Kokkarachedu,Vimala Kanikireddy,Rotimi Sadiku

  • Publisher : Academic Press
  • Release : 2020-05-22
  • Pages : 346
  • ISBN : 012822536X
  • Language : En, Es, Fr & De
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Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their biomedical applications for healthcare. Provides information on all aspects of antibiotic related issues Offers a balanced synthesis of basic and clinical science for each individual case, presenting clinical courses and detailed microbiological information for each infection Describes the prevalence and incidence of global issues and current therapeutic approaches

Cancer Theranostics

Cancer Theranostics
A Book

by Xiaoyuan Chen,Stephen Wong

  • Publisher : Academic Press
  • Release : 2014-03-20
  • Pages : 544
  • ISBN : 0124078842
  • Language : En, Es, Fr & De
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Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Preclinical Evaluation of Antimicrobial Nanodrugs

Preclinical Evaluation of Antimicrobial Nanodrugs
A Book

by Juan Bueno

  • Publisher : Springer Nature
  • Release : 2020-05-08
  • Pages : 117
  • ISBN : 3030438554
  • Language : En, Es, Fr & De
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Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.

Nanotechnology Applied To Pharmaceutical Technology

Nanotechnology Applied To Pharmaceutical Technology
A Book

by Mahendra Rai,Carolina Alves dos Santos

  • Publisher : Springer
  • Release : 2017-11-21
  • Pages : 386
  • ISBN : 3319702998
  • Language : En, Es, Fr & De
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Focusing on the application of nanotechnology in pharmaceutical technology the editors seek to integrate the two in order to obtain innovative products and solutions in pharmacology. Interdisciplinary in content it is of interest to those who are involved in the development of nanoproducts including nanotechnologists, microbiologists, biotechnologists pharmacologists and clinicians. Recent studies are presented that include the biosynthesis of nanoparticles focusing on antimicrobials; nanomaterial-based formulations that treat cancer, infections, skin disorders and wounds;nanomaterials in eye diseases and toxicity and safety issues. It demonstrates the crucial role this plays in tackling multi-drug resistant threats.

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery
A Book

by Ali Demir Sezer

  • Publisher : BoD – Books on Demand
  • Release : 2014-07-25
  • Pages : 554
  • ISBN : 9535116282
  • Language : En, Es, Fr & De
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This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Hydrogels Based on Natural Polymers

Hydrogels Based on Natural Polymers
A Book

by Yu Chen

  • Publisher : Elsevier
  • Release : 2019-10-23
  • Pages : 552
  • ISBN : 0128166185
  • Language : En, Es, Fr & De
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Hydrogels Based on Natural Polymers presents the latest research on natural polymer-based hydrogels, covering fundamentals, preparation methods, synthetic pathways, advanced properties, major application areas, and novel characterization techniques. The advantages and disadvantages of each natural polymer-based hydrogel are also discussed, enabling preparation tactics for specific properties and applications. Sections cover fundamentals, development, characteristics, structures and properties. Additional chapters cover presentation methods and properties based on natural polymers, including physical and chemical properties, stimuli-responsive properties, self-healing properties, and biological properties. The final section presents major applications areas, including the biomedical field, agriculture, water treatments, and the food industry. This is a highly valuable resource for academic researchers, scientists and advanced students working with hydrogels and natural polymers, as well as across the fields of polymer science, polymer chemistry, plastics engineering, biopolymers and biomaterials. The detailed information will also be of great interest to scientists and R&D professionals, product designers, technicians and engineers across industries. Provides systematic coverage of all aspects of hydrogels based on natural polymers, including fundamentals, preparation methods, properties and characterization Offers a balanced assessment of the specific properties and possibilities offered by different natural polymer-based hydrogels, drawing on innovative research Examines cutting-edge applications across biomedicine, agriculture, water treatments, and the food industry

Antibacterial Agents

Antibacterial Agents
A Book

by Ranjith Kumavath

  • Publisher : BoD – Books on Demand
  • Release : 2017-05-31
  • Pages : 138
  • ISBN : 9535131990
  • Language : En, Es, Fr & De
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New drugs are frequently entering into the market along with the existing drugs. The antibacterial agents can be discussed in five major classes, i.e. classification based on the type of action, source, spectrum of activity, chemical structure and function. Resistance of bacteria to antibiotics is an urgent problem of the humanity, which leads us to the lack of therapy for serious bacterial infections. Development of new antibiotics has almost ceased in the last decades - even when a new antibiotic is launched, very soon the resistance of bacteria appears. Industrial textiles exposed as awnings, screens, tents; upholstery used in large public areas such as hospitals, hotels and stations; fabrics for transports; protective clothing and personal protective equipment; bed sheets and blankets; textiles left wet between processing steps; intimate apparel, underwear, socks and sportswear, disinfection of air and water for white rooms, hospitals and operating theatres, food and pharma industries, water depuration, drinkable water supplying and air conditioning systems. Many clinicians recommend alternative approaches to using antimicrobial substances. Moreover, the majority of bioagents demonstrate on antibiotics for treatment of a wide range of diseases in human sectors. However, the misuse and mishandling of drugs lead to microbial, particularly bacterial, resistance as well as result in the difficulty of treating microbial diseases. Hence, the proposed book will give more precise information on novel antibacterial compound(s).

Advances in Biomaterials for Biomedical Applications

Advances in Biomaterials for Biomedical Applications
A Book

by Anuj Tripathi,Jose Savio Melo

  • Publisher : Springer
  • Release : 2017-01-24
  • Pages : 545
  • ISBN : 9811033285
  • Language : En, Es, Fr & De
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This book highlights recent advances in the field of biomaterials design and the state of the art in biomaterials applications for biomedicine. Addressing key aspects of biomaterials, the book explores technological advances at multi-scale levels (macro, micro, and nano), which are used in applications related to cell and tissue regeneration. The book also discusses the future scope of bio-integrated systems. The contents are supplemented by illustrated examples, and schematics of molecular and cellular interactions with biomaterials/scaffolds are included to promote a better understanding of the complex biological mechanisms involved in material-to-biomolecule interactions. The book also covers factors that govern cell growth, differentiation, and regeneration in connection with the treatment and recovery of native biological systems. Tissue engineering, drug screening and delivery, and electrolyte complexes for biomedical applications are also covered in detail. This book offers a comprehensive reference guide for multi-disciplinary communities working in the area of biomaterials, and will benefit researchers and graduate students alike.

Functionalized Nanomaterials

Functionalized Nanomaterials
A Book

by Muhammad Akhyar Farrukh

  • Publisher : BoD – Books on Demand
  • Release : 2016-12-28
  • Pages : 174
  • ISBN : 9535128558
  • Language : En, Es, Fr & De
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Generally the nanometer scale covers from 1 to 100 nm while discussing the nanomaterials. Nanomaterials have very high potency and emerge with large applications piercing through all the discipline of knowledge, leading to industrial and technological growth. Nanotechnology is a multidisciplinary science that has its roots in fields such as colloidal science, device physics, and biomedical and supramolecular chemistry. The main objective of the book is to cover maximum areas focusing on synthesis, characterization with various microscopic techniques, and multiple applications. This book is divided into two sections with Non-carbon Compounds and Carbon Compounds. The synthesis, characterization, and applications of metal, metal oxides, and metal hydroxide nanoparticles are covered in the section Non-carbon Compounds, while the section Carbon Compounds focuses on the carbon nanotubes, graphite oxide, graphene oxide, etc.

Biomedical Applications of Functionalized Nanomaterials

Biomedical Applications of Functionalized Nanomaterials
Concepts, Development and Clinical Translation

by Bruno Sarmento,Jose Das Neves

  • Publisher : William Andrew
  • Release : 2018-03-01
  • Pages : 778
  • ISBN : 0323508790
  • Language : En, Es, Fr & De
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Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies. Provides an overview of the methodologies for biological target identification and ligand screening Includes case studies showing the development of functionalized nanomaterials and their biomedical applications Highlights the importance of functionalized nanomaterials for drug delivery, diagnostics and regenerative medicine applications

Advanced Nanostructured Materials for Environmental Remediation

Advanced Nanostructured Materials for Environmental Remediation
A Book

by Mu. Naushad,Saravanan Rajendran,Francisco Gracia

  • Publisher : Springer
  • Release : 2019-03-14
  • Pages : 391
  • ISBN : 3030044777
  • Language : En, Es, Fr & De
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This book provides a wide-range exploration on the ongoing research and developmental events in environmental nanotechnology. Emerging nanomaterials and its technology have been known to offer unique advantages and are continually showing promising potential attracting continuous global attention. This work thus discusses experimental studies of various nanomaterials along with their design and applications and with specific attention to chemical reactions and their challenges for catalytic systems. It will make a noteworthy appeal to scientists and researchers working in the field of nanotechnology for environmental sciences.

Nanotechnology in Skin, Soft Tissue, and Bone Infections

Nanotechnology in Skin, Soft Tissue, and Bone Infections
A Book

by Mahendra Rai

  • Publisher : Springer Nature
  • Release : 2020-01-14
  • Pages : 285
  • ISBN : 3030351475
  • Language : En, Es, Fr & De
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The main goal of the present book is to deal with the role of nanobiotechnology in skin, soft tissue and bone infections since it is difficult to treat the infections due to the development of resistance in them against existing antibiotics. The present interdisciplinary book is very useful for a diverse group of readers including nanotechnologists, medical microbiologists, dermatologists, osteologists, biotechnologists, bioengineers. Nanotechnology in Skin, Soft-Tissue, and Bone Infections is divided into four sections: Section I- includes role of nanotechnology in skin infections such as atopic dermatitis, and nanomaterials for combating infections caused by bacteria and fungi. Section II- incorporates how nanotechnology can be used for soft-tissue infections such as diabetic foot ulcer and other wound infections; Section III- discusses about the nanomaterials in artificial scaffolds bone engineering and bone infections caused by bacteria and fungi; and also about the toxicity issues generated by the nanomaterials in general and nanoparticles in particular. The readers will be immensely enriched by the knowledge of new and emerging nanobiotechnologies in a variety of platforms.

Nanoparticles in Pharmacotherapy

Nanoparticles in Pharmacotherapy
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2019-04-15
  • Pages : 600
  • ISBN : 0128165049
  • Language : En, Es, Fr & De
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Nanoparticles in Pharmacotherapy explores the most recent findings in how nanoparticles used in pharmacotherapy, starting with their synthesis, characterization and current or potential uses. Offering he book will be a valuable resource of recent scientific progress, along with most known applications of nanoparticles on the pharmacotherapy to be used by researchers, medical doctors and academia individuals.

Near Infrared-Emitting Nanoparticles for Biomedical Applications

Near Infrared-Emitting Nanoparticles for Biomedical Applications
A Book

by Antonio Benayas,Eva Hemmer,Guosong Hong,Daniel Jaque

  • Publisher : Springer Nature
  • Release : 2020-04-13
  • Pages : 384
  • ISBN : 3030320367
  • Language : En, Es, Fr & De
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​This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for in vivo imaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the “nano” level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes. Assembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications; Explains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications; Presents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.

Nanotoxicity

Nanotoxicity
Prevention and Antibacterial Applications of Nanomaterials

by Susai Rajendran,Anita Mukherjee,Tuan Anh Nguyen,Chandraiah Godugu,Ritesh K. Shukla

  • Publisher : Elsevier
  • Release : 2020-04-09
  • Pages : 504
  • ISBN : 012819944X
  • Language : En, Es, Fr & De
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Nanotoxicity: Prevention, and Antibacterial Applications of Nanomaterials focuses on the fundamental concepts for cytotoxicity and genotoxicity of nanomaterials. It sheds more light on the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media. The book provides good guidance for toxic prevention methods and management in the manufacture/application/disposal. The book also discusses the potential applications of nanomaterials-based antibiotics. The potential toxic effects of nanomaterials result not only from the type of base materials, but also from their size/ ligands/surface chemical modifications. This book discusses why different classes of nanomaterials display toxic properties, and what can be done to mitigate this toxicity. It also explores how nanomaterials are being used as antimicrobial agents, being used to purify air and water, and counteract a range of infectious diseases. This is an important reference for materials scientists, environmental scientists and biomedical scientists, who are seeking to gain a greater understanding of how nanomaterials can be used to combat toxic agents, and how the toxicity of nanomaterials themselves can best be mitigated. Explains the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media Outlines major methods for mitigating and prevention of nanotoxicity Discusses the applications of nanomaterials-based antibiotics

Nano-Antimicrobials

Nano-Antimicrobials
Progress and Prospects

by Nicola Cioffi,Mahendra Rai

  • Publisher : Springer Science & Business Media
  • Release : 2012-02-26
  • Pages : 556
  • ISBN : 3642244270
  • Language : En, Es, Fr & De
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There is a high demand for antimicrobials for the treatment of new and emerging microbial diseases. In particular, microbes developing multidrug resistance have created a pressing need to search for a new generation of antimicrobial agents, which are effective, safe and can be used for the cure of multidrug-resistant microbial infections. Nano-antimicrobials offer effective solutions for these challenges; the details of these new technologies are presented here. The book includes chapters by an international team of experts. Chemical, physical, electrochemical, photochemical and mechanical methods of synthesis are covered. Moreover, biological synthesis using microbes, an option that is both eco-friendly and economically viable, is presented. The antimicrobial potential of different nanoparticles is also covered, bioactivity mechanisms are elaborated on, and several applications are reviewed in separate sections. Lastly, the toxicology of nano-antimicrobials is briefly assessed.

Antibiotic Resistance

Antibiotic Resistance
Mechanisms and New Antimicrobial Approaches

by Kateryna Kon,Mahendra Rai

  • Publisher : Academic Press
  • Release : 2016-06-14
  • Pages : 436
  • ISBN : 0128036680
  • Language : En, Es, Fr & De
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Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches discusses up-to-date knowledge in mechanisms of antibiotic resistance and all recent advances in fighting microbial resistance such as the applications of nanotechnology, plant products, bacteriophages, marine products, algae, insect-derived products, and other alternative methods that can be applied to fight bacterial infections. Understanding fundamental mechanisms of antibiotic resistance is a key step in the discovery of effective methods to cope with resistance. This book also discusses methods used to fight antibiotic-resistant infection based on a deep understanding of the mechanisms involved in the development of the resistance. Discusses methods used to fight antibiotic-resistant infection based on a deep understanding of mechanisms involved in the development of the resistance Provides information on modern methods used to fight antibiotic resistance Covers a wide range of alternative methods to fight bacterial resistance, offering the most complete information available Discusses both newly emerging trends and traditionally applied methods to fight antibiotic resistant infections in light of recent scientific developments Offers the most up-to-date information in fighting antibiotic resistance Includes involvement of contributors all across the world, presenting questions of interest to readers of both developed and developing countries