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Inhaled Medicines

Inhaled Medicines
Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches

by Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey

  • Publisher : Academic Press
  • Release : 2021-01-20
  • Pages : 438
  • ISBN : 0128149752
  • Language : En, Es, Fr & De
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Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ● Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ● Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ● Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ● Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Inhaled Medicines

Inhaled Medicines
Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches

by Stavros Kassinos,Per Bäckman,Joy Conway,Anthony J. J. Hickey

  • Publisher : Academic Press
  • Release : 2021-02-05
  • Pages : 438
  • ISBN : 0128149744
  • Language : En, Es, Fr & De
GET BOOK

Inhaled medicines are widely used to treat pulmonary and systemic diseases. The efficacy and safety of these medicines can be influenced by the deposited fraction, the regional deposition pattern within the lungs and by post-depositional events such as drug dissolution, absorption and clearance from the lungs. Optimizing performance of treatments thus requires that we understand and are able to quantify these product and drug attributes. Inhaled Medicines: Optimizing Development through Integration of In Silico, In Vitro and In Vivo Approaches explores the current state of the art with respect to inhalation drug delivery, technologies available to assess product performance, and novel in silico methods now available to link in vitro product performance to clinical performance. Recent developments in the latter field, especially the prospect of integration of three-dimensional Computational Fluid Particle Methods (3D-CFPD) with physiologically based pharmacokinetic (PBPK models), unlocks the potential for in silico population studies that can help inform and optimize treatment and product development strategies. In this highly multidisciplinary field, where progress occurs at the intersection of several disciplines of engineering and science, this work aims to integrate current knowledge and understanding and to articulate a clear vision for future developments. ? Considers the healthcare needs driving the field, and where inhaled drugs could have the maximum impact ? Gives a concise account of the state of the art in key areas and technologies such as device and formulation technologies, clinically relevant in vitro performance assessment, medical imaging, as well as in silico modelling and simulation ? Articulates how the combination of in vitro product performance data, medical imaging and simulations technologies in the framework of large scale in silico pre-clinical trials could revolutionize the field ? Provides systematic and thorough referencing to sources offering a more-in-depth analysis of technical issues

Pharmacokinetic-modifying Effects of Glycerol in Inhaled Medicines

Pharmacokinetic-modifying Effects of Glycerol in Inhaled Medicines
A Book

by Wachirun Terakosolphan

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Mechanics of Inhaled Pharmaceutical Aerosols

The Mechanics of Inhaled Pharmaceutical Aerosols
An Introduction

by Warren H. Finlay

  • Publisher : Academic Press
  • Release : 2019-06-15
  • Pages : 340
  • ISBN : 9780081027493
  • Language : En, Es, Fr & De
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The Mechanics of Inhaled Pharmaceutical Aerosols, Second Edition provides a concise but thorough exposition of the fundamental concepts in the field of pharmaceutical aerosols. The field of inhaled pharmaceutical aerosols has grown rapidly since the original edition was published in 2001. The revised edition will allow researchers in the field to gain an up-to-date, thorough understanding of the field from first principles, allowing them to understand, design, develop and improve inhaled pharmaceutical aerosol devices and therapies. The first four chapters provide an introduction to several fundamental topics. Chapters 5-7 consider mechanics and deposition specifically in the respiratory tract, while the last three chapters consider the mechanics associated with the three main existing types of pharmaceutical aerosol inhalation devices. The text will be used extensively by academics in their research, as well as in courses taught on this topic at both the undergraduate and graduate level. Because of the interdisciplinary nature of this book, it will also serve a wide audience that includes engineers and scientists involved with inhaled aerosol therapies. Provides a concise but thorough exposition of the fundamental concepts in the field of pharmaceutical aerosols Allows researchers in the field to gain an up-to-date, thorough understanding of the field from first principles Introduces the pharmaceutical aerosols field to the many engineers and scientists entering this area

Equivalence Testing of Inhaled Drugs

Equivalence Testing of Inhaled Drugs
The Predictive Value of Cascade Impactor Results for the Detection of Differences in Efficacy and Safety of Medicines for the Treatment of Asthma and COPD

by Marjolein Weda

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 168
  • ISBN : 9789036728966
  • Language : En, Es, Fr & De
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USP dictionary of USAN and international drugs names 1996 V.II

USP dictionary of USAN and international drugs names 1996 V.II
A Book

by United States Pharmacopeial Convention

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 1798
  • ISBN : 9780913595923
  • Language : En, Es, Fr & De
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Complete Drug Reference, 1996

Complete Drug Reference, 1996
A Book

by United States Pharmacopeial Convention

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 1750
  • ISBN : 9780890438497
  • Language : En, Es, Fr & De
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Body Burden

Body Burden
Health and Environment in India

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 339
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Emergency Medicine

Emergency Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Davidson's Principles and Practice of Medicine

Davidson's Principles and Practice of Medicine
A Book

by Sir Stanley Davidson

  • Publisher : W.B. Saunders Company
  • Release : 1995
  • Pages : 1203
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This text on clinical medicine has been updated to aid learning and revision. Topics covered include genetic, climatic and environmental factors in disease, and endocrine and metabolic diseases, whilst a new chapter on geriatric medicine has also been included. An ELBS/LPBB edition is available.

Journal of the American Pharmaceutical Association

Journal of the American Pharmaceutical Association
APhA.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pulmonary Drug Delivery

Pulmonary Drug Delivery
Advances and Challenges

by Ali Nokhodchi,Gary P. Martin

  • Publisher : John Wiley & Sons
  • Release : 2015-08-03
  • Pages : 384
  • ISBN : 1118799542
  • Language : En, Es, Fr & De
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Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.

Postgraduate Medicine

Postgraduate Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1992-11
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Asthma

Asthma
The Complete Guide to Self-management of Asthma and Allergies for Patients and Their Families

by Allan Weinstein

  • Publisher : Fawcett Books
  • Release : 1987
  • Pages : 357
  • ISBN : 9780449215623
  • Language : En, Es, Fr & De
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A practical self-help program explains the nature of the widespread ailment, and shows how sufferers can avoid expense and difficulty by controlling the illness at home

The Journal of Respiratory Diseases

The Journal of Respiratory Diseases
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmacology and Therapeutics of Asthma and COPD

Pharmacology and Therapeutics of Asthma and COPD
A Book

by Clive P. Page,Peter J. Barnes

  • Publisher : Springer
  • Release : 2017-02-06
  • Pages : 285
  • ISBN : 3319521756
  • Language : En, Es, Fr & De
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The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.

Understanding Prescription Drugs

Understanding Prescription Drugs
A Book

by Dorothy L. Smith

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 504
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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After 15 years of pharmaceutical research and experience, Dr. Dorothy L. Smith has written the most up-to-date consumer guide on prescription drugs. Understanding Prescription Drugs provides essential information on over 800 of the most commonly prescribed generic and brand-name drugs in the U.S. plus over 20 drawings and easy-to-read tables.

The Reader's Digest

The Reader's Digest
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nursing Times, Nursing Mirror

Nursing Times, Nursing Mirror
NT

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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U.S. News & World Report

U.S. News & World Report
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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