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Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design
A Book

by Bimal K. Banik

  • Publisher : Advances in Green Chemistry
  • Release : 2020-04
  • Pages : 610
  • ISBN : 0128175923
  • Language : En, Es, Fr & De
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Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Contemporary Chemical Approaches for Green and Sustainable Drugs

Contemporary Chemical Approaches for Green and Sustainable Drugs
A Book

by Marianna Torok

  • Publisher : Elsevier
  • Release : 2021-07-15
  • Pages : 500
  • ISBN : 9780128222485
  • Language : En, Es, Fr & De
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The design, discovery, development and use of medicinal agents produces a whole range of environmental contaminants which have a damaging ecological impact. By acknowledging and addressing these issues, chemists can take preventative steps at multiple stages in the process, from using computational models and selecting green solvents, to designing for degradation and creating new remediation tools. Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate such sustainable approaches into their work. After an introduction to the major focus areas in the field, the book includes four parts, each dealing with different aspects of green and sustainable drug development from design to disposal. These include computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, Contemporary Chemical Approaches for Green and Sustainable Drugs provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs, making it a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practise through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry
A Book

by Peter J. Dunn,Andrew Wells,Michael T. Williams

  • Publisher : John Wiley & Sons
  • Release : 2010-02-02
  • Pages : 388
  • ISBN : 9783527629695
  • Language : En, Es, Fr & De
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Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis

Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-09-06
  • Pages : 188
  • ISBN : 0128175575
  • Language : En, Es, Fr & De
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Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated. Provides an overview of the status of some of the current novel compounds in development as well as new emerging treatment options targeting novel mechanisms of action Identification of hits from phenotypic whole cell screening, followed by target identification Strategies aimed at improving the efficacy of existing clinically used anti-TB drugs by taking advantage inhibitors of mycobacterial transcriptional regulators to boost the anti-tubercular activity, and circumvent acquired-resistance

Green and Sustainable Medicinal Chemistry

Green and Sustainable Medicinal Chemistry
Methods, Tools and Strategies for the 21st Century Pharmaceutical Industry

by Louise Summerton,Helen F Sneddon,Leonie C Jones,James H Clark

  • Publisher : Royal Society of Chemistry
  • Release : 2016-03-08
  • Pages : 272
  • ISBN : 1782625941
  • Language : En, Es, Fr & De
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Pharmaceutical manufacturing was one of the first industries to recognize the importance of green chemistry, with pioneering work including green chemistry metrics and alternative solvents and reagents. Today, other topical factors also have to be taken into consideration, such as rapidly depleting resources, high energy costs and new legislation. This book addresses current challenges in modern green chemical technologies and sustainability thinking. It encompasses a broad range of topics covered by the CHEM21 project – Europe’s largest public-private partnership project which aims to develop a toolbox of sustainable technologies for green chemical intermediate manufacture. Divided into two sections, the book first gives an overview of the key green chemistry tools, guidance and considerations aimed at developing greener processes, before moving on to look at cutting-edge synthetic methodologies. Featuring innovative research, this book is an invaluable reference for chemists across academia and industry wanting to further their knowledge and understanding of this important topic.

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis
A Book

by Inamuddin,Abdullah M. Asiri

  • Publisher : Springer Nature
  • Release : 2020-07-02
  • Pages : 499
  • ISBN : 3030441768
  • Language : En, Es, Fr & De
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Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Chimie Pure Et Appliquée

Chimie Pure Et Appliquée
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Environmentally Sustainable Catalytic Asymmetric Oxidations

Environmentally Sustainable Catalytic Asymmetric Oxidations
A Book

by Konstantin Bryliakov

  • Publisher : CRC Press
  • Release : 2014-09-17
  • Pages : 162
  • ISBN : 1466588578
  • Language : En, Es, Fr & De
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Catalysis plays a vital role in chemical, petroleum, agriculture, polymer, electronics, pharmaceutical, and other industries. Over 90 percent of chemicals originate from catalytic processes. Toughening economic and environmental constraints have proven to be a challenge for meeting the demand of novel efficient and sustainable regio- and stereoselective catalyst systems. Environmentally Sustainable Catalytic Asymmetric Oxidations provides a comprehensive overview of existing ecologically friendly catalyst systems for various asymmetric oxidation processes. Topics include: A survey of existing transition metal-based catalyst systems for asymmetric epoxidations (AEs) with O2 and H2O2 Asymmetric sulfoxidations with H2O2 on chiral metal complexes An overview of various transition metal-catalyzed oxidative transformations with H2O2 or O2 used as the terminal oxidant Organocatalytic asymmetric oxidations Catalytic processes of stereospecific oxidations of C-H functional groups The role that oxoiron(V) intermediates play in chemo- and stereoselective oxidations catalyzed by non-heme iron complexes The book concludes with a discussion of the opportunities and problems associated with the industrial application of stereoselective processes of catalytic oxidation with H2O2 and O2. It also provides examples of processes with industrial potential. Some of the catalysts presented in this book may serve as promising alternatives for existing catalysts—progressively replacing them in manufacturing processes and ultimately making the chemical industry greener and cleaner.

Green and Sustainable Pharmacy

Green and Sustainable Pharmacy
A Book

by Klaus Kümmerer,Maximilian Hempel

  • Publisher : Springer Science & Business Media
  • Release : 2010-06-16
  • Pages : 313
  • ISBN : 3642051995
  • Language : En, Es, Fr & De
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Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Green Approaches To Asymmetric Catalytic Synthesis

Green Approaches To Asymmetric Catalytic Synthesis
A Book

by Angela Patti

  • Publisher : Springer Science & Business Media
  • Release : 2011-08-22
  • Pages : 140
  • ISBN : 9789400714540
  • Language : En, Es, Fr & De
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Nowadays, chirality is widely accepted as an important factor in molecular recognition processes and the biological activity of many pharmaceutical drugs and agrochemicals; this is confirmed by the continuous need for synthetic methods which lead to single or enriched enantiomers of such compounds. By presenting a review of the various and more recently developed approaches for both metal-transition and organocatalysis, this volume describes the development of “greener” asymmetric reactions which preserve stereoselectivity. The author summarizes the impressive amount of research that has been gathered within this field into three chapters focusing on: i)the search of alternative catalysts, ii) alternative solvents, and iii) alternative synthetic strategies and processes. For each topic, the fundamentals and some valuable applications are discussed.

Sustainable Synthesis of Pharmaceuticals

Sustainable Synthesis of Pharmaceuticals
Using Transition Metal Complexes as Catalysts

by Mariette M. Pereira,Mario J. F. Calvete

  • Publisher : Royal Society of Chemistry
  • Release : 2018-03-26
  • Pages : 286
  • ISBN : 1788010655
  • Language : En, Es, Fr & De
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There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

Sustainable Green Chemical Processes and their Allied Applications

Sustainable Green Chemical Processes and their Allied Applications
A Book

by Inamuddin,Abdullah Asiri

  • Publisher : Springer Nature
  • Release : 2020-05-30
  • Pages : 604
  • ISBN : 3030422844
  • Language : En, Es, Fr & De
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Urbanization, industrialization, and unethical agricultural practices have considerably negative effects on the environment, flora, fauna, and the health and safety of humanity. Over the last decade, green chemistry research has focused on discovering and utilizing safer, more environmentally friendly processes to synthesize products like organic compounds, inorganic compounds, medicines, proteins, enzymes, and food supplements. These green processes exist in other interdisciplinary fields of science and technology, like chemistry, physics, biology, and biotechnology, Still the majority of processes in these fields use and generate toxic raw materials, resulting in techniques and byproducts which damage the environment. Green chemistry principles, alternatively, consider preventing waste generation altogether, the atom economy, using less toxic raw materials and solvents, and opting for reducing environmentally damaging byproducts through energy efficiency. Green chemistry is, therefore, the most important field relating to the sustainable development of resources without harmfully impacting the environment. This book provides in-depth research on the use of green chemistry principles for a number of applications.

Indian Journal of Chemistry

Indian Journal of Chemistry
Organic including medicinal

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Operational Organic Chemistry

Operational Organic Chemistry
A Problem-solving Approach to the Laboratory Course

by John W. Lehman

  • Publisher : Prentice Hall
  • Release : 2009
  • Pages : 897
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Preface To the Instructor Acknowledgments Introduction Problem Solving in the Organic Chemistry Laboratory Scientific Methodology Organization of This Book A Guide to Success in the Organic Chemistry Lab Laboratory Safety Safety Standards Protecting Yourself Preventing Laboratory Accidents Reacting to Accidents: First Aid Reacting to Accidents: Fire Chemical Hazards Finding and Using Chemical Safety Information Chemistry and the Environment Disposal of Hazardous Wastes Green Chemistry Part I Mastering the Operations 1 The Effect of pH on a Food Preservative 2 Separating the Components of ldquo;Panacetinrdquo; 3 Identifying a Constituent of ldquo;Panacetinrdquo; 4 Synthesis of Salicylic Acid from Wintergreen Oil 5 Preparation of Synthetic Banana Oil 6 Separation of Petroleum Hydrocarbons 7 A Green Synthesis of Camphor 8 Identification of a Petroleum Hydrocarbon 9 Isolation and Isomerization of Lycopene from Tomato Paste 10 Isolation and Identification of the Major Constituent of Clove Oil 11 Identification of Unknown Ketones 12 The Optical Activity of -Pinene: A Chemical Mystery Part II Correlated Laboratory Experiments 13 Investigation of a Chemical Bond by Infrared Spectrometry 14 Properties of Common Functional Groups 15 Thin-Layer Chromatographic Analysis of Drug Components 16 Separation of an Alkane Clathrate 17 Isomers and Isomerization Reactions 18 Structures and Properties of Stereoisomers 19 Bridgehead Reactivity in an S N 1 Solvolysis Reaction 20 Reaction of Iodoethane with Sodium Saccharin, an Ambident Nucleophile 21 Dehydration of Methylcyclohexanols and the Evelyn Effect 22 Testing Markovnikovrsquo;s Rule 23 Stereochemistry of Bromine Addition totrans-Cinnamic Acid 24 A Green Synthesis of Adipic Acid 25 Preparation of Bromotriphenylmethane and the Trityl Free Radical 26 Chain-Growth Polymerization of Styrene and Methyl Methacrylate 27 Synthesis of Ethanol by Fermentation 28 Reaction of Butanols with Hydrobromic Acid 29 Borohydride Reduction of Vanillin to Vanillyl Alcohol 30 Synthesis of Triphenylmethanol and the TritylCarbocation 31 An Unexpected Reaction of 2,3-Dimethyl-2,3-butanediol 32 Identification.

Sustainable Industries Journal

Sustainable Industries Journal
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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CEPAL Review

CEPAL Review
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1996-08
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Directory of Graduate Research

Directory of Graduate Research
A Book

by American Chemical Society. Committee on Professional Training

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

Index of Conference Proceedings

Index of Conference Proceedings
Annual cumulation

by British Library. Document Supply Centre

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Green Oxidation in Organic Synthesis

Green Oxidation in Organic Synthesis
A Book

by Ning Jiao,Shannon S. Stahl

  • Publisher : John Wiley & Sons
  • Release : 2019-07-13
  • Pages : 536
  • ISBN : 1119304040
  • Language : En, Es, Fr & De
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A valuable introduction to green oxidation for organic chemists interested in discovering new strategies and new reactions for oxidative synthesis Green Oxidation in Organic Synthesis provides a comprehensive introduction and overview of chemical preparation by green oxidative processes, an entry point to the growing journal literature on green oxidation in organic synthesis. It discusses both experimental and theoretical approaches for the study of new catalysts and methods for catalytic oxidation and selective oxidation. The book highlights the discovery of new reactions and catalysts in recent years, discussing mechanistic insights into the green oxidative processes, as well as applications in organic synthesis with significant potential to have a major impact in academia and industry. Chapters are organized according to the functional groups generated in the reactions, presenting interesting achievements for functional group formation by green oxidative processes with O2, H2O2, photocatalytic oxidation, electrochemical oxidation, and enzymatic oxidation. The mechanisms of these novel transformations clearly illustrated. Green Oxidation in Organic Synthesis will serve as an excellent reference for organic chemists interested in discovering new strategies for oxidative synthesis which address the priorities of green and sustainable chemistry.

The Chemical Engineer

The Chemical Engineer
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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