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Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)
The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease

by Michael A. Sirover

  • Publisher : Academic Press
  • Release : 2017-05-22
  • Pages : 324
  • ISBN : 0128098988
  • Language : En, Es, Fr & De
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Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein’s diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. Contextualizes how GAPDH is utilized by cells in vivo Provides detailed insight into GAPDH post-translational modifications, including functional diversity and its subcellular localization Includes forward-thinking exposition on tough topics, such as the exploration of how GAPDG performs functions, how it decides where it should be present and requisite structural requirements

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH)
The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease

by Michael A. Sirover

  • Publisher : Academic Press
  • Release : 2017-06-05
  • Pages : 332
  • ISBN : 9780128098523
  • Language : En, Es, Fr & De
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Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH): The Quintessential Moonlighting Protein in Normal Cell Function and in Human Disease examines the biochemical protein interactions of the multi-dimensional protein GAPDH, further considering the regulatory mechanisms through which cells control their functional diversity. This protein's diverse activities range from nuclear tRNA export and the maintenance of genomic integrity, to cytoplasmic post-transcriptional control of gene expression and receptor mediated cell signaling, to membrane facilitation of iron metabolism, trafficking and fusion. This book will be of great interest to basic scientists, clinicians and students, including molecular and cell biologists, immunologists, pathologists and clinical researchers who are interested in the biochemistry of GAPDH in health and disease. Contextualizes how GAPDH is utilized by cells in vivo Provides detailed insight into GAPDH post-translational modifications, including functional diversity and its subcellular localization Includes forward-thinking exposition on tough topics, such as the exploration of how GAPDG performs functions, how it decides where it should be present and requisite structural requirements

Macromolecular Protein Complexes

Macromolecular Protein Complexes
Structure and Function

by J. Robin Harris,Jon Marles-Wright

  • Publisher : Springer
  • Release : 2017-03-07
  • Pages : 572
  • ISBN : 3319465031
  • Language : En, Es, Fr & De
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This volume of the established Subcellular Biochemistry series presents 20 chapters dealing with a broad range of interesting protein complexes. It will enable researchers to readily appreciate the major contribution from both X-ray crystallography and cryo-electron microscopy in this field of study. The biological significance of these structural studies is emphasised throughout the book. The diversity of the material included here indicates the breadth of this field and the tremendous progress that has been made in recent years. The book is directed primarily to advanced students and researchers in structural biology, and others in the biochemical sciences. It will be supplemented by other related books within the Subcellular Biochemistry series. One of the Editors (JM-W) is actively involved in structural biology and the other (JRH), as a retired academic and the Series Editor of Subcellular Biochemistry, has long experience at editing multi-author books./div

GAPDH: Biological Properties and Diversity

GAPDH: Biological Properties and Diversity
A Book

by Norbert W. Seidler

  • Publisher : Springer Science & Business Media
  • Release : 2012-07-31
  • Pages : 295
  • ISBN : 9400747160
  • Language : En, Es, Fr & De
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The book represents a comprehensive review and synthesis of the biomedical literature that spans over a half-century on a single protein called glyceraldehyde 3-phosphate dehydrogenase (or, GAPDH). Due to the protein’s involvement in a vast array of cellular activities, GAPDH is of interest to the cell biologist, immunologist, virologist, biochemist etc. The protein has a significant role in fertility, cancer and neurodegeneration, suggesting that this book can be a vital resource for drug development. GAPDH function may provide insight into anesthesia. Furthermore, GAPDH is highly conserved meaning that the protein found in microorganisms, such as pathogens, remained relatively unchanged in evolution. Pathogens use GAPDH as a virulence factor, offering a unique challenge in developing anti-microbial agents that target this protein. To the evolutionary biologist, a book on the multi-functionality of GAPDH provides a focal point for a cogent discussion on the very origin of life.

Elsevier's Integrated Review Biochemistry

Elsevier's Integrated Review Biochemistry
A Book

by John W. Pelley

  • Publisher : Elsevier Health Sciences
  • Release : 2011-11-30
  • Pages : 214
  • ISBN : 0323074464
  • Language : En, Es, Fr & De
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Rev. ed. of: Elsevier's integrated biochemistry / John W. Pelley. c2007.

Biochemistry for Medical Professionals

Biochemistry for Medical Professionals
A Book

by Tsugikazu Komoda,Toshiyuki Matsunaga

  • Publisher : Academic Press
  • Release : 2015-06-25
  • Pages : 112
  • ISBN : 0128020113
  • Language : En, Es, Fr & De
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Biochemistry for Medical Professionals contains pivotal advances in the biochemistry field and provides a resource for professionals across medicine, dentistry, pharmaceutical sciences and health professions who need a concise, topical biochemistry reference. Relevant, well-illustrated coverage begins with the composition of the human body and then goes into the technical detail of the metabolism of the human body and biochemistry of internal organs before featuring a biotechnology study inclusive of numerous methods and applications. The work is written at a consistently high level, with technical notes added to aid comprehension for complex topics. Illustrates disease involvement in metabolic maps Contains coverage of cutting-edge technology, including iPS, HPLC and HPLC-MS, and FACS method Provides in-depth technical detail as well as conceptual frameworks of biochemistry and experimental design in the context of the human organism Includes a biotechnology study, featuring application of basic biochemistry principles

Methods of Enzymatic Analysis

Methods of Enzymatic Analysis
A Book

by Hans-UIrich Bergmeyer

  • Publisher : Elsevier
  • Release : 2012-12-02
  • Pages : 1088
  • ISBN : 0323141773
  • Language : En, Es, Fr & De
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Methods of Enzymatic Analysis focuses on the general progress in enzymology and in the special field of enzymatic analysis. This book explores the commercial production of biochemical reagents for analysis and explains the transition from the possible use of enzymatic analysis to its various applications in pure and applied biochemistry. Organized into four sections, this book starts with an overview of the basis of enzymatic analysis and provides general experimental guidelines for the techniques of measurement and for the disintegration of cells and tissues. This text then provides detailed instructions for the determination of substrates and assay of enzyme activities. Other chapters explore the practical aspects and information necessary for the application of reagents to enzymatic analysis, including sources, stability, and purity required. The final section describes the commercially available enzymes, coenzymes, substrates, and several less common reagents. Biochemists, biophysicists, researchers, and graduate students will find this book extremely useful.

Pyridine Nucleotide-Dependent Dehydrogenases

Pyridine Nucleotide-Dependent Dehydrogenases
Proceedings of an Advanced Study Institute held at the University of Konstanz, Germany, September 15–20, 1969

by Horst Sund

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 472
  • ISBN : 3642499740
  • Language : En, Es, Fr & De
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The present volume represents the proceedings of the symposium on npyridine Nucleotide-Dependent Dehydrogenases" which was held on the campus of the re cently established University of Konstanz, Germany, from September 15 to 20, 1969. The aim of the symposium was to provide a forum for discussion among the experts interested in the various aspects of pyridine nucleotide-dependent de hydrogenases and the pyridine coenzymes, so as to evaluate the state of the present knowledge and to stimulate further progress in this field. In order to facilitate discussion and personal contact it was necessary to restrict the number of participants to 90 including the invited speakers, who came from fifteen countries (Australia, Austria, Denmark, England, Finland, France, Germany, Hungary, Israel, Italy, Japan, Netherlands, Sweden, Switzerland, USA). The printed lectures in this volume differ only in minor respects from those circulated be fore the meeting. In some cases speakers presented new experimen tal material during the symposium which was added as an addendum to the papers. The discussions were not recorded. The participants were requested to provide a written report of what they considered worth including in the published re port. This, together with the answers of the speakers is presented in this vo lume. I whish to thank all the speakers and discussants for their cooperativity in preparing the manuscript. The symposium was sponsored by the International Union of Biochemistry whose President, Professor Theorell, was also present and who was acting as one of the speakers and chairmen.

Advances in GAPDH Protein Analysis: A Functional and Biochemical Approach

Advances in GAPDH Protein Analysis: A Functional and Biochemical Approach
A Book

by Shanmugasundaram Ganapathy-Kanniappan

  • Publisher : Springer
  • Release : 2018-01-16
  • Pages : 115
  • ISBN : 9811073422
  • Language : En, Es, Fr & De
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This book presents modern and classic analytical approaches that are crucial for the biochemical and functional characterization of the archetypal protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH). The distinguishing feature of the book is that it covers, in addition to other methods, some of the uncommon but valuable techniques as well. For example, in-gel visualization of enzyme activity, immunoblotting protocols for native (non-denatured) proteins, and proteins resolved by pH-gradient [IEF-isoelectrofocusing], etc. These expedient methods are relevant and vital for the verification of biochemical properties of GAPDH, or similar protein of interest. This work outlines detailed protocols that are essential to investigate classical (cellular) and recently reported extracellular (secretory) isoforms of GAPDH. Precisely, the book covers techniques pertinent to enzymatic and non-enzymatic analysis of GAPDH that include, but not limited to, electrophoretic mobility shift assay (EMSA), two-dimensional (2D)-immunoblotting, immunofluorescence/confocal microscopy, mass spectrometry, ion-exchange and affinity chromatography. Readers will discover the importance of the experimental methods described in the book as they relate to the evaluation of the role and significance of GAPDH. Furthermore, majority of the methods described in the book have also been validated in the author’s laboratory, besides other research groups worldwide, underlining the repeatability and reproducibility of the protocols. Each method begins with an abstract and a brief background emphasizing its application and relevance. This will enable the readers to determine the choice of experimental design according to their research objectives. The book explains the methods systematically with ample illustrations to facilitate quick and easy comprehension of the practical knowledge. Although the book is focused on GAPDH, many of the protocols may be adopted to other proteins or enzymes with minimal modifications. Noteworthy, it is unequivocally established that GAPDH is a multifunctional protein involved in several cellular processes of health & disease conditions. Hence, this book will be a valuable practical guide for young researchers, scientists and clinician-scientists.

Pyridine Nucleotide-Dependent Dehydrogenases

Pyridine Nucleotide-Dependent Dehydrogenases
Proceedings of the second International Symposium held at the University of Konstanz, West Germany. March 28–April 1, 1977

by Horst Sund

  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 2019-10-08
  • Pages : 529
  • ISBN : 3110853701
  • Language : En, Es, Fr & De
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Sulfhydryl and Disulfide Groups of Proteins

Sulfhydryl and Disulfide Groups of Proteins
A Book

by Yu M. Torchinskii

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-22
  • Pages : 275
  • ISBN : 1475701276
  • Language : En, Es, Fr & De
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(Written for the original Russian edition) Out of all the functional groups of protein molecules that be long to the side chains of amino acid residues, the sulfhydryl or thiol (SH) groups of cysteine residues and the disulfide (S-S) groups of cystine have for long attracted particular attention from chemists and biochemists. This is due, on the one hand, to the high chemical reactivity of these groups, which enter into many, and often very characteristic and selective, reactions with several types of compound. On the other hand, this attention is connected with the great significance of SH and S-S groups for the specific functions of a number of enzymes, hormones, and other biological ly active proteins, and consequently for the normal course of many physiological processes. The varied functions of sulfhydryl and disulfide groups in en zymes are particularly interesting; their role can consist of bind ing substrates and cofactors, in direct participation in the catalytic act, or in maintaining (in ways not so far sufficiently studied) the native, catalytically active conformation of the protein. It is entirely natural that the detailed study of the chemical behavior and biological role of these sulfur-containing groups in proteins (and in such low-molecular cofactors as glutathione, co enzyme A, lipoiC acid, etc. ) has, in addition to its academic, gen eral biological interest, great Significance for many applied branches of medicine and biology (toxicology, radiobiology, diagnostics and therapeutics, biochemical engineering, plant growing, etc. ).

Biochemistry

Biochemistry
A Book

by Donald Voet,Judith G. Voet

  • Publisher : John Wiley & Sons Incorporated
  • Release : 2004-03-09
  • Pages : 1591
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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CD-ROM includes computer animated interactive exercizes, guided explorations, and color images.

Allosteric Enzymes

Allosteric Enzymes
A Book

by Guy Herve

  • Publisher : CRC Press
  • Release : 2020-11-25
  • Pages : 269
  • ISBN : 1000098826
  • Language : En, Es, Fr & De
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This book compiles detailed information concerning a dozen of the best known allosteric enzymes, and so allows the comparison of their regulatory mechanisms and the confrontation of these mechanisms with the theoretical models. Stimulating and unexpected ideas emerge from these comparisons and emphasize the importance of developing various methods of investigation such as crystallography, X-ray solution scattering, and the study of fast movements in proteins and site-directed mutagenesis. This book is addressed to students and researchers interested in structure-function relationship in proteins, enzymology and metabolic regulation. It is also a basis for teaching.

Essentials of Medical Biochemistry

Essentials of Medical Biochemistry
With Clinical Cases

by Chung-Eun Ha,N. V. Bhagavan

  • Publisher : Academic Press
  • Release : 2011-01-28
  • Pages : 600
  • ISBN : 9780080916880
  • Language : En, Es, Fr & De
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Expert biochemist N.V. Bhagavan’s new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor. * Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts * Interactive multiple-choice questions to prep for USMLE exams * Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases * Instructional overview figures, flowcharts, and tables to enhance understanding

Moonlighting Proteins

Moonlighting Proteins
Novel Virulence Factors in Bacterial Infections

by Brian Henderson

  • Publisher : John Wiley & Sons
  • Release : 2017-03-14
  • Pages : 472
  • ISBN : 1118951131
  • Language : En, Es, Fr & De
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Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections is a complete examination of the ways in which proteins with more than one unique biological action are able to serve as virulence factors in different bacteria. The book explores the pathogenicity of bacterial moonlighting proteins, demonstrating the plasticity of protein evolution as it relates to protein function and to bacterial communication. Highlighting the latest discoveries in the field, it details the approximately 70 known bacterial proteins with a moonlighting function related to a virulence phenomenon. Chapters describe the ways in which each moonlighting protein can function as such for a variety of bacterial pathogens and how individual bacteria can use more than one moonlighting protein as a virulence factor. The cutting-edge research contained here offers important insights into many topics, from bacterial colonization, virulence, and antibiotic resistance, to protein structure and the therapeutic potential of moonlighting proteins. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections will be of interest to researchers and graduate students in microbiology (specifically bacteriology), immunology, cell and molecular biology, biochemistry, pathology, and protein science.

Neuropsychiatric Disorders

Neuropsychiatric Disorders
An Integrative Approach

by Manfred Gerlach,Jürgen Deckert,Kay Double,Eleni Koutsilieri

  • Publisher : Springer Science & Business Media
  • Release : 2007-12-28
  • Pages : 341
  • ISBN : 9783211735749
  • Language : En, Es, Fr & De
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This multidisciplinary book includes current research papers and reviews in the areas of basic neuroscience, neural mechanisms underlying neurodegenerative disorders. It further includes new approaches for neuroprotective treatments, clinical, neurobiological and treatment aspects of psychiatric disorders. The book was conceived as a celebration of the professional life and work of Peter Riederer to mark the occasion of his retirement.

Structure and Function of Oxidation–Reduction Enzymes

Structure and Function of Oxidation–Reduction Enzymes
Proceedings of the Wenner-Gren Symposium Held at the Wenner-Gren Center, Stockholm, 23–27 August, 1970

by Å. Åkeson,A. Ehrenberg

  • Publisher : Elsevier
  • Release : 2014-05-17
  • Pages : 790
  • ISBN : 148314755X
  • Language : En, Es, Fr & De
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Structure and Function of Oxidation–Reduction Enzymes is a collection of papers presented at the Wenner-Gren Symposium held at the Wenner-Gren Center, Stockholm on August 23-27, 1970. It provides important understanding of the structure and function of oxidation-reduction enzymes: iron, flavin, and nicotinamide enzymes. This book discusses the functional differences among varying structures such cytochrome c, haemoglobins, dehydrogenases, flavins, oestrogens, and peroxidases. It concludes by presenting future expectations, including some questions that need to be addressed. This volume will be of great value to those interested in the present-day research on oxidation-reduction enzymes.

Protein Sequencing and Identification Using Tandem Mass Spectrometry

Protein Sequencing and Identification Using Tandem Mass Spectrometry
A Book

by Michael Kinter,Nicholas E. Sherman

  • Publisher : John Wiley & Sons
  • Release : 2005-04-12
  • Pages : 320
  • ISBN : 0471231886
  • Language : En, Es, Fr & De
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How to design, execute, and interpret experiments for proteinsequencing using mass spectrometry The rapid expansion of searchable protein and DNA databases inrecent years has triggered an explosive growth in the applicationof mass spectrometry to protein sequencing. This timely andauthoritative book provides professionals and scientists inbiotechnology research with complete coverage of procedures foranalyzing protein sequences by mass spectrometry, includingstep-by-step guidelines for sample preparation, analysis, and datainterpretation. Michael Kinter and Nicholas Sherman present their ownhigh-quality, laboratory-tested protocols for the analysis of awide variety of samples, demonstrating how to carry out specificexperiments and obtain fast, reliable results with a 99% successrate. Readers will get sufficient experimental detail to apply intheir own laboratories, learn about the proper selection andoperation of instruments, and gain essential insight into thefundamental principles of mass spectrometry and protein sequencing.Coverage includes: Peptide fragmentation and interpretation of product ionspectra Basic polyacrylamide gel electrophoresis Preparation of protein digests for sequencing experiments Mass spectrometric analysis using capillary liquidchromatography Techniques for protein identification by database searches Characterization of modified peptides using tandem massspectrometry And much more

Medical Biochemistry

Medical Biochemistry
A Book

by N. V. Bhagavan

  • Publisher : Academic Press
  • Release : 2002
  • Pages : 1016
  • ISBN : 0120954400
  • Language : En, Es, Fr & De
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Thoroughly updated and in a new two-color format, this well- respected text presents the fundamentals of biochemistry and related topics to students pursuing a one- or two-semester course in pre-med biochemistry or medical programs. The second edition is equally applicable to other health-related fields such as clinical chemistry, medical technology or pharmacology. Medical Biochemistry, Fourth Edition, focuses on the foundations and clinically relevant applications of normal human biochemistry and pathology. Abundantly illustrated with four-color plates. Revised chapters on molecular biology reflect the latest research in the field Two color throughout with four color plates Reference quality appendices include practical information on clinical lab parameters used to diagnose a range of diseases

Chemistry and Methods of Enzymes

Chemistry and Methods of Enzymes
A Book

by James Batcheller Sumner,George Frederick Somers

  • Publisher : Unknown Publisher
  • Release : 1953
  • Pages : 462
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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