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Human Embryos and Preimplantation Genetic Technologies

Human Embryos and Preimplantation Genetic Technologies
Ethical, Social, and Public Policy Aspects

by E. Scott Sills,Gianpiero D. Palermo

  • Publisher : Academic Press
  • Release : 2019-05-01
  • Pages : 222
  • ISBN : 0128167440
  • Language : En, Es, Fr & De
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Human Embryos and Preimplantation Genetic Technologies: Ethical, Social, and Public Policy Aspects presents the first holistic analysis of PGD and PGS as it is practiced and regulated worldwide. In addition to scientific and technical aspects, the book provides perspectives on the ethical, legal, religious, policy and social implications of global assisted reproduction technologies, including in Africa, Asia, Europe, North and South America, and Australia. Chapters cover history, ethics, feminism, family dynamics, psychological and interpersonal factors, the current state of PGD and PGS in 20 different sovereign nations and religious communities, and provide an analysis of public policy concerns and future directions. Provides an in-depth discussion of PGD and PGS as practiced and regulated worldwide Offers an accessible resource for researchers, medical professionals, patients, regulators and policymakers seeking expert opinions on PGS and PGD Contains chapters contributed by international clinicians, researchers and thought leaders in the field of assisted reproductive technology

Human Reproductive Genetics

Human Reproductive Genetics
Emerging Technologies and Clinical Applications

by Juan A. Garcia-Velasco,Emre Seli

  • Publisher : Academic Press
  • Release : 2020-04-19
  • Pages : 340
  • ISBN : 0128167491
  • Language : En, Es, Fr & De
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Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion. Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction. Provides an essential reference for clinicians involved in reproductive medicine Builds foundational knowledge on new genetic tests coming into the clinical scenario for physicians involved with patients Assembles critically evaluated chapters that cover basic concepts of genetics and epigenetics and the techniques involved, including preimplantation genetic testing, controversies, and more

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine
Improving Patient Success Rates and Infant Health

by Carlos Simón,Carmen Rubio

  • Publisher : CRC Press
  • Release : 2017-12-14
  • Pages : 179
  • ISBN : 1498763316
  • Language : En, Es, Fr & De
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Different genetic diagnostic and treatment options are used worldwide to improve routine IVF procedures for the benefit of patients. This handbook updates the new genetic diagnostic technologies that have been translated to practice aiming to improve outcomes in the clinic and have a healthy baby at home. Chapters cover the use of genetic technologies in a personalized manner to unravel the possible genetic risks for the couple wishing to conceive, in terms of sperm, the embryo, the endometrium, miscarriage, and finally the fetus.

Human Preimplantation Embryo Selection

Human Preimplantation Embryo Selection
A Book

by Jacques Cohen,Kay Elder

  • Publisher : CRC Press
  • Release : 2007-09-26
  • Pages : 384
  • ISBN : 9780203089712
  • Language : En, Es, Fr & De
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The most profound dilemma in assisted reproduction to date is the inability to recognize potentially viable embryos before their replacement into the reproductive tract. Application of increasingly advanced new technology has allowed the field of embryo evaluation to evolve rapidly and dramatically over the past five years. Human Preimplantation Embryo Selection assembles the leaders in the field of assisted reproduction to discuss their visions of dealing with the topic of embryo selection in the light of the limitations involving the fragility of the early human embryo. The purpose of this book is to shed light on the ever-expanding techniques that are being employed and evaluated with regard to embryo selection. A comprehensive overview may guide the ART practitioner in choice of techniques and evaluation of benefits and drawbacks. This book will provide an up-to-date overview and reference source: an invaluable tool for assisted reproductive practice worldwide.

Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions

Comparative Legal Frameworks for Pre-Implantation Embryonic Genetic Interventions
A Book

by Pin Lean Lau

  • Publisher : Springer
  • Release : 2019-08-01
  • Pages : 326
  • ISBN : 3030223086
  • Language : En, Es, Fr & De
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This book discusses the possibilities for the use of ​international human rights law ​(and specifically, international biomedical laws related to the protection of human rights and the human genome) to provide a guiding framework for the future regulation of genetic modifications applied to human embryos and other precursor materials, when these are made with the aim of implanting a genetically altered embryo in a woman. The significance and timeliness of the work derives from the recent availability of CRISPR/​Cas9 and other gene editing tools, and from lacunae in international law regarding the legality of embryo modification with these tools and appropriate governance structures for the oversight of resulting practices. The emergence of ​improved genome editing tools like CRISPR/Cas9, holds the promise of eradicating genetic diseases in the near future. But its possible future applications with Pre-Implantation Genetic Diagnosis (PGD) raises a plethora of legal and ethical concerns about "remaking" future human beings. The work aims to address an urgent call, to embed these rising concerns about biomedical advancements into the fundamental tailoring of legal systems. Suitable regulatory approaches, coupled with careful reflection of global biomedical laws and individual constitutional systems must be explored. The Book analyzes the impact of reproductive biomedical technologies on the legal and ethical dimensions of regulatory frameworks in selected constitutional systems like the US, the UK, Australia, Malaysia and Thailand. Employing a comparative law methodology, the work reveals a dynamic intersection between legal cultures, socio-philosophical reasoning and the development of a human rights-based framework in bio-political studies. Navigating towards a truly internationalized biomedical approach to emerging technologies, it presents an understanding why a renegotiation and reinvigoration of a contemporary and "new" universal shared values system in the ​international human rights discourse is now necessary.

Human Genome Editing

Human Genome Editing
Science, Ethics, and Governance

by National Academies of Sciences, Engineering, and Medicine,National Academy of Medicine,National Academy of Sciences,Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations

  • Publisher : National Academies Press
  • Release : 2017-08-13
  • Pages : 328
  • ISBN : 0309452880
  • Language : En, Es, Fr & De
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Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

Textbook of Human Reproductive Genetics

Textbook of Human Reproductive Genetics
A Book

by Karen Sermon,Stéphane Viville

  • Publisher : Cambridge University Press
  • Release : 2014-04-10
  • Pages : 200
  • ISBN : 1107683580
  • Language : En, Es, Fr & De
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This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Regulating Pre-implantation Genetic Diagnosis

Regulating Pre-implantation Genetic Diagnosis
A Comparative and Theoretical Analysis

by Sheila McLean,Sarah Elliston

  • Publisher : Routledge
  • Release : 2012
  • Pages : 250
  • ISBN : 041568644X
  • Language : En, Es, Fr & De
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The successful achievement of pregnancies following pre-implantation genetic diagnosis (PGD) was first reported in April 1990. The technology is often used for patients who are at substantial risk of conceiving a pregnancy affected by a known genetic disorder, however from this technology other more controversial uses have arisen such as HLA typing to save the life of a sibling, gender selection for social reasons, the prevention of late onset diseases, or the prevention of diseases which may be genetically predisposed to developing such as breast cancer. The technology surrounding PGD is constantly developing, giving rise to new and unexpected consequences that create fresh ethical and legal dilemmas. Featuring internationally recognized experts in the field, this book critically explores the regulation of PGD and the broader legal and ethical issues associated with it. It looks at the regulatory situation in a number of jurisdictions including New Zealand, Australia and the United Kingdom, but it also explores a number of themes of wide significance including a historical consideration of PGD and its part in the creation of the "genetic embryo" as a political tool, the over regulation of PGD and the ethical difficulties in handling additional unexpected medical information yielded by new technologies. This book will be of particular interest to academics and students of law, medicine and ethics.

Preimplantation Genetic Testing

Preimplantation Genetic Testing
Recent Advances in Reproductive Medicine

by Darren K. Griffin,Gary L. Harton

  • Publisher : CRC Press
  • Release : 2020-06-19
  • Pages : 163
  • ISBN : 0429820305
  • Language : En, Es, Fr & De
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Preimplantation genetic testing (PGT) is now well established as a valuable treatment option for patients wishing to start or continue a family, for a range of indications from advanced maternal age to high risk of transmitting inherited disease. This text brings together contemporary thinking from international opinion leaders and will be an invaluable guide for practitioners in Reproductive Medicine wishing to keep pace with the latest developments and clinical data.

The End of Sex and the Future of Human Reproduction

The End of Sex and the Future of Human Reproduction
A Book

by Henry T. Greely

  • Publisher : Harvard University Press
  • Release : 2016-05-30
  • Pages : 381
  • ISBN : 0674728963
  • Language : En, Es, Fr & De
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Within twenty, maybe forty, years most people in developed countries will stop having sex for the purpose of reproduction. Instead, prospective parents will be told as much as they wish to know about the genetic makeup of dozens of embryos, and they will pick one or two for implantation, gestation, and birth. And it will be safe, lawful, and free. In this work of prophetic scholarship, Henry T. Greely explains the revolutionary biological technologies that make this future a seeming inevitability and sets out the deep ethical and legal challenges humanity faces as a result. “Readers looking for a more in-depth analysis of human genome modifications and reproductive technologies and their legal and ethical implications should strongly consider picking up Greely’s The End of Sex and the Future of Human Reproduction...[It has] the potential to empower readers to make informed decisions about the implementation of advancements in genetics technologies.” —Dov Greenbaum, Science “[Greely] provides an extraordinarily sophisticated analysis of the practical, political, legal, and ethical implications of the new world of human reproduction. His book is a model of highly informed, rigorous, thought-provoking speculation about an immensely important topic.” —Glenn C. Altschuler, Psychology Today

Preimplantation Genetic Diagnosis

Preimplantation Genetic Diagnosis
A Book

by Joyce C. Harper,Joy D. A. Delhanty,Alan H. Handyside

  • Publisher : John Wiley & Sons
  • Release : 2003-01-17
  • Pages : 278
  • ISBN : 0470851732
  • Language : En, Es, Fr & De
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Preimplantation Genetic Diagnosis (PGD) is the detection and screening of genetic abnormality in gametes prior to fertilisation and embryos fertilised in vitro prior to implantation. This exciting new text provides an introduction and overview of the principles of PGD. An exciting fusion of prenatal diagnosis (PD) with in vitro fertilisation (IVF), this book is will appeal to both the prenatal diagnosis community, of clinical geneticists and foetal medicine specialists within obstetrics and gynaecology, and the IVF community within reproductive medicine. It is also an essential introduction to PD, clinical genetics and IVF for non-specialists. A concise introduction to the field of PGD Detailed explanations of the techniques and procedures used The law and ethical implications of PGD Future uses of PGD

Genetic Diversity and Disease Susceptibility

Genetic Diversity and Disease Susceptibility
A Book

by Yamin Liu

  • Publisher : BoD – Books on Demand
  • Release : 2018-10-17
  • Pages : 164
  • ISBN : 1789842018
  • Language : En, Es, Fr & De
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Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.

Cloning and the Future of Human Embryo Research

Cloning and the Future of Human Embryo Research
A Book

by Paul Lauritzen

  • Publisher : Oxford University Press, USA
  • Release : 2001
  • Pages : 291
  • ISBN : 9780195128581
  • Language : En, Es, Fr & De
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Hailed as revolutionary, the prospect of human cloning is actually the next logical step in a series of developments in reproductive technology that began with the first test-tube baby in 1978. This book addresses the debates over cloning in the context of new reproductive technology and human embryo research. It examines the status of preimplantation embryos, the ethical issues related to cloning and embryo research, and the formulation of public policy.

Born and Made

Born and Made
An Ethnography of Preimplantation Genetic Diagnosis

by Sarah Franklin,Celia Roberts

  • Publisher : Princeton University Press
  • Release : 2006-10-30
  • Pages : 288
  • ISBN : 1400835429
  • Language : En, Es, Fr & De
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Are new reproductive and genetic technologies racing ahead of a society that is unable to establish limits to their use? Have the "new genetics" outpaced our ability to control their future applications? This book examines the case of preimplantation genetic diagnosis (PGD), the procedure used to prevent serious genetic disease by embryo selection, and the so-called "designer baby" method. Using detailed empirical evidence, the authors show that far from being a runaway technology, the regulation of PGD over the past fifteen years provides an example of precaution and restraint, as well as continual adaptation to changing social circumstances. Through interviews, media and policy analysis, and participant observation at two PGD centers in the United Kingdom, Born and Made provides an in-depth sociological examination of the competing moral obligations that define the experience of PGD. Among the many novel findings of this pathbreaking ethnography of reproductive biomedicine is the prominence of uncertainty and ambivalence among PGD patients and professionals--a finding characteristic of the emerging "biosociety," in which scientific progress is inherently paradoxical and contradictory. In contrast to much of the speculative futurology that defines this field, Born and Made provides a timely and revealing case study of the on-the-ground decision-making that shapes technological assistance to human heredity.

The Human Embryo Research Debates

The Human Embryo Research Debates
Bioethics in the Vortex of Controversy

by Ronald M. Green

  • Publisher : Oxford University Press
  • Release : 2001-06-28
  • Pages : 256
  • ISBN : 0199761892
  • Language : En, Es, Fr & De
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Research on the early human embryo has long been recognized as essential to progress in a host of biomedical areas from reproductive medicine to the treatment of pediatric cancers. Now, with the possibility of stem cell research and cell replacement therapies, embryo research holds out the promise of cures for many serious disease conditions such as diabetes and Alzheimer's disease. Despite its importance, however, human embryo research has met powerful opposition. Drawing on his experience as a member of the NIH's Human Embryo Research Panel, Green offers a first-hand account of the embryo research debates. In telling this story, he periodically pauses to reflect on some of the leading philosophical challenges posed by embryo research and new interventions at the start of life. Among the questions he examines are: What is the impact of new biological information on our thinking about life's beginning? May parents risk injuring a child in order to have it? What role should religion play in shaping biomedical policy in a controversial area like this? This is a fascinating insider's account of one of the most important, if unsuccessful, recent efforts to come to terms with a controversial area of scientific research.

Human Germline Modification and the Right to Science

Human Germline Modification and the Right to Science
A Comparative Study of National Laws and Policies

by Andrea Boggio,Cesare P. R. Romano,Jessica Almqvist

  • Publisher : Cambridge University Press
  • Release : 2020-01-09
  • Pages : 324
  • ISBN : 1108499872
  • Language : En, Es, Fr & De
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A survey of the regulation of human germline genome modification in eighteen countries and the emerging international standards.

A Color Atlas for Human Assisted Reproduction

A Color Atlas for Human Assisted Reproduction
Laboratory and Clinical Insights

by Pasquale Patrizio,Michael J. Tucker,Vanessa Guelman

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2003
  • Pages : 319
  • ISBN : 9780781737692
  • Language : En, Es, Fr & De
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Featuring more than 300 full-color photographs, this atlas is a comprehensive guide to the complex procedures used in assisted reproduction. It shows readers how to utilize the latest technologies and correlates the laboratory and clinical components of assisted reproduction. The book depicts oocytes, embryos, and blastocysts at various stages of division and offers guidelines for assessing oocytes and embryos. The authors give detailed instructions on ovarian stimulation, intracytoplasmic sperm injection, assisted hatching, cryopreservation, extended in vitro culturing, preimplantation genetic diagnosis, and embryo transfer techniques. Close attention is also given to assessment of oocytes and embryos from patients with endometriosis and other pathologies.

Regulating Preimplantation Genetic Diagnosis in the United States

Regulating Preimplantation Genetic Diagnosis in the United States
The Limits of Unlimited Selection

by M. Bayefsky,B. Jennings

  • Publisher : Springer
  • Release : 2015-01-20
  • Pages : 113
  • ISBN : 1137515449
  • Language : En, Es, Fr & De
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Reproductive technology allows us to test embryos' genes before deciding whether to transfer them to a woman's uterus. Embryo selection raises many ethical questions but is virtually unregulated in the United States. This comprehensive study considers the ethical, medical, political, and economic aspects of developing appropriate regulation.

Preimplantation Genetic Diagnosis in Clinical Practice

Preimplantation Genetic Diagnosis in Clinical Practice
A Book

by Tarek El-Toukhy,Peter Braude

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-08
  • Pages : 228
  • ISBN : 1447129482
  • Language : En, Es, Fr & De
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Preimplantation genetic diagnosis (PGD) is a rapidly advancing field of reproductive genetics. With the significant improvements achieved over the last few years in the understanding of many genetic diseases and in the techniques of molecular genetic testing, new genetic diseases are being added to the list of conditions amenable to PGD almost on a weekly basis. Therefore, the subject of PGD is becoming relevant to a much wider variety of medical disciplines and an increasing number of patients who may wish to know more about this treatment option. This unique book offers a comprehensive yet practical “user-friendly” guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD. Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics.

Human Gametes and Preimplantation Embryos

Human Gametes and Preimplantation Embryos
Assessment and Diagnosis

by David K. Gardner,Denny Sakkas,Emre Seli,Dagan Wells

  • Publisher : Springer Science & Business Media
  • Release : 2013-05-27
  • Pages : 306
  • ISBN : 1461466512
  • Language : En, Es, Fr & De
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In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates have a higher rate of pre-term delivery, compromising their survival chances and increasing their risk of lifelong disability. By optimizing the selection of gametes and embryos with high probabilities of implantation, it is possible to reduce the number of embryos transferred and, by extension, the number of high-risk multiple gestations, while maintaining or increasing pregnancy rates. Human Gametes and Preimplantation Embryos: Assessment and Diagnosis provides a broad yet concise overview of established and developing methodologies for assessment of gamete and embryo viability in assisted reproduction. This book elucidates the best practices for precisely selecting viable specimens based on morphology and cleavage rate and covers the spectrum of emerging adjunctive technologies for predicting reproductive potential. The authors present their extensive knowledge of “omics” approaches (genomics, transcriptomics, proteomics, and metabolomics), with unbiased delineation of the associated advantages and potential pitfalls. This valuable clinical resource is well suited to infertility specialists, Ob/Gyn physicians, IVF laboratory technicians, and researchers in the fields of embryology and reproductive medicine.