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iPSCs from Diverse Species

iPSCs from Diverse Species
A Book

by ALEXANDER BIRBRAIR

  • Publisher : Academic Press
  • Release : 2020-10-12
  • Pages : 272
  • ISBN : 0323851851
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs from Diverse Species, Volume 2 addresses how induced pluripotent stem cells (iPSCs) can be derived from different species. The volume teaches the reader about modern state-of-the-art methodologies to derive iPSCs from distinct species. This volume will cover how to derive iPSCs from species like nonhuman primates, horses, dogs, pigs, rats, rabbits, and others. It also discusses the importance of iPSCs in species conservation. Detailed description on methods used to obtain iPSCs from humans and other species expands the knowledge and understanding of stem cell biology and provides a potent tool to model diseases. The volume is written for researchers and scientists in stem cell biology, and regenerative medicine and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers the following signaling pathways: notch, hedgehog, TGFβ, PAR2 and more Contributions from stem cell leaders around the world

Epigenetics and Regeneration

Epigenetics and Regeneration
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-05-24
  • Pages : 541
  • ISBN : 0128148802
  • Language : En, Es, Fr & De
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Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Recent Advances in iPSC Disease Modeling, Volume 1

Recent Advances in iPSC Disease Modeling, Volume 1
A Book

by ALEXANDER BIRBRAIR

  • Publisher : Academic Press
  • Release : 2020-07-16
  • Pages : 320
  • ISBN : 0128232692
  • Language : En, Es, Fr & De
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Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Reproductive Sciences in Animal Conservation

Reproductive Sciences in Animal Conservation
Progress and Prospects

by William V. Holt,Janine L. Brown,Pierre Comizzoli

  • Publisher : Springer
  • Release : 2014-08-04
  • Pages : 533
  • ISBN : 1493908200
  • Language : En, Es, Fr & De
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Reproductive biology is more than the development of techniques for helping with too little or too much breeding. While some of the relevant techniques are useful for individual species, technical developments have to be backed up by thorough biological understanding of the background behind the problems. This book is therefore threefold; (1) it provides a snapshot of the state of the art in terms of species-specific reproductive technologies, whether for individual animals or whole taxonomic groups; (2) it sets the reproductive problems in context and emphasizes the links between animal-based problems and the wider world, e.g. reproductive fitness and (3) it looks forward and presents realistic assessments of how effective some of the more recently developed techniques in reproductive technology might be at combating extinctions. This is a wide-ranging book that will be relevant to anyone involved in reproductive biology or in species conservation and provides provide them some useful perspectives about the real utility of current and emerging technologies. It has contributions from experts in reproduction and related fields.

Advances in Animal Biotechnology

Advances in Animal Biotechnology
A Book

by Birbal Singh,Gorakh Mal,Sanjeev K. Gautam,Manishi Mukesh

  • Publisher : Springer
  • Release : 2019-07-09
  • Pages : 562
  • ISBN : 3030213099
  • Language : En, Es, Fr & De
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This book entitled, “Advances in Animal Biotechnology,” is a compilation of state-of-the-art in the field of Animal Biotechnology including fishery, that are not sheltered in depth in earlier publications. It offers an update on avant-garde technologies and advances in key aspects of genetic engineering, metagenomics, assisted reproduction, animal genomics, biotechnology in veterinary health, as well as the role of gut and marine microbial ecosystems in livestock and industrial development. The book is divided broadly into five different sections, viz., Gut Microbiome and Nutritional Biotechnology, Assisted Reproduction Biotechnology, Livestock Genomics, Health Biotechnology, and Animal Biotechnology in Global Perspective. The book covers the syllabi of Animal Biotechnology courses in various universities, academia and competitive examinations at various levels. Researchers, Continuing Graduates, and Academicians, Research Institutions, and Biotech Companies will be benefited from this valuable compilation of research. Its broad spectrum makes this work a valuable resource for professionals, researchers, academics and students in the field of veterinary and animal production as well as the biotechnology industry.

Principles of Regenerative Medicine

Principles of Regenerative Medicine
A Book

by Anthony Atala,Robert Lanza,Tony Mikos,Robert Nerem

  • Publisher : Academic Press
  • Release : 2018-08-09
  • Pages : 1454
  • ISBN : 0128098937
  • Language : En, Es, Fr & De
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Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Essentials of Stem Cell Biology

Essentials of Stem Cell Biology
A Book

by Robert Lanza,John Gearhart,Brigid Hogan,Douglas Melton,Roger Pedersen,E. Donnall Thomas,James A. Thomson,Ian Sir Wilmut

  • Publisher : Academic Press
  • Release : 2009-06-05
  • Pages : 680
  • ISBN : 9780080884974
  • Language : En, Es, Fr & De
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First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing the latest advances in stem cells. Representing the combined effort of seven editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, methods to application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Contributions by Nobel Laureates and leading international investigators Includes two entirely new chapters devoted exclusively to induced pluripotent stem (iPS) cells written by the scientists who made the breakthrough Edited by a world-renowned author and researcher to present a complete story of stem cells in research, in application, and as the subject of political debate Presented in full color with glossary, highlighted terms, and bibliographic entries replacing references

Transgenic Animal Technology

Transgenic Animal Technology
A Laboratory Handbook

by Carl A. Pinkert

  • Publisher : Newnes
  • Release : 2014-06-17
  • Pages : 714
  • ISBN : 0124095364
  • Language : En, Es, Fr & De
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Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions. This well-illustrated handbook covers the technical aspects of gene transfer — from molecular methods to whole animal considerations — for important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. This second edition incorporates updates on a variety of genetic engineering technologies ranging from microinjection and ES cell transfer to nuclear transfer in a broad range of animal modeling systems. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Fully revised with updates to reflect state-of-the-art technology and associated changes to date

Pluripotent Stem Cells

Pluripotent Stem Cells
From the Bench to the Clinic

by Minoru Tomizawa

  • Publisher : BoD – Books on Demand
  • Release : 2016-07-20
  • Pages : 532
  • ISBN : 9535124714
  • Language : En, Es, Fr & De
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Pluripotent stem cells have distinct characteristics: self-renewal and the potential to differentiate into various somatic cells. In recent years, substantial advances have been made from basic science to clinical applications. The vast amount knowledge available makes obtaining concise yet sufficient information difficult, hence the purpose of this book. In this book, embryonic stem cells, induced pluripotent stem cells, and mesenchymal stem cells are discussed. The book is divided into five sections: pluripotency, culture methods, toxicology, disease models, and regenerative medicine. The topics covered range from new concepts to current technologies. Readers are expected to gain useful information from expert contributors.

Tissue Regeneration

Tissue Regeneration
A Book

by Hussein Abdelhay Essayed Kaoud

  • Publisher : BoD – Books on Demand
  • Release : 2018-06-06
  • Pages : 206
  • ISBN : 1789232600
  • Language : En, Es, Fr & De
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Tissue regeneration is a vast subject, with many different important aspects to consider. Regenerative medicine is a new branch of medicine that tries to change the course of chronic diseases and, in many cases, regenerates the organ systems that fail due to age, disease, damage, or genetic defects. The main purpose of this book is to point out the interest of some important topics of tissue regeneration and the progress in this field as well as the variety of different surgical fields and operations. This book includes 7 sections and 11 chapters that provide an overview of the essentials in tissue regeneration science and their potential applications in surgery. The authors of each chapter have given consolidated information on ground realities and attempted to provide a comprehensive knowledge of tissue engineering and regeneration. This book will be useful to researchers and students of biological and biomedical sciences (medical and veterinarian researchers).

Regenerative Nephrology

Regenerative Nephrology
A Book

by Michael S. Goligorsky

  • Publisher : Academic Press
  • Release : 2010-11-26
  • Pages : 442
  • ISBN : 9780123809292
  • Language : En, Es, Fr & De
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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Diversity in the Neuronal Machine

Diversity in the Neuronal Machine
Order and Variability in Interneuronal Microcircuits

by Ivan Soltesz

  • Publisher : Oxford University Press
  • Release : 2006
  • Pages : 238
  • ISBN : 0195177010
  • Language : En, Es, Fr & De
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Aims to provide insights into the striking degree of cellular diversity found in the interneuronal microcircuits in the brain's neocortex and hippocampus. This book elaborates on different ideas about interneuronal diversity that rest upon theoretical and experimental results and is useful for neuroscientists.

Human Embryonic Stem Cells

Human Embryonic Stem Cells
A Book

by Arlene Chiu,Mahendra S. Rao

  • Publisher : Springer Science & Business Media
  • Release : 2003-08-01
  • Pages : 461
  • ISBN : 1592594239
  • Language : En, Es, Fr & De
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A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.

Update on Multiple Myeloma

Update on Multiple Myeloma
A Book

by Khalid Ahmed Al-Anazi

  • Publisher : Unknown Publisher
  • Release : 2019-02
  • Pages : 234
  • ISBN : 178985217X
  • Language : En, Es, Fr & De
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Principles of Tissue Engineering

Principles of Tissue Engineering
A Book

by Robert Lanza,Robert Langer,Joseph P. Vacanti

  • Publisher : Elsevier
  • Release : 2000-05-16
  • Pages : 995
  • ISBN : 008053967X
  • Language : En, Es, Fr & De
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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features * Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves * Essential to anyone working in the field * Educates and directs both the novice and advanced researcher * Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves * Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell * Considered the definitive reference in the field * List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

Handbook of Models for Human Aging

Handbook of Models for Human Aging
A Book

by P. Michael Conn

  • Publisher : Elsevier
  • Release : 2011-04-28
  • Pages : 1075
  • ISBN : 9780080460062
  • Language : En, Es, Fr & De
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The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Patient-Specific Induced Pluripotent Stem Cell Models

Patient-Specific Induced Pluripotent Stem Cell Models
Generation and Characterization

by Andras Nagy,Kursad Turksen

  • Publisher : Humana Press
  • Release : 2015-11-08
  • Pages : 368
  • ISBN : 9781493930333
  • Language : En, Es, Fr & De
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This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases. Specifically, representative protocols on various disease models have been collected from labs around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization is an ideal reference for scientists working on furthering iPS research.

Pluripotent Stem Cell Biology

Pluripotent Stem Cell Biology
Advances in Mechanisms, Methods and Models

by Craig Atwood,Sivan Vadakkadath Meethal

  • Publisher : BoD – Books on Demand
  • Release : 2014-07-02
  • Pages : 242
  • ISBN : 9535115901
  • Language : En, Es, Fr & De
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Pluripotent stem cells have the potential to revolutionize treatment options for a range of diseases and conditions. This book presents recent advances in our understanding of the biological mechanisms of stem cell self-renewal, reprograming and regeneration. Also covered are novel methodological advances in the culture, purification and use of stem cells, as well as the ethical and moral dilemmas of embryo donation and adoption. These advances will shape the utilization of stem cells for future basic and applied applications.

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
A Book

by Toshio Nakanishi,H. Scott Baldwin,Jeffrey R. Fineman,Hiroyuki Yamagishi

  • Publisher : Springer Nature
  • Release : 2020-01-01
  • Pages : 374
  • ISBN : 9811511853
  • Language : En, Es, Fr & De
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This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Transgenic models of cardiac arrhythmias and sudden death

Transgenic models of cardiac arrhythmias and sudden death
A Book

by Carol Ann Remme

  • Publisher : Frontiers E-books
  • Release : 2021
  • Pages : 329
  • ISBN : 2889191370
  • Language : En, Es, Fr & De
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