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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters
Concepts, Methods and Translational Sciences

by Shuguang Ma,Swapan Chowdhury

  • Publisher : Elsevier
  • Release : 2020-07-09
  • Pages : 708
  • ISBN : 0128200197
  • Language : En, Es, Fr & De
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Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism. Four sections in the book with 24 chapters give readers an overview of state-of-the-art techniques for identifying and quantifying drugs, metabolites and biomarkers, including a chapter on new approaches for quantification of enzymes and transporters in different tissues Focuses on the role of drug metabolism enzymes, transporters in disposition and drug-drug interactions, as well as strategies for evaluating drug metabolism and safety using advanced liver and kidney models. Discussions on immunogenicity risks of biologics and their evaluation methods have been included Includes several chapters on advanced translational sciences to predict human dosage, pharmacokinetics and efficacy for small molecules and biotherapeutics All chapters are written by experts with a wide range of practical experience from the industry and academia

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS

Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS
A Book

by Swapan Chowdhury

  • Publisher : Elsevier
  • Release : 2005-11-04
  • Pages : 354
  • ISBN : 9780080456065
  • Language : En, Es, Fr & De
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As new techniques of transferring from liquid to gas phase and measuring masses of drug molecules and metabolites become more prevalent, so do the technical challenges of putting these techniques into proper use, as well as the task of consolidating emerging applications. Identification and Quantification of Drugs, Metabolites and Metabolizing Enzymes by LC-MS, Volume 6 fills the gap in the lack of presently available literature by providing a critical review in the current use of liquid chromatography-mass spectrometry (LC-MS) in drug discovery and development. With chapters written by experts with a wide range of practical experience from the pharmaceutical industry, emphasis is placed on techniques and applications. The book also includes chapters on how to utilize LC-MS instrumentation for current drug metabolism problems. This book is intended for those beginning to use LC-MS for drug metabolism studies as well as for those considered advanced practitioners. * Introduces readers to the practical applications of modern liquid chromatography-mass spectrometry (LC-MS) in a wide range of drug metabolism studies· * Provides a comprehensive description of different forms of metabolites, with detailed discussion on the wide range of methodologies used to identify them * Highlights problems associated with drug quantification and offers practical solutions

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
A Book

by John B. Taylor,D. J. Triggle

  • Publisher : Elsevier Science Ltd
  • Release : 2007
  • Pages : 7200
  • ISBN : 9780080445137
  • Language : En, Es, Fr & De
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The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Journal of the Indian Institute of Science

Journal of the Indian Institute of Science
A Book

by Indian Institute of Science, Bangalore

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicology Research Projects Directory

Toxicology Research Projects Directory
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1980
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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An indexed directory of current research project abstracts in toxicology and related fields.

Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition

Goodman and Gilman's The Pharmacological Basis of Therapeutics, 13th Edition
A Book

by Laurence Brunton,Bjorn Knollman,Randa Hilal-Dandan

  • Publisher : McGraw Hill Professional
  • Release : 2017-10-26
  • Pages : 1808
  • ISBN : 1259584747
  • Language : En, Es, Fr & De
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The gold-standard of pharmacology texts – completely updated to reflect the latest research and developments A Doody’s Core Title for 2019! Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Thirteenth Edition represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. The Thirteenth Edition includes more than 500 color illustrations, with many new figures emphasizing mechanisms of drug action. More than 30 new contributors have added to this edition, while the focus on basic principles is undiminished. This edition is enhanced by timely new content: •NEW chapters including Treatment of Pulmonary Arterial Hypertension, Immunity and Inflammation, Immunoglobulins and Vaccines, and Treatment of Viral Hepatitis •Expanded coverage of cardiovascular disease, with separate chapters on myocardial ischemia, hypertension, and heart failure •Increased emphasis on cellular signaling pathways involved in drug action •Summary tables at the end of each chapter that organize drugs discussed in that chapter into relevant categories and detail therapeutic usage, clinical pharmacology, and tips •Chapter Content Outlines at the beginning of each chapter •Abbreviation boxes in every chapter to easily identify the abbreviations appearing in that chapter More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice.

Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition

Goodman and Gilman's The Pharmacological Basis of Therapeutics, Twelfth Edition
A Book

by Laurence Brunton,Bruce Chabner,Bjorn Knollman

  • Publisher : McGraw Hill Professional
  • Release : 2010-12-20
  • Pages : 1808
  • ISBN : 0071624422
  • Language : En, Es, Fr & De
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The landmark text in medical pharmacology is now in full color Includes DVD with image bank A Doody's Core Title ESSENTIAL PURCHASE for 2011! 4 STAR DOODY'S REVIEW! "This 12th edition of the most authoritative book in pharmacology is the best both in content and physical appearance....This edition of Goodman & Gilman's continues to be the most authoritative and widely used resource bridging the discipline of pharmacology with therapeutics. Moreover, readers will find this edition to be substantially improved from past editions in both content and physical appearance."--Doody's Review Service The most universally respected and read medical text in all of pharmacology, Goodman & Gilman’s The Pharmacological Basis of Therapeutics represents the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. Goodman & Gilman’s careful balance of basic science and clinical application has guided thousands of practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing, and treating disease. Enriched by a new full-color presentation and updated to reflect all critical new developments in drug action and drug-disease interaction, the twelfth edition includes more than 440 color illustrations depicting key principles and actions of specific pathways and therapeutic agents. The companion DVD includes all the images and tables in the text along with narrated animations. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 12e is divided into nine sections, covering: General Principles Neuropharmacology Modulation of Cardiovascular Function Inflammation, Immunomodulation, and Hematopoiesis Endocrine Pharmacology Gastrointestinal Pharmacology Chemotherapy of Infectious Disease Chemotherapy of Neoplastic Diseases Special Systems Pharmacology More than a textbook, Goodman & Gilman's is a working template for the effective and rational prescribing of drugs in daily practice.

American Doctoral Dissertations

American Doctoral Dissertations
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmacogenomics An Introduction and Clinical Perspective

Pharmacogenomics An Introduction and Clinical Perspective
A Book

by Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,C. Lindsay DeVane,Uwe Fuhr

  • Publisher : McGraw Hill Professional
  • Release : 2012-10-09
  • Pages : 288
  • ISBN : 0071741690
  • Language : En, Es, Fr & De
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Pharmacogenomics is comprehensive textbook detailing how genetic makeup affects a body's response to drugs.

Peterson's Annual Guides to Graduate Study

Peterson's Annual Guides to Graduate Study
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1980
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Psychopharmacology Abstracts

Psychopharmacology Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drugs During Pregnancy and Lactation

Drugs During Pregnancy and Lactation
Handbook of prescription drugs and comparative risk assessment

by H. Garbis,P. McElhatton,M. Reuvers,E. Robert,M. Rost van Tonningen,A. Scialli,P. Peters

  • Publisher : Elsevier Science
  • Release : 2002-01-04
  • Pages : 380
  • ISBN : 9780444507631
  • Language : En, Es, Fr & De
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The care of pregnant women presents one of the paradoxes of modern medicine. Women usually require little medical intervention during an (uneventful) pregnancy. Conversely, those at high risk of damage to their own health or that of their unborn require the help of appropriate medicinal technology, including drugs. Accordingly, there are two classes of pregnant women, the larger group requires support but not much intervention, while the other needs the full range of diagnostic and therapeutic measures applied in any other branch of medicine. This book presents the current state of knowledge about drugs in pregnancy. In each chapter information is presented separately for two different aspects of the problem seeking a drug appropriate for prescription during pregnancy, and assessing the risk of a drug when exposure has already taken place. Practising clinicians who prescribe medicinal products to women who are, or who may become, pregnant, will find this volume an invaluable reference.

Examining the Regulation of Hepatic Drug Disposition and Metabolism by Organic Anion Transporting Polypeptide, P-glycoprotein and Multidrug Resistance-associated Protein 2

Examining the Regulation of Hepatic Drug Disposition and Metabolism by Organic Anion Transporting Polypeptide, P-glycoprotein and Multidrug Resistance-associated Protein 2
A Book

by Yvonne Yi-Yang Lau

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 218
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Overall, the results from the IPRL study correlates well with in vivo studies and support our hypothesis that transporters are the major players in hepatic drug elimination, even for substrates that undergo extensive metabolism.

Current Programs

Current Programs
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicology abstracts

Toxicology abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bibliography of Agriculture

Bibliography of Agriculture
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Casarett & Doull's Toxicology: The Basic Science of Poisons, Ninth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Ninth Edition
A Book

by Curtis D. Klaassen

  • Publisher : McGraw Hill Professional
  • Release : 2018-11-23
  • Pages : 1696
  • ISBN : 1259863751
  • Language : En, Es, Fr & De
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Toxicology’s gold-standard text - completely updated to reflect the latest breakthroughs and discoveries Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition equips you with an unsurpassed understanding of modern toxicology, including the key principles, concepts, mechanisms, chemical-specific toxicity, and modes of thought that are the foundation of the discipline. This trusted classic not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Casarett & Doull’s Toxicology: The Basic Science of Poisons, Ninth Edition is logically divided into seven sections:•General Principles of Toxicology•Disposition of Toxicants•Non-Organ Directed Toxicity•Target Organ Toxicity•Toxic Agents•Environmental Toxicology•Applications of Toxicology Many new contributors capture the progress made in toxicology over the past few years:This edition is markedly updated from the previous edition, with more than one-third of the chapters authored by scientists who have not made previous contributions to the book. Sharing their expertise, they deliver dynamic new coverage of the importance of apoptosis, autophagy, cytokines, growth factors, oncogenes, cell cycling, receptors, gene regulation, protective mechanisms, repair mechanisms, transcription factors, signaling pathways, transgenic mice, knock-out mice, humanized mice, polymorphisms, microarray technology, second-generation sequencing, genomics, proteomics, epigenetics, exposome, microbiota, read across, adverse outcome pathways, high-content screening, computational toxicology, innovative test methods, and organ-on-a-chip in understanding the mechanisms of toxicity and the regulation of chemicals. A true “essential”If you are in need of an up-to-date, all-in-one overview of the biomedical and environmental aspects of toxicology - written by experts, and presented in full color, your search ends here.

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
A Book

by Curtis Klaassen

  • Publisher : McGraw Hill Professional
  • Release : 2013-04-25
  • Pages : 1473
  • ISBN : 0071769226
  • Language : En, Es, Fr & De
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The most trusted all-in-one overview of the biomedical and environmental aspects of toxicology--NOW more complete, up-to-date, and in full color The world's leading and most authoritative textbook on poisons has more to offer students,toxicologists, and pharmacologists than ever before. Now in full color, and thoroughly revised, the eighth edition of Casarett & Doull's TOXICOLOGY: The Basic Science of Poisons not only delivers a comprehensive review of the essential components of toxicology, it offers the most up-to-date, revealing, and in-depth look at the systemic responses of toxic substance available anywhere. Combined with the latest thinking by the field's foremost scholars plus solid coverage of general principles, modes of action, and chemical-specific toxicity, this landmark text continues to set the standard for toxicology references. NEW to the Eighth Edition FULL-COLOR design to allow for a clearer interpretation of the basic components of toxicology featured throughout the text EXPANDED tables, illustrations, and other visuals are updated with state-of-the-art standards that makes this edition even more current and relevant DVD with image bank features all tables and illustrations from the text in presentation-ready format NEW CHAPTERS include "Toxic Effects of Calories" and "Toxic Effects of Nanoparticles"

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition

Casarett & Doull's Toxicology: The Basic Science of Poisons, Eighth Edition
A Book

by Louis J. Casarett,John Doull

  • Publisher : McGraw Hill Professional
  • Release : 2013-06-19
  • Pages : 1454
  • ISBN : 0071769234
  • Language : En, Es, Fr & De
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Casarett and Doull's has set the standard for toxicology reference texts for years, and is the market leading title to this day. It serves the general toxicology market, and is to the field what Goodman and Gilman is to pharmacology. The books are often purchased together, and form a knock-out punch along with our DiPiro textbook; combined, these three titles produce millions of dollars in revenue and more than 100,000 in unit sales. Casarett & Doull's is, in other words, one part of a triad that forms the best pharmacology/pharmacy/toxicology collection in all of medical publishing