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Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes

Statistical Approaches to Gene X Environment Interactions for Complex Phenotypes
A Book

by Michael Windle

  • Publisher : MIT Press
  • Release : 2016-07-08
  • Pages : 304
  • ISBN : 0262034689
  • Language : En, Es, Fr & De
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Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits.

Gene Environment Interactions

Gene Environment Interactions
Nature and Nurture in the Twenty-first Century

by Moyra Smith

  • Publisher : Academic Press
  • Release : 2020-01-14
  • Pages : 438
  • ISBN : 0128197978
  • Language : En, Es, Fr & De
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Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome’s intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Gene-Environment Interaction Analysis

Gene-Environment Interaction Analysis
Methods in Bioinformatics and Computational Biology

by Sumiko Anno

  • Publisher : CRC Press
  • Release : 2016-03-30
  • Pages : 212
  • ISBN : 9814669644
  • Language : En, Es, Fr & De
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Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It compiles and details cutting-edge research in bioinformatics and computational biology and will appeal to anyone involved in bioinformatics and computational biology.

Gene-Environment Interactions in Developmental Psychopathology

Gene-Environment Interactions in Developmental Psychopathology
A Book

by Kenneth A. Dodge,Michael Rutter

  • Publisher : Guilford Press
  • Release : 2011-09-01
  • Pages : 286
  • ISBN : 1609181905
  • Language : En, Es, Fr & De
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Bringing together foremost experts, this book reviews groundbreaking gene–environment research and explores implications for clinical practice, prevention, and public policy. Presented is cutting-edge work on the interplay of genetic factors and childhood experiences in the development of mental disorders such as depression, conduct disorder, and schizophrenia. Essential topics include what scientists currently know about "susceptibility genes"; the mechanisms by which maltreatment and other stressors interact with biological susceptibilities across development; and factors that make certain children more resilient than others. Future directions for personalizing treatment and prevention efforts, thus making them more effective, are discussed.

Gene-Environment Interactions

Gene-Environment Interactions
Fundamentals of Ecogenetics

by Lucio G. Costa,David L. Eaton

  • Publisher : John Wiley & Sons
  • Release : 2005-12-16
  • Pages : 576
  • ISBN : 0471758035
  • Language : En, Es, Fr & De
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Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Gene-Environment Interactions in Psychiatry

Gene-Environment Interactions in Psychiatry
Nature, Nurture, Neuroscience

by Bart Ellenbroek,Ji Un Youn

  • Publisher : Academic Press
  • Release : 2016-07-26
  • Pages : 366
  • ISBN : 012801783X
  • Language : En, Es, Fr & De
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Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail. Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions. The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience. Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists Includes descriptions of the major psychiatric disorders Provides detailed descriptions of animal models and basic genetic information Presents well-illustrated color figures to explain complex features in a simple manner

Schizophrenia: A Consequence of Gene-Environment Interactions?

Schizophrenia: A Consequence of Gene-Environment Interactions?

by Tim Karl, Jonathon C. Arnold

  • Publisher : Frontiers Media SA
  • Release : 2015-06-06
  • Pages : 329
  • ISBN : 2889195317
  • Language : En, Es, Fr & De
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Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems.

Schizophrenia

Schizophrenia
A Consequence of Gene-environment Interactions?

by Tim Karl,Jonathon C. Arnold

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 126
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gene-environment Interactions

Gene-environment Interactions
Is the Repair of Pyridylozobutylguanine Adducts Modified by AGT Genotype?

by Renee Suzanne Mijal

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 362
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gene-environment Interactions

Gene-environment Interactions
Roles of DNA Repair Proteins in Preventing Disease and Injury

by Mitsuko Lynn Yamamoto

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 286
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gene-environment Interactions in the Etiology of Adolescent Externalizing Psychopathology

Gene-environment Interactions in the Etiology of Adolescent Externalizing Psychopathology
A Book

by Lisa Nicole Legrand

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 210
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Gene Environment Interaction in the Chicken

Gene Environment Interaction in the Chicken
A Book

by Jorge Ponzini-Ibarrart

  • Publisher : Unknown Publisher
  • Release : 1960
  • Pages : 44
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Tobacco Consumption, Genetic Susceptibility, Gene-environment Interaction and Lung Cancer Risk

Tobacco Consumption, Genetic Susceptibility, Gene-environment Interaction and Lung Cancer Risk
A Book

by Rayjean Jui-chun Hung

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 506
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Study of Genotype-environment Interactions in Relation to Developmental Homeostasis in Barley

A Study of Genotype-environment Interactions in Relation to Developmental Homeostasis in Barley
A Book

by David Veluppillai Ariyanayagam

  • Publisher : Unknown Publisher
  • Release : 1961
  • Pages : 306
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Effect of Cyanogenesis on Genotype-environment Interactions in Ladino White Clover, Trifolium Repens Var. Latum

The Effect of Cyanogenesis on Genotype-environment Interactions in Ladino White Clover, Trifolium Repens Var. Latum
A Book

by Mohamed el-Sayed Radwan Ahmed

  • Publisher : Unknown Publisher
  • Release : 1964
  • Pages : 244
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Exposed Science

Exposed Science
Genes, the Environment, and the Politics of Population Health

by Sara Shostak

  • Publisher : Univ of California Press
  • Release : 2013-02-15
  • Pages : 297
  • ISBN : 0520275187
  • Language : En, Es, Fr & De
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We rely on environmental health scientists to document the presence of chemicals where we live, work, and play and to provide an empirical basis for public policy. In the last decades of the 20th century, environmental health scientists began to shift their focus deep within the human body, and to the molecular level, in order to investigate gene-environment interactions. In Exposed Science, Sara Shostak analyzes the rise of gene-environment interaction in the environmental health sciences and examines its consequences for how we understand and seek to protect population health. Drawing on in-depth interviews and ethnographic observation, Shostak demonstrates that what we know – and what we don’t know – about the vulnerabilities of our bodies to environmental hazards is profoundly shaped by environmental health scientists’ efforts to address the structural vulnerabilities of their field. She then takes up the political effects of this research, both from the perspective of those who seek to establish genomic technologies as a new basis for environmental regulation, and from the perspective of environmental justice activists, who are concerned that that their efforts to redress the social, political, and economical inequalities that put people at risk of environmental exposure will be undermined by molecular explanations of environmental health and illness. Exposed Science thus offers critically important new ways of understanding and engaging with the emergence of gene-environment interaction as a focal concern of environmental health science, policy-making, and activism.

Beyond Our Genes

Beyond Our Genes
Pathophysiology of Gene and Environment Interaction and Epigenetic Inheritance

by Raffaele Teperino

  • Publisher : Springer Nature
  • Release : 2020-01-24
  • Pages : 266
  • ISBN : 3030352137
  • Language : En, Es, Fr & De
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The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

Genotype X Environment Interaction, Yield Stability and Adaption Responses of 25 Single-cross Maize (Zea Mays L.) Hybrids Grown in Michigan

Genotype X Environment Interaction, Yield Stability and Adaption Responses of 25 Single-cross Maize (Zea Mays L.) Hybrids Grown in Michigan
A Book

by Kingstone Mashingaidze

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 330
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genes, Behavior, and the Social Environment

Genes, Behavior, and the Social Environment
Moving Beyond the Nature/Nurture Debate

by Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health

  • Publisher : National Academies Press
  • Release : 2006-12-07
  • Pages : 384
  • ISBN : 0309101964
  • Language : En, Es, Fr & De
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Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Genes, Environments, and Interactions

Genes, Environments, and Interactions
Specifying Influences on Alcohol Use and Related Phenotypes

by Danielle Marie Dick

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 238
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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