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Improving the Therapeutic Ratio in Head and Neck Cancer

Improving the Therapeutic Ratio in Head and Neck Cancer
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-10-04
  • Pages : 376
  • ISBN : 0128178698
  • Language : En, Es, Fr & De
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Improving the Therapeutic Ratio in Head and Neck Cancer provides a complete review of current approaches to modulating therapeutic sensitivity in head and neck cancer. It presents a broad background of current approaches and by highlighting the potential for clinical translational, introduces a roadmap for how to move promising preclinical findings into the clinic. The book discusses topics such as immunotherapy and molecularly targeted therapies in head and neck cancer, PI3k/mTOR pathway, autophagy inhibition to sensitize HNC to radiation and chemotherapy, TAM and Eph/Ephrin family proteins and metabolic reprogramming to modulate therapeutic sensitivity. Additionally, it details approaches to improve the response to immunotherapy, and Chk1/2 inhibition in radiation and cetuximab resistance. This book is a valuable source to head and neck cancer researchers and advanced students, and to those studying specific approaches in other model systems and disease sites. Provides key scientific background for clinicians when developing novel clinical trials and important examples for basic scientists of the types of work required to move a concept from the lab to the clinic Presents consistent pathway diagrams in each chapter, thus making it easier to understand complicated pathways Includes chapter summaries of the critical next steps needed to move studies from their current state into practice changing clinical data

Increasing the Therapeutic Ratio of Radiotherapy

Increasing the Therapeutic Ratio of Radiotherapy
A Book

by Philip J. Tofilon,Kevin Camphausen

  • Publisher : Springer
  • Release : 2016-11-21
  • Pages : 280
  • ISBN : 3319408542
  • Language : En, Es, Fr & De
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Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the variety of disparate approaches available for potentially improving the efficacy of radiotherapy, which may then stimulate discussion across disciplines and foster further translational investigations. Although a goal of each chapter will be to highlight advances within an approach, of equal importance will be the delineation of barriers to successful clinical application and how to overcome or minimize such impediments. Along these lines, because therapeutic ratio incorporates both tumor and normal tissue radio response, a point of emphasis will be the mechanistic rationale for selectively modifying tumor (sensitization) or normal cells (protection). Finally, whereas the literature is replete with studies describing potential targets/strategies for increasing the therapeutic ratio for radiotherapy, this book will focus on those supported by in vivo data consistent with impending translational application along with those that are already being evaluated in the clinic.

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment

Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
A Book

by Mitchell S. Anscher,Kristoffer Valerie

  • Publisher : Springer
  • Release : 2016-10-20
  • Pages : 305
  • ISBN : 331945594X
  • Language : En, Es, Fr & De
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This volume will describe recent progress and future directions in radiation oncology and biology research, focusing on strategies designed to improve disease control and reduce the risk of long-term adverse effects on patients. As more and more patients are becoming long-term survivors, this strategy will become increasingly important--in radiation oncology and throughout the field of oncology.

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy

Antiangiogenic Drugs as Chemosensitizers in Cancer Therapy
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2022-01-26
  • Pages : 294
  • ISBN : 0323905560
  • Language : En, Es, Fr & De
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Anti-angiogenic Drugs as Chemosensitizers in Cancer Therapy, Volume 19 focuses on the use of anti-angiogenic drugs as sensitizers of tumor cells to the inhibitory activity of antitumor agents. Conventional and novel anti-neoplastic agents (cytotoxic molecules, hormones/antihormones, immunotherapies) are taken into consideration, along with advances made in combination therapies. The book encompasses examples of studies on the use of antiangiogenic compounds—molecules that inhibit the growth of vessels inside a tumor—together with antineoplastic drugs in order to sensitize the resistant tumor to their cytotoxic effects, thus reducing adverse side reactions and resistance and improving the therapeutic response of cancer patients. In addition, the book discusses clinical applications in various types of cancer, such as colorectal, lung, breast, renal, genitourinary, skin and brain and circulating tumors. It is a valuable resource for cancer researchers, clinicians and members of the biomedical field who wants to be up-to-date on the most recent and promising developments in the field. Provides the most updated reviews on anti-angiogenic drugs as chemosensitizers by leaders in the field Encompasses summarized tables and schematic diagrams in each chapter to give a clear overview on recent findings in a didactic manner Brings not only relevant information of current research but also new ideas and suggestions for further investigations to help advance the field

pH-Interfering Agents as Chemosensitizers in Cancer Therapy

pH-Interfering Agents as Chemosensitizers in Cancer Therapy
A Book

by Claudiu Supuran,Simone Carradori

  • Publisher : Academic Press
  • Release : 2020-09-15
  • Pages : 228
  • ISBN : 0128209283
  • Language : En, Es, Fr & De
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pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. The continuous discovery and assessment of the role played by old/new synthetic drugs, natural compounds and technological applications has led to the urgent need of classification in terms of biological activity, mechanism of action, clinical outcomes, cancer cell lines sensible to the treatment, and potentialities to better orient research in this field. Moreover, all the aspects relevant for medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, and molecular modeling studies) are strictly considered. Presents a broad view of the topic according to a medicinal chemistry-based approach beyond syntheses and biological assays, focusing on SAR studies, chemoinformatic, drug targeting and molecular modeling Explains the mechanism of action of the chemosensitizers by means of schemes and figures to facilitate comprehension Discusses novel targets to explore new possibilities that enhance research in the field

Principles and Practice of Head and Neck Surgery and Oncology, Second Edition

Principles and Practice of Head and Neck Surgery and Oncology, Second Edition
A Book

by Peter H. Rhys Evans,Paul Q. Montgomery,Patrick J. Gullane

  • Publisher : CRC Press
  • Release : 2009-07-09
  • Pages : 658
  • ISBN : 1439825467
  • Language : En, Es, Fr & De
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This second edition of an award winning title has been thoroughly updated by a team of world leading head and neck surgeons, oncologists and allied healthcare professionals. Principles and Practice of Head & Neck Surgery and Oncology, 2nd edition is a comprehensive evidence-based account of the current scientific knowledge about head and neck tumors and their management. This book, with over 570 colour images, will provide a valuable source of knowledge and reference for all established specialists and trainees entrusted with the care of patients with head and neck tumors.

Carcinomas of the Head and Neck

Carcinomas of the Head and Neck
Evaluation and Management

by Charlotte Jacobs

  • Publisher : Springer Science & Business Media
  • Release : 1990-07-31
  • Pages : 292
  • ISBN : 9780792306689
  • Language : En, Es, Fr & De
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It was not too many years ago that the role of chemotherapy for head and neck cancer consisted of single-agent methotrexate for selected patients with recurrent disease. In the past decade, multiple new agents, high-dose chemotherapy, combinations, and intra-arterial approaches have been used for the patient with recurrent disease. Wheeler critically assesses the current status of these approaches. When oncologists began testing chemotherapy in the combined modality approach, trials consisted of induction chemotherapy and use of single agents as radiosensitizers. Although a great deal has been learned from these trials, benefit in terms of survival has been marginal. Even more promising may be the concomitant use of combination chemo therapy and radiation. Taylor describes the encouraging results as well as the potential. Induction chemotherapy may have a second important goal in addition to improving curability-it could be used for organ preservation. Dimery et al., present the background for this approach in the patient with laryngeal cancer as well as a description of their randomized trial for voice preservation. Head and neck squamous cancers are a heterogeneous group of diseases, and surgeons have long sought parameters that will help predict outcome.

Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition

Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-07-22
  • Pages : 423
  • ISBN : 1481659146
  • Language : En, Es, Fr & De
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Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Head and Neck Cancer: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Head and Neck Surgery and Oncology

Head and Neck Surgery and Oncology
A Book

by Jatin P. Shah,Snehal G. Patel,Bhuvanesh Singh

  • Publisher : Elsevier Health Sciences
  • Release : 2012
  • Pages : 838
  • ISBN : 0323055893
  • Language : En, Es, Fr & De
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Head and Neck Surgery and Oncology, by Drs. Jatin P. Shah Snehal G. Patel, and Bhuvanesh Singh, offers you authoritative, multidisciplinary guidance on the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer. With this medical reference book, you'll have all the help you need to offer your patients the best possible prognoses and to optimally preserve and restore form and function. Overcome any challenge in head and neck surgery with comprehensive coverage of the scalp, skull base, paranasal sinuses, oral cavity, pharynx, larynx, cervical lymph nodes, thyroid, salivary glands, and soft tissue and bone tumors - from incidence, diagnosis, and work up through treatment planning, operative techniques, rehabilitation, and outcomes. Increase your understanding of head and neck oncology with this completely reorganized edition, presenting a uniform flow of topics, which includes the latest information on Diagnostic approaches, staging, algorithms for selection of therapy, and outcomes of treatment for head and neck tumors. Offer today's best treatment options with outcomes of therapy data from the NCDB, institutional data from MSKCC, and evidence-based information Diagnose patients using the latest advances in radiographic imaging, diagnostic pathology and molecular biology. Take fullest advantage of every multidisciplinary management approach available including radiation oncology, medical oncology (including targeted therapies), maxillofacial prosthodontics and dental oncology, surgical procedures for salvage of recurrences after chemoradiation therapy, and rehabilitation measures to improve functional outcomes (speech, swallowing, etc.). Understand the nuances of day-to-day practical care of patients with basic operating room techniques and technology, intraoperative decisions, and post operative care for patients undergoing head and neck surgery. Know what to look for and how to proceed with sequential operative photographs of each surgical procedure and full-color artwork to demonstrate anatomical relationships. Particular emphasis is placed on surgical management of patients after chemo-radiotherapy, reflecting the changing paradigms in head and neck oncology and the special challenges that confront modern day head and neck surgeons. This comprehensive text will assist in improved survival and preserving and restoring form and function with the surgical treatment of tumors.

Oral, Head and Neck Oncology and Reconstructive Surgery - E-Book

Oral, Head and Neck Oncology and Reconstructive Surgery - E-Book
A Book

by R. Bryan Bell,Peter A. Andersen,Rui Fernandes

  • Publisher : Elsevier Health Sciences
  • Release : 2017-08-25
  • Pages : 968
  • ISBN : 0323265693
  • Language : En, Es, Fr & De
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Oral, Head and Neck Oncology and Reconstructive Surgery is the first multidisciplinary text to provide readers with a system for managing adult head and neck cancers based upon stage. Using an evidence-based approach to the management and treatment of a wide variety of clinical conditions, the extensive experience of the author and contributors in head and neck surgery and oncology are highlighted throughout the text. This includes computer aided surgical simulation, intraoperative navigation, robotic surgery, endoscopic surgery, microvascular reconstructive surgery, molecular science, and tumor immunology. In addition, high quality photos and illustrations are included, which are easily accessible on mobile devices. Management protocols and outcomes assessment provide clear guidelines for managing problems related to adult head and neck oncology and reconstructive surgery. State-of-the art guidance by recognized experts details current techniques as well as technological advances in head and neck/cranio-maxillofacial surgery and oncology. Evidence-based content details the latest diagnostic and therapeutic options for treating a wide-variety of clinical problems with an emphasis on surgical technique and outcomes. Multidisciplinary approach reflects best practices in managing head and neck oncology and cranio-maxillofacial surgery. 900 highly detailed images clearly demonstrate pathologies and procedures. Designed for the modern classroom which lets you access important information anywhere through mobile tablets and smart phones.

Stereotactic Body Radiotherapy

Stereotactic Body Radiotherapy
A Practical Guide

by Andrew Gaya,Anand Mahadevan

  • Publisher : Springer
  • Release : 2015-01-24
  • Pages : 332
  • ISBN : 0857295977
  • Language : En, Es, Fr & De
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This is a single, comprehensive handbook for clinical oncology trainees and consultants, covering the basic aspects of stereotactic radiotherapy systems and treatment.

Topics in Anti-Cancer Research

Topics in Anti-Cancer Research
Volume: 1

by Atta-ur-Rahman,Khurshid Zaman

  • Publisher : Bentham Science Publishers
  • Release : 2012-11-19
  • Pages : 424
  • ISBN : 1608054780
  • Language : En, Es, Fr & De
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The Topics in Anti-Cancer Research e-Book series covers important advances on both experimental (preclinical) and clinical cancer research in drug development. Major developments in the fields of oncology are covered including mechanisms, tumor and stem cell biology, metastasis, tumor suppressors, cancer drug targets, drug clinical trials, cellular and molecular pathology, genomics and genetics, diagnostics, translational therapeutics, tumor immunology, and cancer prevention and epidemiology. Topics in Anti-Cancer Research is an essential e-book series for oncologists, pharmaceutical scientists, clinicians, and to researchers in other related disciplines.

Jatin Shah's Head and Neck Surgery and Oncology E-Book

Jatin Shah's Head and Neck Surgery and Oncology E-Book
A Book

by Jatin P. Shah,Snehal G. Patel,Bhuvanesh Singh,Richard Wong

  • Publisher : Elsevier Health Sciences
  • Release : 2019-04-09
  • Pages : 842
  • ISBN : 0323417892
  • Language : En, Es, Fr & De
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Providing practical, multidisciplinary coverage of the latest diagnostic and multidisciplinary therapeutic approaches for head and neck cancer, the 5th Edition of this award-winning text helps you achieve the best possible surgical outcomes and preserve and restore form and function. Internationally renowned surgeon Dr. Jatin P. Shah, joined by colleagues Snehal G. Patel, Bhuvanesh Singh, and Richard Wong, guides you step by step through every aspect of this challenging field, helping you take advantage of every multidisciplinary management approach available for your patients. Offers complete coverage of the scalp, skull base, paranasal sinuses, oral cavity, pharynx, larynx, cervical lymph nodes, thyroid, salivary glands, and soft tissue and bone tumors - from incidence, diagnosis, and work up through treatment planning, operative techniques, rehabilitation, and outcomes. Features new diagnostic approaches, staging, algorithmic thought processes for therapy selection, and outcomes of treatment for head and neck tumors, allowing for a better overall understanding of head and neck oncology. Includes new information on multimodal management of head and neck cancer; a new Radiation Therapy Glossary; and hundreds of new surgical photographs presented in sequential order from the surgeon's point of view. Provides outcomes of therapy data from the NCDB, institutional data from MSKCC, and evidence-based information throughout. Covers key topics such as radiation oncology, medical oncology including targeted therapies, and maxillofacial prosthodontics and dental oncology. Addresses the day-to-day, practical care of patients with basic operating room techniques and technology, intraoperative decisions, and post-operative care for patients undergoing head and neck surgery.

Head and Neck Cancer

Head and Neck Cancer
Multimodality Management

by Jacques Bernier

  • Publisher : Springer Science & Business Media
  • Release : 2011-06-15
  • Pages : 709
  • ISBN : 1441994645
  • Language : En, Es, Fr & De
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In recent years, great advances in translational research have led to new paradigms in the treatment of cancers of the head and neck. Written by leading international physicians and investigators, this innovative multi-disciplinary book presents the most up-to-date research and clinical approaches. Coverage is given to progress in a variety of clinical settings, including programs of organ and function preservation, curative treatments, unresectable disease, adjuvant treatments in high-risk patients, and recurrent/metastatic disease. Complementary to the techniques of surgery, radiotherapy, and systemic treatments, the authors present data on epidemiology, molecular pathology, normal tissue complications, rehabilitation, palliative care, and treatment in the elderly. State-of-the-art functional imaging is elucidated; and the latest developments in high precision techniques in irradiation, sequencing of chemo- and radiotherapy, as well as the integration of biomolecular therapies into cytotoxic treatments are explored.

Radiotherapy and Clinical Radiobiology of Head and Neck Cancer

Radiotherapy and Clinical Radiobiology of Head and Neck Cancer
A Book

by Loredana G. Marcu,Iuliana Toma-Dasu,Alexandru Dasu,Claes Mercke

  • Publisher : CRC Press
  • Release : 2018-05-15
  • Pages : 220
  • ISBN : 135100199X
  • Language : En, Es, Fr & De
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Common factors that lead to treatment failure in head and neck cancer are the lack of tumour oxygenation, the accelerated division of cancer cells during treatment, and radioresistance. These tumour-related challenges and possible ways to overcome them are covered in this book, authored by three medical physicists and a clinical oncologist who explain how different radiobiological findings have led to the development of various treatment techniques for head and neck cancer. Novel treatment techniques as supported by current scientific evidence are comprehensively explored, as well as the major challenges that arise in the retreatment of patients who have already undergone a form of radiotherapy for primary head and neck cancer. Features: Uses an interdisciplinary approach, encompassing clinical aspects of radiotherapy, radiation biology, and medical physics Applies content by relating all radiobiological characteristics to their respective clinical implications Explains the radiobiological rationale for all previous and current clinical trials for head and neck cancer

Squamous Cell Head and Neck Cancer

Squamous Cell Head and Neck Cancer
Recent Clinical Progress and Prospects for the Future

by David J. Adelstein

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-06
  • Pages : 358
  • ISBN : 1592599389
  • Language : En, Es, Fr & De
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Leading expert physicians and investigators from around the world review the state-of-the-art in the management of squamous cell head and neck cancer, with emphasis on coordinating different treatment modalities. The authors address several surgical issues, including laser-based surgery, larynx preservation approaches, salvage surgery, and neck management after non-operative treatment. They also discuss definitive radiation for larynx cancer, brachytherapy, altered fractionation radiation, intensity modulated radiation therapy, and the importance of tumor hypoxia, as well as the role of chemotherapy in sequential, concurrent, and adjuvant multi-modality treatment schedules. Other topics of special interest include targeted and gene therapies, multimodality management of nasopharyngeal cancer, chemoprevention, toxicity modification, quality of life outcomes, symptom palliation, and epidemiology.

Leibel and Phillips Textbook of Radiation Oncology - E-Book

Leibel and Phillips Textbook of Radiation Oncology - E-Book
Expert Consult

by Richard Hoppe,Theodore L. Phillips,Mack Roach

  • Publisher : Elsevier Health Sciences
  • Release : 2010-09-09
  • Pages : 1664
  • ISBN : 1437737757
  • Language : En, Es, Fr & De
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Stay on top of the latest scientific and therapeutic advances with the new edition of Leibel and Phillips Textbook of Radiation Oncology. Dr. Theodore L. Phillips, in collaboration with two new authors, Drs. Richard Hoppe and Mack Roach, offers a multidisciplinary look at the presentation of uniform treatment philosophies for cancer patients emphasizing the "treat for cure" philosophy. You can also explore the implementation of new imaging techniques to locate and treat tumors, new molecularly targeted therapies, and new types of treatment delivery. Supplement your reading with online access to the complete contents of the book, a downloadable image library, and more at expertconsult.com. Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text. Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more. Use new imaging techniques to anatomically locate tumors before and during treatment. Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology. Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs. Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.

Radiobiology Self-Assessment Guide

Radiobiology Self-Assessment Guide
A Book

by Jennifer Yu, MD, PhD,Mohamed Abazeed, MD, PhD

  • Publisher : Springer Publishing Company
  • Release : 2016-11-03
  • Pages : 520
  • ISBN : 1617052914
  • Language : En, Es, Fr & De
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Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute. Key Features: Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents

Biomedical Physics in Radiotherapy for Cancer

Biomedical Physics in Radiotherapy for Cancer
A Book

by Loredana Marcu,Eva Bezak,B. J. Allen

  • Publisher : CSIRO PUBLISHING
  • Release : 2012
  • Pages : 430
  • ISBN : 0643094040
  • Language : En, Es, Fr & De
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The scientific and clinical foundations of Radiation Therapy are cross-disciplinary. This book endeavours to bring together the physics, the radiobiology, the main clinical aspects as well as available clinical evidence behind Radiation Therapy, presenting mutual relationships between these disciplines and their role in the advancements of radiation oncology.

Treatment of Cancer Fifth Edition

Treatment of Cancer Fifth Edition
A Book

by Pat Price,Karol Sikora,Tim Illidge

  • Publisher : CRC Press
  • Release : 2008-05-30
  • Pages : 1488
  • ISBN : 1444109782
  • Language : En, Es, Fr & De
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Since the first edition was published in 1982, Treatment of Cancer has become a standard text for postgraduate physicians in the UK and beyond, providing all information necessary for modern cancer management in one comprehensive but accessible volume. By inviting experts from a number of disciplines to share their knowledge, the editors have succeeded in delivering a truly integrated approach to the care of the patient with cancer. This fifth edition adopts the successful structure of previous editions, whilst being thoroughly revised and updated, and with several completely new chapters, covering important topics such as drug development, cancer prevention, and economics of cancer care, as well as treatments such as radioimmunotherapy, biological therapies and antibody therapy. Part One considers the scientific basis and fundamental principles underlying cancer treatment and examines the likely developments that will occur over the next decade at the leading edge of oncology. Part Two is divided into two sections; the first covering general issues of cancer management, including planning techniques, concomitent chemoradiotherapy, surgical oncology and palliative care; and the second using a system-based approach to cover the clinical aspects and management plans for the whole spectrum of malignant disease. Treatment of Cancer surpasses other oncology texts in condensing the essential information for exemplary cancer care into one readable and accessible guide, and will be an invaluable addition to the bookshelves of the busy oncologist in training or in practice.