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Gene Therapy for Neurological Disorders and Brain Tumors

Gene Therapy for Neurological Disorders and Brain Tumors
A Book

by E. Antonio Chiocca,Xandra O. Breakefield

  • Publisher : Springer Science & Business Media
  • Release : 1997-10-23
  • Pages : 458
  • ISBN : 1592594786
  • Language : En, Es, Fr & De
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Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Gene Therapy for Neurological Disorders

Gene Therapy for Neurological Disorders
Methods and Protocols

by Fredric P. Manfredsson

  • Publisher : Humana Press
  • Release : 2016-08-23
  • Pages : 493
  • ISBN : 9781493948963
  • Language : En, Es, Fr & De
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This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

Gene Therapy in Neurological Disorders

Gene Therapy in Neurological Disorders
A Book

by Mingjie Li,B. Joy Snider

  • Publisher : Academic Press
  • Release : 2018-05-25
  • Pages : 450
  • ISBN : 012809821X
  • Language : En, Es, Fr & De
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Gene therapy has tremendous potential for the treatment of neurological disorders. There has been substantial progress in the development of gene therapy strategies for neurological disorders over the last two decades. Gene Therapy in Neurological Disorders thoroughly reviews currently available gene therapy tools and presents examples of their application in a variety of neurological diseases. The book begins with general reviews of gene therapy strategies with a focus on neurological disorders. The remainder of the chapters present approaches to specific neurological disorders. Each chapter gives an in-depth introduction to the relevant field before diving into the specific tool or application. The book aims to help investigators, students and research staff better understand the principles of gene therapy and its application in the nervous system. Provides background information and experimental details of gene therapy tools applied for neuroscience research and neurological disorders Covers a broad range of gene delivery and regulation tools, therapeutic agents, and target cells, including emerging new technologies such as CRISPR/Cas9 genome editing Discusses applications of gene therapy tools to neurological disorders including neurodegeneration, muscular dystrophy, trauma and chronic pain, and neoplastic diseases

Gene Therapy for Neurological Disorders and Brain Tumors

Gene Therapy for Neurological Disorders and Brain Tumors
A Book

by E. Antonio Chiocca,Xandra O. Breakefield

  • Publisher : Humana Press
  • Release : 2013-10-03
  • Pages : 458
  • ISBN : 9781475753141
  • Language : En, Es, Fr & De
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Leading gene therapy researchers and clinicians illuminate the field-from basic vector technology to current and future clinical applications in neurology. The authoritative contributors provide cutting-edge reviews of the vectors available for gene transfer to the central nervous system, the strategies against CNS tumors, the potential strategies against neurologic disorder, and the limitations of today's gene therapy approaches. Also discussed are significant applications of gene therapy to brain tumors, Parkinson's disease, ischemia, and Huntington's chorea. Readers will learn the current delivery methods for transgenes, will learn the characteristics of transgene delivery vectors, and come to understand the therapy for both neuro-oncologic and neurologic disorders.

Gene Therapy for Neurological Disorders

Gene Therapy for Neurological Disorders
A Book

by Pedro R. Lowenstein,Maria G. Castro

  • Publisher : CRC Press
  • Release : 2006-05-01
  • Pages : 384
  • ISBN : 9780824728472
  • Language : En, Es, Fr & De
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Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.

Protocols for Gene Transfer in Neuroscience

Protocols for Gene Transfer in Neuroscience
Towards Gene Therapy of Neurological Disorders

by P. R. Lowenstein,L. W. Enquist

  • Publisher : John Wiley & Sons Incorporated
  • Release : 1996-07-25
  • Pages : 417
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Protocols for Gene Transfer in Neuroscience Towards Gene Therapy of Neurological Disorders Edited by P. R. Lowenstein University of Manchester, UK and L. W. Enquist Princeton University, USA The brain and the cells that compose it have always presented unique barriers to any kind of outside interventions, including drug delivery, surgical procedures and the genetic manipulation of cells. However, these barriers are now being bypassed by the new technology of gene delivery. Protocols for Gene Transfer in Neuroscience is the first practical guide to gene delivery, providing over 150 easy to follow, step-by-step protocols, together with troubleshooting hints and the theoretical background needed for neuroscientists to understand, adapt and expand the technology as needed. Written by a team of international expert neuroscientists, geneticists, molecular biologists and biochemists, Protocols for Gene Transfer in Neuroscience describes the latest techniques from the top gene-delivery labs, ranging from physical transfection techniques, through the use of a wide range of viral vectors, to retrovirally transduced cell and bone marrow transplantation. Several variations of a single protocol are given, thus demonstrating how different labs have solved a common problem in different ways. The protocols are also indexed and cross-referenced so that an investigator can find all the details required for a particular problem.

Gene Delivery and Therapy for Neurological Disorders

Gene Delivery and Therapy for Neurological Disorders
A Book

by Xuenong Bo,Joost Verhaagen

  • Publisher : Humana Press
  • Release : 2016-10-05
  • Pages : 359
  • ISBN : 9781493953165
  • Language : En, Es, Fr & De
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This volume aims to explore the latest developments in adeno-associated viral and lentiviral vectors as well as the gene therapy strategies for the most common neurological disorders, followed by chapters that include step-by-step guides to viral vector-based gene delivery in animal models used in the authors’ laboratories. Although safe gene manipulation in neural cells can be achieved, it may still be years away from efficacious gene-based treatment of neurological disorders such as Parkinson's and Alzheimer’s diseases due to the complexity of the underlying genetic/molecular mechanisms and the difficulty of developing reliable animal models. Gene Delivery and Therapy for Neurological Disorders seeks to aid researchers in this vital work. Written in the popular Neuromethods series format, chapters include the kind of detailed description and expert implementation advice that leads to success in the lab. Meticulous and authoritative, Gene Delivery and Therapy for Neurological Disorders serves as an ideal guide for researchers attempting to explore the potentials of gene therapy for neurological disorders.

Development of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases

Development of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases
A Book

by Yingying Zhang

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Development of Foamy Virus Vectors for Gene Therapy for Neurological Disorders and Other Diseases.

Gene Therapy for Neurological Disorders

Gene Therapy for Neurological Disorders
Stem Cell and Optogenetic Strategies

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 165
  • ISBN : 9789186443313
  • Language : En, Es, Fr & De
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Pediatric Neurology Part III

Pediatric Neurology Part III
Chapter 191. Gene therapy for disorders of the central nervous system

by Patrick Aubourg

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-04-24
  • Pages : 732
  • ISBN : 012808457X
  • Language : En, Es, Fr & De
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Though heavily hyped in the early 1990s as the answer to many genetic diseases, gene therapy has largely failed to live up to its promises up to now. The scientific challenges of conveying replacement genes into the brain have prevented it from having an impact on more than a handful of conditions. In addition, gene therapy has been beset by safety problems. During the last 5 years, new vectors and techniques have started to resolve not only safety issues that once held gene therapy back but also markedly to improve efficient gene delivery within the brain and even the spinal cord. Brain gene therapy will not be suitable for every neurological disease, but considerable progress made in the field means we can now envisage that CNS gene therapy will be able to treat many neurological conditions that are not obviously treatable in any other way.

Gene Therapy of the Central Nervous System: From Bench to Bedside

Gene Therapy of the Central Nervous System: From Bench to Bedside
A Book

by Michael G. Kaplitt,Matthew During

  • Publisher : Gulf Professional Publishing
  • Release : 2006
  • Pages : 355
  • ISBN : 9780123976321
  • Language : En, Es, Fr & De
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Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use

Proceedings of 6th International Conference and Exhibition on Cell and Gene Therapy 2018

Proceedings of 6th International Conference and Exhibition on Cell and Gene Therapy 2018
Journal of Stem Cell Research & Therapy : Volume 7

by ConferenceSeries

  • Publisher : ConferenceSeries
  • Release : 2021
  • Pages : 79
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mar 27-28, 2017 Madrid, Spain Key Topics : Cell Therapy, Cellular Therapy Technologies, Cell Therapy of Cardiovascular Disorders, Cell Therapy for Cancer, Cell Culture & Bioprocessing:, Cell Science & Stem Cell Research:, Cell Line Development, Tissue Science & Regenerative Medicine, Gene Therapy, Viral gene therapy, Diabetis Gene Therapy, Vectors for Gene Therapy, Molecular Epigenetics, Genetics & Genomic Medicine, Gene Therapy Commercialization, Clinical trials in cell and gene therapy, Gene Therapy for rare & Common Diseases, Gene Editing Technology, Cell Therapy for Neurological Disorders, Ethical Issues in Cell & Gene Therapy, Regulatory & Safety Aspects of Cell & Gene Therapy, Clinical Trails on Cell & Gen Therapy, Markets & Future Prospects for Cell & Gene Therapy, Cell & Gene Therapy Products,

Textbook of Neurogenetics

Textbook of Neurogenetics
A Book

by Adriano Jiménez Escrig

  • Publisher : Unknown Publisher
  • Release : 2007-09
  • Pages : 316
  • ISBN : 9788479787929
  • Language : En, Es, Fr & De
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This text constitutes a comprehensive sinopsis of our current knowledge of thegenetics on neurological diseases. The book presents the wiews from various disciplines who share a common interest on Neurogenetics. The first sever chapters review basic genetics, from historical aspectcs to molecular genetic tools, the internet resources, and the statistics and software used in research and clinical ground. The remaining fourteen chapters provide valuable information on causes, clinical aspects, genetic diagnosis, treatment strategies and management of the main hereditary neurological disorders. These chapters covers miscellaneous neurological diseases as well as those categorized into groups, review the genetics in each process and provide advice about the steps involved to enable the clinician to make clinical, genetic and differential diagnoses. Besides the practical nature of each chapter, the book aims help neurologists select the most appropriate test, and interpret the results within the context of the genetic evaluation of hereditary neurological disorders. CONTENTS: Principles of genetics. Molecular Biology Techniques in Investigation and Diagnosis. Transgenic animals in Neurology. Gene Therapy of Neurological Diseases. Overview of Computer Software for Genetics. Internet Genetic Resources. Primer of Statistical Genetics. Strategies for the Genetic Molecular Study of a Neurological Disease. Neurogenetics from a Clinical point of view. Hereditary Muscular Dystrophies. Genetics of Movement Disorders. Genetics of Dementia. Genetics of Cerebrovascular Diseases. Genetic Bases of Neurological Disorders. Etc.

Anti-Apoptotic Activity of the Herpes Simplex Virus Type 2 Gene ICP10 PK

Anti-Apoptotic Activity of the Herpes Simplex Virus Type 2 Gene ICP10 PK
Implications for the Therapy of Neurological Disorders That Involve Apoptosis

by Dana Perkins

  • Publisher : Createspace Independent Publishing Platform
  • Release : 2009-12-30
  • Pages : 334
  • ISBN : 9781449991319
  • Language : En, Es, Fr & De
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PhD Thesis (2002). Apoptosis is an etiologic component of neurodegenerative disorders [e.g. Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS)] and acute brain injury ischemia/hypoxia and trauma). Previous studies have shown that a Herpes Simplex Virus Type 2 (HSV-2) gene, ICP10 PK, activates the Ras/MEK/ERK pathway in non-neuronal cells. Because this pathway was implicated in neuronal cell survival, the present studies tested whether ICP10 PK blocks apoptosis in various experimental paradigms of neuronal apoptosis. The broad anti-apoptotic activity of ICP10 PK suggests that it may be used in gene therapy of neurological disorders that involve apoptosis. In addition, the gene can be delivered non-invasively to the central nervous system using a replication-deficient HSV-2 mutant (ICP10deltaRR).

The Prospects of Gene Therapy

The Prospects of Gene Therapy
A Conference Sponsored by the National Institute of Neurological Diseases and /Stroke and the John E. Fogarty International Center for Advanced Study in the Health Sciences, May 24-26, 1971., National Institutes of Health, Bethesda, Maryland

by Ernst Freese

  • Publisher : Unknown Publisher
  • Release : 1972
  • Pages : 22
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Viral Vectors for Treating Diseases of the Nervous System

Viral Vectors for Treating Diseases of the Nervous System
A Book

by David S. Latchman

  • Publisher : Gulf Professional Publishing
  • Release : 2003-09-05
  • Pages : 329
  • ISBN : 9780123668561
  • Language : En, Es, Fr & De
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Gene therapy offers considerable potential for the treatment of various incurable diseases of the nervous system. Viral Vectors for Treating Disease of the Nervous System describes a number of different viral vectors developed for achieving high efficiency gene delivery to the brain. Vectors described include those based on adenovirus, adeno-associated virus, Herpes Simplex Virus, lentivirus, and other retroviruses. It also discusses the potential application of such viruses in treating brain tumors, Parkinson's disease, and other diseases of the nervous system. Provides up-to-date account of gene therapy approaches for incurable neurological disorders Describes a range of gene delivery methods based on different viruses

Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Advancing Gene-Targeted Therapies for Central Nervous System Disorders
Proceedings of a Workshop

by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

  • Publisher : National Academies Press
  • Release : 2019-12-01
  • Pages : 92
  • ISBN : 0309495849
  • Language : En, Es, Fr & De
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On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Applications of Biotechnology in Neurology

Applications of Biotechnology in Neurology
A Book

by Kewal K. Jain

  • Publisher : Springer Science & Business Media
  • Release : 2013-01-05
  • Pages : 638
  • ISBN : 162703272X
  • Language : En, Es, Fr & De
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Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.

Genetic Manipulation of the Nervous System

Genetic Manipulation of the Nervous System
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 1995-11-24
  • Pages : 276
  • ISBN : 9780080532400
  • Language : En, Es, Fr & De
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Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. The recent development of Gene Therapy procedures which allow specific genes to be delivered to human patients who lack functional copies of them is of major therapeutic importance. In addition such gene delivery methods can be used in other organisms to define the function of particular genes. These studies are of particular interest in the nervous system where there are many incurable diseases like Alzheimer's and Parkinson's diseases which may benefit from therapies of this kind. Unfortunately gene delivery methods for use in the nervous system have lagged behind those in other systems due to the fact that the methods developed in other systems are often not applicable to cells like neurons which do not divide. This book discusses a wide range of methods which have now been developed to overcome these problems and allow safe and efficient delivery of particular genes to the brain. Methods discussed include virological methods, physical methods (such as liposomes) and the transplantation of genetically modified cells. In a single volume therefore this book provides a complete view of these methods and indicates how they can be applied to the development of therapies for treating previously incurable neurological disorders.

Gene Transfer and Therapy for Neurological Disorders

Gene Transfer and Therapy for Neurological Disorders
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 550
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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