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Inflammation and Natural Products

Inflammation and Natural Products
A Book

by Sreeraj Gopi,Augustine Amalraj,Ajaikumar B Kunnumakkara,Sabu Thomas

  • Publisher : Academic Press
  • Release : 2020-09-15
  • Pages : 435
  • ISBN : 9780128192184
  • Language : En, Es, Fr & De
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Inflammation and Natural Products: Recent Development and Current Status brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries. Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation

Discovery and Development of Anti-inflammatory Agents from Natural Products

Discovery and Development of Anti-inflammatory Agents from Natural Products
A Book

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2019-07-11
  • Pages : 332
  • ISBN : 0128169931
  • Language : En, Es, Fr & De
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Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Plant Natural Products for Human Health

Plant Natural Products for Human Health
A Book

by Chun-Tao Che,Hongjie Zhang

  • Publisher : MDPI
  • Release : 2019-03-21
  • Pages : 514
  • ISBN : 3038977128
  • Language : En, Es, Fr & De
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Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs. This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases

Novel Natural Products: Therapeutic Effects in Pain, Arthritis and Gastro-intestinal Diseases
A Book

by K. D. Rainsford,M. C. Powanda,M.W. Whitehouse

  • Publisher : Springer
  • Release : 2015-08-11
  • Pages : 286
  • ISBN : 9783034809269
  • Language : En, Es, Fr & De
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In recent years there have been a number of significant developments of natural products for the treatment of rheumatic diseases, pain and gastro-intestinal ulcers and inflammation. The volume covers some of these novel developments of natural products which are of current and future interest as therapies for the above-mentioned conditions. Most available volumes cover a wide range of biological and technicological aspects of natural products and their discovery, some involving synthesis and properties of chemical compounds. The difference in this volume is that the natural products have a focus on their therapeutic effects on pain, arthritic and gastrointestinal diseases. Some of the natural products covered are either at the experimental stage of development while others are well-established clinically-used products. Each has its own unique place in therapy.

Development of Food Chemistry, Natural Products, and Nutrition Research

Development of Food Chemistry, Natural Products, and Nutrition Research
A Book

by Antonello Santini ,Nicola Cicero

  • Publisher : MDPI
  • Release : 2020-11-13
  • Pages : 196
  • ISBN : 3039364618
  • Language : En, Es, Fr & De
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This Special Issue is dedicated to gathering the latest advances in the food sources, chemistry, analysis, composition, formulation, use, experience in clinical use, mechanisms of action, available data of nutraceuticals, and natural sources that represent a new frontier for therapy and provide valuable tools to reduce the costs for both environment and healthcare systems.

Functional Foods, Nutraceuticals and Natural Products

Functional Foods, Nutraceuticals and Natural Products
Concepts and Applications

by Dhiraj A. Vattem,Vatsala Maitin

  • Publisher : DEStech Publications, Inc
  • Release : 2015-10-06
  • Pages : 836
  • ISBN : 1605951013
  • Language : En, Es, Fr & De
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Bioactive ingredients in foods and their pharmacological and health effects. Functional foods and bioactives of microbial, plant and animal origin, including probiotics, herbs, spices, vegetables, specialty fruits, seafood and milk components. Impact on the microbiome, emerging metabolic pathways and prevention of chronic and infectious diseases.Techniques for functional food development and evaluation.Regulatory and safety considerations. This volume presents basic and advanced technical information on the sources, mechanisms and safety of food bioactives in the etiology and prevention of chronic and infectious diseases. In this context, it offers details useful not only for understanding but also improving the functionality of foods. It reviews advances in multiple phytochemicals and food ingredients known for positive effects on human physiology, including interactions with the human microbiome. Metabolomic and proteomic techniques are explored as ways of improving the understanding of mechanisms of action, and increasing the therapeutic effectiveness of selected food ingredients. Special attention is given to chemistry, molecular structure and pharmacological effects of bioactive ingredients. Bioactives from a wide range of foods are investigated, including pro- and prebiotics, fungi, yeasts, herbs, spices, fruits, vegetables, seafood and many more. The text provides systematic information needed to develop and validate commercial products incorporating functional ingredients.

The Benefits of Natural Products for Neurodegenerative Diseases

The Benefits of Natural Products for Neurodegenerative Diseases
A Book

by M. Mohamed Essa,Mohammed Akbar,Gilles Guillemin

  • Publisher : Springer
  • Release : 2016-09-20
  • Pages : 496
  • ISBN : 3319283839
  • Language : En, Es, Fr & De
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Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Medicinal Natural Products: A Disease-Focused Approach

Medicinal Natural Products: A Disease-Focused Approach
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-11-15
  • Pages : 310
  • ISBN : 0128210192
  • Language : En, Es, Fr & De
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Medicinal Natural Products: A Disease-Focused Approach, Volume 55 in the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition, with chapters in this new release covering Medicinal Natural Products - An Introduction, Anticancer Natural Products, Antimicrobial Natural Products, Antimalarial and Antiparasitic Natural Products, Anti-inflammatory Natural Products, Neuroprotective Natural Products, Hepatoprotective Natural Products, Nephroprotective Natural Products, Cancer Chemopreventive Natural Products, Antipsoriatic Natural Products, Medicinal Natural Products in Osteoporosis, Antidiabetic Natural Products, Anti-obesity Natural Products, and much more. Presents a disease-focused perspective Includes the latest on the medicinal chemistry of natural products Covers natural products in drug delivery

Inflammation and Natural Products

Inflammation and Natural Products
A Book

by Sreeraj Gopi,Augustine Amalraj,Ajaikumar B. Kunnumakkara,Sabu Thomas

  • Publisher : Academic Press
  • Release : 2021-01-29
  • Pages : 462
  • ISBN : 0128192194
  • Language : En, Es, Fr & De
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Inflammation and Natural Products brings together research in the area of the natural products and their anti-inflammatory action in medical, nutraceutical and food products, addressing specific chronic inflammatory diseases like cancer and the mechanistic aspects of the mode of action of some key natural products. Inflammation is a complicated process, driven by infection or injury or genetic changes, which results in triggering signalling cascades, activation of transcription factors, gene expression, increased levels of inflammatory enzymes, and release of various oxidants and pro-inflammatory molecules in inflammatory cells. Excessive oxidants and inflammatory mediators have a harmful effect on normal tissue, including toxicity, loss of barrier function, abnormal cell proliferation, inhibiting normal function of tissues and organs and finally leading to systemic disorders. The emerging development of natural product formulations utilizing the unique anti-inflammatory compounds such as polyphenols, polysaccharides, terpenes, fatty acids, proteins and several other bioactive components has shown notable successes. Inflammation and Natural Products: Recent Development and Current Status provides a comprehensive resource, ranging from detailed explanation on inflammation to molecular docking strategies for naturally occurring compounds with anti-inflammatory activity. It is useful for graduate students, academic and professionals in the fields of pharmaceutical and medical sciences and specialists from natural product-related industries. Increases the knowledge of anti-inflammatory activities of natural products and their mechanism of action Provides a new perspective and forward-thinking ideas to researchers, the scientific community and industry Intensifies the understanding of synergistic action of biologically active naturally occurring molecules and their biological activities against inflammation

Research Focus on Natural Products and the Body's Immune and Inflammatory Systems

Research Focus on Natural Products and the Body's Immune and Inflammatory Systems
A Book

by Kyoungho Suk

  • Publisher : Nova Publishers
  • Release : 2007
  • Pages : 313
  • ISBN : 9781600217517
  • Language : En, Es, Fr & De
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The definition of 'natural' is 'produced or existing in nature.' Natural products refer to as any natural constituents, natural substances, or a group of the secondary metabolites that derive from plants, insects, marine plants and animals through their own metabolic pathways. Natural products are usually of high value and small quantity, and they have a variety of biological activities. Extensive research has been performed to understand the effects of natural products on the immune and inflammatory systems. However, the results have been published individually focusing on a particular aspect of immunity or inflammation. The readers in this field may benefit from a comprehensive review book that describes different aspects of immune/inflammatory responses together. This book provides an overview of how a variety of naturally occurring compounds may influence the body's immune and inflammatory systems with an emphasis on the actions of medicinal herbs. In this book, experts in each field present their recent data on the mechanisms by which natural products influence the immune and inflammatory responses. The experimental results that are described in this book are based on various in vitro as well as in vivo model systems. It is also discussed how such effects of natural products are related with their therapeutic applications for the treatment of immune and inflammatory diseases.

Medicinal Natural Products: A Disease-Focused Approach

Medicinal Natural Products: A Disease-Focused Approach
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-11-01
  • Pages : 530
  • ISBN : 0128210206
  • Language : En, Es, Fr & De
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Medicinal Natural Products: A Disease-Focused Approach, Volume 55 in the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition, with chapters in this new release covering Medicinal Natural Products – An Introduction, Anticancer Natural Products, Antimicrobial Natural Products, Antimalarial and Antiparasitic Natural Products, Anti-inflammatory Natural Products, Neuroprotective Natural Products, Hepatoprotective Natural Products, Nephroprotective Natural Products, Cancer Chemopreventive Natural Products, Antipsoriatic Natural Products, Medicinal Natural Products in Osteoporosis, Antidiabetic Natural Products, Anti-obesity Natural Products, and much more. Presents a disease-focused perspective Includes the latest on the medicinal chemistry of natural products Covers natural products in drug delivery

Natural Products to Target Inflammation

Natural Products to Target Inflammation
A Book

by Iris Eva Allijn

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 164
  • ISBN : 9789036542050
  • Language : En, Es, Fr & De
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Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Bioactive Natural Products

by Atta-ur-Rahman

  • Publisher : Elsevier
  • Release : 2020
  • Pages : 510
  • ISBN : 0128179066
  • Language : En, Es, Fr & De
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Studies in Natural Products Chemistry: Bioactive Natural Products (Part XII), Volume 65, is the latest in a series that covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to quickly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

Chemopreventive Activities of Phytochemicals

Chemopreventive Activities of Phytochemicals
A Book

by Toshio Morikawa

  • Publisher : MDPI
  • Release : 2020-12-15
  • Pages : 210
  • ISBN : 3039365037
  • Language : En, Es, Fr & De
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Inflammation is caused by a variety of stimuli including physical damage, UV irradiation, microbial invasion, and immune reactions. The classical key features of inflammation are redness, warmth, swelling, and pain, and their cascades can lead to the inflammatory bowel disease and psoriasis. Many inflammatory diseases are becoming common among the elderly worldwide. Clinically used anti-inflammatory drugs suffer from the disadvantages of side effects and high treatment costs in the case of biologics. Therefore, research on new anti-inflammatory molecules and the elucidation of their molecular mechanisms are being actively conducted. This Special Issue on "Chemopreventive Activities of Phytochemicals" is intended to offer anti-inflammatory active natural products as candidates and/or leads for pharmaceuticals. The research fields of this Special Issue include natural products, chemistry, phytochemistry, pharmacognosy, food chemistry, bioorganic synthetic chemistry, chemical biology, molecular biology, molecular pharmacology, and other related research fields.

Terpenes from Natural Products with Potential Anti-Inflammatory Activity

Terpenes from Natural Products with Potential Anti-Inflammatory Activity
A Book

by Roberto José Serrano

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The development and progression of many diseases is related with an inflammatory process, which could affect different organs or tissues. Currently, many drugs are used to treat inflammation. However, some of these compounds induce severe side effects. For this reason, the search of new therapeutic options for the treatment of inflammation is very desirable. Medicinal plants have been an interesting source for obtaining new active compounds, including several terpenes and terpenoids with anti-inflammatory activity. This book chapter includes 62 sesquiterpenes, 34 diterpenes, and 22 triterpenes with anti-inflammatory activity. The anti-inflammatory effect was evaluated using in vitro, in vivo, and both models. These terpenes were obtained from 44 plant species belonging to 25 botanical families. Eight of theses species belong to the Asteraceae family and four to Lamiaceae family, respectively, and the other species belong to 13 different botanical families, one sesquiterpene was obtained from a sponge and two diterpenes were isolated from corals.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry
Chapter 7. Lessons from the Sea: Distribution, SAR, and Molecular Mechanisms of Anti-inflammatory Drugs from Marine Organisms

by David M. Pereira,Patrícia Valentão,Paula B. Andrade

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-06-25
  • Pages : 538
  • ISBN : 0128084723
  • Language : En, Es, Fr & De
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Marine organisms have been increasingly regarded as excellent sources of new drugs for human therapeutics due to their remarkable chemistry, which, in turn, is reflected in their wide range of biological applications, including cancer, inflammation, infection, and pain. In the past 20 years, several new drugs have been discovered, some of them with novel pharmacological targets and the first sea-derived approved medicines are now paving their way into the market. In this chapter, we will focus on small-molecule drugs obtained from marine animals (sponges, gorgonians, mollusks, echinoderms) for the treatment of inflammation. The distribution of these compounds by different taxonomical families will be discussed, as well as the state-of-the-art regarding their structure–activity relationship. The most important chemical classes will be presented, such as terpenes, alkaloids, among others. The most important molecular targets, including phospholipase A2 (PLA2), cyclooxygenases (COXs), nitric oxide synthase (NOS), and NF-κB will be discussed.

Bioactive Natural Products Detection, Isolation, and Structural Determination

Bioactive Natural Products Detection, Isolation, and Structural Determination
A Book

by Steven M. Colegate,Russell J. Molyneux

  • Publisher : CRC Press
  • Release : 1993-09-29
  • Pages : 544
  • ISBN : 9780849343728
  • Language : En, Es, Fr & De
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Bioactive Natural Products covers all the aspects of bioactive natural product research from ethnobotanical investigations to modern, technologically assisted isolation and structural determination of active compounds. An internationally selected group of experts share their knowledge of a wide range of bioactivities and chemical compound classes. Topics in the chapters describing the modern application of detection, isolation, and structural determination techniques are strongly supported by chapters detailing and reviewing research involving various classes of bioactivity. Research areas include the immunomodulatory, antiviral, cytotoxic, anti-inflammatory, and insect behavior classes of bioactivity. Extensive referencing throughout the text is helpful to those readers not familiar with this subject and serves as a critical review for more experienced researchers. The book is also excellent for upper division or post-graduate courses.

Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions

Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions
A Book

by Hiroshi Sakagami

  • Publisher : MDPI
  • Release : 2019-06-12
  • Pages : 212
  • ISBN : 3038979929
  • Language : En, Es, Fr & De
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Oral health is general health. If the oral cavity is kept healthy, the whole body is always healthy. Bacteria in the oral cavity do not stay in the oral cavity, but rather they travel throughout the body and can induce various diseases. Periodontal pathogens are involved in tooth loss. The number of remaining teeth decreases with age. People with more residual teeth can bite food well and live longer with lower incidence of dementia. There are many viruses in the oral cavity that also cause various diseases. Bacteria and viruses induce and aggravate inflammation, and therefore should be removed from the oral cavity. In the natural world, there are are many as yet undiscovered antiviral, antibacterial and anti-inflammatory substances. These natural substances, as well as chemically modified derivatives, help our oral health and lead us to more fulfilling, high quality lives. This Special Issue, entitled “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”, was written by specialists from a diverse variety of fields. It serves to provide readers with up-to-date information on incidence rates in each age group, etiology and treatment of stomatitis, and to investigate the application of such treatments as oral care and cosmetic materials.

Nutraceuticals and Natural Product Derivatives

Nutraceuticals and Natural Product Derivatives
Disease Prevention & Drug Discovery

by Mohammad Fahad Ullah,Aamir Ahmad

  • Publisher : Wiley-Blackwell
  • Release : 2019-03-06
  • Pages : 456
  • ISBN : 1119436672
  • Language : En, Es, Fr & De
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Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Natural Products as Source of Molecules with Therapeutic Potential

Natural Products as Source of Molecules with Therapeutic Potential
Research & Development, Challenges and Perspectives

by Valdir Cechinel Filho

  • Publisher : Springer
  • Release : 2018-12-07
  • Pages : 531
  • ISBN : 3030005453
  • Language : En, Es, Fr & De
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This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.