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Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
Ethnopharmacology, Systems Biology and Holistic Targeting

by Bhushan Patwardhan,Rathnam Chaguturu

  • Publisher : Academic Press
  • Release : 2016-10-03
  • Pages : 480
  • ISBN : 0128018224
  • Language : En, Es, Fr & De
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Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis in drug discovery. The authors illustrate the benefits of systems biology and pharmacogenomics approaches, and advocate the expansion from disease-centric discovery to person-centric therapeutics involving holistic, multi-target, whole systems approaches. This book lays a path for reigniting pharmaceutical innovation through a disciplined reemergence of pharmacognosy, embracing open innovation models and collaborative, trusted public-private partnerships. With unprecedented advances made in the development of biomedically-relevant tools and technologies, the need is great and the time is now for a renewed commitment towards expanding the repertoire of medicines. By incorporating real-life examples and state-of-the-art reviews, this book provides valuable insights into the discovery and development strategies for professionals, academicians, and students in the pharmaceutical sciences. Analyzes the reasons behind historical drug failures to provide valuable insights on lessons learned Uses current scientific research to promote learning from traditional knowledge systems and through the integration of traditional and western medicines Discusses advances in technologies and systems biology to support the transition from formulation discovery to therapeutic discovery

Innovative Approaches in Drug Research

Innovative Approaches in Drug Research
Proceedings of the Third Noordwijkerhout Symposium on Medicinal Chemistry, Held in the Netherlands, September 3-6, 1985

by A. F. Harms

  • Publisher : Elsevier Publishing Company
  • Release : 1986
  • Pages : 481
  • ISBN : 9780444426062
  • Language : En, Es, Fr & De
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Innovative Approaches in Drug Research

Innovative Approaches in Drug Research
Proceedings of the Third Noordwijkerhout Symposium on Medicinal Chemistry, Held in the Netherlands, September 3-6, 1985

by A. F. Harms

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 481
  • ISBN : 9780444415646
  • Language : En, Es, Fr & De
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Innovative Approaches in Drug Research

Innovative Approaches in Drug Research
Proceedings of the Third Noordwijkerhout Symposium on Medicinal Chemistry, Held in the Netherlands, September 3-6, 1985

by A. F. Harms

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 481
  • ISBN : 9780444415646
  • Language : En, Es, Fr & De
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New Approaches to Drug Discovery

New Approaches to Drug Discovery
A Book

by Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch

  • Publisher : Springer
  • Release : 2018-04-25
  • Pages : 341
  • ISBN : 9783319804552
  • Language : En, Es, Fr & De
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This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug discovery process, starting with new developments in the target identification and validation area. The lead generation part as a next step focuses on the requirements and technologies to identify new small molecules as lead compounds for further optimization; in a second section the technologies to identify biologics as leads are addressed. The final part focuses on the pharmacological models and technologies to characterize new compounds and the impact of biomarkers to facilitate the transfer of drug candidates into the development phase.

Drug Discovery & Development

Drug Discovery & Development
Traditional Medicine and Ethnopharmacology

by Bhushan Patwardhan

  • Publisher : New India Publishing
  • Release : 2007
  • Pages : 362
  • ISBN : 9788189422295
  • Language : En, Es, Fr & De
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While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Antiepileptic Drug Discovery: Novel Approaches

Antiepileptic Drug Discovery: Novel Approaches
A Book

by Alan Talevi,Luisa Rocha

  • Publisher : Methods in Pharmacology and To
  • Release : 2018-10-08
  • Pages : 400
  • ISBN : 9781493981748
  • Language : En, Es, Fr & De
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Collaborative Innovation in Drug Discovery

Collaborative Innovation in Drug Discovery
Strategies for Public and Private Partnerships

by Rathnam Chaguturu

  • Publisher : John Wiley & Sons
  • Release : 2014-03-28
  • Pages : 752
  • ISBN : 111877812X
  • Language : En, Es, Fr & De
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Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent needfor novel therapies cannot stem the skyrocketing costs andplummeting productivity plaguing R&D, and many key products arefacing patent expiration. Dr. Rathnam Chaguturu presents a case forcollaboration between the pharmaceutical industry and academia thatcould reverse the industry's decline. CollaborativeInnovation in Drug Discovery: Strategies for Public and PrivatePartnerships provides insight into the potential synergyof basing R&D in academia while leaving drug companies to turnhits into marketable products. As Founder and CEO ofiDDPartners, focused on pharmaceutical innovation, Foundingpresident of the International Chemical Biology Society, and SeniorDirector-Discovery Sciences, SRI International, Dr. Chaguturu hasassembled a panel of experts from around the world to weigh in onissues that affect the two driving forces in medicaladvancement. Gain global perspectives on the benefits and potential issuessurrounding collaborative innovation Discover how industries can come together to prevent another"Pharma Cliff" Learn how nonprofits are becoming the driving force behindinnovation Read case studies of specific academia-pharma partnerships forreal-life examples of successful collaboration Explore government initiatives that help foster cooperationbetween industry and academia Dr. Chaguturu’s thirty-five years of experience inacademia and industry, managing new lead discovery projects andforging collaborative partnerships with academia, diseasefoundations, nonprofits, and government agencies lend him aninformative perspective into the issues facing pharmaceuticalprogress. In Collaborative Innovation in Drug Discovery:Strategies for Public and Private Partnerships, he and hisexpert team provide insight into the various nuances of thedebate.

Molecular Modeling with the Aim: Innovative Approaches for Drug Design

Molecular Modeling with the Aim: Innovative Approaches for Drug Design
A Book

by Dusanka Janezic

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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We have developed new computational tools at the molecular scale for protein-ligand binding in drug discovery, ProBiS Tools (algorithm, database, and web servers) for predicting and modeling of medically interesting proteins based on graph theoretical approaches, combined with molecular simulations based on our earlier developed fast maximum clique algorithm, for finding a maximum clique in an undirected graph that is up to 100 times faster than the best comparable algorithm. ProBiS Tools opens a whole new range of possibilities in drug discovery. Our newly developed approach is particularly useful in the context of precision medicine. Precision medicine promises more effective and safer treatments with lesser side effects. It depends on the advances within genomics, proteomics and transcriptomics fields that generate extensive amounts of data as well as it depends on the advances of computational biology. Our aim is extensive integration of the genomic, proteomic, and system level information (Figure 1) that enable evaluation of drug's effects on each and every person individually based on his/her genetic make-up. Our tools enable joining several otherwise disconnected areas of research, i.e., genome sequence studies, protein structures, and MD simulations.

The Effectiveness of Innovative Approaches in the Treatment of Drug Abuse

The Effectiveness of Innovative Approaches in the Treatment of Drug Abuse
A Book

by Frank M. Tims,James A. Inciardi,Bennett W. Fletcher,Arthur MacNeill Horton, Jr.

  • Publisher : Praeger
  • Release : 1997
  • Pages : 268
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A continuation of the study researched in their previous volumes, this new book looks at the effectiveness of various treatment approaches. These essays represent an effort to systematically integrate science and practice in order to improve drug abuse treatment.

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials

Innovative Strategies, Statistical Solutions and Simulations for Modern Clinical Trials
A Book

by Mark Chang,John Balser,Jim Roach,Robin Bliss

  • Publisher : CRC Press
  • Release : 2019-03-20
  • Pages : 362
  • ISBN : 1351214535
  • Language : En, Es, Fr & De
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"This is truly an outstanding book. [It] brings together all of the latest research in clinical trials methodology and how it can be applied to drug development.... Chang et al provide applications to industry-supported trials. This will allow statisticians in the industry community to take these methods seriously." Jay Herson, Johns Hopkins University The pharmaceutical industry's approach to drug discovery and development has rapidly transformed in the last decade from the more traditional Research and Development (R & D) approach to a more innovative approach in which strategies are employed to compress and optimize the clinical development plan and associated timelines. However, these strategies are generally being considered on an individual trial basis and not as part of a fully integrated overall development program. Such optimization at the trial level is somewhat near-sighted and does not ensure cost, time, or development efficiency of the overall program. This book seeks to address this imbalance by establishing a statistical framework for overall/global clinical development optimization and providing tactics and techniques to support such optimization, including clinical trial simulations. Provides a statistical framework for achieve global optimization in each phase of the drug development process. Describes specific techniques to support optimization including adaptive designs, precision medicine, survival-endpoints, dose finding and multiple testing. Gives practical approaches to handling missing data in clinical trials using SAS. Looks at key controversial issues from both a clinical and statistical perspective. Presents a generous number of case studies from multiple therapeutic areas that help motivate and illustrate the statistical methods introduced in the book. Puts great emphasis on software implementation of the statistical methods with multiple examples of software code (both SAS and R). It is important for statisticians to possess a deep knowledge of the drug development process beyond statistical considerations. For these reasons, this book incorporates both statistical and "clinical/medical" perspectives.

Retrometabolic Drug Design and Targeting

Retrometabolic Drug Design and Targeting
A Book

by Nicholas Bodor,Peter Buchwald

  • Publisher : John Wiley & Sons
  • Release : 2012-08-29
  • Pages : 418
  • ISBN : 1118407768
  • Language : En, Es, Fr & De
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Innovative approach to drug design that's more likely to result in an approvable drug product Retrometabolic drug design incorporates two distinct drug design approaches to obtain soft drugs and chemical delivery systems, respectively. Combining fundamentals with practical step-by-step examples, Retrometabolic Drug Design and Targeting gives readers the tools they need to take full advantage of retrometabolic approaches in order to develop safe and effective targeted drug therapies. The authors, both pioneers in the fields of soft drugs and retrometabolic drug design, offer valuable ideas, approaches, and solutions to a broad range of challenges in drug design, optimization, stability, side effects, and toxicity. Retrometabolic Drug Design and Targeting begins with an introductory chapter that explores new drugs and medical progress as well as the challenges of today's drug discovery. Next, it discusses: Basic concepts of the mechanisms of drug action Drug discovery and development processes Retrometabolic drug design Soft drugs Chemical delivery systems Inside the book, readers will find examples from different pharmacological areas detailing the rationale for each drug design. These examples set forth the relevant pharmacokinetic and pharmacodynamic properties of the new therapeutic agents, comparing these properties to those of other compounds used for the same therapeutic purpose. In addition, the authors review dedicated computer programs that are available to support and streamline retrometabolic drug design efforts. Retrometabolic Drug Design and Targeting is recommended for all drug researchers interested in employing this newly tested and proven approach to developing safe and effective drugs.

Essentials of Medicinal Chemistry

Essentials of Medicinal Chemistry
A Book

by Andrejus Korolkovas

  • Publisher : Wiley-Interscience
  • Release : 1988-08-16
  • Pages : 1204
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This text/reference presents fundamental aspects of medicinal chemistry and contains comprehensive information on approximately 5,000 drugs currently in use, describing their therapeutic uses, their mechanisms of action, and their main side and harmful effects. Employs the latest World Health Organization (WHO) pharmacological classification and provides extensive information for drugs on WHO's latest list of basic or essential pharmaceuticals, including history: chemical, trade and generic names; chemical structure; obtention; physical and chemical properties; mechanisms of action; therapeutic uses; adverse reactions; biotransformation; chemical and pharmacological incompatibilities; bioavailability; dosage; storage; and assay.

Innovative Dosage Forms

Innovative Dosage Forms
Design and Development at Early Stage

by Yogeshwar Bachhav

  • Publisher : John Wiley & Sons
  • Release : 2019-08-09
  • Pages : 352
  • ISBN : 3527812202
  • Language : En, Es, Fr & De
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Teaches future and current drug developers the latest innovations in drug formulation design and optimization This highly accessible, practice-oriented book examines current approaches in the development of drug formulations for preclinical and clinical studies, including the use of functional excipients to enhance solubility and stability. It covers oral, intravenous, topical, and parenteral administration routes. The book also discusses safety aspects of drugs and excipients, as well as regulatory issues relevant to formulation. Innovative Dosage Forms: Design and Development at Early Stage starts with a look at the impact of the polymorphic form of drugs on the preformulation and formulation development. It then offers readers reliable strategies for the formulation development of poorly soluble drugs. The book also studies the role of reactive impurities from the excipients on the formulation shelf life; preclinical formulation assessment of new chemical entities; and regulatory aspects for formulation design. Other chapters cover innovative formulations for special indications, including oncology injectables, delayed release and depot formulations; accessing pharmacokinetics of various dosage forms; physical characterization techniques to assess amorphous nature; novel formulations for protein oral dosage; and more. -Provides information that is essential for the drug development effort -Presents the latest advances in the field and describes in detail innovative formulations, such as nanosuspensions, micelles, and cocrystals -Describes current approaches in early pre-formulation to achieve the best in vivo results -Addresses regulatory and safety aspects, which are key considerations for pharmaceutical companies -Includes case studies from recent drug development programs to illustrate the practical challenges of preformulation design Innovative Dosage Forms: Design and Development at Early Stage provides valuable benefits to interdisciplinary drug discovery teams working in industry and academia and will appeal to medicinal chemists, pharmaceutical chemists, and pharmacologists.

Journal of Pharmacological Methods

Journal of Pharmacological Methods
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Scientist

New Scientist
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cognitive Enhancement

Cognitive Enhancement
A Book

by Kathleen M. Kantak,Joseph G. Wettstein

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9783319165233
  • Language : En, Es, Fr & De
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This book highlights the behavioral and neurobiological issues relevant for drug development, reviews evidence for an innovative approach for drug discovery and presents perspectives on multiple special topics ranging from therapeutic drug use in children, emerging technologies and non-pharmacological approaches to cognitive enhancement.

Drug Discovery

Drug Discovery
A Casebook and Analysis

by Robert A. Maxwell,Shohreh B. Eckhardt

  • Publisher : Springer Science & Business Media
  • Release : 1990-10-02
  • Pages : 438
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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In their novel approach to Drug Discovery, Maxwell and Eckhardt explore their thesis that the discovery of new drugs-especially of innovative therapeutic agents-is an independent dynamic process that demands the full attention of researchers, rather than a spontaneous consequence of investigative research. Faced with a dearth of quantitative information on how and where innovative drugs were discovered, the authors have developed considerable quantitative data about this process in order to provide a deeper understanding of its true nature.Drug Discovery: A Casebook and Analysis offers a unique quantitative survey of research since World War II that led to the development of 32 innovative therapeutic agents. Factual and concise, each chapter presents a review of the original scientific contributions associated with the discovery of a specific drug. These chapters are followed by a computer analysis of important variables and finally by an interpretation. Drug categories discussed include: • cardiovascular and renal (including renal transplantation) • psychiatric • neurological • rheumatological • anesthesiological • pulmonary • gastrointestinal.Everyone interested in the basic or clinical research leading to important drugs-and the institutional interplay inherent in the process-will find Drug Discovery: A Casebook and Analysis a comprehensive, invaluable reference compendium!

Chemistry International

Chemistry International
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Design of Anti-AIDS Drugs

Design of Anti-AIDS Drugs
A Book

by Erik De Clercq,C. Callebaut

  • Publisher : Elsevier Science Limited
  • Release : 1990
  • Pages : 371
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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There are several steps in the replicative cycle of human immunodeficiency virus (HIV) that could be considered as adequate targets for chemotherapeutic intervention, e.g., virus attachment to the cells, virus penetration and uncoating, transcription of the viral (RNA) genome to proviral DNA, integration of the proviral DNA into host cell DNA, transcription of the proviral precursor proteins to mature viral proteins, assembly and release ('budding') of the viral particles. These processes depend on, and are regulated by, specific viral proteins. This makes many of these processes and proteins plausible targets for the design of selective inhibitors. The contributions assembled in this book are aimed at presenting what is known anno 1990 about (1) the different steps in the HIV replicative cycle that could be considered as targets for anti-HIV agents, (2) the compounds that interact with these targets and offer promise as candidate drugs for the treatment of HIV infection, and (3) to the extent that it has been resolved, the mechanism of interaction of the anti-HIV agents with their putative targets.