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Fundamentals of Toxicologic Pathology

Fundamentals of Toxicologic Pathology
A Book

by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig

  • Publisher : Academic Press
  • Release : 2009-11-23
  • Pages : 714
  • ISBN : 9780080919324
  • Language : En, Es, Fr & De
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Toxicologic pathology integrates toxicology and the disciplines within it (such as biochemistry, pharmacodynamics and risk assessment) to pathology and its related disciplines (such as physiology, microbiology, immunology, and molecular biology). Fundamentals of Toxicologic Pathology Second Edition updates the information presented in the first edition, including five entirely new chapters addressing basic concepts in toxicologic pathology, along with color photomicrographs that show examples of specific toxicant-induced diseases in animals. The current edition also includes comparative information that will prove a valuable resource to practitioners, including diagnostic pathologists and toxicologists. 25% brand new information, fully revised throughout New chapters: Veterinary Diagnostic Toxicologic Pathology; Clinical Pathology; Nomenclature: Terminology for Morphologic Alterations; Techniques in Toxicologic Pathology New color photomicrographs detailing specific toxicant-induced diseases in animals Mechanistic information integrated from both toxicology and pathology discussing basic mechanisms of toxic injury and morphologic expression at the subcellular, cellular, and tissue levels

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology
Volume 1: Principles and Practice of Toxicologic Pathology

by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon

  • Publisher : Academic Press
  • Release : 2021-09-15
  • Pages : 850
  • ISBN : 9780128210444
  • Language : En, Es, Fr & De
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Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Toxicologic Pathology for Non-Pathologists

Toxicologic Pathology for Non-Pathologists
A Book

by Thomas J. Steinbach,Daniel J. Patrick,Mary Ellen Cosenza

  • Publisher : Springer Nature
  • Release : 2019-10-31
  • Pages : 919
  • ISBN : 1493997777
  • Language : En, Es, Fr & De
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This extensive volume began as a short course primarily geared toward toxicologists who want to expand their understanding of toxicologic pathology in order to be better study directors while also proving to be of great interest to other drug development scientists and regulatory reviewers. The overall goal is to help non-pathologists understand, contextualize, and communicate the pathology data and interpretations from the study pathologist in a practical and usable format. Within the book, readers will find an overview of general pathology concepts that include fundamental vocabulary and the basics of pathophysiological processes, along with numerous chapters devoted to pathology in specific organ systems as well as topics such as biomarkers, correlation of clinical pathology endpoints (chemistry and hematology) with microscopic changes, and well-known pathology findings for classes of toxic substances. Authoritative, practical, and comprehensive, Toxicologic Pathology for Non-Pathologists aims to help non-pathologists understand, converse in, and apply a basic understanding of pathology in their day-to-day careers.

Principles and Methods of Toxicology, Fifth Edition

Principles and Methods of Toxicology, Fifth Edition
A Book

by A. Wallace Hayes

  • Publisher : CRC Press
  • Release : 2007-09-25
  • Pages : 2296
  • ISBN : 9780849337789
  • Language : En, Es, Fr & De
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Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.

Fundamentals of Translational Neuroscience in Toxicologic Pathology

Fundamentals of Translational Neuroscience in Toxicologic Pathology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A half-day Society of Toxicologic Pathology continuing education course on "Fundamentals of Translational Neuroscience in Toxicologic Pathology" presented some current major issues faced when extrapolating animal data regarding potential neurological consequences to assess potential human outcomes. Two talks reviewed functional–structural correlates in rodent and nonrodent mammalian brains needed to predict behavioral consequences of morphologic changes in discrete neural cell populations. The third lecture described practical steps for ensuring that specimens from rodent developmental neurotoxicity tests will be processed correctly to produce highly homologous sections. The fourth talk detailed demographic factors (e.g., species, strain, sex, and age); physiological traits (body composition, brain circulation, pharmacokinetic/pharmacodynamic patterns, etc.); and husbandry influences (e.g., group housing) known to alter the effects of neuroactive agents. The last presentation discussed the appearance, unknown functional effects, and potential relevance to humans of polyethylene glycol (PEG)–associated vacuoles within the choroid plexus epithelium of animals. Speakers provided real-world examples of challenges with data extrapolation among species or with study design considerations that may impact the interpretability of results. Translational neuroscience will be bolstered in the future as less invasive and/or more quantitative techniques are devised for linking overt functional deficits to subtle anatomic and chemical lesions.

Fundamentals of Analytical Toxicology

Fundamentals of Analytical Toxicology
A Book

by Robert J. Flanagan

  • Publisher : John Wiley & Sons
  • Release : 2007
  • Pages : 505
  • ISBN : 0470319348
  • Language : En, Es, Fr & De
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The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay ? are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: ?This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.? Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists ?Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background ?Boxes?. The many and up to date literature references in each chapter demonstrate the authors? thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.? GTFCh Bulletin ?Toxichem + Krimtech?, May 2008 (translated, original review in German) ?Many toxicologists will add this important reference to their libraries because it competently fills a need ...? International Journal of Toxicology ?The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.? International Journal of Environmental Analytical Chemistry

Handbook of Toxicologic Pathology

Handbook of Toxicologic Pathology
A Book

by Wanda M. Haschek,Colin G. Rousseaux

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 1127
  • ISBN : 1483288617
  • Language : En, Es, Fr & De
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This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come. Comprehensive, "user friendly" reference text on toxicologic pathology Large, easy-to-use 8 1/2" x 11", double-column format Systematic approach to each organ or system More than 500 illustrations and 90 tables complement the text Over 2,000 references for easy access to the primary literature Unique chapters written by leading authorities

Scientific Report

Scientific Report
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Choice

Choice
Publication of the Association of College and Research Libraries, a Division of the American Library Association

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles for Evaluating Chemical Effects on the Aged Population

Principles for Evaluating Chemical Effects on the Aged Population
A Book

by International Program on Chemical Safety,United Nations Environment Programme,World Health Organization

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 159
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Agricultural & Veterinary Sciences International Who's who

Agricultural & Veterinary Sciences International Who's who
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cytobios

Cytobios
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Present and Future Conservation of the Wadden Sea

Present and Future Conservation of the Wadden Sea
Proceedings of the 7th International Wadden Sea Symposium, Ameland, 22-26 October 1990

by C. J. Smit,N. Dankers,M. Scholl

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 301
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Environmental Health Criteria

Environmental Health Criteria
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 112
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Fundamental Neuropathology for Pathologists and Toxicologists

Fundamental Neuropathology for Pathologists and Toxicologists
Principles and Techniques

by Brad Bolon,Mark Butt

  • Publisher : John Wiley & Sons
  • Release : 2011-08-08
  • Pages : 648
  • ISBN : 1118002237
  • Language : En, Es, Fr & De
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This book offers pathologists, toxicologists, other medical professionals, and students an introduction to the discipline and techniques of neuropathology – including chemical and environmental, biological, medical, and regulatory details important for performing an analysis of toxicant-induced neurodiseases. In addition to a section on fundamentals, the book provides detailed coverage of current practices (bioassays, molecular analysis, and nervous system pathology) and practical aspects (data interpretation, regulatory considerations, and tips for preparing reports).

Role of Inflammation in the Synergistic Hepatotoxicity of Monocrotaline and Bacterial Lipopolysaccharide

Role of Inflammation in the Synergistic Hepatotoxicity of Monocrotaline and Bacterial Lipopolysaccharide
A Book

by Steven Byron Yee

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings of the 7th International Wadden Sea Symposium

Proceedings of the 7th International Wadden Sea Symposium
A Book

by Norbert Dankers,C. J. Smit,M. Scholl

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 301
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Forensic Medicine

Forensic Medicine
Fundamentals and Perspectives

by Reinhard B. Dettmeyer,Marcel A. Verhoff,Harald F. Schütz

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-09
  • Pages : 584
  • ISBN : 3642388183
  • Language : En, Es, Fr & De
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This book presents the latest developments in the field of forensic pathology/forensic medicine, including important advances in forensic histopathology, forensic radiology, medical malpractice, understanding of child abuse, and forensic toxicology. Various forms of trauma are addressed in individual chapters, and among the other topics covered are traffic medicine, forensic alcohol toxicology, forensic DNA analysis, forensic osteology, and international regulations. The book includes a wealth of color illustrations and numerous tables presenting key facts. The authors are leading experts in general pathology, forensic radiology, and forensic toxicology. Forensic Pathology/Forensic Medicine: Fundamentals and Perspectives will be of interest not only to specialist pathologists and those working in forensic medicine, but also to coroners, forensic physicians, students, lawyers, attorneys, and policemen.

Dermal and Ocular Toxicology

Dermal and Ocular Toxicology
Fundamentals and Methods

by David W. Hobson

  • Publisher : CRC Press
  • Release : 2020-11-26
  • Pages : 656
  • ISBN : 1000159701
  • Language : En, Es, Fr & De
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Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.

Newsletter

Newsletter
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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