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Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
Ethnopharmacology, Systems Biology and Holistic Targeting

by Bhushan Patwardhan,Rathnam Chaguturu

  • Publisher : Academic Press
  • Release : 2016-10-03
  • Pages : 480
  • ISBN : 0128018224
  • Language : En, Es, Fr & De
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Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Molecular Modeling with the Aim: Innovative Approaches for Drug Design

Molecular Modeling with the Aim: Innovative Approaches for Drug Design
A Book

by Dusanka Janezic

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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We have developed new computational tools at the molecular scale for protein-ligand binding in drug discovery, ProBiS Tools (algorithm, database, and web servers) for predicting and modeling of medically interesting proteins based on graph theoretical approaches, combined with molecular simulations based on our earlier developed fast maximum clique algorithm, for finding a maximum clique in an undirected graph that is up to 100 times faster than the best comparable algorithm. ProBiS Tools opens a whole new range of possibilities in drug discovery. Our newly developed approach is particularly useful in the context of precision medicine. Precision medicine promises more effective and safer treatments with lesser side effects. It depends on the advances within genomics, proteomics and transcriptomics fields that generate extensive amounts of data as well as it depends on the advances of computational biology. Our aim is extensive integration of the genomic, proteomic, and system level information (Figure 1) that enable evaluation of drug's effects on each and every person individually based on his/her genetic make-up. Our tools enable joining several otherwise disconnected areas of research, i.e., genome sequence studies, protein structures, and MD simulations.

Innovative Methods for Rare Disease Drug Development

Innovative Methods for Rare Disease Drug Development
A Book

by Shein-Chung Chow

  • Publisher : CRC Press
  • Release : 2020-11-12
  • Pages : 306
  • ISBN : 1000208214
  • Language : En, Es, Fr & De
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In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because there are only limited number of subjects available for clinical trials. In this case, innovative approaches are needed for providing substantial evidence meeting the same standards for statistical assurance as drugs used to treat common conditions. Innovative Methods for Rare Disease Drug Development focuses on biostatistical applications in terms of design and analysis in pharmaceutical research and development from both regulatory and scientific (statistical) perspectives. Key Features: Reviews critical issues (e.g., endpoint/margin selection, sample size requirements, and complex innovative design). Provides better understanding of statistical concepts and methods which may be used in regulatory review and approval. Clarifies controversial statistical issues in regulatory review and approval accurately and reliably. Makes recommendations to evaluate rare diseases regulatory submissions. Proposes innovative study designs and statistical methods for rare diseases drug development, including n-of-1 trial design, adaptive trial design, and master protocols like platform trials. Provides insight regarding current regulatory guidance on rare diseases drug development like gene therapy.

Antiepileptic Drug Discovery

Antiepileptic Drug Discovery
Novel Approaches

by Alan Talevi,Luisa Rocha

  • Publisher : Humana Press
  • Release : 2016-09-24
  • Pages : 386
  • ISBN : 9781493963539
  • Language : En, Es, Fr & De
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This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the potential benefits that network pharmacology and rational drug repurposing could bring to the antiepileptic drug discovery community. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of detailed description and implementation advice to ensure results in the laboratory. Authoritative and practical, Antiepileptic Drug Discovery: Novel Approaches aims to provide medicinal chemists, pharmacologists, and other researchers with the tools need to further explore the study of pharmacoresistant epilepsy and the discovery of new antiepileptic drugs.

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research
Proceedings of the Third Noordwijkerhout Symposium on Medicinal Chemistry, Held in the Netherlands, September 3-6, 1985

by A. F. Harms

  • Publisher : Elsevier Publishing Company
  • Release : 1986
  • Pages : 481
  • ISBN : 9780444426062
  • Language : En, Es, Fr & De
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Drug Design and Discovery in Alzheimer’s Disease

Drug Design and Discovery in Alzheimer’s Disease
A Book

by Atta-ur-Rahman,Muhammad Iqbal Choudhary

  • Publisher : Elsevier
  • Release : 2015-06-27
  • Pages : 784
  • ISBN : 0128039604
  • Language : En, Es, Fr & De
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Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Drug Discovery Targeting Drug-Resistant Bacteria

Drug Discovery Targeting Drug-Resistant Bacteria
A Book

by Prashant Kesharwani,Sidharth Chopra,Arunava Dasgupta

  • Publisher : Academic Press
  • Release : 2020-05-15
  • Pages : 432
  • ISBN : 0128184817
  • Language : En, Es, Fr & De
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Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Drug Design Strategies

Drug Design Strategies
Quantitative Approaches

by David J. Livingstone,Andrew M. Davis

  • Publisher : Royal Society of Chemistry
  • Release : 2011-11
  • Pages : 498
  • ISBN : 1849731667
  • Language : En, Es, Fr & De
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Shows how different parts of the drug discovery process have developed, with particular emphasis on quantitative aspects and possible future progress.

Innovative Dosage Forms

Innovative Dosage Forms
Design and Development at Early Stage

by Yogeshwar Bachhav

  • Publisher : John Wiley & Sons
  • Release : 2019-08-09
  • Pages : 352
  • ISBN : 3527812202
  • Language : En, Es, Fr & De
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Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design

Innovations and Implementations of Computer Aided Drug Discovery Strategies in Rational Drug Design
A Book

by Sanjeev Kumar Singh

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 9811589364
  • Language : En, Es, Fr & De
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Drug Discovery and Development - Present and Future

Drug Discovery and Development - Present and Future
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Discovery in Africa

Drug Discovery in Africa
Impacts of Genomics, Natural Products, Traditional Medicines, Insights into Medicinal Chemistry, and Technology Platforms in Pursuit of New Drugs

by Kelly Chibale,Mike Davies-Coleman,Collen Masimirembwa

  • Publisher : Springer Science & Business Media
  • Release : 2012-08-09
  • Pages : 440
  • ISBN : 3642281753
  • Language : En, Es, Fr & De
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Drug discovery originating in Africa has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa. Compiled by leading African and international experts, this book presents the science and strategies of modern drug discovery. It explores how the use of natural products and traditional medicines can benefit from conventional drug discovery approaches, and proposes solutions to current technological, infrastructural, human resources, and economic challenges, which are presented when attempting to engage in full-scale drug discovery. Topics addressed are varied; from African medicinal plants to marine bioprospecting, pharmacogenetics and the use of nanotechnology. This book brings together for the first time a collection of strategies and techniques that need to be considered when developing drugs in an African setting. It is an unprecedented and truly international effort, highlighting the remarkable effort made so far in the area of drug discovery research by African scientists, and scientists from other parts of the world working on African health problems.

Mixed Signals

Mixed Signals
The Administration's Policy on Marijuana : Hearing Before the Subcommittee on Government Operations of the Committee on Oversight and Government Reform, House of Representatives, One Hundred Thirteenth Congress, Second Session

by United States. Congress. House. Committee on Oversight and Government Reform. Subcommittee on Government Operations

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Approaches to Drug Discovery

New Approaches to Drug Discovery
A Book

by Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch

  • Publisher : Springer
  • Release : 2016-03-30
  • Pages : 341
  • ISBN : 3319289144
  • Language : En, Es, Fr & De
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This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Innovative Methods for Rare Disease Drug Development

Innovative Methods for Rare Disease Drug Development
A Book

by Shein-Chung Chow

  • Publisher : CRC Press
  • Release : 2020-11-11
  • Pages : 306
  • ISBN : 1000208338
  • Language : En, Es, Fr & De
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In the United States, a rare disease is defined by the Orphan Drug Act as a disorder or condition that affects fewer than 200,000 persons. For the approval of "orphan" drug products for rare diseases, the traditional approach of power analysis for sample size calculation is not feasible because there are only limited number of subjects available for clinical trials. In this case, innovative approaches are needed for providing substantial evidence meeting the same standards for statistical assurance as drugs used to treat common conditions. Innovative Methods for Rare Disease Drug Development focuses on biostatistical applications in terms of design and analysis in pharmaceutical research and development from both regulatory and scientific (statistical) perspectives. Key Features: Reviews critical issues (e.g., endpoint/margin selection, sample size requirements, and complex innovative design). Provides better understanding of statistical concepts and methods which may be used in regulatory review and approval. Clarifies controversial statistical issues in regulatory review and approval accurately and reliably. Makes recommendations to evaluate rare diseases regulatory submissions. Proposes innovative study designs and statistical methods for rare diseases drug development, including n-of-1 trial design, adaptive trial design, and master protocols like platform trials. Provides insight regarding current regulatory guidance on rare diseases drug development like gene therapy.

Drug Discovery & Development

Drug Discovery & Development
Traditional Medicine and Ethnopharmacology

by Bhushan Patwardhan

  • Publisher : New India Publishing
  • Release : 2007
  • Pages : 362
  • ISBN : 9788189422295
  • Language : En, Es, Fr & De
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While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 2012

Departments of Labor, Health and Human Services, and Education, and Related Agencies Appropriations for Fiscal Year 2012
Hearings Before a Subcommittee of the Committee on Appropriations, United States Senate, One Hundred Twelfth Congress, First Session on S. 1599, an Act Making Appropriations for the Departments of Labor, Health and Human Services, and Education, and Related Agencies for the Fiscal Year Ending September 30, 2012, and for Other Purposes

by United States. Congress. Senate. Committee on Appropriations. Subcommittee on Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 893
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Microbial Genomics and Drug Discovery

Microbial Genomics and Drug Discovery
A Book

by Thomas J. Dougherty,Steven J. Projan

  • Publisher : CRC Press
  • Release : 2003-05-14
  • Pages : 264
  • ISBN : 9780203911464
  • Language : En, Es, Fr & De
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Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates. The book discusses potential pathways for effective infection control, inhibition

Natural Products and Drug Discovery

Natural Products and Drug Discovery
An Integrated Approach

by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi

  • Publisher : Elsevier
  • Release : 2018-02-16
  • Pages : 776
  • ISBN : 0081021046
  • Language : En, Es, Fr & De
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Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Lead Generation Approaches in Drug Discovery

Lead Generation Approaches in Drug Discovery
A Book

by Zoran Rankovic,Richard Morphy

  • Publisher : John Wiley & Sons
  • Release : 2010-04-07
  • Pages : 308
  • ISBN : 9780470584163
  • Language : En, Es, Fr & De
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An integrated overview of modern approaches to lead discovery Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including: The evolution of the lead discovery process, key concepts, current challenges, and future directions Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process Knowledge-based in silico or "virtual" screening Theory and practice of the fragment-based approach to lead discovery The opportunities and challenges presented by multi-target drug discovery (MTDD) De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery The utility of parallel synthesis and purification in lead discovery With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.