Download Heart Development and Regeneration Ebook PDF

Heart Development and Regeneration

Heart Development and Regeneration
A Book

by Nadia Rosenthal,Richard P. Harvey

  • Publisher : Academic Press
  • Release : 2010-05-28
  • Pages : 1136
  • ISBN : 0123813336
  • Language : En, Es, Fr & De
GET BOOK

The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. Authored by world experts in heart development and disease New research on epigenetic modifiers in cardiac development Comprehensive coverage of stem cells and prospects for cardiac regeneration Up-to-date research on transcriptional and proteomic circuits in cardiac disease Full-color, detailed illustrations

Heart Development and Regeneration

Heart Development and Regeneration
Herzentwicklung und Regeneration

by Felix B. Engel

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

RNA Regulons During Heart Development and Regeneration

RNA Regulons During Heart Development and Regeneration
A Book

by Wenjie Yao

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 176
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Heart Development

Heart Development
A Book

by Benoit G. Bruneau

  • Publisher : Academic Press
  • Release : 2012
  • Pages : 391
  • ISBN : 0123877865
  • Language : En, Es, Fr & De
GET BOOK

The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews. Cutting-edge science Authority of contributors Exciting field of research

Dioxin Inhibits Epicardium Development and Regeneration of the Zebrafish Heart

Dioxin Inhibits Epicardium Development and Regeneration of the Zebrafish Heart
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 182
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Zebrafish (Danio rerio) are an established vertebrate model for studying heart development, regeneration and cardiotoxicity. Zebrafish embryo-larvae exposed during the temporal window of epicardium development to the aryl hydrocarbon receptor (AHR) agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit severe heart malformation. Thus, we sought to determine if epicardium development was affected by TCDD exposure. TCDD exposure prevents development of the epicardial progenitors (proepicardium; PE) and subsequent formation of the epicardium. Exposure to TCDD later in development, after the epicardium has formed, does not produce acute cardiac toxicity. However, in adult zebrafish, TCDD exposure prior to ventricular resection prevents cardiac regeneration; the epicardially-derived white epithelium that envelops the blood clot fails to form and cardiomyocyte proliferation is markedly reduced. It is likely that TCDD-induced inhibition of epicardium development and cardiac regeneration occur via a common mechanism. Using the embryonic zebrafish, we have identified sox9b as a downstream AHR target gene in the heart. We find that while sox9b is expressed in the myocardium, it is not expressed in the affected epicardial cells or progenitors. TCDD exposed zebrafish embryos had significantly reduced levels of cardiac sox9b during epicardium development. Furthermore, we found manipulation of sox9b expression could phenocopy most of the effects of TCDD at the heart. Loss of sox9b prevented the formation of epicardial progenitors comprising the PE on the pericardial wall, and prevented the formation and migration of the epicardium around the heart. Zebrafish lacking sox9b showed pericardial edema, heart elongation, reduced blood circulation and lacked endocardial valve cushions and leaflets. Furthermore, sox9b mRNA injection prior to TCDD exposure rescued PE formation, but the epicardium failed to form. Myocardial contractility remained severely affected in sox9b mRNA injected TCDD-treated fish. This led us to investigate the role of myocardial contractility during epicardium formation. Lack of heart contractility resulted in a phenotype analogous to our sox9b rescue experiments; the PE formed but failed to migrate and form the epicardium. These experiments demonstrate myocardial contractility is required for PE cell migration and epicardium formation. Together, zebrafish epicardium development requires sox9b and normal cardiac contractility, which in our model, are severely affected by TCDD.

Biomaterials for Cardiac Regeneration

Biomaterials for Cardiac Regeneration
A Book

by Erik J. Suuronen,Marc Ruel

  • Publisher : Springer
  • Release : 2014-11-12
  • Pages : 323
  • ISBN : 3319109723
  • Language : En, Es, Fr & De
GET BOOK

This book offers readers a comprehensive biomaterials-based approach to achieving clinically successful, functionally integrated vasculogenesis and myogenesis in the heart. Coverage is multidisciplinary, including the role of extracellular matrices in cardiac development, whole-heart tissue engineering, imaging the mechanisms and effects of biomaterial-based cardiac regeneration, and autologous bioengineered heart valves. Bringing current knowledge together into a single volume, this book provides a compendium to students and new researchers in the field and constitutes a platform to allow for future developments and collaborative approaches in biomaterials-based regenerative medicine, even beyond cardiac applications.

Cardiac Regeneration using Stem Cells

Cardiac Regeneration using Stem Cells
A Book

by Keiichi Fukuda,Shinsuke Yuasa

  • Publisher : CRC Press
  • Release : 2013-04-10
  • Pages : 342
  • ISBN : 1466578394
  • Language : En, Es, Fr & De
GET BOOK

To achieve cardiac regeneration using pluripotent stem (iPS) cells, researchers must understand iPS cell generation methods, cardiomyocyte differentiation protocols, cardiomyocyte characterization methods, and tissue engineering. This book presents the current status and future possibilities in cardiac regeneration using iPS cells. Written by top researchers who present new data in these fields, this book reviews cardiac cell therapy for ischemic heart disease and explores in vitro generation of efficacious platelets from iPS cells. It also discusses modeling arrhythmogenic heart disease with patient-specific induced pluripotent stem cells.

Bioengineering Approach to Study the Role of Cell Migration During Zebrafish Heart Regneration

Bioengineering Approach to Study the Role of Cell Migration During Zebrafish Heart Regneration
A Book

by Işil Tekeli

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 122
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Zebrafish heart regeneration remains one of the most interesting phenomena of the 21st century. Considering the extremely high rate of deaths due to cardiovascular diseases in the developed countries, 1 out of every 3 people, understanding natural cardiac regeneration would address a worldwide challenge. Even though many aspects of zebrafish heart regeneration have been elucidated, there are still many open questions to be answered. Among these, the work presented here focuses on understanding cell migration mechanisms of cardiomyocytes and epicardial cells during heart regeneration. The first approach involves the development of a cardiomyocyte-specific, photoinducible Cre/lox genetic labeling system and its use in lineage tracing of embryonic cardiomyocytes during heart development and regeneration. By using this method we showed that cardiomyocytes labeled in embryonic hearts survive and contribute to all myocardial layers of the adult zebrafish heart. Moreover, lineage tracing during regeneration showed that only cardiomyocytes immediately adjacent to the injury site contribute to the regeneration, and cardiomyocyte fate is extensively predetermined, with cells from each myocardial layer giving rise to cells that retain their layer identity in the regenerated myocardium. Then, we showed that by coupling this labeling system to three-photon microscopy activation, we can perform prospective labeling, and increase the spatial resolution of our labeling system. Three-photon illumination has been used for in vivo imaging of deep structures, but whether it can be used for photo-activation had never been tested. Here we showed, theoretically and experimentally for the first time, that three-photon illumination is suitable for activating molecules in deep tissues and improving our system in terms of spatial resolution and prospective labeling. The final approach consisted on developing an ex vivo experimental set up in order to investigate physical characteristics of epicardial cell migration during zebrafish heart regeneration. This method allowed us to measure physical features that are essential for cell migration such as migration velocity and traction forces of the epicardial explants obtained from zebrafish hearts. All the approaches developed in this thesis offer new bioengineering tools to study zebrafish heart regeneration, and reveal new insights on this process. Moreover, these techniques present wide applicability to perform lineage tracing of other cell types during zebrafish heart regeneration or in other biological processes.

Cardiac Regeneration and Tumor Growth - what Do They Have in Common?

Cardiac Regeneration and Tumor Growth - what Do They Have in Common?
A Book

by Severin Dicks,Lonny Jürgensen,Florian Leuschner,David Hassel,Andrieux Geoffroy,Melanie Börries

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Abstract: Acute myocardial infarction is a leading cause of death. Unlike most adult mammals, zebrafish have the capability to almost fully regenerate their hearts after injury. In contrast, ischemic damage in adult human and mouse hearts usually results in scar tissue. mRNA-Sequencing (Seq) and miRNA-Seq analyses of heart regeneration in zebrafish over time showed that the process can be divided into three phases: the first phase represents dedifferentiation and proliferation of cells, the second phase is characterized by migration, and in the third phase cell signals indicate heart development and differentiation. The first two phases seem to share major similarities with tumor development and growth. To gain more insight into these similarities between cardiac regeneration and tumor development and growth, we used patient matched tumor normal ("healthy") RNA-Seq data for several tumor entities from The Cancer Genome Atlas (TCGA). Subsequently, RNA data were processed using the same pipeline for both the zebrafish samples and tumor datasets. Functional analysis showed that multiple Gene Ontology terms (GO terms) are involved in both early stage cardiac regeneration and tumor development/growth across multiple tumor entities. These GO terms are mostly associated with cell cycle processes. Further analysis showed that orthologous genes are the same key players that regulated these changes in both diseases. We also observed that GO terms associated with heart development in the third late phase of cardiac regeneration are downregulated in the tumor entities. Taken together, our analysis illustrates similarities between cardiac remodeling and tumor progression

Genomic Landscapes of Cardiac Arrhythmia and Heart Regeneration

Genomic Landscapes of Cardiac Arrhythmia and Heart Regeneration
A Book

by Min Zhang

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Use of high-throughput sequencing technology has revolutionized our ability to study heart development and regeneration. However, extracting crucial information from large-scale datasets is challenging. Here we demonstrated using bioinformatics analysis to identify genetic features causing human cardiac arrhythmias, as well as key components of heart regeneration. Pitx2 is the homeobox gene located in proximity to the human 4q25 familial atrial fibrillation locus. Previous work focused on Pitx2 developmental functions that predispose to atrial fibrillation. It is unknown whether Pitx2 has distinct postnatal functions. Furthermore, it is unclear whether the 4q25 locus directly controls the expression of Pitx2 via physical interaction that forms three-dimensional chromatin structure. Inactivating Pitx2 in the postnatal atrium, unstressed adult Pitx2 homozygous mutant mice display sinus node dysfunction, an atrial fibrillation risk factor in human patients. An integrated genomics approach revealed Pitx2 target genes encoding cell junction proteins, ion channels, and critical transcriptional regulators. Importantly, many Pitx2 target genes have been implicated in human atrial fibrillation by genome wide association studies. Moreover, chromatin conformation capture sequencing (4C-Seq) demonstrated a direct interaction of Pitx2 promoters and atrial-fibrillation-associated region. The mammalian heart regenerates poorly, and damage commonly leads to heart failure. Hippo signaling is kinase cascade that regulates organ size during development and prevents adult mammalian cardiomyocyte regeneration by inhibiting the transcription factor Yap. To identify Yap target genes that are activated during cardiomyocyte renewal and regeneration, we performed Yap chromatin immunoprecipitation sequencing (ChIP-Seq) and mRNA expression profiling in Hippo-deficient mouse hearts. We found that Yap directly regulated genes encoding cell cycle progression proteins, as well genes encoding proteins that promote F-actin polymerization and link the actin cytoskeleton to the extracellular matrix. Border-zone cardiomyocytes of injured Hippo-deficient mouse hearts showed cellular protrusions, indicating cytoskeletal remodeling. Our findings, revealing an independent postnatal role of Pitx2 in arrhythmias, unveil direct Pitx2 target genes that include channel and calcium handling genes as well as genes that stabilize the intercalated disc in postnatal atrium. In the context of mammalian cardiomyocyte regeneration, in addition to activating cell cycle genes, Yap regulated genes enhance cytoskeletal remodeling and the cellular response to local mechanical microenvironment. The electronic version of this dissertation is accessible from http://hdl.handle.net/1969.1/155482

Cardiovascular Regenerative Medicine

Cardiovascular Regenerative Medicine
Tissue Engineering and Clinical Applications

by Vahid Serpooshan,Sean M. Wu

  • Publisher : Springer
  • Release : 2019-06-29
  • Pages : 233
  • ISBN : 3030200477
  • Language : En, Es, Fr & De
GET BOOK

This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Heart Development

Heart Development
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2012-05-10
  • Pages : 408
  • ISBN : 0123877903
  • Language : En, Es, Fr & De
GET BOOK

The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews. Cutting-edge science Authority of contributors Exciting field of research

Sagor för barn till de ungas nöje och bildning. Med 8 kolorerade kopparstick. Stockholm. På Ludvig Öbergs förlag. (Stockholm, Elméns och Granbergs tryckeri, 1828.).

Sagor för barn till de ungas nöje och bildning. Med 8 kolorerade kopparstick. Stockholm. På Ludvig Öbergs förlag. (Stockholm, Elméns och Granbergs tryckeri, 1828.).
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1828
  • Pages : 126
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

En Route to Cardiac Regeneration

En Route to Cardiac Regeneration
Generation of Cardiovascular Progenitor Cells from Stem Cells

by Chetan Chinmaya Shatapathy,King's College London. Guy's, King's and St. Thomas's School of Biomedical & Health Sciences. Wolfson Centre for Age-Related Diseases

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 666
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Cardiovascular disease is the leading cause of mortality in the western world. Stem cells have potential for therapeutic application and are a valuable research tool to study cardiac development. Conventional differentiation strategies to generate cardiomyocytes from murine and human embryonic stem (ES) cells, employing growth factors, co-culture with specific cell lines, and defined chemicals, have suboptimal efficiency and result in generation of heterogeneous cell populations. Compared to cardiomyocytes, cardiovascular progenitor cells (CPCs) offer the advantage of being lineage committed, capable of proliferation, and the potential to differentiate into desired cardiac, vascular or smooth cells in response to micro-environmental cues following transplantation. The aim of this study was to isolate or generate CPCs from foetal heart of rodents or from ES cells, and also to determine whether CPCs could be generated from ES cells by over-expression of developmentally critical cardiac transcription factors. -- Examination of cells isolated from foetal Fischer 344 rat heart revealed a rapidly proliferative and expandable population of cells that include Isll, GATA4, and nestin-expressing cells, suggesting the presence of a putative multipotent cardiovascular progenitor cell population. However, at extended passage differentiated cardiomyocytes were rarely observed, and hence ES cells were thereafter studied as a model to generate CPCs. GATA4, Nkx2.5, and Isll genes, expressed during the early stages of cardiac development, were sub-cloned into a plasmid vector with an enhanced green fluorescent protein (EGFP) marker under the transcriptional control of a CAG promoter and an IRES subunit, and also into a lentiviral vector.

Vasculogenesis and Angiogenesis

Vasculogenesis and Angiogenesis
from Embryonic Development to Regenerative Medicine

by Dan Simionescu,Agneta Simionescu

  • Publisher : BoD – Books on Demand
  • Release : 2011-11-07
  • Pages : 240
  • ISBN : 9533078820
  • Language : En, Es, Fr & De
GET BOOK

Vasculogenesis is the process of new blood vessel formation during embryonic development of the cardiovascular system. This is followed by formation of a vascular tree and finally the cardiovascular system with the myriad of blood vessels that nourish all tissues and organs. Angiogenesis, on the other hand is the process by which new blood vessels take shape from existing blood vessels by "sprouting" of endothelial cells thus expanding the vascular tree. Both scenarios are based on activation, migration, proliferation and maturation of unique precursor cells. The study of blood vessel formation is an essential component of embryonic development, congenital malformations, degenerative diseases, inflammation and cancer and thus has widespread appeal to the biomedical field. Moreover, scientists are now harnessing this information for the purpose of building living blood vessel substitutes for replacement of diseased arteries and veins. This book highlights novel advances in the field of vasculogenesis and angiogenesis, including embryogenesis and development, regulation of progenitor cells, cancer and blood vessel regeneration. We consider this book a good initial source of information for graduate students, medical students and scientists interested in the intricacies of blood vessel formation, maturation, disease and replacement.

Etiology and Morphogenesis of Congenital Heart Disease

Etiology and Morphogenesis of Congenital Heart Disease
From Gene Function and Cellular Interaction to Morphology

by Toshio Nakanishi,Roger R. Markwald,H.Scott Baldwin,Bradley B. Keller,Deepak Srivastava,Hiroyuki Yamagishi

  • Publisher : Springer
  • Release : 2016-06-24
  • Pages : 383
  • ISBN : 4431546286
  • Language : En, Es, Fr & De
GET BOOK

This volume focuses on the etiology and morphogenesis of congenital heart diseases. It reviews in detail the early development and differentiation of the heart, and later morphologic events of the cardiovascular system, covering a wide range of topics such as gene functions, growth factors, transcription factors and cellular interactions that are implicated in cardiac morphogenesis and congenital heart disease. This book also presents recent advances in stem cell and cell sheet tissue engineering technologies which have the potential to provide novel in vitro disease models and to generate regenerative paradigms for cardiac repair and regeneration. This is the ideal resource for physician scientists and investigators looking for updates on recent investigations on the origins of congenital heart disease and potential future therapies.

Cardiac Growth and Regeneration

Cardiac Growth and Regeneration
A Book

by William C. Claycomb,Paolo Di Nardo

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 525
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Mammalian cardiac muscle, unlike that in amphibians, reptiles and the mammalian atrium, cannot regenerate after injury, and the mechanism for the irreversible blockage of mitosis in these monocytes during early development is still not understood. This book attempts to study the mechanisms that control the cardiac muscle cell cycle so that treatments to initiate repair of the myocardium can be designed. An ideal model would allow study of cardiac muscle cells in the intact heart in the biochemical state they were in during foetal growth, when they were actively dividing. This volume gathers the most current information dealing with the regenerative potential of cardiac muscle in the vertebrate heart.

Stem Cells & Regenerative Medicine

Stem Cells & Regenerative Medicine
From Molecular Embryology to Tissue Engineering

by Krishnarao Appasani,Raghu K. Appasani

  • Publisher : Springer Science & Business Media
  • Release : 2010-11-01
  • Pages : 629
  • ISBN : 1607618605
  • Language : En, Es, Fr & De
GET BOOK

Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
A Book

by Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem

  • Publisher : Academic Press
  • Release : 2018-08-09
  • Pages : 1454
  • ISBN : 0128098937
  • Language : En, Es, Fr & De
GET BOOK

Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

The SAGE Encyclopedia of Stem Cell Research

The SAGE Encyclopedia of Stem Cell Research
A Book

by Eric E. Bouhassira

  • Publisher : SAGE Publications
  • Release : 2015-06-15
  • Pages : 1552
  • ISBN : 1483347672
  • Language : En, Es, Fr & De
GET BOOK

The SAGE Encyclopedia of Stem Cell Research, Second Edition is filled with new procedures and exciting medical breakthroughs, including executive orders from the Obama administration reversing barriers to research imposed under the Bush administration, court rulings impacting NIH funding of research based on human embryonic stem cells, edicts by the Papacy and other religious leaders, and the first success in cloning human stem cells. Stem cell biology is clearly fueling excitement and potential in traditional areas of developmental biology and in the field of regenerative medicine, where they are believed to hold much promise in addressing any number of intractable medical conditions. This updated second edition encyclopedia will expand on information that was given in the first edition and present more than 270 new and updated articles that explore major topics in ways accessible to nonscientists, thus bringing readers up-to-date with where stem cell biology stands today, including new and evolving ethical, religious, legal, social, and political perspectives. This second edition reference work will serve as a universal resource for all public and academic libraries. It is an excellent foundation for anyone who is interested in the subject area of stem cell biology. Key Features: Reader’s Guide, Further Readings, Cross References, Chronology, Resource Guide, Index A Glossary will elucidate stem cell terminology for the nonscientist Statistics and selected reprints of major journal articles that pertain to milestones achieved in stem cell research Documents from Congressional Hearings on stem cells and cloning Reports to the President’s Council on Bioethics, and more