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Hematopoietic Cell Transplantation for Malignant Conditions

Hematopoietic Cell Transplantation for Malignant Conditions
A Book

by Qaiser Bashir,Mehdi Hamadani

  • Publisher : Elsevier Health Sciences
  • Release : 2019-02-14
  • Pages : 438
  • ISBN : 0323568033
  • Language : En, Es, Fr & De
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Get a quick, expert overview of hematologic and non-hematologic malignancies for which hematopoietic cell transplantation is a treatment option. Drs. Qaiser Bashir and Mehdi Hamadani provide easy-to-find information on basic science of hematopoietic cell transplantation, pharmacology, workflows and procedures, possible complications and side effects, in addition to the role of HCT in conjunction with clinical cellular therapy. Discusses high-dose chemotherapeutic regimens and radiation therapy, patient and donor selection and workup, as well as other key aspects of hematopoietic cell transplantation. Includes practical information on complications, infectious disease, and special populations such as patients with HIV infection. Consolidates today’s available information in this fast-changing area into one convenient resource.

Hematopoietic Stem Cell Transplantation in Clinical Practice

Hematopoietic Stem Cell Transplantation in Clinical Practice
A Book

by Jennifer G. Treleaven,A. John Barrett

  • Publisher : Elsevier Health Sciences
  • Release : 2008-09-02
  • Pages : 568
  • ISBN : 0702033537
  • Language : En, Es, Fr & De
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A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
In Clinical Practice

by Jennifer Treleaven,Austin John Barrett

  • Publisher : Churchill Livingstone
  • Release : 2009
  • Pages : 555
  • ISBN : 9780443101472
  • Language : En, Es, Fr & De
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A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team. An up to date guide to best practice in the use of stem cell transplantation, covering current status in the treatment of malignant and non-malignant conditions, practical aspects and problems such as infection and graft versus host disease. Has a practical, accessible approach with free use of algorithms, list tables. Aimed at the whole transplant team - this is an interdisciplinary field. International contributor team with editors in the UK and USA. Illustrated in colour throughout.

Allogeneic Immunotherapy for Malignant Diseases

Allogeneic Immunotherapy for Malignant Diseases
A Book

by John Barrett,Yin-Zhen Jiang

  • Publisher : CRC Press
  • Release : 2000-01-27
  • Pages : 408
  • ISBN : 0824746767
  • Language : En, Es, Fr & De
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This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

Allogeneic Immunotherapy for Malignant Diseases

Allogeneic Immunotherapy for Malignant Diseases
A Book

by John Barrett,Yin-Zhen Jiang

  • Publisher : CRC Press
  • Release : 2000-01-27
  • Pages : 408
  • ISBN : 9781135548261
  • Language : En, Es, Fr & De
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This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

Nijkamp and Parnham's Principles of Immunopharmacology

Nijkamp and Parnham's Principles of Immunopharmacology
A Book

by Michael J. Parnham,Frans P. Nijkamp,Adriano G. Rossi

  • Publisher : Springer Nature
  • Release : 2019-12-10
  • Pages : 888
  • ISBN : 3030108112
  • Language : En, Es, Fr & De
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Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
A Book

by Michael R. Bishop

  • Publisher : Springer Science & Business Media
  • Release : 2009-09-25
  • Pages : 589
  • ISBN : 9780387785806
  • Language : En, Es, Fr & De
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The dogmas of the quiet past are inadequate to the stormy present. The occasion is piled high with difficulty, and we must rise with the occasion. As our case is new, so we must think anew and act anew. Abraham Lincoln, 1862 When I came across this quote, it made me recall my first participation at an international meeting on bone marrow transplantation, at a time when this was the only term that was used to describe the field. During a particular session there was a presentation on the use of peripheral blood as the sole source of stem cells for transplantation, and a member of the audience rose to state that it was medically unethical to consider such treatment, as it certainly could not contain stem cells. Now nearly twenty years later, peripheral blood is the predominant source of stem cells used for hematopoietic stem cell transplantation. In the same period of time there have been several other dogmatic opinions, which permeate all of medicine, that have come and gone in the field of hematopoietic stem cell transplantation, and will continue to do so with advancements from basic and clinical research. It is within this context that the format of this book was devised. Traditionally reviews on specific topics related to hematopoietic stem cell transplantation reflect the views of a single author or a research group.

Hematopoietic Stem Cells

Hematopoietic Stem Cells
New Research

by Wesley G. Montgomery,Heather I. Burton

  • Publisher : Nova Science Pub Incorporated
  • Release : 2012-01-01
  • Pages : 176
  • ISBN : 9781622574681
  • Language : En, Es, Fr & De
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Hematopoietic Stem Cell Transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. In autologous HSCT, the stem cells are collected from the patient then infused back after high dose chemotherapy. On the other hand, in allogeneic HSCT, the stem cells are donated from another individual (who may be related or unrelated and unmatched or matched). In this book, the authors present new research in the study of hematopoietic stem cells including pulmonary complications following HSCT; psychological health and adjustment of families of children who undergo HSCT; the immunogenetics of unrelated HSCT for thalassemia; HSCT for inflammatory bowel diseases; and extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in the murine spleen.

Advances in Allogeneic Hematopoietic Stem Cell Transplantation

Advances in Allogeneic Hematopoietic Stem Cell Transplantation
A Book

by Richard K. Burt,Mary M. Brush

  • Publisher : Springer
  • Release : 2012-11-28
  • Pages : 414
  • ISBN : 1461549876
  • Language : En, Es, Fr & De
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The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation
A Book

by Hillard M. Lazarus,Mary J. Laughlin

  • Publisher : Springer Science & Business Media
  • Release : 2010-03-02
  • Pages : 881
  • ISBN : 1597454788
  • Language : En, Es, Fr & De
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Since the original publication of Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Allogeneic hematopoietic stem cell transplantation (HSC) has undergone several fast-paced changes. In this second edition, the editors have focused on topics relevant to evolving knowledge in the field in order to better guide clinicians in decision-making and management of their patients, as well as help lead laboratory investigators in new directions emanating from clinical observations. Some of the most respected clinicians and scientists in this discipline have responded to the recent advances in the field by providing state-of-the-art discussions addressing these topics in the second edition. The text covers the scope of human genomic variation, the methods of HLA typing and interpretation of high-resolution HLA results. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Second Edition offers concise advice on today's best clinical practice and will be of significant benefit to all clinicians and researchers in allogeneic HSC transplantation.

Hematopoietic Stem Cells

Hematopoietic Stem Cells
New Research

by Wesley G. Montgomery,Heather I. Burton

  • Publisher : Nova Science Publishers
  • Release : 2014-05-14
  • Pages : 186
  • ISBN : 9781622575060
  • Language : En, Es, Fr & De
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Hematopoietic Stem Cell Transplantation (HSCT) is an established treatment for a variety of malignant and nonmalignant conditions. In autologous HSCT, the stem cells are collected from the patient then infused back after high dose chemotherapy. On the other hand, in allogeneic HSCT, the stem cells are donated from another individual (who may be related or unrelated and unmatched or matched). In this book, the authors present new research in the study of hematopoietic stem cells including pulmonary complications following HSCT; psychological health and adjustment of families of children who undergo HSCT; the immunogenetics of unrelated HSCT for thalassemia; HSCT for inflammatory bowel diseases; and extramedullary hematopoiesis leading to the production of a novel antigen-presenting cell type in the murine spleen.

Handbook of Pediatric Hematology and Oncology

Handbook of Pediatric Hematology and Oncology
Children's Hospital and Research Center Oakland

by Caroline A. Hastings,Joseph C. Torkildson,Anurag K. Agrawal

  • Publisher : John Wiley & Sons
  • Release : 2012-04-30
  • Pages : 378
  • ISBN : 0470670886
  • Language : En, Es, Fr & De
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"This new edition of Handbook of Pediatric Hematology and Oncology: Children's Hospital & Research Center Oakland features practical guidance on how to handle common inpatient and outpatient challenges seen in pediatric hematology and oncology. Designed as a rapid reference to the latest diagnostic and therapeutic protocols, the text is short and didactic and supplemented with practical algorithms and case studies throughout. Completely revised and updated, there are brand-new chapters on subjects including bone marrow transplantation, pain management and palliative care. Comprehensive, yet concise, the handbook presents essential guidelines on the diagnosis and management of the most common pediatric blood disorders and malignancies, in addition to chemotherapeutic drug information and transfusion protocols. Designed for medical students, residents, and fellows, this user-friendly portable reference is also the perfect companion on the ward for pediatric hematology and oncology nurses."--Publisher's website.

Antibodies—Advances in Research and Application: 2013 Edition

Antibodies—Advances in Research and Application: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-06-21
  • Pages : 529
  • ISBN : 1481672819
  • Language : En, Es, Fr & De
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Antibodies—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Monoclonal Antibodies. The editors have built Antibodies—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monoclonal Antibodies in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Antibodies—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hematopoietic Stem Cell Transplantation

Hematopoietic Stem Cell Transplantation
A Book

by Robert J. Soiffer

  • Publisher : Springer Science & Business Media
  • Release : 2008-11-14
  • Pages : 736
  • ISBN : 9781597454384
  • Language : En, Es, Fr & De
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Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

The Washington Manual Hematology and Oncology Subspecialty Consult

The Washington Manual Hematology and Oncology Subspecialty Consult
A Book

by Giancarlo Pillot,Marcia Chantler

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2004
  • Pages : 279
  • ISBN : 9780781743754
  • Language : En, Es, Fr & De
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This handbook is a practical guide to the diagnosis and treatment of hematologic disorders and adult malignancies. Coverage includes both symptom-oriented and disease-oriented management strategies and both acute and chronic problems. The authors discuss the major clinical manifestations and usual management options for each disease entity. Each chapter ends with a list of "key points to remember" and includes current references.

Practical Obstetric Hematology

Practical Obstetric Hematology
A Book

by Peter Clark,Ian Greer

  • Publisher : CRC Press
  • Release : 2005-11-24
  • Pages : 194
  • ISBN : 9781842142622
  • Language : En, Es, Fr & De
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With notable expansion in the clinical interaction between hematologists and obstetricians over the last decade, understanding and managing the clinical manifestations of hemato-obstetric science has become increasingly important. A new reference work in this growing field, this text is a key tool in the diagnosis and treatment of these conditions, providing the reader with a user-friendly, authoritative source of information, which incorporates best practice within internationally accepted guidelines. Clearly presented and easy to use, each chapter includes: * pathophysiology * presentation * differential diagnosis * diagnostic tests and difficulties * maternal, fetal, and potential management complications * implications for screening and future management * tables summarizing the key points in diagnosis and management. A practical, reader-friendly book, this text will be an important resource for clinical staff involved in the management of pregnancy - from trainees in obstetrics, hematology and vascular medicine, to general practitioners involved in day-to-day maternity care, as well as midwifery staff and specialists in hematology, obstetrics and vascular medicine.

Essentials of Pediatric Anesthesiology

Essentials of Pediatric Anesthesiology
A Book

by Alan David Kaye,Charles James Fox,James H. Diaz

  • Publisher : Cambridge University Press
  • Release : 2014-10-16
  • Pages : 434
  • ISBN : 1107698685
  • Language : En, Es, Fr & De
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Provides a clinically relevant and easy-to-read review of all key topics, written and edited by leading pediatric anesthesiology physicians.

Allogeneic Stem Cell Transplantation

Allogeneic Stem Cell Transplantation
A Book

by Mary J. Laughlin,Hillard M. Lazarus

  • Publisher : Springer Science & Business Media
  • Release : 2002-11-08
  • Pages : 454
  • ISBN : 159259333X
  • Language : En, Es, Fr & De
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Internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-versus-host disease They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of nonmyeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation.

Sickle Cell Disease and Hematopoietic Stem Cell Transplantation

Sickle Cell Disease and Hematopoietic Stem Cell Transplantation
A Book

by Emily Riehm Meier,Allistair Abraham,Ross M. Fasano

  • Publisher : Springer
  • Release : 2017-09-19
  • Pages : 334
  • ISBN : 3319623281
  • Language : En, Es, Fr & De
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This book provides a comprehensive, state-of-the art review of hematopoietic stem cell transplantation (HSCT) for sickle cell disease (SCD). The book reviews new data about risk prediction for severe SCD, outlines the unique challenges of HSCT for patients with SCD, profiles the supportive care guidelines for patients who are undergoing HSCT, highlights our current understanding of the best transfusion support for SCD patients prior to, during and after HSCT, and provides new perspectives about the ethics of HSCT for pediatric patients with SCD. Published in the last few years, several landmark phase III trials that utilize matched unrelated and haploidentical donors for HSCT in SCD patients are also placed in context with respect to current management. Written by experts in the field, Sickle Cell Disease and Hematopoietic Stem Cell Transplantation is a valuable resource for physicians and researchers dealing with and interested in this challenging, yet exciting, curative therapy for sickle cell disease, that will help guide patient management and stimulate investigative efforts.

Stem Cell Transplantation for Hematologic Malignancies

Stem Cell Transplantation for Hematologic Malignancies
A Book

by Robert J. Soiffer

  • Publisher : Springer Science & Business Media
  • Release : 2004-01-29
  • Pages : 486
  • ISBN : 1592597335
  • Language : En, Es, Fr & De
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A comprehensive survey of the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic GVHD, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation.