Download Hands-on Approach for the Conduct of Nonclinical Studies Ebook PDF

Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research
A Book

by Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson

  • Publisher : John Wiley & Sons
  • Release : 2015-10-08
  • Pages : 320
  • ISBN : 1118468686
  • Language : En, Es, Fr & De
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Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

The Role of the Study Director in Nonclinical Studies

The Role of the Study Director in Nonclinical Studies
Pharmaceuticals, Chemicals, Medical Devices, and Pesticides

by William J. Brock,Barbara Mounho,Lijie Fu

  • Publisher : John Wiley & Sons
  • Release : 2014-05-02
  • Pages : 560
  • ISBN : 1118874080
  • Language : En, Es, Fr & De
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A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry

Handbook of Bioequivalence Testing

Handbook of Bioequivalence Testing
A Book

by Sarfaraz K. Niazi

  • Publisher : CRC Press
  • Release : 2014-10-29
  • Pages : 1007
  • ISBN : 1482226383
  • Language : En, Es, Fr & De
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As the generic pharmaceutical industry continues to grow and thrive, so does the need to conduct adequate, efficient bioequivalence studies. In recent years, there have been significant changes to the statistical models for evaluating bioequivalence. In addition, advances in the analytical technology used to detect drug and metabolite levels have m

Directory of Research Grants 2002

Directory of Research Grants 2002
A Book

by Grants Program,Oryx Publishing

  • Publisher : Greenwood
  • Release : 2002
  • Pages : 908
  • ISBN : 9781573564885
  • Language : En, Es, Fr & De
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More than 5,100 current programs from 1,880 sponsors, including U.S. and foreign foundations, corporations, government agencies, and other organizations.

The Hindu Index

The Hindu Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Scientist

New Scientist
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Current Index to Journals in Education

Current Index to Journals in Education
CIJE.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1996-10
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Veterinary and Human Toxicology

Veterinary and Human Toxicology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Handbook of Organizational Design: Adapting organizations to their environments

Handbook of Organizational Design: Adapting organizations to their environments
A Book

by Professor of Business Administration Paul C Nystrom,Paul C. Nystrom,William H. Starbuck

  • Publisher : Oxford ; New York : Oxford University Press
  • Release : 1981
  • Pages : 582
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The two volumes summarize and reinterpret research and suggest applications to the design of organizations. Volume I analyses the effects of environments on organizations, and discusses the adaptive capabilities of organizations such as planning, forecasting, and innovation.

Cancer Research

Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Psychology

Psychology
A Book

by Addison-Wesley Longman, Incorporated

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9780673998965
  • Language : En, Es, Fr & De
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Schizophrenia Bulletin

Schizophrenia Bulletin
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology
A Practical Approach, Third Edition

by Ronald D Hood

  • Publisher : CRC Press
  • Release : 2011-12-14
  • Pages : 856
  • ISBN : 9781841847771
  • Language : En, Es, Fr & De
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The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics. The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches. Developmental and Reproductive Toxicology, Third Edition: Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies. Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity. Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference. Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment. This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

Current Cancer Research on Cancer Patient Supportive Care and Pain Management

Current Cancer Research on Cancer Patient Supportive Care and Pain Management
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 39
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmacokinetics

Pharmacokinetics
Processes, Mathematics, and Applications

by Peter G. Welling

  • Publisher : Amer Chemical Society
  • Release : 1997
  • Pages : 393
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.

Medical Management and Computing

Medical Management and Computing
Proceedings of the Second Annual Conference

by American Association for Medical Systems and Informatics. Conference

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 209
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles and Practice of Hospital Medicine, 2nd Edition

Principles and Practice of Hospital Medicine, 2nd Edition
A Book

by Sylvia C. McKean,John J. Ross,Daniel D. Dressler,Danielle Scheurer

  • Publisher : McGraw Hill Professional
  • Release : 2016-10-22
  • Pages : 2352
  • ISBN : 0071843140
  • Language : En, Es, Fr & De
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The leading textbook of hospital medicine – completely updated to reflect today’s challenges Since its publication in 2012, Principles and Practice of Hospital Medicine, Second Edition has become the field’s premier resource. Comprehensive, authoritative, and practical, this landmark text provides a solid grounding in clinical, organizational, and administrative areas central to the practice of hospital medicine. The Second Edition has been completely updated to reflect the evolving practice responsibilities of hospitalists. Examples include value-based medicine, expanded surgical content, bedside clinical reasoning, and a new segment devoted to rehabilitation and skilled nursing care. This edition also features a more accessible and streamlined full-color design enriched by more than 600 illustrations. Each clinical chapter opens with boxed Key Clinical Questions that are addressed in the text and summarized in hundreds of tables. Case studies demonstrate how to apply this information specifically to the management of hospitalized patients. Representing the expertise of more than two hundred renowned contributors, Principles and Practice of Hospital Medicine, Second Edition is logically divided into six sections: • The Specialty of Hospital Medicine and Systems of Care • Medical Consultation • Rehabilitation and Skilled Nursing Care • The Approach to the Patient at the Bedside • Diagnostic Testing and Procedures • Clinical Conditions in the Inpatient Setting Principles and Practice of Hospital Medicine, Second Edition is essential reading for clinicians who strive to optimize inpatient care and sharpen their leadership skills.

Population Studies

Population Studies
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1948
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive toxicology

Comprehensive toxicology
A Book

by I. Glenn Sipes,Charlene A. McQueen,A. Jay Gandolfi

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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International Co-ordination of Drug Trials. Rheumatological Research, and the Fight Against Rheumatic Diseases in Switzerland

International Co-ordination of Drug Trials. Rheumatological Research, and the Fight Against Rheumatic Diseases in Switzerland
Papers and Discussions Held at the 30th Anniversary of the European League Against Rheumatism in Zürich, 28th - 30th April 1977

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 290
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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