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Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16

Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume 16
A Book

by James Galloway

  • Publisher : Handbook of Systemic Autoimmun
  • Release : 2020-03-16
  • Pages : 226
  • ISBN : 044464217X
  • Language : En, Es, Fr & De
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Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.

Pulmonary Involvement in Systemic Autoimmune Diseases

Pulmonary Involvement in Systemic Autoimmune Diseases
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2004-09-11
  • Pages : 314
  • ISBN : 0080515444
  • Language : En, Es, Fr & De
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In this book is found the information essential to diagnosing, managing and treating the lung complications of connective tissue diseases. This is a notoriously difficult area, which continues to puzzle clinicians, despite the fact that these disorders are increasingly frequent (as a result of longer survival in connective tissue disease). In separate chapters, the major connective tissue diseases are reviewed, with detailed discussion of a variety of lung abnormalities, including pleural disease, parenchymal lung disease and pulmonary vascular disease. There are also invaluable overviews of lung histological and CT appearances in these disorders, and a deeply insightful chapter on drug-induced lung disease in connective tissue disease. The emphasis in this book is on accuracy of evaluation and the construction of a logical management plan, based on disease severity and intrinsic progressiveness.

The Digestive Involvement in Systemic Autoimmune Diseases

The Digestive Involvement in Systemic Autoimmune Diseases
A Book

by Manuel Ramos-Casals,Munther Khamashta,Pilar Brito-Zeron,Fabiola Atzeni,Joan Rodes

  • Publisher : Elsevier
  • Release : 2017-01-18
  • Pages : 494
  • ISBN : 0444637176
  • Language : En, Es, Fr & De
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The Digestive System in Systemic Autoimmune Diseases, Second Edition, represents the state-of-the-art in the field of digestive disorders in the most common systemic autoimmune diseases. This volume consists of an introductory chapter on imaging techniques in digestive diseases, followed by eight chapters on digestive manifestations in specific systemic autoimmune diseases. The final five chapters deal with digestive diseases with an autoimmune pathogenesis and systemic manifestations. International in scope, the table of contents reads like a Who's who in clinical research on systemic autoimmune diseases. More than 20 contributors from the European Union, the United States, Mexico, and South Africa share their knowledge in this detailed volume. The book provides an overview of our current understanding of digestive disorders in the most common systemic autoimmune diseases. Completely updated, including five new chapters Presents up-to-date information, giving the reader easy access to individual topics in one place Written by leading international clinical and scientific experts on autoimmune and digestive diseases Provides a practical guide to the identification, diagnosis, and treatment of digestive involvement in patients with autoimmune diseases that will be useful for all medical specialties Includes several diseases and conditions not included in other texts, some of which have only recently emerged Designed to serve as a guide to clinical practice

Infections in Systemic Autoimmune Diseases: Risk Factors and Management

Infections in Systemic Autoimmune Diseases: Risk Factors and Management
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2020-03-08
  • Pages : 228
  • ISBN : 0444642188
  • Language : En, Es, Fr & De
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Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who’s who of clinical researchers in the field. Written by leading international clinical/surgical and scientific experts on Infection problems in systemic autoimmune diseases Provides a practical guide to the safer treatment of infections in patients with autoimmune diseases Includes a number of problems and recommendation that cannot be found in other books Designed as a ‘guide to clinical practice’ for management and risk interventions required by patients with SAD’s

The Skin in Systemic Autoimmune Diseases

The Skin in Systemic Autoimmune Diseases
A Book

by Piercarlo Sarzi-Puttini

  • Publisher : Elsevier
  • Release : 2006-01-26
  • Pages : 358
  • ISBN : 9780080461922
  • Language : En, Es, Fr & De
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This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy

The Kidney in Systemic Autoimmune Diseases

The Kidney in Systemic Autoimmune Diseases
A Book

by Justin C Mason,Charles Pusey

  • Publisher : Elsevier
  • Release : 2007-12-14
  • Pages : 432
  • ISBN : 9780080557045
  • Language : En, Es, Fr & De
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This volume brings together an international group of clinicians and clinical scientists to contribute to a state-of the-art review of the underlying pathogenic mechanisms, methods of clinical assessment, classification and diagnosis of renal disease, combined with a detailed overview of treatment strategies. An essential reference source for all those involved with the care of patients with renal involvement in systemic autoimmune disease, and for those contributing to research into the underlying pathogenic mechanisms in these disorders.

Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases

Reproductive and Hormonal Aspects of Systemic Autoimmune Diseases
A Book

by Michael Lockshin,D. Ware Branch

  • Publisher : Gulf Professional Publishing
  • Release : 2006
  • Pages : 183
  • ISBN : 0444518010
  • Language : En, Es, Fr & De
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This volume of the Handbook of Systemic Autoimmune Diseases series represents a medical collaboration focusing primarily on female aspects of rheumatic diseases. This collaboration recognizes the need to understand and optimally manage the care of women with autoimmune conditions that may affect their reproduction and hormonal status. This handbook will prove useful to clinicians and researchers alike. It covers practical points, ranging from which anti-rheumatic medications are safe in pregnancy to how to counsel women with scleroderma contemplating pregnancy. * Authors share an academic interest in the unique relationship between being a woman and having an autoimmune disease * Touches on controversial topics, such as the mechanism of antiphospholipid-related fetal loss and whether or not non-steroidal anti-inflammatory agents should be used in pregnancy * Includes critical and balanced reviews of the controversial association between autoimmune disease and female infertility

Antiphospholipid Syndrome in Systemic Autoimmune Diseases

Antiphospholipid Syndrome in Systemic Autoimmune Diseases
A Book

by Ricard Cervera,Gerard Espinosa,Munther Khamashta

  • Publisher : Elsevier
  • Release : 2016-06-18
  • Pages : 326
  • ISBN : 0444636560
  • Language : En, Es, Fr & De
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Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics. Brings the reader up-to-date and allows easy access to individual topics in one place Written by a respected panel of distinguished physicians/scientists actively involved in the field of Antiphospholipid Syndrome Includes box summaries at the end of each chapter that highlight important topics Gives up-to-date, basic knowledge and a modern approach to diagnosis and therapy Provides a comprehensive review of this major disease Includes information on treatment options available

The Heart in Systemic Autoimmune Diseases

The Heart in Systemic Autoimmune Diseases
A Book

by Andrea Dorea

  • Publisher : Elsevier
  • Release : 2004-01-20
  • Pages : 276
  • ISBN : 9780080507965
  • Language : En, Es, Fr & De
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This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined. This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.

The Microbiome in Rheumatic Diseases and Infection

The Microbiome in Rheumatic Diseases and Infection
A Book

by Gaafar Ragab,T. Prescott Atkinson,Matthew L. Stoll

  • Publisher : Springer
  • Release : 2018-06-19
  • Pages : 490
  • ISBN : 3319790269
  • Language : En, Es, Fr & De
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This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

Vascular Manifestations of Systemic Autoimmune Diseases

Vascular Manifestations of Systemic Autoimmune Diseases
A Book

by Ronald A. Asherson,Ricard Cervera,Douglas A. Triplett,Steven B. Abramson

  • Publisher : CRC Press
  • Release : 2001-01-25
  • Pages : 624
  • ISBN : 9781420040395
  • Language : En, Es, Fr & De
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Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all

Pediatrics in Systemic Autoimmune Diseases

Pediatrics in Systemic Autoimmune Diseases
A Book

by Rolando Cimaz,Thomas J.A. Lehman

  • Publisher : Elsevier
  • Release : 2016-06-08
  • Pages : 606
  • ISBN : 0444635971
  • Language : En, Es, Fr & De
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Pediatrics in Systemic Autoimmune Diseases, Second Edition, provides a good starting point for physicians and scientists new to the field and for anyone looking for the most up-to-date summary of a particular disease. While many questions are answered, many more are raised for which we do not yet have the answers. The book provides inspiration to readers conducting their own research and helps to answer their questions. The care of children with systemic autoimmune diseases is moving forward at a rapid pace. The systemic autoimmune diseases of childhood have always represented a special problem for the physicians and scientists who care for the affected children and study their diseases. Some conditions, such as Kawasaki disease, are virtually unique to childhood, while systemic lupus erythematosus, progressive systemic sclerosis, and juvenile onset spondyloarthropathies may be thought of as the early onset of the same disease which is seen in adults. The autoinflammatory disorders appear to be of clear genetic origin, accounting for their frequent discovery in childhood. For many other conditions, such as juvenile dermatomyositis, the relationship between the conditions seen in children and that seen in adults is less certain. This book explores these phenomena, giving users a foundation on which to understand certain diseases. Includes completely updated chapters and five new chapters Explains the differences in systemic autoimmune diseases seen in children vs. those seen in adults Covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices, benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties Brings the reader up-to-date and allows easy access to individual topics in one place Provides the latest information available in a format that would give the clinician both a clear understanding of what has been done in the past and a scientific basis for deciding what to do for the next afflicted child in their care

Diagnostic Criteria in Autoimmune Diseases

Diagnostic Criteria in Autoimmune Diseases
A Book

by Yehuda Shoenfeld,Ricard Cervera,M. Eric Gershwin

  • Publisher : Springer Science & Business Media
  • Release : 2010-06-08
  • Pages : 593
  • ISBN : 9781603272858
  • Language : En, Es, Fr & De
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According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

Autoimmune Diseases

Autoimmune Diseases
Acute and Complex Situations

by Munther A Khamashta,Manuel Ramos-Casals

  • Publisher : Springer Science & Business Media
  • Release : 2011-05-26
  • Pages : 416
  • ISBN : 9780857293589
  • Language : En, Es, Fr & De
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Autoimmune Diseases: Acute and Complex Situations provides a detailed overview of conditions associated with autoimmune diseases that are considered either life-threatening or requiring complex management. These include abdominal pain, arthritis, cutaneous ulcers, gastrointestinal hemorrhage, epilepsy, pancreatitis, stroke and white-matter CNS lesions. Autoimmune Diseases: Acute and Complex Situations addresses the latest clinical and immunological prognostic factors that may help to identify patients at higher risk of developing potentially life-threatening involvement. This book comprehensively helps the reader to diagnose these patients, in whom an early therapeutic approach is essential. Autoimmune Diseases: Acute and Complex Situations is a valuable reference tool for rheumatologists, internists, immunologists, and all the specialists involved in the multidisciplinary care of patient with rheumatic and systemic autoimmune diseases.

Infection and Autoimmunity

Infection and Autoimmunity
A Book

by Yehuda Shoenfeld,Nancy Agmon-Levin,Noel R Rose

  • Publisher : Elsevier
  • Release : 2015-01-27
  • Pages : 1040
  • ISBN : 0444632727
  • Language : En, Es, Fr & De
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Autoimmune diseases are conditions where the immune system attacks the body organs instead of foreign invaders. This book deals with the various mechanisms by which infectious agents can trigger autoimmunity such as molecular mimicry and polyclonal activation. An overview is given with regard to bacteria, viruses, and parasites associated with autoimmunity, and a summary is given on classical autoimmune diseases and the infecting agents that can induce them. Includes completely updated and new chapters Brings the reader up to date and allows easy access to individual topics in one place Identifies infectious agents as pathogenic or protective in many autoimmune diseases

The Neurologic Involvement in Systemic Autoimmune Diseases

The Neurologic Involvement in Systemic Autoimmune Diseases
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2004-11-05
  • Pages : 296
  • ISBN : 9780080479682
  • Language : En, Es, Fr & De
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Systemic autoimmune diseases can affect both the central and peripheral nervous systems in a myriad of ways and through a heterogeneous number of mechanisms leading to many different clinical manifestations. As a result, neurological complications of these disorders can result in significant morbidity and mortality. Advances in the diagnosis, laboratory investigations, and management of these conditions has placed an increasing burden on the practicing clinician to correctly assess and treat these patients. This volume of the Handbook of the Systemic Autoimmune Diseases will help the clinician and researcher better understand the current concepts of nervous system involvement from systemic autoimmune disorders, recognize current approaches to diagnosis and treatment, current controversies, and areas that need significant research efforts. It is believed that providing this approach in a single volume will facilitate its use as a frequent resource for all those caring for or investigating these patients and their diseases. Each chapter follows a consistent outline to provide the reader with important and useful information in an easy-to-navigate manner and is also liberally referenced to provide more primary source material for further consideration. The standardized approach to each chapter will allow the reader to be able to compare and contrast more efficiently the neurological complications of the autoimmune diseases discussed.

The Autoimmune Diseases

The Autoimmune Diseases
A Book

by Ian R. Mackay,Noel R Rose

  • Publisher : Academic Press
  • Release : 2013-12-03
  • Pages : 1304
  • ISBN : 0123849306
  • Language : En, Es, Fr & De
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Since publication of the 4th Edition of The Autoimmune Diseases in 2006, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This fully revised 5th Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels and includes expanded coverage of autoinflammatory disease and autoimmune responses to tumors. Gives a thorough and an important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications, in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant

Drugs Targeting B-Cells in Autoimmune Diseases

Drugs Targeting B-Cells in Autoimmune Diseases
A Book

by Xavier Bosch,Manuel Ramos-Casals,Munther A Khamashta

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-22
  • Pages : 292
  • ISBN : 3034807066
  • Language : En, Es, Fr & De
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This book provides a detailed overview of B-cell directed therapies in patients with rheumatic and systemic autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, Sjögren syndrome, ANCA-associated vasculitis and cryoglobulinemia. Organ-specific autoimmune diseases are discussed with respect to the use of B-cell directed therapies in neurological autoimmune diseases and autoimmune cytopenias. Situations in which B-cell targeted therapy may be indicated are identified, thereby offering comprehensive support for therapeutic decisions on the basis of the latest published evidence. The book also offers a valuable reference tool for rheumatologists, internists, nephrologists, immunologists, and all specialists involved in the multidisciplinary care of patients with rheumatic and systemic autoimmune diseases.

Systemic Lupus Erythematosus

Systemic Lupus Erythematosus
A Book

by Caroline Gordon,David Isenberg

  • Publisher : Oxford University Press
  • Release : 2016-03-10
  • Pages : 170
  • ISBN : 0191059706
  • Language : En, Es, Fr & De
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Systemic Lupus Erythematosus (often abbreviated to SLE or lupus) is a systemic autoimmune disease that can affect any part of the body, causing the immune system to attack the body's cells and tissue, and resulting in inflammation and tissue damage. This new addition to the Oxford Rheumatology Library series provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications. It provides comprehensive but easy to assimilate reading for consultant rheumatologists, dermatologists, nephrologists, obstetricians and other specialists and their trainees, interested GPs, specialist nurses, and clinical trial teams both in hospitals and contract research organizations.

NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology

NETosis: At the Intersection of Cell Biology, Microbiology, and Immunology
A Book

by Mariana J. Kaplan,Marko Radic

  • Publisher : Frontiers E-books
  • Release : 2013-08-08
  • Pages : 129
  • ISBN : 2889191583
  • Language : En, Es, Fr & De
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NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.