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Introduction to Cancer Metastasis

Introduction to Cancer Metastasis
A Book

by Aamir Ahmad

  • Publisher : Academic Press
  • Release : 2016-11-14
  • Pages : 416
  • ISBN : 0128040335
  • Language : En, Es, Fr & De
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Introduction to Cancer Metastasis provides, in one place, an overview of organ-specific cancer metastasis and the most common sites of cancer metastasis. Through specific chapters on individual primary cancers, their metastasis, and chapters on common metastatic sites, this volume comprehensively informs readers about the broader knowledge base in cancer metastasis. The process of metastasis is particularly responsible for making cancer so lethal. This volume explores both metastasis from sites of origin and common metastatic sites, thus increasing understanding of both perspectives. Includes basic biology and translational approaches to organ-specific cancer sites Provides readers with information on emerging therapeutic targets for cancer metastasis Contains contributions from leading researchers around the globe

Introduction to Cancer Biology

Introduction to Cancer Biology
A Book

by Anonim

  • Publisher : Bookboon
  • Release : 2010
  • Pages : 46
  • ISBN : 8776814785
  • Language : En, Es, Fr & De
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"Introduction to Cancer Biology is a short primer on how cancers develop and grow. The aim of this book is to provide a gentle exploration of the fundamental concepts in a easy-to-understand format, using examples and key figures for illustration. It is written in a style to help the reader understand the six basic principles that inform our current understanding of cancer, at the molecular, cellular and physiological level. The text can be used either as a first step towards a deeper understanding of the mechanisms of cancer progression or it can be used as a quick revision guide. It would be suitable for anyone, with or without a background in biology."--Website.

Introduction to Cancer Biology

Introduction to Cancer Biology
A Book

by Robin Hesketh

  • Publisher : Cambridge University Press
  • Release : 2013
  • Pages : 335
  • ISBN : 1107013984
  • Language : En, Es, Fr & De
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A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.

Understanding Cancer Therapies

Understanding Cancer Therapies
A Book

by Prakash Srinivasan Timiri Shanmugam

  • Publisher : CRC Press
  • Release : 2018-03-09
  • Pages : 174
  • ISBN : 1351982958
  • Language : En, Es, Fr & De
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This book is an introduction to cancer treatment, the basics of radio- and chemotherapy, drug actions, the eradication of cancer cells, and the origins and persistence of pharmacological and toxicological effects of drugs. It further provides ideas for research based on knowledge of cancer metastasis, invasive and molecular pathways, and diagnosis and treatment. Many of the adaptive features of cancer biology, clinical features, pathology and treatment are reviewed. In addition to introducing the major themes and theories, the book also advances the current discussion by moving beyond explanations for clinical implementation. Key Selling Features: Reviews basic cancer treatments Summarizes chemotherapies Discusses radiotherapies Examines pharmacological and toxicological approaches to treatment Introduces oncological drug development

The Role of JNK2 and JNK1 in Breast Cancer Mediated Invasion and Metastasis

The Role of JNK2 and JNK1 in Breast Cancer Mediated Invasion and Metastasis
A Book

by Azadeh Nasrazadani

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 350
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Receptor tyrosine kinase (RTK) inhibitors are emerging as an effective therapeutic option for treatment of breast cancer patients overexpressing particular RTKs. However, more patients may benefit from an inhibitor targeting a common effector protein downstream several RTKs. The presented studies herein identify c-Jun N-Terminal Kinase 2 (JNK2), a kinase downstream multiple RTKs, as a novel target to effectively inhibit Phosphatidylinositol 3-kinase/AKT activation and metastasis. Knockdown of JNK2 in the highly metastatic 4T1.2 mammary cancer cells significantly decreased growth factor induced invasion in Boyden chambers, orthotopic tumor growth, and metastatic lesions in lungs and bone. Intra-cardiac introduction of cancer cells is utilized to specifically study the later steps in the metastatic cascade including travel of disseminated cancer cells to a secondary location. Thus, earlier steps such as the process of acquiring a malignant phenotype leading to escape from the primary tumor are bypassed. Survival was prolonged in mice receiving intra-cardiac injection of cells deficient of JNK2 either in the host or in the tumor cells, suggesting a potential role for JNK2 as a therapeutic target for advanced stage breast cancer patients. Using siRNA and inhibitors against Src and PI3K, we determined that JNK2 activity is dependent on Src and PI3K, positioning JNK2 downstream of two critical factors involved in tumor progression. Microarray analysis of JNK2 deficient tumors revealed that JNK2 positively regulates the adaptor protein Grb2 associated binding protein 2 (Gab2). Knockdown of Gab2 in 4T1.2 cells resulted in decreased tumor growth and a trend for decreased lung metastasis. In vitro, stimulation of 4T1.2 shJNK2 or 4T1.2 shGab2 cells with HGF, heregulin, or insulin resulted in impaired AKT activation, suggesting involvement of Gab2 and JNK2 in multiple RTK signaling pathways. Understanding of the intricate mechanisms involved in RTK signal transduction can contribute to drug design geared towards more effective targets, namely JNK2. The secondary goal of this research was to decipher the individual roles of JNK2 and JNK1 in metastatic breast cancer. Survival was significantly shortened in mice injected intra-cardiac with 4T1.2 shJNK1 cells. In congruence, serum Cathepsin K levels were increased and bone lesions observed were higher in mice injected with shJNK1 expressing tumor cells compared to mice injected with control cells. In sharp contrast, jnk1-/- mice displayed dramatically increased survival and fewer bone lesions upon intra-cardiac injections of 4T1.2 cells. Collectively, these data suggest cell and isoform specific roles for JNKs.

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors
A Book

by Alison L. Allan

  • Publisher : Springer Science & Business Media
  • Release : 2011-08-12
  • Pages : 478
  • ISBN : 1617792462
  • Language : En, Es, Fr & De
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The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Understanding Cancer

Understanding Cancer
An Introduction to the Biology, Medicine, and Societal Implications of this Disease

by Richard Mcintosh/Mcd Biology

  • Publisher : Garland Science
  • Release : 2019-05-02
  • Pages : 446
  • ISBN : 0429576269
  • Language : En, Es, Fr & De
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Understanding Cancer is a brand-new undergraduate textbook that uses simple language and well-chosen examples to explain the biological processes that underlie cancer and inform our methods for the diagnosis and treatment of this disease. The book has been carefully designed to provide key information relevant for students seeking a broad and accessible introduction to the cancer problem, even if they have no prior training in biology or chemistry.

Breast Cancer

Breast Cancer
From Biology to Medicine

by Phuc Van Pham

  • Publisher : BoD – Books on Demand
  • Release : 2017-04-05
  • Pages : 568
  • ISBN : 9535129996
  • Language : En, Es, Fr & De
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Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.

Metastatic Cancer: Clinical and Biological Perspectives

Metastatic Cancer: Clinical and Biological Perspectives
A Book

by Rahul Jandial

  • Publisher : CRC Press
  • Release : 2013-08-08
  • Pages : 312
  • ISBN : 9781587066597
  • Language : En, Es, Fr & De
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Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

The Biological Basis of Cancer

The Biological Basis of Cancer
A Book

by Robert G. McKinnell

  • Publisher : Cambridge University Press
  • Release : 2006-08-28
  • Pages : 475
  • ISBN : 0521844584
  • Language : En, Es, Fr & De
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This is a revised and updated edition of a text used in undergraduate courses on cancer biology. It covers everything from the molecular basis of cancer to clinical aspects of the subject, and has a lengthy bibliography designed to assist newcomers with the cancer literature. An introduction acquaints students with the biological principles of cancer and the human dimensions of the disease by considering genuine cases of cancer in fictionalized letters. Other chapters discuss cancer pathology, metastasis, carcinogenesis, genetics, oncogenes and tumor suppressors, epidemiology, and the biological basis of cancer treatment. Also included are an appendix with descriptions of common forms of cancer, a glossary of cancer-related terms and colour plates to illustrate the pathology of many of the types of cancer discussed in the text. Upper-division undergraduates with a background in freshman biology and chemistry, as well as beginning graduate students will find this a valuable text.

Circulating Tumor Cells

Circulating Tumor Cells
Isolation and Analysis

by Z. Hugh Fan

  • Publisher : John Wiley & Sons
  • Release : 2016-03-29
  • Pages : 464
  • ISBN : 1119244536
  • Language : En, Es, Fr & De
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Introduces the reader to Circulating Tumor Cells (CTCs), their isolation method and analysis, and commercially available platforms Presents the historical perspective and the overview of the field of circulating tumor cells (CTCs) Discusses the state-of-art methods for CTC isolation, ranging from the macro- to micro-scale, from positive concentration to negative depletion, and from biological-property-enabled to physical-property-based approaches Details commercially available CTC platforms Describes post-isolation analysis and clinical translation Provides a glossary of scientific terms related to CTCs

An Introduction to Physical Oncology

An Introduction to Physical Oncology
How Mechanistic Mathematical Modeling Can Improve Cancer Therapy Outcomes

by Vittorio Cristini,Eugene Koay,Zhihui Wang

  • Publisher : CRC Press
  • Release : 2017-06-26
  • Pages : 164
  • ISBN : 1315356880
  • Language : En, Es, Fr & De
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Physical oncology has the potential to revolutionize cancer research and treatment. The fundamental rationale behind this approach is that physical processes, such as transport mechanisms for drug molecules within tissue and forces exchanged by cancer cells with tissue, may play an equally important role as biological processes in influencing progression and treatment outcome. This book introduces the emerging field of physical oncology to a general audience, with a focus on recent breakthroughs that help in the design and discovery of more effective cancer treatments. It describes how novel mathematical models of physical transport processes incorporate patient tissue and imaging data routinely produced in the clinic to predict the efficacy of many cancer treatment approaches, including chemotherapy and radiation therapy. By helping to identify which therapies would be most beneficial for an individual patient, and quantifying their effects prior to actual implementation in the clinic, physical oncology allows doctors to design treatment regimens customized to each patient’s clinical needs, significantly altering the current clinical approach to cancer treatment and improving the outcomes for patients.

Matrix Manipulation Affects Attachment And Growth Of Breast Cancer Cells In A Bone-like Microenvironment In Vitro

Matrix Manipulation Affects Attachment And Growth Of Breast Cancer Cells In A Bone-like Microenvironment In Vitro
A Book

by Shelby Foster

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Breast cancer is one of the most common and deadly cancers, but treatment of the primary tumor is usually very successful if the condition is realized early. The disease becomes more deadly once metastasis occur sand cancer cells spread from the primary tumor to secondary sites. One of the most common sites of breast cancer metastasis is the skeletal system. Breast cancer metastasis to bone is a painful process for a patient to endure, as breast cancer cells interrupt the healthy balance of buildup and breakdown of the bone. Introduction of breast cancer cells into the bone microenvironment causes an upregulation of bone degradation by increasing the activity of osteoclasts. Osteoblasts, bone forming cells, also are affected. They are unable to make up for the increased degradation, and the breast cancer invasion causes bones to become weak and more susceptible to trauma. It was hypothesized that specific changes to the bone microenvironment altered the attachment and growth of breast cancer cells within the bone. The aim was to determine the role of the bone extracellular matrix in breast cancer colonization. Experiments were conducted in vitro by differentiating mouse osteoblasts for four weeks until they created a bone matrix. In order to distinguish the osteoblasts from their secreted matrix, the cultures were altered through fixation and decellularization. Human metastatic breast cancer cells, MDA-MB-231 and an isologous line that carries a metastasis suppressor gene, MDA-MB-231 BRMS1 were added to the cultures of osteoblasts and attachment and growth of the cancer cells were Monitored. Most notably, breast cancer cells attached and proliferated more on a fixed osteoblast cultures than on decellurized or live osteoblast cultures. It was concluded that the growth was due to a change in the structure of the matrix after fixation. This result may correlate with a reduction of EPLIN, a protein responsible for fixation of surfaces, in metastatic cancer cells including MDA-MB-231.A second aim was to test another relevant modification of the bone environment, brought about by estrogen during osteoblast differentiation. Estrogen effects were important to test because breast cancer metastasis to bone occurs most often in women after menopause when less estrogen is produced in the body. Inhibiting estrogen receptors during osteoblast differentiation noticeably changed collagen fiber rearrangement and reduced the total amount of protein produced by the osteoblasts. Estrogen inhibition, however, did not affect breast cancer cell attachment or proliferation on a decellularized matrix, but significant changes in both attachment and proliferation were observed when the live osteoblasts were left intact. ELISA analysis also showed that more of the inflammatory and bone remodeling cytokine IL-6 is produced by MC3T3-E1 cells when they are grown with the estrogen inhibitor and exposed to the breast cancer cells. It was concluded that estrogen inhibition causes an inflammatory environment that is more supportive of breast cancer cells.

Pharmaceutical Perspectives of Cancer Therapeutics

Pharmaceutical Perspectives of Cancer Therapeutics
A Book

by Yi Lu,Ram I. Mahato

  • Publisher : Springer Science & Business Media
  • Release : 2009-06-23
  • Pages : 694
  • ISBN : 9781441901316
  • Language : En, Es, Fr & De
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Pharmaceutical Perspectives of Cancer Therapeutics covers a wide variety of therapeutic approaches including gene therapy, immunological therapy; cancer vaccines; strategy for solid tumors as well as for hematological cancers; methods to suppress tumor angiogenesis and metastasis; development and utilization of relevant animal models; introduction of new concepts such as cancer stem cells and new technologies, such as DNA and tissue microarrays; and RNA interference. In addition, clinical application, the development of DNA diagnosis biomarkers and cancer prevention, as well as the utilization of imaging in cancer therapy are also discussed. The use of synthetic carriers, such as lipids, polymers, and peptides for delivery and targeting of small molecules, proteins, and nucleic acids to cancer cells in vivo are discussed. Pharmaceutical Perspectives of Cancer Therapeutics also includes cancer therapy modality in surgery, chemotherapy, and radiotherapy, as well as in combination or multi-modality, giving our book a more focused view of cancer therapy.

Recent Advances in Management of Digestive Cancers

Recent Advances in Management of Digestive Cancers
Proceedings of UICC Kyoto International Symposium on Recent Advances in Management of Digestive Cancers, March 31–April 2, 1993

by Toshio Takahashi

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 867
  • ISBN : 443168252X
  • Language : En, Es, Fr & De
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Cancer is the leading cause of death in many countries, and digestive cancer is one of the most common types of neoplasms. Advances in research on the management of digestive cancer therefore represent an important contribution to the welfare of humankind throughout the world. The VICC Kyoto International Symposium on Recent Advances in the Management of Digestive Cancer was held in Kyoto from March 31 to April 2, 1993 under the presidency of Dr. T. Takahashi of the Kyoto Prefectural Vniversity of Medicine. At this event, leading researchers and clinicians presented new findings and the latest results of clinical trials concerning digestive cancers. The VICC President and other members of the Executive Committee of the VICC also gave speeches on their own fields, and more than 1000 participants from 28 countries were very well received. This book presents the proceedings of this symposium. In addition to 30 selected papers presented at special lectures and symposia by invited speakers, this book contains 230 free papers presented at poster sessions during this conference.

Acute Bacterial Infection Facilitates Lung Cancer Metastasis Through Toll-like Receptor 2 and 4 Activation

Acute Bacterial Infection Facilitates Lung Cancer Metastasis Through Toll-like Receptor 2 and 4 Activation
A Book

by Simon Chow

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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INTRODUCTION: Lung cancer is the leading cause of cancer death, with low five-year survival rates and high percentage of local or metastatic recurrence. Surgical resection is integral for cure, however this procedure is associated with increased systemic inflammation and circulating tumour cells. This is further compounded by infectious postoperative complications, the most common of which is pneumonia, caused by both gram-positive and gram-negative bacteria. There is emerging clinical data to suggest that bacterial complications after lung cancer surgery may decrease survival, however the mechanism for this finding is not clear. Interactions between bacteria and host cells are mediated by specialized pathogen receptor proteins termed, Toll like receptors. Cancer cells have recently been shown to express Toll ike receptors, but their function in these malignant cells is unknown. The aim of this study is to investigate the mechanisms of bacterial infection...

Multidisciplinary Management of Liver Metastases in Colorectal Cancer

Multidisciplinary Management of Liver Metastases in Colorectal Cancer
Early Diagnosis and Treatment

by Xinyu Qin,Jianmin Xu,Yunshi Zhong

  • Publisher : Springer
  • Release : 2016-12-12
  • Pages : 288
  • ISBN : 9401777551
  • Language : En, Es, Fr & De
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This book focuses on early diagnosis and multidisciplinary treatment, which is the key to preventing the occurrence of the liver metastases in colorectal cancer, and to increasing the resection rate of the liver metastasis foci and the 5-year survival after surgery. This book is divided into five parts: the introduction, basics, diagnosis, treatment and prevention. It has 20 chapters in total, covering the latest advances in colorectal cancer liver metastases epidemiology, pathogenesis, molecular diagnostics, marker screening, imaging technology, surgery, chemotherapy and prevention, etc. It provides professionals with up-to-date and comprehensive information on colorectal liver metastases. This book is relevant for senior surgeons and physicians working in oncology, general surgery, chemotherapy, digestive medicine, liver medicine and hepatic surgery.

Small Animal Oncology E-Book

Small Animal Oncology E-Book
An Introduction

by Susan M. North,Tania Ann Banks

  • Publisher : Elsevier Health Sciences
  • Release : 2009-07-20
  • Pages : 304
  • ISBN : 0702042501
  • Language : En, Es, Fr & De
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A highly practical guide suitable for in-clinic reference, Small Animal Oncology has been designed for maximum ease of use and accessibility of information. Whilst giving clear and up-to-date briefing for the busy practitioner, it also is a valuable resource to the student with a special interest in oncology. This Introduction gives an overview of cancer biology and explains the principles of available therapies. There is up to date discussion on new and developing techniques and treatments, and guidance on when these are indicated. The book covers all common, most less common and some rare aspects of small animal oncology. accompanying Evolve website includes over 20 clinical cases to try your knowledge all-round practical, useful, every day essential guide to small animal oncology schematic approach gives quick access to information when you need it explains biology and the basic principles as well as indicating treatment options

Basic Science of Oncology, Fifth Edition

Basic Science of Oncology, Fifth Edition
A Book

by Ian Tannock,Richard Hill,Robert Bristow,Lea Harrington

  • Publisher : McGraw Hill Professional
  • Release : 2013-09-22
  • Pages : 576
  • ISBN : 0071813497
  • Language : En, Es, Fr & De
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NOW IN FULL COLOR! Discover the science of cancer--with this newly revised, essential introduction to cancer biology and genetics Here in one well-organized, reader-friendly volume, you'll find everything you must know about the biology underlying cancer and its treatment, supported by the latest peer-reviewed research. Written by preeminent oncology researchers and clinicians, the book highlights the full range of important oncology topics and takes you through the biological basis of current and future biological therapy as well as more traditional approaches to cancer treatment. Presented in full color, the Fifth Edition of The Basic Science of Oncology is thoroughly updated and refreshed to reflect the latest critical thinking in oncology. For graduate students, oncologists, residents, and fellows, there can be no more useful guide to the bedrock science and practice of oncology than this all-in-one reference. FEATURES: The most current, evidence-based oncology primer--one that encapsulates the science of cancer causation, cancer biology, and cancer therapy Key insights into molecular and genetic aspects of cancer familiarize you with cancer biology as applied to prognosis and personalized cancer medicine In-depth focus on the discovery, evaluation, and biology of anti-cancer drugs, immunotherapy, and molecularly-targeted agents Up-to-date coverage of the basic science of radiation therapy Specific chapters/sections on intratumor heterogeneity as it relates to potential new treatment strategies--including tumor microenvironment and metabolism, tumor stem cells, and genomic/proteomic heterogeneity NEW! Chapter Essentials synthesize chapter content in a convenient list NEW! Color diagrams and schematics summarize important data

The Genetics of Cancer

The Genetics of Cancer
Genes Associated with Cancer Invasion, Metastasis, and Cell Proliferation

by Gajanan V. Sherbet,M. S. Lakshmi

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 338
  • ISBN : 9780126398755
  • Language : En, Es, Fr & De
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Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Key Features The contents include: * Clonal evolution of the metastasis phenotype * Cell Cycle regulation * Apoptosis in tumour growth and metastasis * Angiogenesis in cancer * Cell surface glycoproteins and their receptors * Proteinases and their inhibitors in cancer invasion * Oncogenes and cancer metastasis * Developmental genes * Tumour suppressor genes * Metastasis suppressor genes * Dominant metastasis-associated genes