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Genomic Medicine in Emerging Economies

Genomic Medicine in Emerging Economies
Genomics for Every Nation

by George Patrinos,Catalina Lopez-Correa

  • Publisher : Academic Press
  • Release : 2018-06-29
  • Pages : 204
  • ISBN : 0128115513
  • Language : En, Es, Fr & De
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Genomic Medicine in Resource-limited Countries: Genomics for Every Nation provides in-depth analysis and key examples of the implementation of medical genomics in low-income nations across the globe, demonstrating how this advancing medical science has not only transformed health systems, but also led to improved patient care in Indonesian, Nepalese, Chilean, Malaysian, Tanzanian, Argentinian, Chinese, Sri Lankan and Columbian populations, among others. In addition to defining tools, diagnostics and treatment pathways at the population-wide level for medical geneticists, genomic researchers and public health workers, this book offers a case-study based approach that helps users understand how genomic medicine is used in disease-management. Examines essential concepts and protocols, and economic, social and legal considerations related to the implementation of genomic medicine in resource-limited nations Features concrete success stories of the implementation of medical genomics in Indonesian, Nepalese, Chilean, Malaysian, Tanzanian, Argentinian, Chinese, Sri Lankan and Columbian populations, amongst others Provides tools, diagnostics and treatment pathways for medical geneticists, genomic researchers and public health workers to apply in their own work Establishes clear precedents on how genomic technologies can be accessed by nations with limited means and financial support for healthcare

Economic Evaluation in Genomic Medicine

Economic Evaluation in Genomic Medicine
A Book

by Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos

  • Publisher : Academic Press
  • Release : 2015-03-20
  • Pages : 174
  • ISBN : 0128016116
  • Language : En, Es, Fr & De
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Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine. Interrelates economic evaluation and genomic medicine Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine Teaches health economists about application of economic evaluation in genomic medicine Introduces health economics and economic evaluation to clinicians and researchers involved in genomics Includes process guides, maps, flow charts and diagrams

Genomic Medicine in Developing Countries

Genomic Medicine in Developing Countries
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 27
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genomics and Health in the Developing World

Genomics and Health in the Developing World
A Book

by Dhavendra Kumar

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 1569
  • ISBN : 9780199392995
  • Language : En, Es, Fr & De
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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance o.

Genomics and Health in the Developing World

Genomics and Health in the Developing World
A Book

by Dhavendra Kumar

  • Publisher : Oxford University Press
  • Release : 2012-05-11
  • Pages : 1536
  • ISBN : 019970547X
  • Language : En, Es, Fr & De
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Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address: - Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent - The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide - Rising ethical and legal concerns of medical genetics in the developing world - Social, cultural, and religious issues related to genetic diseases across continents Both timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.

Economic Evaluation in Genomic and Precision Medicine

Economic Evaluation in Genomic and Precision Medicine
A Book

by Christina Mitropoulou,Sarah Wordsworth,James Buchanan,George P. Patrinos

  • Publisher : Academic Press
  • Release : 2020-10-01
  • Pages : 264
  • ISBN : 0128133945
  • Language : En, Es, Fr & De
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Economic Evaluation in Genomic and Precision Medicine provides an in-depth examination of essential concepts, protocols and applications of economic evaluation in genomic and precision medicine. Contributions from leading international medical geneticists and health economists compile new ways to effectively assess the costs and outcomes of different genomic care pathways, implement cost-effective medical interventions, and enhance the value of genomic and precision healthcare. Foundational chapters and discipline-specific case studies cover topics ranging from the economic analysis of genomic trial design, to health technology assessment of next-generation sequencing, ethical aspects, economic policy in genomic medicine, and pricing and reimbursement in clinical genomics. Introduces clinicians, researchers and students to essential concepts, protocols and applications of economic evaluation in genomic and precision medicine Demonstrates, through foundational chapters and discipline-specific case studies, how to assess the relative costs and outcomes of different genomic care pathways and implement cost-effective budgets Establishes clear precedents on how genomic technologies can be leveraged to simultaneously reduce costs and enhance the value of healthcare Features contributions from leading international medical geneticists and health economists that are actively evolved in economic assessments of genomic and precision medicine

Applied Genomics and Public Health

Applied Genomics and Public Health
A Book

by George P. Patrinos

  • Publisher : Academic Press
  • Release : 2019-11-13
  • Pages : 404
  • ISBN : 0128136960
  • Language : En, Es, Fr & De
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Applied Genomics and Public Health examines the interdisciplinary and growing area of how evidence-based genomic knowledge can be applied to public health, population health, healthcare and health policies. The book gathers experts from a variety of disciplines, including life sciences, social sciences, and health care to develop a comprehensive overview of the field. In addition, the book delves into subjects such as pharmacogenomics, genethics, big data, data translation and analysis, economic evaluation, genomic awareness and education, sociology, pricing and reimbursement, policy measures and economic evaluation in genomic medicine. This book is essential reading for researchers and students exploring applications of genomics to population and public health. In addition, it is ideal for those in the biomedical sciences, medical sociologists, healthcare professionals, nurses, regulatory bodies and health economists interested in learning more about this growing field. Explores the growing application of genomics to population and public health Features internationally renowned contributors from a variety of related fields Contains chapters on important topics such as genomic data sharing, genethics and public health genomics, genomics and sociology, and regulatory aspects of genomic medicine and pharmacogenomics

Educating Health Professionals in Genomic Medicine: Evidence-Based Strategies and Approaches

Educating Health Professionals in Genomic Medicine: Evidence-Based Strategies and Approaches
A Book

by Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty

  • Publisher : Frontiers Media SA
  • Release : 2020-10-09
  • Pages : 129
  • ISBN : 2889660591
  • Language : En, Es, Fr & De
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Genomics and Society

Genomics and Society
Ethical, Legal, Cultural and Socioeconomic Implications

by Dhavendra Kumar,Ruth Chadwick

  • Publisher : Academic Press
  • Release : 2015-10-29
  • Pages : 438
  • ISBN : 0127999213
  • Language : En, Es, Fr & De
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Genomics and Society; Ethical, Legal-Cultural, and Socioeconomic Implications is the first book to address the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011. The work addresses fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system. Of particular interest to healthcare practitioners, bioethicists, and health economists, and of tangential interest to the gamut of applied social scientists investigating the societal impact of new medical paradigms, the work describes a myriad of issues around consent, confidentiality, rights, patenting, regulation, and legality in the new era of genomic medicine. Addresses the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011 Presents the core fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system Describes a myriad of issues around consent, including confidentiality, rights, patenting, regulation, and more

Human Genome Informatics

Human Genome Informatics
Translating Genes into Health

by Christophe Lambert,Darrol Baker,George P. Patrinos

  • Publisher : Academic Press
  • Release : 2018-08-02
  • Pages : 314
  • ISBN : 0128134313
  • Language : En, Es, Fr & De
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Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field. Provides an overview of the most commonly used electronic tools to translate genomic information Brings an update on the existing human genomic databases that directly impact genome interpretation Summarizes and comparatively analyzes interpretation methods of whole genome data and their application in genomic medicine

Molecular Diagnostics

Molecular Diagnostics
A Book

by George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson

  • Publisher : Academic Press
  • Release : 2016-10-27
  • Pages : 520
  • ISBN : 0128029889
  • Language : En, Es, Fr & De
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Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Economic Dimensions of Personalized and Precision Medicine

Economic Dimensions of Personalized and Precision Medicine
A Book

by Ernst R. Berndt,Dana P. Goldman,John Rowe

  • Publisher : University of Chicago Press
  • Release : 2019-04-22
  • Pages : 400
  • ISBN : 022661123X
  • Language : En, Es, Fr & De
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Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

Chapter 28 Genomics in Emerging and Developing Economies

Chapter 28 Genomics in Emerging and Developing Economies
A Book

by Duana Fullwiley,Martyn Pickersgill,Sahra Gibbon

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 12
  • ISBN : 9781138211957
  • Language : En, Es, Fr & De
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Low and middle-income countries have become a site of increasing research interest and investment with the transnational expansion and spread of genomic knowledge and technologies (Kumar 2012, Seguin and others 2008). This reflects a dynamic terrain in which genomics is being harnessed to address a range of healthcare challenges.

Genomics and Health in the Developing World

Genomics and Health in the Developing World
A Book

by Dhavendra Kumar

  • Publisher : Oxford University Press
  • Release : 2012-06-14
  • Pages : 1501
  • ISBN : 0195374754
  • Language : En, Es, Fr & De
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This book is designed to be the first major text to discuss advances in medical genetics in the developing world.

The Biologist's Imagination

The Biologist's Imagination
Innovation in the Biosciences

by William Hoffman,William R. Hoffman,Leo Furcht

  • Publisher : Oxford University Press (UK)
  • Release : 2014
  • Pages : 284
  • ISBN : 0199974594
  • Language : En, Es, Fr & De
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"Scholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. But despite the lion's share offederal research dollars being devoted to innovation in the biosciences, the field has yet to live up to its billing as a source of economic productivity and growth. With vast untapped potential to imagine and innovate in the biosciences, adaptation of the innovative model is needed. In The Biologist's Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioscientific innovation to discuss current trends as they relate to medicine, agriculture, biofuels, stem-cell research, neuroscience, and more. Ultimately, Hoffman and Furcht argue that, as things currently stand, we fall short in our efforts to innovate in the biosciences; our system of innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies, globalization in higher education as well as in finance, and increases in entrepreneurship. The Biologist's Imagination is both an analysis of past models for bioscience innovation and a forward-looking, original argument for how future models should be developed"--

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-04-08
  • Pages : 288
  • ISBN : 0128178205
  • Language : En, Es, Fr & De
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Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Public Health Genomics and International Wealth Creation

Public Health Genomics and International Wealth Creation
A Book

by Ebomoyi, E. William

  • Publisher : IGI Global
  • Release : 2016-03-30
  • Pages : 463
  • ISBN : 1466685603
  • Language : En, Es, Fr & De
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In 2003, the secrets of the human genome were cracked open, creating a flurry of anticipation (and more than a little commercial buzz) about the role that genetic modification would play in years to come. This burgeoning field stands poised to redefine old paradigms and reshape industries such as medicine, agriculture, pharmacology, and biotechnology. Public Health Genomics and International Wealth Creation seeks to explore new opportunities and challenges in genomic commercialization by presenting a roadmap of current research, setting forth clear guidelines for how genomics can be wielded safely and ethically in a manner concordant with public welfare. Addressing problems such as chronic disease, world hunger, and global economic disparity, this book is an essential reference source for doctors, bioethicists, human genome specialists, and scientists in the fields of genetics and genomics. This authored monograph contains chapters on topics ranging from agronomics and biotechnology to commercial genomics, genome sequencing, cancer genomics, and more.

Genomics, Health and Society

Genomics, Health and Society
Emerging Issues for Public Policy

by Policy Research Initiative (Canada)

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 215
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Examines critical issues that will need to be addressed to realize the health and economic benefits that genomics promises, while managing the associated risks. Topics include: genetic medicine and privacy, issues of intellectual property, and implications for the developing world.

Routledge Handbook of Genomics, Health and Society

Routledge Handbook of Genomics, Health and Society
A Book

by Sahra Gibbon,Barbara Prainsack,Stephen Hilgartner,Janelle Lamoreaux

  • Publisher : Routledge
  • Release : 2018-04-17
  • Pages : 316
  • ISBN : 1315451670
  • Language : En, Es, Fr & De
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The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary ‘bioeconomies’; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs – and is shaped by – developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Presenting cutting edge research from leading social science scholars, the Handbook provides a unique and important contribution to the field. It brings a rich and varied cross disciplinary social science perspective that engages with both the history and contemporary context of genomics and ‘post-genomics’, and considers the now global and transnational terrain in which these developments are unfolding.

Bringing Leadership to Life in Health: LEADS in a Caring Environment

Bringing Leadership to Life in Health: LEADS in a Caring Environment
Putting LEADS to work

by Graham Dickson,Bill Tholl

  • Publisher : Springer Nature
  • Release : 2020-03-06
  • Pages : 334
  • ISBN : 3030385361
  • Language : En, Es, Fr & De
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This edited volume, featuring five new chapters from invited authors, provides an updated and evidence-based explanation of leadership within a healthcare environment. The book discusses new insights garnered from recent research into the importance of leadership in health system redesign and highlights the practice of shared or distributed health care leadership. New chapters covering LEADS in a national, regional, Indigenous, health profession, and people-centred care context provide new insights into how LEADS is being put to work to transform health systems. The LEADS framework has been refreshed in relation to each of its different elements and tools, with an emphasis on providing real-life examples of how LEADS has been put to work. LEADS is also explained as a change leadership model and in relation to how it helps to level the playing field in terms of gender and diversity in health leadership. The book aims to inform the leadership needs of health reform and its emergent system wide challenges. The content is relevant to health care administrators and professionals working within the public service, academic institutions, and health care delivery organisations.