Download Immunopotentiators in Modern Vaccines Ebook PDF

Immunopotentiators in Modern Vaccines

Immunopotentiators in Modern Vaccines
A Book

by Virgil Schijns,Derek O'Hagan

  • Publisher : Elsevier
  • Release : 2005-12-19
  • Pages : 384
  • ISBN : 9780080457215
  • Language : En, Es, Fr & De
GET BOOK

Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines

Novel Immune Potentiators and Delivery Technologies for Next Generation Vaccines
A Book

by Manmohan Singh

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-03
  • Pages : 370
  • ISBN : 1461453801
  • Language : En, Es, Fr & De
GET BOOK

Development of new-generation vaccines is now more challenging than ever, as identifying, purifying and evaluating vaccine antigens is a complex undertaking. Most importantly, once the relevant antigens have been identified, key focus then shifts to the development of suitable delivery systems and formulations to achieve maximum in vivo potency with minimum potential side effects. These novel formulations—many of which will be nanoparticulates—can deliver the antigens to the desired site, to the relevant antigen presenting cells, and prevent systemic exposure of the immune potentiators. The proposed book will outline all the critical steps that need to be considered for successful development of various types of nanoparticulate delivery systems for vaccine antigens. These contributions from leading experts in the area of vaccine formulation and delivery systems will tie in what is the most current status, including clinical evaluations with these novel vaccine technologies.​

Subunit Vaccine Delivery

Subunit Vaccine Delivery
A Book

by Camilla Foged,Thomas Rades,Yvonne Perrie,Sarah Hook

  • Publisher : Springer
  • Release : 2014-11-22
  • Pages : 431
  • ISBN : 1493914170
  • Language : En, Es, Fr & De
GET BOOK

This comprehensive volume compiles the concepts essential for the understanding of the pharmaceutical science and technology associated with the delivery of subunit vaccines. Twenty-one chapters are divided into four main parts: (I) Background; (2) Delivery Systems for Subunit Vaccines; (3) Delivery Routes, Devices and Dosage Forms; and (4) Pharmaceutical Analysis and Quality Control of Vaccines. Part one provide a basic background with respect to immunology and general vaccine classification. In part two, it presents representative types of vaccine delivery systems individually with focus on the physicochemical properties of the systems and their significance for the immune response they stimulate. These delivery systems include aluminum adjuvants, emulsions, liposomes, bilosomes, cubosomes/hexosomes, ISCOMs, virus-like particles, polymeric nano- and microparticles, gels, implants and cell-based delivery systems. Following these chapters, part three addresses the challenges associated with vaccine delivery via specific routes of administration—in particular subcutaneous, intramuscular, oral, nasal, pulmonary, transdermal and vaginal administration. Furthermore, the specific administration routes are discussed in combination with device technologies relevant for the respective routes as well as dosage forms appropriate for the device technology. Finally, the fourth part concerns pharmaceutical analysis and quality control of subunit vaccines.

The Human Microbiota and Chronic Disease

The Human Microbiota and Chronic Disease
Dysbiosis as a Cause of Human Pathology

by Luigi Nibali,Brian Henderson

  • Publisher : John Wiley & Sons
  • Release : 2016-09-26
  • Pages : 544
  • ISBN : 1118982878
  • Language : En, Es, Fr & De
GET BOOK

Microbiota-associated pathology can be a direct result of changes in general bacterial composition, such as might be found in periodontitis and bacterial vaginosis, and/or as the result of colonization and/or overgrowth of so called keystone species. The disruption in the composition of the normal human microbiota, or dysbiosis, plays an integral role in human health and human disease. The Human Microbiota and Human Chronic Disease: Dysbioses as a Cause of Human Pathology discusses the role of the microbiota in maintaining human health. The text introduces the reader to the biology of microbial dysbiosis and its potential role in both bacterial disease and in idiopathic chronic disease states. Divided into five sections, the text delineates the concept of the human bacterial microbiota with particular attention being paid to the microbiotae of the gut, oral cavity and skin. A key methodology for exploring the microbiota, metagenomics, is also described. The book then shows the reader the cellular, molecular and genetic complexities of the bacterial microbiota, its myriad connections with the host and how these can maintain tissue homeostasis. Chapters then consider the role of dysbioses in human disease states, dealing with two of the commonest bacterial diseases of humanity – periodontitis and bacterial vaginosis. The composition of some, if not all microbiotas can be controlled by the diet and this is also dealt with in this section. The discussion moves on to the major ‘idiopathic’ diseases afflicting humans, and the potential role that dysbiosis could play in their induction and chronicity. The book then concludes with the therapeutic potential of manipulating the microbiota, introducing the concepts of probiotics, prebiotics and the administration of healthy human faeces (faecal microbiota transplantation), and then hypothesizes as to the future of medical treatment viewed from a microbiota-centric position. Provides an introduction to dysbiosis, or a disruption in the composition of the normal human microbiota Explains how microbiota-associated pathology and other chronic diseases can result from changes in general bacterial composition Explores the relationship humans have with their microbiota, and its significance in human health and disease Covers host genetic variants and their role in the composition of human microbial biofilms, integral to the relationship between human health and human disease Authored and edited by leaders in the field, The Human Microbiota and Human Chronic Disease will be an invaluable resource for clinicians, pathologists, immunologists, cell and molecular biologists, biochemists, and system biologists studying cellular and molecular bases of human diseases.

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology
Fundamentals and Applications, Second Edition

by Daan J. A. Crommelin,Robert D. Sindelar

  • Publisher : CRC Press
  • Release : 2002-11-14
  • Pages : 456
  • ISBN : 9780415285018
  • Language : En, Es, Fr & De
GET BOOK

The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems

Endotoxin Detection and Control in Pharma, Limulus, and Mammalian Systems
A Book

by Kevin L. Williams

  • Publisher : Springer
  • Release : 2019-07-24
  • Pages : 869
  • ISBN : 3030171485
  • Language : En, Es, Fr & De
GET BOOK

Endotoxin detection and control is a dynamic area of applied science that touches a vast number of complex subjects. The intersection of test activities includes the use of an ancient blood system from an odd “living fossil” (Limulus). It is used to detect remnants of the most primitive and destructive forms of life (prokaryotes) as contaminants of complex modern systems (mammalian and Pharma). Recent challenges in the field include those associated with the application of traditional methods to new types of molecules and manufacturing processes. The advent of “at will” production of biologics in lieu of harvesting animal proteins has revolutionized the treatment of disease. While the fruits of the biotechnology revolution are widely acknowledged, the realization of the differences in the means of production and changes in the manner of control of potential impurities and contaminants in regard to the new versus the old are less widely appreciated. Endotoxin as an ancient, dynamic interface between lifeforms, provides a singular perspective from which to view the parallel development of ancient and modern organisms as well as the progress of man in deciphering the complexity of their interactions in his efforts to overcome disease.

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology
Fundamentals and Applications

by Daan J. A. Crommelin,Robert D. Sindelar,Bernd Meibohm

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-22
  • Pages : 544
  • ISBN : 1461464862
  • Language : En, Es, Fr & De
GET BOOK

This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fourth Edition will completely update the previous edition, and will also include additional coverage on the newer approaches such as oligonucleotides, siRNA, gene therapy and nanotech.

In Defense of Self

In Defense of Self
How the Immune System Really Works

by William R. Clark

  • Publisher : Oxford University Press, USA
  • Release : 2008
  • Pages : 265
  • ISBN : 0195335554
  • Language : En, Es, Fr & De
GET BOOK

William Clark invites readers on a tour of the immune system, introducing some of the most important medical advances and challenges of the past 100 years, from the development of vaccines and the treatment of allergies, automimmunity and cancer, to prolonging organ transplants and combating AIDS.

Current Applications of Pharmaceutical Biotechnology

Current Applications of Pharmaceutical Biotechnology
A Book

by Ana Catarina Silva,João Nuno Moreira,José Manuel Sousa Lobo,Hugo Almeida

  • Publisher : Springer Nature
  • Release : 2020-02-06
  • Pages : 400
  • ISBN : 3030404641
  • Language : En, Es, Fr & De
GET BOOK

This book offers an authoritative review of biopharmaceuticals and their clinical relevance. Biopharmaceuticals have been showing high therapeutic potential by means of biological and biosimilar medicines, particularly for the treatment of cancer, chronic diseases (e.g. diabetes, Crohn's disease, psoriasis and rheumatoid arthritis), neurodegenerative disorders (e.g. multiple sclerosis), and they have also been contributing to the progress of innovative therapies such as assisted reproductive medicine. Since the eighties, several biopharmaceuticals have been approved and, due to patents expiration, many biosimilars are also marketed. In this book, readers will find the most relevant updated information about the main clinical applications of pharmaceutical biotechnology. The authors provide expert analysis about the industrial challenges of recombinant proteins and the different classes of biopharmaceuticals, including monoclonal antibodies, vaccines, growth factors and stem cells. Topics such as bioprinting technologies in tissue engineering, gene therapy and personalized medicine are also covered in this book. Professionals, students and researchers interested in this field will find this work an important account.

Low-dose antibiotics: current status and outlook for the future

Low-dose antibiotics: current status and outlook for the future

by Robert Paul Hunter, Carlos F Amábile-Cuevas,Jun Lin,Joshua D Nosanchuk, Rustam Aminov

  • Publisher : Frontiers E-books
  • Release : 2014-12-01
  • Pages : 329
  • ISBN : 2889193551
  • Language : En, Es, Fr & De
GET BOOK

Antimicrobial therapy is a key factor in our success against pathogens poised to ravage at risk or infected individuals. However, we are currently at a watershed point as we face a growing crisis of antibiotic resistance among diverse pathogens. One area of intense interest is the impact of the application of antibiotics for uses other than the treatment of patients and the association with such utilization with emerging drug resistance. This Research Topic “Low- dose antibiotics: current status and outlook for the future” in Frontiers in Microbiology: Antimicrobials, Resistance and Chemotherapy details various aspects of the wide ranging effects of antimicrobial therapy from areas such as the regulation of host responses to modulation of bacterial virulence factors to acquisition of antibiotic resistance genes.

Micro- and Nanotechnology in Vaccine Development

Micro- and Nanotechnology in Vaccine Development
A Book

by Mariusz Skwarczynski,Istvan Toth

  • Publisher : William Andrew
  • Release : 2016-09-20
  • Pages : 460
  • ISBN : 0323400299
  • Language : En, Es, Fr & De
GET BOOK

This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles. Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines

Advances in Chitin/Chitosan Characterization and Applications

Advances in Chitin/Chitosan Characterization and Applications
A Book

by Marguerite Rinaudo,Francisco M. Goycoolea

  • Publisher : MDPI
  • Release : 2019-04-23
  • Pages : 414
  • ISBN : 3038978027
  • Language : En, Es, Fr & De
GET BOOK

Functional advanced biopolymers have received far less attention than renewable biomass (cellulose, rubber, etc.) used for energy production. Among the most advanced biopolymers known is chitosan. The term chitosan refers to a family of polysaccharides obtained by partial de-N-acetylation from chitin, one of the most abundant renewable resources in the biosphere. Chitosan has been firmly established as having unique material properties as well as biological activities. Either in its native form or as a chemical derivative, chitosan is amenable to being processed—typically under mild conditions—into soft materials such as hydrogels, colloidal nanoparticles, or nanofibers. Given its multiple biological properties, including biodegradability, antimicrobial effects, gene transfectability, and metal adsorption—to name but a few—chitosan is regarded as a widely versatile building block in various sectors (e.g., agriculture, food, cosmetics, pharmacy) and for various applications (medical devices, metal adsorption, catalysis, etc.). This Special Issue presents an updated account addressing some of the major applications, including also chemical and enzymatic modifications of oligos and polymers. A better understanding of the properties that underpin the use of chitin and chitosan in different fields is key for boosting their more extensive industrial utilization, as well as to aid regulatory agencies in establishing specifications, guidelines, and standards for the different types of products and applications.

Research Advances in Rabies

Research Advances in Rabies
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2011-07-13
  • Pages : 486
  • ISBN : 9780123870414
  • Language : En, Es, Fr & De
GET BOOK

Volume 79 of Advances in Virus Research focuses on developments surrounding rabies, an ancient disease that remains a prominent public health problem for humans. This volume highlights important research advances extending from our understanding of how the rabies virus replicates and assembles to how the disease can be prevented and treated in humans and how rabies can be controlled in wildlife hosts. Experts in the field provide insightful and up-to-date chapters that summarize our current state of knowledge in diverse aspects of this very interesting and important viral disease. Contributions from leading authorities and industry experts Informs and updates on all the latest developments in the field

Mosaic of Autoimmunity

Mosaic of Autoimmunity
The Novel Factors of Autoimmune Diseases

by Carlo Perricone,Yehuda Shoenfeld

  • Publisher : Academic Press
  • Release : 2019-02-15
  • Pages : 1136
  • ISBN : 012814307X
  • Language : En, Es, Fr & De
GET BOOK

The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Emerging Technologies to Benefit Farmers in Sub-Saharan Africa and South Asia

Emerging Technologies to Benefit Farmers in Sub-Saharan Africa and South Asia
A Book

by National Research Council,Division on Earth and Life Studies,Board on Agriculture and Natural Resources,Committee on a Study of Technologies to Benefit Farmers in Africa and South Asia

  • Publisher : National Academies Press
  • Release : 2009-02-21
  • Pages : 292
  • ISBN : 0309124948
  • Language : En, Es, Fr & De
GET BOOK

Increased agricultural productivity is a major stepping stone on the path out of poverty in sub-Saharan Africa and South Asia, but farmers there face tremendous challenges improving production. Poor soil, inefficient water use, and a lack of access to plant breeding resources, nutritious animal feed, high quality seed, and fuel and electricity-combined with some of the most extreme environmental conditions on Earth-have made yields in crop and animal production far lower in these regions than world averages. Emerging Technologies to Benefit Farmers in Sub-Saharan Africa and South Asia identifies sixty emerging technologies with the potential to significantly improve agricultural productivity in sub-Saharan Africa and South Asia. Eighteen technologies are recommended for immediate development or further exploration. Scientists from all backgrounds have an opportunity to become involved in bringing these and other technologies to fruition. The opportunities suggested in this book offer new approaches that can synergize with each other and with many other activities to transform agriculture in sub-Saharan Africa and South Asia.

American Book Publishing Record

American Book Publishing Record
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies
A Book

by Manmohan Singh,Maya Salnikova

  • Publisher : Academic Press
  • Release : 2014-12-30
  • Pages : 520
  • ISBN : 012416661X
  • Language : En, Es, Fr & De
GET BOOK

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies. Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapy Highlights novel cases from current clinical trials as well as marketed products Reviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Immunopathology in Toxicology and Drug Development

Immunopathology in Toxicology and Drug Development
Volume 2, Organ Systems

by George A. Parker

  • Publisher : Springer
  • Release : 2017-03-27
  • Pages : 826
  • ISBN : 3319473859
  • Language : En, Es, Fr & De
GET BOOK

This book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system–based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.

Fundamentals of Food Biotechnology

Fundamentals of Food Biotechnology
A Book

by Byong H. Lee

  • Publisher : John Wiley & Sons
  • Release : 2015-02-16
  • Pages : 544
  • ISBN : 1118384954
  • Language : En, Es, Fr & De
GET BOOK

Food biotechnology is the application of modern biotechnological techniques to the manufacture and processing of food, for example through fermentation of food (which is the oldest biotechnological process) and food additives, as well as plant and animal cell cultures. New developments in fermentation and enzyme technological processes, molecular thermodynamics, genetic engineering, protein engineering, metabolic engineering, bioengineering, and processes involving monoclonal antibodies, nanobiotechnology and quorum sensing have introduced exciting new dimensions to food biotechnology, a burgeoning field that transcends many scientific disciplines. Fundamentals of Food Biotechnology, 2nd edition is based on the author's 25 years of experience teaching on a food biotechnology course at McGill University in Canada. The book will appeal to professional food scientists as well as graduate and advanced undergraduate students by addressing the latest exciting food biotechnology research in areas such as genetically modified foods (GMOs), bioenergy, bioplastics, functional foods/nutraceuticals, nanobiotechnology, quorum sensing and quenching. In addition, cloning techniques for bacterial and yeast enzymes are included in a "New Trends and Tools" section and selected references, questions and answers appear at the end of each chapter. This new edition has been comprehensively rewritten and restructured to reflect the new technologies, products and trends that have emerged since the original book. Many new aspects highlight the short and longer term commercial potential of food biotechnology.

Bioinformatics for Vaccinology

Bioinformatics for Vaccinology
A Book

by Darren R. Flower

  • Publisher : Wiley
  • Release : 2008-12-15
  • Pages : 312
  • ISBN : 9780470027110
  • Language : En, Es, Fr & De
GET BOOK

“… this book was written from start to finish by one extremely dedicated and erudite individual. The author has done an excellent job of covering the many topics that fall under the umbrella of computational biology for vaccine design, demonstrating an admirable command of subject matter in fields as disparate as object-oriented databases and regulation of T cell response. Simply put, it has just the right breadth and depth, and it reads well. In fact, readability is one of its virtues—making the book enticing and useful, all at once…” Human Vaccines, 2010 "... This book has several strong points. Although there are many textbooks that deal with vaccinology, few attempts have been made to bring together descriptions of vaccines in history, basic bioinformatics, various computational solutions and challenges in vaccinology, detailed experimental methodologies, and cutting-edge technologies... This book may well serve as a first line of reference for all biologists and computer scientists..." –Virology Journal, 2009 Vaccines have probably saved more lives and reduced suffering in a greater number of people than any other medical intervention in human history, succeeding in eradicating smallpox and significantly reducing the mortality and incidence of other diseases. However, with the emergence of diseases such as SARS and the threat of biological warfare, vaccination has once again become a topic of major interest in public health. Vaccinology now has at its disposal an array of post-genomic approaches of great power. None has a more persuasive potential impact than the application of computational informatics to vaccine discovery; the recent expansion in genome data and the parallel increase in cheap computing power have placed the bioinformatics exploration of pathogen genomes centre stage for vaccine researchers. This is the first book to address the area of bioinformatics as applied to rational vaccine design, discussing the ways in which bioinformatics can contribute to improved vaccine development by introducing the subject of harnessing the mathematical and computing power inherent in bioinformatics to the study of vaccinology putting it into a historical and societal context, and exploring the scope of its methods and applications. Bioinformatics for Vaccinology is a one-stop introduction to computational vaccinology. It will be of particular interest to bioinformaticians with an interest in immunology, as well as to immunologists, and other biologists who need to understand how advances in theoretical and computational immunobiology can transform their working practices.