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Industrial Process Scale-up

Industrial Process Scale-up
A Practical Innovation Guide from Idea to Commercial Implementation

by Jan Harmsen

  • Publisher : Elsevier
  • Release : 2013-04-25
  • Pages : 112
  • ISBN : 0444627391
  • Language : En, Es, Fr & De
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This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale-up Methodology for Chemical Processes

Scale-up Methodology for Chemical Processes
A Book

by Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

  • Publisher : Editions TECHNIP
  • Release : 1993
  • Pages : 240
  • ISBN : 9782710806462
  • Language : En, Es, Fr & De
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Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scaleup and Design of Industrial Mixing Processes

Scaleup and Design of Industrial Mixing Processes
A Book

by Gary B. Tatterson

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 392
  • ISBN : 9780972663519
  • Language : En, Es, Fr & De
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Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Process Understanding

Process Understanding
For Scale-Up and Manufacture of Active Ingredients

by Ian Houson

  • Publisher : John Wiley & Sons
  • Release : 2011-06-09
  • Pages : 370
  • ISBN : 3527637168
  • Language : En, Es, Fr & De
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Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Pharmaceutical Process Scale-Up, Third Edition

Pharmaceutical Process Scale-Up, Third Edition
A Book

by Michael Levin

  • Publisher : CRC Press
  • Release : 2011-02-02
  • Pages : 530
  • ISBN : 9781616310011
  • Language : En, Es, Fr & De
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The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes: New material on tableting scale-up and compaction. Regulatory appendices that cover FDA and EU Guidelines. New chapters on risk evaluation and validation as related to scale-up. Practical advice on scale-up solutions from world renowned experts in the field. Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

Pharmaceutical Process Scale-Up

Pharmaceutical Process Scale-Up
A Book

by Michael Levin

  • Publisher : CRC Press
  • Release : 2001-12-12
  • Pages : 584
  • ISBN : 082474196X
  • Language : En, Es, Fr & De
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Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating and regulatory requirements for scale-up and postapproval changes. Drawing on the experience of twenty contributing researchers, the book employs dimensional analysis as a unified scientific approach to quantify similar processes on different scales.

Pharmaceutical Process Scale-Up, Second Edition

Pharmaceutical Process Scale-Up, Second Edition
A Book

by Michael Levin

  • Publisher : Informa Health Care
  • Release : 2005-10-18
  • Pages : 576
  • ISBN : 9781574448764
  • Language : En, Es, Fr & De
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Keeping pace with the increased influence of PAT in the pharmaceutical industry, this completely updated reference spans the latest research and regulations, technologies, and expert solutions for every significant aspect of pharmaceutical process scale-up-clearly introducing readers to the theoretical concept of dimensional analysis to quantify similar processes on varying scales.

Advances in Food and Nutrition Research

Advances in Food and Nutrition Research
A Book

by Francisco J. Barba

  • Publisher : Academic Press
  • Release : 2020-06
  • Pages : 230
  • ISBN : 0128202165
  • Language : En, Es, Fr & De
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Aquaculture and By-products: Challenges and Opportunities, Volume 92 in the Advances in Food and Nutrition Research series, explores the potential use of aquaculture and by-products as sources of proteins and bioactive compounds. Alternative extraction techniques to obtain, isolate and purify proteins and bioactive from aquaculture and by-products are thoroughly discussed. Chapters in this new volume include Alternative extraction techniques to obtain, isolate and purify proteins and bioactive from aquaculture and by-products, Development of new food and pharmaceutical products: Nutraceuticals and food additives, Evaluation of the protein and bioactive compound bioaccessibility/bioavailability and citotoxicity of the extracts obtained from aquaculture and by-products, and more.

Plants

Plants
The Potentials for Extracting Protein, Medicines, and Other Useful Chemicals : Workshop Proceedings

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1983
  • Pages : 252
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Process Scale Bioseparations for the Biopharmaceutical Industry

Process Scale Bioseparations for the Biopharmaceutical Industry
A Book

by Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam

  • Publisher : CRC Press
  • Release : 2006-07-07
  • Pages : 575
  • ISBN : 1420016024
  • Language : En, Es, Fr & De
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The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends. Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

Scaling Up

Scaling Up
Science, Engineering, and the American Chemical Industry

by John A. Heitmann

  • Publisher : Chemical Heritage Foundation
  • Release : 2005-06
  • Pages : 24
  • ISBN : 9780941901017
  • Language : En, Es, Fr & De
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This tribute to the engineers who transformed laboratory reactions into large production facilities focuses on petroleum refining and penicillin production. The book accompanies CHF's traveling exhibit by the same name.

Pharmaceutical Inhalation Aerosol Technology, Third Edition

Pharmaceutical Inhalation Aerosol Technology, Third Edition
A Book

by Anthony J. Hickey,Sandro R. da Rocha

  • Publisher : CRC Press
  • Release : 2019-03-26
  • Pages : 730
  • ISBN : 0429619561
  • Language : En, Es, Fr & De
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This fully revised and updated third edition of Pharmaceutical Inhalation Aerosol Technology encompasses the scientific and technical foundation for the rationale, design, componentry, assembly and quality performance metrics of therapeutic inhalers in their delivery of pharmaceutical aerosols to treat symptoms or the underlying causes of disease. It focuses on the importance of pharmaceutical engineering as a foundational element of all inhaler products and their application to pulmonary drug delivery. The expanded scope considers previously unaddressed aspects of pharmaceutical inhalation aerosol technology and the patient interface by including aerosol delivery, lung deposition and clearance that are used as measures of effective dose delivery.

Chemical Engineering Progress

Chemical Engineering Progress
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chemical Engineering in the Pharmaceutical Industry

Chemical Engineering in the Pharmaceutical Industry
Drug Product Design, Development, and Modeling

by Mary T. am Ende,David J. am Ende

  • Publisher : John Wiley & Sons
  • Release : 2019-04-09
  • Pages : 688
  • ISBN : 1119285496
  • Language : En, Es, Fr & De
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A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.

Encyclopedia of Physical Science and Technology

Encyclopedia of Physical Science and Technology
A Book

by Robert Allen Meyers

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 871
  • ISBN : 9780122274190
  • Language : En, Es, Fr & De
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Following in the footsteps of the earlier editions, hundreds of the most respected scientists and engineers participated in the creation of this new edition, including many Nobel Laureates. The articles are in-depth, yet accessible, and address all of the key areas of physical science--including aeronautics, astronomy, chemistry, communications, computers, earth sciences, electronics, engineering, materials science, mathematics, nuclear technology, physics, power systems, propulsion, and space technology. (Midwest).

Chilled Ammonia Process Scale-up and Lessons Learned

Chilled Ammonia Process Scale-up and Lessons Learned
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: The GE Chilled Ammonia Process (CAP) is a post combustion CO2 capture technology that produces a high purity CO2 product stream that can be utilized in the existing and new markets. The development of the CAP technology began with laboratory bench-scale experiments to confirm that aqueous ammonia solution effectively absorbs CO2 with sufficiently low vapor phase ammonia emissions at reduced temperatures. From these results, a technology development program was initiated to scale-up and validate the process for commercialization. The approach taken here is illustrative of industrial scale process development and improvement. For the CAP CO2 capture technology, the development effort involved an iterative approach as information from the different development stages was obtained to set environmental & economic targets, develop predictive tools and models for process optimization, and to support validation efforts at operating facilities. Over the course of the program, the technology was successfully tested on flue gasses produced from coal, oil, and natural gas combustion, in addition to flue gas produced from refinery applications. Process know-how and operational experience was gained and together with validated data from bench-scale and pilot plant facilities was returned to push process design improvement and the development of predictive models. Currently, the CAP design is also modified and extended into applications involving Urea, Methanol, and Soda Ash Production. While many lessons learned and process improvement opportunities have been extracted from pilot plant and other test facilities, pilot plant results and process modeling studies are still unveiling potential for further improvement. Optimization and integration with the power generation facility occurred in the development phases of several FEED studies for large CCS plants. The CAP design is ready for a demonstration-scale project and now is much improved from the design that was tested originally at laboratory bench-scale. For example, the CAP scrubbing solution is now operated in a non-solids mode where precipitation is not a part of the overall operational strategy and the process flow scheme is now modified and improved from original flow schemes implemented at early pilot facilities to improve performance at reduced cost. This work summarizes the bench-scale, pilot-scale, and validation facility results and offers insights into the lessons learned and effort required bringing the technology into commercialization at an industrial scale. The lessons learned from each of the pilot plants at different sizes are illustrated and the associated impact of the results from each pilot plant in the current CAP product offering is also discussed. A summary of the important results from CAP test facilities including Stanford Research International (SRI), WE energies, EONCAP-Karlshamm, AEP Mountaineer, TCM and GE's pilot facility in Vaxjo, Sweden are presented. Distinguishing features of the GE CAP are provided drawing comparison to open literature versions of ammonia based CO2 capture processes. Evolution of key performance parameters such as energy demand, product quality, solvent strength, process flow scheme, etc., at the different plant sizes are also discussed. In addition, the current state of development for extending the technology into areas where CO2 may be utilized productively are also be addressed in addition to the latest improvement concepts currently being studied on CAP. Finally, the paper will also summarize the advantages of CAP as compared to conventional amine based processes.

Hazards of Chemical Rockets and Propellants: Solid propellants and ingrediants

Hazards of Chemical Rockets and Propellants: Solid propellants and ingrediants
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Production technology of the materials used for nuclear energy

Production technology of the materials used for nuclear energy
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1956
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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AIChE Symposium Series

AIChE Symposium Series
A Book

by American Institute of Chemical Engineers

  • Publisher : Unknown Publisher
  • Release : 1972
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Solid/liquid Separation Equipment Scale-up

Solid/liquid Separation Equipment Scale-up
A Book

by Derek B. Purchas,Richard J. Wakeman

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 749
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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