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Handbook of Neuroemergency Clinical Trials

Handbook of Neuroemergency Clinical Trials
A Book

by Brett E. Skolnick,Wayne M. Alves

  • Publisher : Academic Press
  • Release : 2017-11-13
  • Pages : 400
  • ISBN : 0128041013
  • Language : En, Es, Fr & De
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Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

American Book Publishing Record

American Book Publishing Record
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Handbook of Neurosurgery, Neurology, and Spinal Medicine for Nurses and Advanced Practice Health Professionals

Handbook of Neurosurgery, Neurology, and Spinal Medicine for Nurses and Advanced Practice Health Professionals
A Book

by Michael Wang,Andrea Strayer,Odette Harris,Cathy Rosenberg,Praveen Mummaneni

  • Publisher : Routledge
  • Release : 2017-12-15
  • Pages : 558
  • ISBN : 1498719449
  • Language : En, Es, Fr & De
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This practical handbook allows nurses, advanced practice nurses, physician assistants, and allied health professionals practicing in the fields of neurosurgery, neurology, and spinal care to quickly review essentials while in the work environment. It emphasizes procedural steps and critical elements in patient management, including intensive care, the neurological examination, differential diagnoses, and pain management. Written by a multidisciplinary team of experts, the handbook is expected to become a well-worn companion and essential aid to the busy practitioner.

Neurosurgical Ethics in Practice: Value-based Medicine

Neurosurgical Ethics in Practice: Value-based Medicine
A Book

by Ahmed Ammar,Mark Bernstein

  • Publisher : Springer
  • Release : 2014-06-26
  • Pages : 286
  • ISBN : 3642549802
  • Language : En, Es, Fr & De
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Good neurosurgical practice is based not only on evidence, skills, and modern equipment, but also on good values. This book is the first to discuss specifically the ethical issues that arise during the daily practice of neurosurgery. It is divided into three parts addressing patients’ rights, ethical issues relating to the working environment, and wider societal aspects such as dealings of neurosurgeons with the legal system, the media, and companies. The authors are well-established neurosurgeons who present the ethical problems that they have encountered during their careers and explain what they have learned in confronting these problems. In all, more than 50 neurosurgical cases drawn from real life are reported and discussed from an ethical point of view. This book will be especially informative for young neurosurgeons and will provide all who work in this very special field with a road map on how to avoid violations of medical ethics in neurosurgical practice.

The British National Bibliography

The British National Bibliography
A Book

by Arthur James Wells

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Atlas of Common Pain Syndromes E-Book

Atlas of Common Pain Syndromes E-Book
A Book

by Steven D. Waldman

  • Publisher : Elsevier Health Sciences
  • Release : 2011-06-09
  • Pages : 408
  • ISBN : 1455733555
  • Language : En, Es, Fr & De
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Noted pain authority Dr. Steven Waldman returns with a new edition of Atlas of Common Pain Syndromes. Delivering complete, concise, step-by-step visual guidance, this innovative, popular atlas equips you to effectively diagnose and manage pain syndromes commonly encountered in any clinical practice. Clearly labeled, vivid illustrations depict the physical symptoms and anatomy of each pain site, and diagnostic images demonstrate key findings from MRI, CT, and conventional radiography. With an easy-to use, templated format, you’ll have Dr. Waldman’s preferred approaches right at your fingertips. Accurately diagnose and treat common pain syndromes by following a step-by-step approach that progresses from signs and symptoms through physical findings, laboratory and radiographic testing, treatment options, clinical pearls, and diagnostic codes. Practice with confidence by consulting with Steven D. Waldman, MD - author of numerous groundbreaking pain management references - as well as a team of leading international authorities. Quickly and easily find the information you need thanks to highly templated chapters that explore signs and symptoms, physical findings, laboratory and radiographic testing, treatment options, clinical pearls, and diagnostic codes for each pain syndrome. Ensure proper reimbursement with comprehensive coverage of insurance coding information. Avoid potential pitfalls in diagnosis and treatment by referring to "Side Effects and Complications" sections in each chapter. See, identify, and diagnose patients’ issues with help from clinically relevant illustrations that connect pain syndromes to clearly labeled anatomic illustrations. Effectively apply the latest techniques and approaches with 29 new chapters covering subarachnoid hemorrhage, adhesive capsulitis, iliopectineal bursitis, discitis, and more!

The Massachusetts General Hospital Handbook of Neurology

The Massachusetts General Hospital Handbook of Neurology
A Book

by Alice W. Flaherty,Natalia S. Rost

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2011-12-26
  • Pages : 240
  • ISBN : 1451178638
  • Language : En, Es, Fr & De
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Now in its revised, updated Second Edition, this pocket-sized handbook is a practical quick-reference guide to the diagnosis and management of neurologic diseases. It presents specific management recommendations in a succinct outline format and includes protocols, step-by-step tests and procedures, and treatment algorithms. This handbook is unique in its inclusion of material from related disciplines such as general medicine, cardiology, psychiatry, neurosurgery, neuroanatomy, and radiology. The authors offer guidance in using contemporary neuroimaging techniques in diagnosis.

Small Animal Neurological Emergencies

Small Animal Neurological Emergencies
A Book

by Simon Platt,Laurent Garosi

  • Publisher : CRC Press
  • Release : 2012-03-15
  • Pages : 672
  • ISBN : 1482261715
  • Language : En, Es, Fr & De
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This new book deals systematically with the assessment and treatment of small animal neurological patients in light of latest research findings and greatly improved imaging techniques. The authors first discuss step-wise neurological and systemic approaches to common emergency cases-examination, critical care and rapid assessment-based on presentin

Diseases of the Brain, Head and Neck, Spine 2020–2023

Diseases of the Brain, Head and Neck, Spine 2020–2023
Diagnostic Imaging

by Juerg Hodler,Rahel A. Kubik-Huch,Gustav K. von Schulthess

  • Publisher : Springer Nature
  • Release : 2020-02-14
  • Pages : 254
  • ISBN : 303038490X
  • Language : En, Es, Fr & De
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This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Emergency Neurology

Emergency Neurology
A Book

by Morris Levin

  • Publisher : Oxford University Press
  • Release : 2013-03-25
  • Pages : 200
  • ISBN : 0199991065
  • Language : En, Es, Fr & De
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What Do I Do Now? Emergency Neurology is designed as a resource for clinicians at all levels of training in all fields of medicine who treat patients with urgent and emergent neurological syndromes. It uses a novel approach focusing on the "clinical impasse" that so often occurs in complex cases, and emphasizes the creative intellectual process clinicians relish. Authored by Morris Levin, along with colleagues from the Dartmouth-Hitchcock Medical Center, this volume presents 32 common urgent/emergent cases divided in to four distinct sections: (1) Diagnostic Questions (ADULT), (2) Treatment Considerations (ADULT), (3) Ethical, Neuropsychiatric and Legal issues and 4) Pediatric issues. The chapters are short and to the point, bearing in mind the increasing work demands on physicians. Thus, the approach in this book, as in the "What Do I Do Now?" series in general, is highly practical, logical and fun.

Drugs in Neurology

Drugs in Neurology
A Book

by Sathiji Nageshwaran,David Ledingham,Heather C. Wilson,Anthony Dickenson

  • Publisher : Oxford University Press
  • Release : 2017-01-26
  • Pages : 656
  • ISBN : 0191641243
  • Language : En, Es, Fr & De
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Part of the Drugs in series, this book provides an easily accessible pocket-sized guide to the use of medications when treating patients with neurological ailments. Drugs in Neurology covers the breadth of medications used in modern neurology, including each drug's indications, contra-indications, side-effects and important interactions. The underlying pharmacology also feature (where known). Practical aspects related to prescribing and therapeutic drug monitoring are covered and based on the most up-to-date evidence-based guidance. Each drug monograph contains a small section drawing on the wisdom of the senior contributors of each chapter with regards to using the medication.

Neurological Emergencies in Clinical Practice

Neurological Emergencies in Clinical Practice
A Book

by Abdul Qayyum Rana,John Anthony Morren

  • Publisher : Springer Science & Business Media
  • Release : 2013-07-01
  • Pages : 203
  • ISBN : 1447151917
  • Language : En, Es, Fr & De
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Neurological Emergencies in Clinical Practice discusses neurological emergencies in a stepwise fashion including stabilizing the patient, identifying the cause, and treating the underlying cause. It is useful in several settings including the emergency room, hospital in-patient service as well as the intensive care unit. Neurological Emergencies in Clinical Practice has a wide appeal and relevance to disciplines including neurology, emergency medicine, critical care medicine, internal medicine and family medicine. Medical students and residents may use this convenient, pocket-sized book to prepare for and succeed in their training examinations and it is also useful for other house staff and practicing physicians.

Toxicology of Organophosphate and Carbamate Compounds

Toxicology of Organophosphate and Carbamate Compounds
A Book

by Ramesh C. Gupta

  • Publisher : Academic Press
  • Release : 2011-04-28
  • Pages : 768
  • ISBN : 9780080543109
  • Language : En, Es, Fr & De
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This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

Joyce in the Belly of the Big Truck; Workbook

Joyce in the Belly of the Big Truck; Workbook
A Book

by Joyce A. Cascio

  • Publisher : Unknown Publisher
  • Release : 2005-05
  • Pages : 329
  • ISBN : 9780976237310
  • Language : En, Es, Fr & De
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The Blade Itself

The Blade Itself
A Novel

by Marcus Sakey

  • Publisher : Macmillan
  • Release : 2010-04-01
  • Pages : 320
  • ISBN : 1429916915
  • Language : En, Es, Fr & De
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How far would you go to protect everything you love? On the South Side of Chicago, you're only as strong as your reputation. Danny Carter and his best friend, Evan, earned theirs knocking over pawnshops and liquor stores, living from score to score, never thinking of tomorrow. Then a job went desperately wrong, and in the roar of a gun blast, everything changed. Years later, Danny doesn't think about his past. He's built a new world for himself: a legitimate career, a long-term girlfriend, and a clean conscience. He's just like anyone else. Normal. Successful. Happy. Until he spots his old partner staring him down in a smoky barroom mirror. The prison-hardened Evan is barely recognizable. Having served his time without dropping Danny's name, his old friend believes he's owed major payback---and he's willing to do anything to get it. With all he loves on the line and nowhere to turn, Danny realizes his new life hinges on a terrible choice: How far will he go to protect his future from his past? A debut novel that's drawn comparison to Dennis Lehane, Laura Lippman, and Quentin Tarantino, The Blade Itself is the story of a good man held hostage by circumstance; a riveting exploration of class, identity, and the demons that shape us, where every effort to do the right thing leads to terrifying consequences and one inevitable conclusion: The more you have, the more you have to lose.

Neurologic Emergencies

Neurologic Emergencies
How to Do a Fast, Focused Evaluation of Any Neurologic Complaint

by Latha Ganti,Joshua N. Goldstein

  • Publisher : Springer
  • Release : 2018-01-04
  • Pages : 319
  • ISBN : 3319645234
  • Language : En, Es, Fr & De
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This book is an unparalleled resource on neurologic emergencies. Most books on neurologic emergencies focus on treatment of a disease after it is diagnosed (such as stroke, subarachnoid hemorrhage, or meningitis). There are but a few books that focus on how to evaluate the patient with a neurologic symptom, before the diagnosis is made. This is the area that frontline providers, including emergency physicians, family physicians, primary care physicians, hospitalists, urgent care physicians, and midlevel providers struggle with. This book is written by clinicians with a clear understanding of the needs of non-neurologists in the front lines of medicine. The editors are board-certified emergency physicians with fellowship training and expertise in neurologic emergencies. Neurologic Emergencies includes these point-of-care-friendly features: Extensive number of algorithms for distinct presenting symptoms Classic neuroimaging findings A concise bullet on what information needs to be conveyed to consultants Reference to relevant national guidelines where applicable Common chapter format to facilitate quick look-up

The Neurologic Examination

The Neurologic Examination
Scientific Basis for Clinical Diagnosis

by Hiroshi Shibasaki MD, PhD,Mark Hallett MD

  • Publisher : Oxford University Press
  • Release : 2016-06-15
  • Pages : 352
  • ISBN : 0190240989
  • Language : En, Es, Fr & De
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Whereas most book about the neurologic examination are disease and anatomy oriented, The Neurologic Examination: Scientific Basis for Clinical Diagnosis focuses on a pathophysiological approach to the nervous system. The authors emphasize that the scientific interpretation of symptoms obtained from carefully taking the patient's history and noting signs found during physical examination are essential in the diagnosis of neurologic diseases, even if laboratory testing, such as electrophysiology and neuroimaging, are more widely used. This book aims to provide a bridge from the basic sciences such as anatomy, physiology, pharmacology, and molecular biology to the neurologic symptoms. Neurologic examinations provide the foundation for diagnosis, and only after a thorough and expertly executed examination can one begin to incorporate laboratory testing and treatment. The Neurologic Examination: Scientific Basis for Clinical Diagnosis, based on the widely successful Japanese book Diagnosis of Neurological Diseases (Igakushoin, Japan, second edition 2013) by Dr. Shibasaki, hopes to revitalize the use of neurologic examinations before jumping into laboratory testing. Doing so can help cut down on time, patient and physician anxiety, and unnecessary testing expenses. This book is a must-read for all practicing neurologists, residents, and medical students. Key Features Include · The chapters are arranged in order of the actual steps in a neurologic examination; · Highly illustrated with figures and tables indicative of the neurologic signs and symptoms that may appear during the given step; and · 99 discussion boxes are inserted throughout to provide a more in-depth look at particular topics without interrupting the reading flow of the text.

Emergencies in Neuro-ophthalmology

Emergencies in Neuro-ophthalmology
A Case Based Approach

by Andrew G. Lee,Paul W. Brazis,Mansoor Mughal

  • Publisher : World Scientific
  • Release : 2010
  • Pages : 184
  • ISBN : 9814295019
  • Language : En, Es, Fr & De
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Covers life-threatening scenarios that a general ophthalmologist might encounter, and is designed to make the ophthalmologist make emergency triage decisions for initial evaluation and treatment of potentially vision- or life-threatening conditions.

Intracerebral Hemorrhage Therapeutics

Intracerebral Hemorrhage Therapeutics
Concepts and Customs

by Bruce Ovbiagele,Adnan I. Qureshi

  • Publisher : Springer
  • Release : 2018-08-29
  • Pages : 206
  • ISBN : 3319770632
  • Language : En, Es, Fr & De
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This book provides a framework for goal-targeted management of the adult patient with spontaneous non-traumatic intracerebral hemorrhage (ICH). Topics addressed in a comprehensive yet practical manner in the book include pre-hospital/emergency department care, early inpatient work-up, antithrombotic- and thrombolytic-related strokes, optimal blood pressure management, avoidance of medical complications, surgical interventions, outcome prognostication, recurrence prevention, rehabilitation/recovery, special situations, systems of care, and the design of clinical trials for patients with ICH. Procedures, processes, and helpful decision-making algorithms are presented with the aid of complementary illustrations that facilitate understanding of practical aspects and enable the reader to promptly retrieve relevant information. In addition, the most current evidence-based therapies for routine management of ICH patients and a glimpse of promising future treatment strategies are reviewed. Timely and consolidated, clinicians will find this to be an indispensable resource to navigating the ever-increasing pace of discovery that is transforming what we know about ICH and its treatment.

The Prevention and Treatment of Missing Data in Clinical Trials

The Prevention and Treatment of Missing Data in Clinical Trials
A Book

by National Research Council,Division of Behavioral and Social Sciences and Education,Committee on National Statistics,Panel on Handling Missing Data in Clinical Trials

  • Publisher : National Academies Press
  • Release : 2011-01-21
  • Pages : 162
  • ISBN : 0309158141
  • Language : En, Es, Fr & De
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Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.