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Gene Therapy of Cancer

Gene Therapy of Cancer
Methods and Protocols

by Wolfgang Walther,Ulrike Stein

  • Publisher : Springer Science & Business Media
  • Release : 2000
  • Pages : 645
  • ISBN : 1592590861
  • Language : En, Es, Fr & De
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In Gene Therapy of Cancer: Methods and Protocols, Wolfgang Walther and Ulrike Stein survey the rapidly evolving field cancer gene therapy and provide a broad array of leading-edge protocols for the delivery of therapeutic genes into tumors. Described in step-by-step fashion and enriched with each author's own practical tips, these readily reproducible methods are currently being widely applied in cancer gene therapy investigations, including immunotherapy and tumor vaccination, suicide gene therapy, antioncogene therapy, and antisense and ribozyme gene therapy. Representative strategies are provided for gene targeting and for viral or nonviral gene delivery in cancer therapy, as well as a significant number of clinical protocols for the development of novel cancer gene therapies. Gene Therapy of Cancer: Methods and Protocols offers basic and clinical researchers a broad ranging overview and collection of the most recent advances in gene transfer techniques. Written by leading international authorities, its readily reproducible, cutting-edge methods constitute today's most valuable tools for the study of cancer gene therapy in both the laboratory and clinical trials.

Gene Therapy in Cancer

Gene Therapy in Cancer
A Book

by Grace W. Redberry

  • Publisher : Nova Publishers
  • Release : 2005
  • Pages : 228
  • ISBN : 9781594542886
  • Language : En, Es, Fr & De
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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book offers the latest research in a field bursting with new developments, hope and expectations.

Gene Therapy of Cancer

Gene Therapy of Cancer
Translational Approaches from Preclinical Studies to Clinical Implementation

by Stanton L. Gerson,Edmund C. Lattime

  • Publisher : Elsevier
  • Release : 2002-04-04
  • Pages : 534
  • ISBN : 9780080491363
  • Language : En, Es, Fr & De
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The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer. The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer. Key Features * Provides in-depth description of targeted systems and treatment strategies * Explains the underlying cancer biology necessary for understanding a given therapeutic approach * Extensively covers immune therapeutics of vaccines, cytokines, and peptide-induced responses * Presents translational focus with emphasis on requirements for clinical implementation * Incorporates detailed illustrations of vectors and therapeutic approaches ideal for classroom presentations and general reference

Gene Therapy of Cancer

Gene Therapy of Cancer
A Book

by Peter Walden,Uwe Trefzer,Wolfram Sterry,Farzin Farzaneh

  • Publisher : Springer
  • Release : 2012-10-29
  • Pages : 568
  • ISBN : 9781461374442
  • Language : En, Es, Fr & De
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The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.

Gene-Based Therapies for Cancer

Gene-Based Therapies for Cancer
A Book

by Jack A. Roth

  • Publisher : Springer Science & Business Media
  • Release : 2010-07-28
  • Pages : 278
  • ISBN : 144196102X
  • Language : En, Es, Fr & De
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Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Gene Therapy and Cancer Research Focus

Gene Therapy and Cancer Research Focus
A Book

by Rebecca N. Campbell

  • Publisher : Nova Publishers
  • Release : 2008
  • Pages : 335
  • ISBN : 9781600219702
  • Language : En, Es, Fr & De
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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. The volume presents significant new research results in this promising field.

Cancer Gene Therapy by Viral and Non-viral Vectors

Cancer Gene Therapy by Viral and Non-viral Vectors
A Book

by Malcolm Brenner,Mien-Chie Hung

  • Publisher : John Wiley & Sons
  • Release : 2014-02-25
  • Pages : 176
  • ISBN : 1118501659
  • Language : En, Es, Fr & De
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Provides expert, state-of-the-art insight into the currentprogress of viral and non-viral gene therapy Translational medicine has opened the gateway to the era ofpersonalized or precision medicine. No longer a one-size-fits-allapproach, the treatment of cancer is now based on an understandingof underlying biologic mechanisms and is increasingly beingtailored to the molecular specificity of a tumor. This book provides a comprehensive overview of the pertinentmolecular discoveries in the cancer field and explains how theseare being used for gene-based cancer therapies. Designed as avolume in the Translational Oncology book series, Cancer GeneTherapy by Viral and Non-viral Vectors deals with the practiceof gene-therapy, with reference to vectors for gene expression andgene transfer, as well as viral therapy. It covers the history andcurrent and future applications of gene transfer in cancer, andprovides expert insight on the progress of viral and non-viral genetherapy with regard to delivery system, vector design, potentialtherapeutic genes, and principles and regulations for cancer genetherapy. Presented in three parts, Cancer Gene Therapy by Viral andNon-viral Vectors covers: Delivery Systems • Translational Cancer Research: Gene Therapy by Viraland Non-viral Vectors • Retroviruses for Cancer Therapy • DNA Plasmids for Non-viral Gene Therapy ofCancer • Cancer Therapy with RNAi delivered by Non-viralMembrane/Core Nanoparticles Targeted Expression • Cancer Gene Therapy by Tissue-specific andCancer-targeting Promptors • MicroRNAs as Drugs and Drug Targets in Cancer Principles of Clinical Trials in Gene Therapy • Regulatory issues for Manufacturers of Viral Vectorsand Vector-transduced Cells for Phase I/II Trials • US Regulations Governing Clinical Trials in GeneTherapy • Remaining Obstacles to the Success of Cancer GeneTherapy Focusing on speeding the process in clinical cancer care bybringing therapies as quickly as possible from bench to bedside,Cancer Gene Therapy by Viral and Non-viral Vectors is anabsolutely vital book for physicians, clinicians, researchers, andstudents involved in this area of medicine.

Gene Therapy for Cancer

Gene Therapy for Cancer
A Book

by Kelly K. Hunt,Stephan A. Vorburger,Stephen G. Swisher

  • Publisher : Humana Press
  • Release : 2007-02-02
  • Pages : 469
  • ISBN : 9781588294722
  • Language : En, Es, Fr & De
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The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.

Gene Therapy and Cancer Research Progress

Gene Therapy and Cancer Research Progress
A Book

by Jessica L. Lewis

  • Publisher : Nova Publishers
  • Release : 2008
  • Pages : 225
  • ISBN : 9781600218118
  • Language : En, Es, Fr & De
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Genes, which are carried on chromosomes, are the basic physical and functional units of heredity. Genes are specific sequences of bases that encode instructions on how to make proteins. Although genes get a lot of attention, it's the proteins that perform most life functions and even make up the majority of cellular structures. When genes are altered so that the encoded proteins are unable to carry out their normal functions, genetic disorders can result. Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This new book presents the latest research in the field from around the world.

New Gene Therapy and Cancer Research

New Gene Therapy and Cancer Research
A Book

by Wilma B. Gustafsson

  • Publisher : Nova Publishers
  • Release : 2008
  • Pages : 314
  • ISBN : 9781600219696
  • Language : En, Es, Fr & De
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Gene therapy is an experimental treatment that involves introducing genetic material into a person's cells to fight disease. Gene therapy is being studied in clinical trials for many different types of cancer and for numerous other diseases. This book offers research from around the globe dedicated to this subject.

Cancer Gene Therapy

Cancer Gene Therapy
A Book

by David T. Curiel,Joanne T. Douglas

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-03
  • Pages : 490
  • ISBN : 1592597858
  • Language : En, Es, Fr & De
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A complete introduction and guide to the latest developments in cancer gene therapy-from bench to bedside. The authors comprehensively review the anticancer genes and gene delivery methods currently available for cancer gene therapy, including the transfer of genetic material into the cancer cells, stimulation of the immune system to recognize and eliminate cancer cells, and the targeting of the nonmalignant stromal cells that support their growth. They also thoroughly examine the advantages and limitations of the different therapies and detail strategies to overcome obstacles to their clinical implementation. Topics of special interest include vector-targeting techniques, the lessons learned to date from clinical trials of cancer gene therapy, and the regulatory guidelines for future trials. Noninvasive techniques to monitor the extent of gene transfer and disease regression during the course of treatment are also discussed.

A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy.

A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy.
A Book

by Dr.Hakim Saboowala

  • Publisher : Dr.Hakim Saboowala
  • Release : 2020-05-06
  • Pages : 57
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Glance at Advances in the Techniques and Methodologies of Cancer Gene Therapy. Cancer is the second leading cause of mortality worldwide after cardiovascular diseases, predominantly due to the lack of early symptoms and early diagnosis, and high relapse rate after radical surgery and conventional therapies. Therefore, novel approaches such as gene therapy have raised hope to significantly improve the survival rate of patients with cancers. Thus it would be worth at this stage providing an up-to-date information concerning gene therapy including: · Improved vectors, · Suicide genes, · Cancer suppressor genes, · Anti-tumor angiogenesis, · Gene silencing, · Oncolytic virotherapy, and · Gene-editing technology. Whilst specific issues still exist before gene therapy can completely cure cancers, an effort has been made in this Booklet to highlight the potential of gene therapy in cancer treatment and expect to see continuous breakthroughs in techniques therapy. …Dr. H. K. Saboowala. M.B.(Bom) .M.R.S.H.(London)

Cancer Gene Therapy

Cancer Gene Therapy
Past Achievements and Future Challenges

by Nagy Habib

  • Publisher : Springer Science & Business Media
  • Release : 2006-04-11
  • Pages : 496
  • ISBN : 0306468174
  • Language : En, Es, Fr & De
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With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

Gene Therapy in the Treatment of Cancer

Gene Therapy in the Treatment of Cancer
Progress and Prospects

by Brian E. Huber,Ian Magrath

  • Publisher : Cambridge University Press
  • Release : 1998-09-24
  • Pages : 216
  • ISBN : 0521444365
  • Language : En, Es, Fr & De
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Reviews progress and considers future developments in the fast-evolving field of gene therapy in oncology.

Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches

Cellular Therapy Of Cancer: Development Of Gene Therapy Based Approaches
A Book

by Robert E Hawkins

  • Publisher : World Scientific
  • Release : 2014-05-05
  • Pages : 212
  • ISBN : 9814618535
  • Language : En, Es, Fr & De
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Cancer research has progressed enormously in recent years. This review volume will address recent findings in the area of T-cell therapy for cancer, including use of tumour infiltrating lymphocytes (TILs) as a therapy for melanoma, choice of target antigens, advances in engineered receptors, methods of gene transfer to T cells, review of cell processing methods and clinical trial design. Written by leadings scientists in the field, this up-to-date review on cancer research will be an important reference source to the researchers and healthcare professionals in the field.

Suicide Gene Therapy

Suicide Gene Therapy
Methods and Protocols

by Nejat Düzgüneş

  • Publisher : Humana Press
  • Release : 2019-02-04
  • Pages : 190
  • ISBN : 9781493989218
  • Language : En, Es, Fr & De
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This detailed volume explores the methods used for most of the recent approaches to suicide gene therapy of cancer, which exploits promoters that are specific to cancer cells, thereby ensuring (or greatly increasing the likelihood) that the therapeutic gene is expressed only in cancer cells. The book also contains chapters describing methods to improve the safety of cell therapy and techniques utilizing bone marrow mesenchymal cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Suicide Gene Therapy: Methods and Protocols serves as an ideal guide for researchers expanding upon our knowledge and application of this vital form of cancer therapy.

Cancer Gene Therapy: New Insights for the Healthcare Professional: 2012 Edition

Cancer Gene Therapy: New Insights for the Healthcare Professional: 2012 Edition
ScholarlyBrief

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-10
  • Pages : 91
  • ISBN : 1464972451
  • Language : En, Es, Fr & De
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Cancer Gene Therapy: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Cancer Gene Therapy in a concise format. The editors have built Cancer Gene Therapy: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer Gene Therapy in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer Gene Therapy: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Novel Gene Therapy Approaches

Novel Gene Therapy Approaches
A Book

by Ming Wei,David Good

  • Publisher : BoD – Books on Demand
  • Release : 2013-02-13
  • Pages : 406
  • ISBN : 9535109669
  • Language : En, Es, Fr & De
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Gene therapy has the potential to be a tailor-made therapeutic with increased specificity and decreased side effects that can offer a "cure" for many disorders. The aim of this book is to provide up-to-date reviews of the rapidly growing field of gene therapy. Chapters cover a large range of topics including methods of gene delivery, and identification of targets with several papers on cancer gene therapy. If more people become aware of the true nature and potential of gene therapy, perhaps we can achieve the full benefit of such an innovative approach for the treatment of a range of diseases, including cancer.

Current Status and Future of Gene Therapy for Cancer

Current Status and Future of Gene Therapy for Cancer
A Book

by K. K. Jain

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cancer

Cancer
The Role of Genes, Lifestyle, and Environment

by Joseph Panno

  • Publisher : Infobase Publishing
  • Release : 2009-01-01
  • Pages : 177
  • ISBN : 0816067325
  • Language : En, Es, Fr & De
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Examines what is known about cancer cells and current cancer research.