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Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology
A Book

by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig

  • Publisher : Academic Press
  • Release : 2013-05-01
  • Pages : 3054
  • ISBN : 0124157653
  • Language : En, Es, Fr & De
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Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more. Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Handbook of Toxicologic Pathology

Handbook of Toxicologic Pathology
A Book

by Wanda M. Haschek,Colin G. Rousseaux

  • Publisher : Elsevier
  • Release : 2013-10-22
  • Pages : 1127
  • ISBN : 1483288617
  • Language : En, Es, Fr & De
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This is the first comprehensive reference work on toxicologic pathology, an emerging field that integrates the mechanisms of toxic injury with the resulting pathology. Chapters deal systematically with organ-specific toxic injury, describing the mechanisms of injury, morphological expression of the injury, and evaluation of the pathology. Additional chapters introduce the field to the uninitiated and address such topics as techniques used for morphological evaluation, risk assessment, and regulatory aspects. The Handbook of Toxicologic Pathology will quickly establish itself as the classic reference work in this field for years to come. Comprehensive, "user friendly" reference text on toxicologic pathology Large, easy-to-use 8 1/2" x 11", double-column format Systematic approach to each organ or system More than 500 illustrations and 90 tables complement the text Over 2,000 references for easy access to the primary literature Unique chapters written by leading authorities

Haschek and Rousseaux's Handbook of Toxicologic Pathology

Haschek and Rousseaux's Handbook of Toxicologic Pathology
Volume 1: Principles and Practice of Toxicologic Pathology

by Wanda M. Haschek,Colin G. Rousseaux,Matthew A. Wallig,Brad Bolon

  • Publisher : Academic Press
  • Release : 2021-09-01
  • Pages : 850
  • ISBN : 0128218290
  • Language : En, Es, Fr & De
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Haschek and Rousseaux's Handbook of Toxicologic Pathology: Volume 1: Principles and Practice of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. Volume 1 of the Fourth Edition covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Completely revised with a number of new chapters, Volume 1 of the Handbook of Toxicologic Pathology is an essential part of the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Fundamentals of Toxicologic Pathology

Fundamentals of Toxicologic Pathology
A Book

by Wanda M. Haschek,Brad Bolon,Colin G. Rousseaux,Matthew A. Wallig

  • Publisher : Academic Press
  • Release : 2017-10-25
  • Pages : 902
  • ISBN : 0128098422
  • Language : En, Es, Fr & De
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Fundamentals of Toxicologic Pathology, Third Edition, presents an essential overview of systems toxicologic pathology in a clear-and-concise manner. Toxicologic pathology integrates toxicology and its interdisciplinary components, including biochemistry, pharmacodynamics and risk assessment to pathology and its related disciplines, such as physiology, microbiology, immunology and molecular biology. This wholly revised and updated edition presents the newest information on the topic, and is an essential reference for advanced students, early career researchers, toxicologic pathologists, pharmaceutical scientists, medical pathologists and clinicians, and anyone involved with drug and device development. The book includes a new section describing the application of toxicologic pathology, such as diagnostic and forensic toxicologic pathology, environmental toxicologic pathology, experimental and industrial toxicologic pathology, and pathology issues in the design of toxicology studies. There are also new chapters on special senses (the eye and ear) and the biochemical and molecular basis of toxicity, among others. Presents revised and updated information for each chapter on systems Contains expanded sections on applied toxicologic pathology Includes the essential information necessary to understand toxicologic pathology in an accessible language

Indian Journal of Veterinary Pathology

Indian Journal of Veterinary Pathology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008-12
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings of the Society for Experimental Biology and Medicine

Proceedings of the Society for Experimental Biology and Medicine
A Book

by Society for Experimental Biology and Medicine (New York, N.Y.)

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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List of members in each volume.

International Classification of Rodent Tumours

International Classification of Rodent Tumours
A Book

by International Agency for Research on Cancer

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 46
  • ISBN : 9789283201236
  • Language : En, Es, Fr & De
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This series of fascicles comprising an international classification of rodent tumors provides information and guidelines especially adapted for international use in practical toxicologic pathology. This is expressed particularly in the concise easy-to-use format of the narrative in all sections. Included in this classification are tumors and relevant pre-neoplastic lesions of the rat for all organ systems. The third fascicle covers the urinary system and is divided into data-sheets which represent the essential information on a particular lesion. Each data-sheet is prepared in a standard layout, always starting on a new page with a header section. The descriptions of the diagnostic features comprise the main histopathological features of the specified lesion in a concise list. Most data-sheets include at least one typical micrograph, selected from among both spontaneous and induced lesions.

Reference Sources in Science, Engineering, Medicine, and Agriculture

Reference Sources in Science, Engineering, Medicine, and Agriculture
A Book

by Harold Robert Malinowsky

  • Publisher : Greenwood
  • Release : 1994
  • Pages : 355
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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"Thoughtfully compiled, current, and reasonably priced.... Recommended as a 'one-stop-shopping' source..". -- Library Journal "This work is an essential purchase for libraries with collections in the four designated areas". -- ARBA Both print and nonprint sci-tech information sources can be quickly located, and their uses evaluated, with this new resource -- the only sourcebook to cover all four major branches of science. More than 2,400 entries of complete bibliographic information are accompanied by a brief description of each work. Every source is indexed by author, subject, and title. Special chapters cover how technology is changing the way scientists communicate, and how to build a viable collection in specific disciplines.

Books in Print

Books in Print
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reviews in Biochemical Toxicology

Reviews in Biochemical Toxicology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The 71F Advantage

The 71F Advantage
Applying Army Research Psychology for Health and Performance Gains

by Paul T. Bartone,Ross Harvey Pastel,Mark A. Vaitkus

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 523
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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From the back cover: This book, which grew out of an Army research psychology conference, is the first of its kind, intended to provide a comprehensive overview of what Army research psychologists do. Chapters cover the diverse activity areas of 71Fs, from the neurophysiology of sleep, to traumatic brain injury, to leadership and organizational process, as well as several personal and historical accounts. Army research psychologists are making a difference. Through their research, 71Fs provide leaders with new insights and tools for increasing the health and performance of military personnel. This is the "71F Advantage."

Growth Factors and Tumor Promotion

Growth Factors and Tumor Promotion
Implications for Risk Assessment

by R. Michael McClain,Thomas J. Slaga,Robert Le Boeuf,Henry C. Pitot

  • Publisher : Wiley-Liss
  • Release : 1995-08-11
  • Pages : 470
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Progress in Clinical and Biological Research, Volume 391 Growth Factors and Tumor Promotion Implications for Risk Assessment R. Michael McClain, Thomas J. Slaga, Robert LeBoeuf, and Henry Pitot, Editors Understanding the biological, cellular, and molecular mechanisms of growth factors in carcinogenesis is essential to predicting tumor development both in research and clinical settings. An up-to-date and much needed overview of this field, Growth Factors and Tumor Promotion: Implications for Risk Assessment presents cutting-edge work from scientists involved in all areas of oncology and cancer biology. The book presents 32 chapters exploring a wide range of specialized topics in this field. Material in the text ranges from the biological changes caused by growth factors to quantifying cancer risk based on the biological data and the carcinogen bioassay. Extensive coverage is given to the complex mechanisms of growth factors in the process of tumor progression, in addition to numerous studies involving both animal models and analogous clinical cases. Growth Factors and Tumor Promotion addresses such specific topics as: a decision tree approach for carcinogenesis risk assessment hypomethlyation of DNA: a possible epigenetic mechanism involved in tumor promotion transforming growth factor-ßs in mammary tumorigenesis genetic factors controlling skin tumor promotion in mice benzoyl peroxide: review of experimental carcinogenesis and human safety data mechanistic considerations in risk assessment for epigenetic tumor-promoting carcinogens Growth Factors and Tumor Promotion: Implications for Risk Assessment features the contributions of laboratory investigators and clinical practitioners from leading medical and research institutions around the world. It is a current, authoritative work that will be of interest to cancer researchers, pathologists, toxicologists, pharmacologists, and molecular and cellular biologists—as well as scientists working with regulatory agencies that target environmental health hazards.

Neurological Research

Neurological Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Fluoroquinolone Antimicrobial Agent Enrofloxacin as a Therapeutic Entity for Finfish Aquaculture Studies of Efficacy and Safety

The Fluoroquinolone Antimicrobial Agent Enrofloxacin as a Therapeutic Entity for Finfish Aquaculture Studies of Efficacy and Safety
A Book

by Dana Alan Stoffregen

  • Publisher : Unknown Publisher
  • Release : 1996
  • Pages : 640
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bibliography of Reproduction

Bibliography of Reproduction
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Technical Report Series

Technical Report Series
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Encyclopedia of Human Biology

Encyclopedia of Human Biology
A Book

by Renato Dulbecco

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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General and Applied Toxicology

General and Applied Toxicology
A Book

by Bryan Ballantyne,Timothy C. Marrs,Tore L. M. Syversen

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 3755
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of the American Statistical Association

Journal of the American Statistical Association
A Book

by American Statistical Association

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles and Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals

Principles and Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals
A Book

by World Health Organization

  • Publisher : Environmental Health Criteria
  • Release : 1996
  • Pages : 390
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A comprehensive guide to general strategies and specific methods for testing the immunotoxicity of chemicals in animal models and humans. Addressed to those seeking a basic introduction to the field as well as specialist researchers the book takes its focus from growing concern in scientific and public communities about the capacity of environmental agents to disrupt normal immune functions and thus increase susceptibility to tumours and infectious diseases. Compounds known to adversely affect the immune system are numerous and include drugs pesticides solvents halogenated and aromatic hydrocarbons and metals. The book draws on considerable recent progress in understanding the immunological consequences of chemical insults as well as increasingly sophisticated methodologies for assessing such effects. Close to 1000 references are included in this authoritative guide. The book opens with a detailed basic introduction to immunotoxicology. An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Chapter two on the health impact of selected immunotoxic agents gives illustrative examples for some 30 chemicals that have been shown to exert immunotoxic effects in laboratory animals and for an additional seven groups of chemicals known to disturb immune functions in humans. For each brief discussions illustrate the chemical's distinct immunosuppressive properties and the mechanisms by which it exerts its toxic effects on the immune system. Chapter three provides detailed descriptions of a number of tests used in a tiered approach to the assessment of immunotoxicity. Against this background specific nonfunctional and functional tests for the assessment of immunotoxicology in experimental animals are presented and explained in full detail. Information on individual tests includes an explanation of why the test is important the types of data it can yield and exactly how it should be performed. Also included are sections offering advice on assessments in non-rodent species in vitro approaches and approaches using biomarkers in epidemiological studies and monitoring. The chapter concludes with a discussion of good laboratory practices for immunotoxicology studies and procedures for the validation of tests. Chapter five explains the much more complicated procedures needed to assess immunotoxicity in humans. An explanation of general questions to be considered when designing epidemiological studies is followed by presentation of three recommended testing schemes proposed by WHO and other agencies for preliminary evaluation of individuals exposed to immunotoxicants. Specific assays for assessing immune status are also described. The final chapter outlines a step-by-step process of risk assessment specific to the evaluation of potentially immunotoxic chemicals.