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Genetic Toxicology Testing

Genetic Toxicology Testing
A Laboratory Manual

by Ray Proudlock

  • Publisher : Academic Press
  • Release : 2016-05-28
  • Pages : 460
  • ISBN : 0128010061
  • Language : En, Es, Fr & De
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Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab

Genetic toxicology testing

Genetic toxicology testing
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 99
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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OECD Series on Testing and Assessment Overview on genetic toxicology TGs

OECD Series on Testing and Assessment Overview on genetic toxicology TGs
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 2017-04-13
  • Pages : 60
  • ISBN : 9264274766
  • Language : En, Es, Fr & De
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Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...

Mutation Research. Genetic Toxicology Testing

Mutation Research. Genetic Toxicology Testing
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles of Genetic Toxicology

Principles of Genetic Toxicology
A Book

by D. Brusick

  • Publisher : Springer Science & Business Media
  • Release : 2013-06-29
  • Pages : 284
  • ISBN : 1489919805
  • Language : En, Es, Fr & De
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The field of genetic toxicology has gone through remarkable development in the seven years since the appearance of the first edition of Principles of Genetic Toxicology. One branch of toxicology research, chemical mutagenesis, has been elucidated and expanded as a result of increased effort, testing, and the sharing of data. This expansion has occurred not only in the industrialized countries, but also in countries that are comparatively less advanced in scientific implementation. These developing countries have taken advan tage of the basic practical methods that were so well described in the first edition of this work. It is significant to note how many centers have been established throughout the world and are now studying the basic concepts and applying them to practical problems such as the detection of genetic effects caused by exposure to chemicals. In fact, there are now toxicology training centers in twelve countries. Genetic toxicology, in addition to being investigated as a science unto itself, has been taught to people in the applied fields so that these techniques may be put to use in solving other biological problems. For these reasons, it is most useful to have an update of the basic methods and their development. Dr. Brusick should be congratulated for doing such an excellent job of assembling a text that will be worthwhile to any researcher who is interested in the principles of genetic toxicology. Alexander Hollaender Council for Research Planning in Biological Sciences, Inc. Washington, D. C.

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test

Test No. 478: Genetic Toxicology: Rodent Dominant Lethal Test
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1984-04-04
  • Pages : 6
  • ISBN : 9264071369
  • Language : En, Es, Fr & De
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Dominant lethal (DL) effects cause embryonic or foetal death. Induction of a dominant lethal event after exposure to a test substance (liquid, solid, vapour or gas, ...) indicates that the substance has affected germinal tissue of the test species ...

Features on the Assays Described in the OECD Guidelines on Genetic Toxicology Testing

Features on the Assays Described in the OECD Guidelines on Genetic Toxicology Testing
A Book

by Organisation for Economic Co-operation and Development

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 12
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Aspects of Validation, Standardization, and Statistical Analysis in Bacterial Genetic Toxicology Testing

Aspects of Validation, Standardization, and Statistical Analysis in Bacterial Genetic Toxicology Testing
A Book

by Stephen William Mamber

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 809
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Features of the Assays Described in the OECD Guidelines on Genetic Toxicology Testing

Features of the Assays Described in the OECD Guidelines on Genetic Toxicology Testing
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 12
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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OECD Guidelines for the Testing of Chemicals / Section 4: Health Effects Test No. 484: Genetic Toxicology: Mouse Spot Test

OECD Guidelines for the Testing of Chemicals / Section 4: Health Effects Test No. 484: Genetic Toxicology: Mouse Spot Test
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1986-10-23
  • Pages : 4
  • ISBN : 9264071482
  • Language : En, Es, Fr & De
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The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...

Pharmaceutical Toxicology in Practice

Pharmaceutical Toxicology in Practice
A Guide to Non-clinical Development

by Alberto Lodola,Jeanne Stadler

  • Publisher : John Wiley & Sons
  • Release : 2011-03-31
  • Pages : 280
  • ISBN : 0470922729
  • Language : En, Es, Fr & De
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This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.

Current Issues in Genetic Toxicology

Current Issues in Genetic Toxicology
A Book

by Stephan Madle

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 113
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Comet Assay in Toxicology

The Comet Assay in Toxicology
2nd Edition

by Alok Dhawan,Diana Anderson

  • Publisher : Royal Society of Chemistry
  • Release : 2016-10-07
  • Pages : 590
  • ISBN : 178262287X
  • Language : En, Es, Fr & De
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Concerns about the adverse effects of chemicals present in the environment have created a need for better systems to assess their potential consequences on human health. One potential solution is the versatile and state-of-the-art Comet assay. Simple, sensitive, rapid and visual, this modern toxicological method allows quantitative and qualitative assessment of DNA damage in single cells. This unique reference is devoted exclusively to the Comet assay and addresses, in-depth, the different protocols, statistical analyses and applications being used worldwide. It also includes the guidelines recommended by the working group on Comet assay. The book is aimed at students as well as scientists in the area of molecular epidemiology and genetic toxicology.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1986-10-23
  • Pages : 5
  • ISBN : 9264071407
  • Language : En, Es, Fr & De
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This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...

Insight on Genotoxicity

Insight on Genotoxicity
A Book

by Shiv Shankar Shukla,Ravindra Kumar Pandey,Bina Gidwani,Gunjan Kalyani

  • Publisher : CRC Press
  • Release : 2020-10-14
  • Pages : 152
  • ISBN : 1000197255
  • Language : En, Es, Fr & De
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Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1984-04-04
  • Pages : 6
  • ISBN : 9264071342
  • Language : En, Es, Fr & De
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Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...

Insight on Genotoxicity

Insight on Genotoxicity
A Book

by Shiv Shankar Shukla,Ravindra Kumar Pandey,Bina Gidwani,Gunjan Kalyani

  • Publisher : CRC Press
  • Release : 2020-10-15
  • Pages : 152
  • ISBN : 100019731X
  • Language : En, Es, Fr & De
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Genetic toxicology is considered to be an important assessment tool as there is genetic impact of artificial chemicals. Insight on Genotoxicity discusses testing, mechanism, prediction, and bioindicator of genotoxicity taking into consideration recent advances in nano-engineered particles. Corollary of DNA dent is also discussed in detail taking into consideration the impact of ICH guidelines on genotoxicity testing, which is important for drug discovery innovation and development. Perspective review of genotoxicity evaluation in phytopharmaceuticals has been mentioned along with the prevention of genotoxicity in brief viewpoint. Salient Features Presents methods, standard protocols, and guidelines for genotoxicity testing Examines the impact of ICH Guidelines on genetic toxicity testing which is a regulatory requirement for drug discovery and development Defines appropriate strategies about advances in in vivo genotoxicity testing which have been listed along with progress and prospects Discusses advancement in the high-throughput approaches for genotoxicity testing Details computational prediction of genotoxicity with consideration of mutagenicity, chromosomal damage caused and strategies for computational prediction in drug development

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 484: Genetic Toxicology: Mouse Spot Test
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1986-10-23
  • Pages : 4
  • ISBN : 9264071482
  • Language : En, Es, Fr & De
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The mouse spot test detects presumed somatic mutations in fetal cells following transplacental absorption of the test substance. This is an in vivo test in mice in which developing embryos are exposed to a chemical (solid, liquid, vapour or ...

Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in Vitro

Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in Vitro
A Book

by Organisation for Economic Co-operation and Development

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 7
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Following the OECD Council decision, the Test Guideline 482 'Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro' was deleted on 2nd April 2014.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
A Book

by OECD

  • Publisher : OECD Publishing
  • Release : 1986-10-23
  • Pages : 5
  • ISBN : 9264071385
  • Language : En, Es, Fr & De
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The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...