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Kidney Development, Disease, Repair and Regeneration

Kidney Development, Disease, Repair and Regeneration
A Book

by Melissa Helen Little

  • Publisher : Academic Press
  • Release : 2015-08-06
  • Pages : 614
  • ISBN : 012800438X
  • Language : En, Es, Fr & De
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Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Regenerative Nephrology

Regenerative Nephrology
A Book

by Michael S. Goligorsky

  • Publisher : Academic Press
  • Release : 2010-11-26
  • Pages : 442
  • ISBN : 9780123809292
  • Language : En, Es, Fr & De
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Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Kidney Development and Disease

Kidney Development and Disease
A Book

by Rachel K. Miller

  • Publisher : Springer
  • Release : 2017-04-13
  • Pages : 372
  • ISBN : 3319514369
  • Language : En, Es, Fr & De
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Kidney Development and Disease brings together established and young investigators who are leading authorities in nephrology to describe recent advances in three primary areas of research. The first section describes the use of animal models as powerful tools for the discovery of numerous molecular mechanisms regulating kidney development. The second section focuses on nephric cell renewal and differentiation, which lead to diverse cell fates within the developing kidney, and discusses diseases resulting from the aberrant regulation of the balance between cell fate decisions. The final section concentrates on morphogenesis of the developing kidney and its maintenance after formation as well as the diseases resulting from failures in these processes. Kidney form and function have been extensively studied for centuries, leading to discoveries related to their development and disease. Recent scientific advances in molecular and imaging techniques have broadened our understanding of nephron development and maintenance as well as the diseases related to these processes.

Regenerative Potential of Colony-stimulating Factor-1 Therapy and Macrophages in Renal Disease

Regenerative Potential of Colony-stimulating Factor-1 Therapy and Macrophages in Renal Disease
A Book

by Maliha Alikhan

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 434
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Kidney disease is a growing public health concern, and current therapies inflict substantial strain on both patients and the health care system. Fortunately, the adult kidney can repair itself following transient damage. While the cellular events that lead to kidney regeneration are well defined, less is understood about the endogenous repair mechanisms that control these pathways. In adult organs, macrophages display significant heterogeneity during disease progression. The surrounding microenvironment ultimately influences disease outcome via polarisation of macrophages toward a classically activated M1-like state or an alternatively activated M2-like phenotype. M1-like macrophages are a pro-inflammatory population that are involved in host defence and tissue destruction, whereas M2-like macrophages secrete anti-inflammatory mediators that induce inflammatory resolution and wound healing. In the mouse model of renal ischemia-reperfusion (IR) injury, M2-like macrophages play a fundamental role in repair by resolving inflammation and mediating the restoration of injured renal epithelial cells. Colony-stimulating factor (CSF)-1 is a hematopoietic growth factor that primarily regulates the development, proliferation and survival of macrophages. In addition, CSF-1 exhibits important pleiotropic roles during development, homeostasis, injury and cancer. Studies also demonstrate that CSF-1 can foster epithelial cell repair and tissue remodelling in animal models of acute injury. The overall aim of this thesis was to investigate the regenerative potential of CSF-1 therapy in an acute renal IR injury model, with particular attention to the functional role of M2-like macrophages. Chapter 2 reports the structural and functional kidney recovery following CSF-1 administration to mice with established IR injury. Five days after injection of CSF-1 to IR mice, increased epithelial cell proliferation and reduced intratubular cast formation and interstitial matrix expansion was evident compared to vehicle-treated mice. Structural recovery at day 7 also coincided with reduced collagen accumulation and improved functional recovery as evident by reduced urinary albumin compared to vehicle-treated mice.In Chapter 3, extensive characterisation of macrophage phenotype and function was performed to determine the functional contribution of CSF-1-mediated renal regeneration. CSF-1 influenced renal macrophage number and maturity following IR injury. The number of CSF-1-responsive macrophages increased at day 5 and then declined at day 7 when recovery was complete. This coincided with macrophage maturity with increased expression of F4/80 and MHC II at day 5 when damage was still evident followed by reduced expression at day 7. Flow cytometry and real-time PCR analysis of the expression of known M1- and M2-associated genes provided further insight into the influence of CSF-1 therapy on macrophage phenotype and function. CSF-1-responsive macrophages displayed increased expression of common M2-like genes including arginase, CCL17, scavenger receptor and macrophage mannose receptor. To further corroborate these findings, microarray analysis was performed in order to investigate the specific macrophage signalling pathways and genes involved in the CSF-1-accelerated repair response. The most significant differences in macrophage gene expression occurred at day 5 post-IR injury, where the genes differentially expressed in CSF-1-responsive macrophages were primarily associated with M2-like signalling pathways. These included the glucocorticoid receptor, IL-10 and insulin-like growth factor (IGF)-1 signalling pathways, which are important in inflammatory resolution and wound healing. Of significant interest was the differential expression of genes associated with the IGF-1 signalling pathways. IGF-1 is known to play important reparative roles in post-ischemic kidneys, and CSF-1 can also control the expression of macrophage-derived IGF-1. Further analysis and validation was therefore performed using real-time PCR analysis, which revealed increased IGF-1 expression in CSF-1-responsive macrophages at both time-points compared to vehicle-treated mice. These findings suggest that CSF-1 accelerates renal regeneration following acute IR injury via alteration of macrophage phenotype, and in part by macrophage-derived IGF-1 production. However, reports from other investigators also indicate that CSF-1 can signal to epithelial cells in the body by direct autocrine and paracrine actions.In Chapter 4, the precise contribution of macrophages, macrophage-derived IGF-1 and renal epithelial cells following CSF-1 therapy was therefore examined in vitro using co-culture assays with bone marrow-derived macrophages and the immortalised renal mouse cortical tubular cell line. While the findings from the functional assays did not provide further insight into the mechanisms underlying the renoprotective effects of CSF-1 therapy, they did support our hypothesis that CSF-1 regulates macrophage-derived IGF-1 production. However, additional mechanistic experiments in a variety of animal models of renal disease in combination with blocking antibodies are needed to fully elucidate the functional contribution of CSF-1 therapy. A better understanding of the role of macrophages and the factors that control their phenotype and function may ultimately lead to the development of therapies that attenuate acute renal disease and prevent the progression to chronic renal failure for patients with renal disease.

Amino Acids in Nutrition and Health

Amino Acids in Nutrition and Health
Amino acids in systems function and health

by Guoyao Wu

  • Publisher : Springer Nature
  • Release : 2020-08-06
  • Pages : 220
  • ISBN : 3030453286
  • Language : En, Es, Fr & De
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This edited volume comprehensively highlights recent advances in the metabolism, nutrition, physiology, and pathobiology of amino acids in all the systems of humans and other animals (including livestock, poultry, companion animals, and fish). It enables readers to understand the crucial roles of amino acids and their metabolites in the health and diseases of the circulatory, digestive, endocrine, immune, muscular, nervous, reproductive, respiratory, skeletal, and urinary systems, as well as the sense organs (eyes, ears, nose, skin, and tongue). Readers will learn that amino acids are not only the building blocks of protein, but are also signalling molecules, as well as regulators of gene expression, metabolic processes and developmental changes in the body. This knowledge will guide nutritional practices to improve the growth, development and health of humans and other animals, as well as prevent and treat chronic (e.g., obesity, diabetes, and cardiovascular disorders) and infectious (e.g., bacterial, fungal, parasite, and viral) diseases. Editor of this volume is an internationally recognized expert in nutritional biochemistry. He has over 38 years of experience with research and teaching at world-class universities in the area of amino acid biochemistry, nutrition, and physiology. He has published more than 625 papers in peer-reviewed journals, 62 chapters in books, and authored two text/reference books, with an H-index of 117 and more than 55,000 citations in Google Scholar. This publication is a useful reference for professionals as well as undergraduate and graduate students in animal science, biochemistry, biomedical engineering, biology, human medicine, food science, kinesiology, nursing, nutrition, pharmacology, physiology, toxicology, veterinary medicine, and other related disciplines. In addition, all chapters provide general and specific references to amino acids in systems health for researchers and practitioners in biomedicine, animal and plant agriculture, and aquaculture, and for government policy makers.

Essays on Developmental Biology

Essays on Developmental Biology
A Book

by Paul M Wassarman

  • Publisher : Academic Press
  • Release : 2016-03-10
  • Pages : 734
  • ISBN : 0128016167
  • Language : En, Es, Fr & De
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In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman

Virtual Prototyping & Bio Manufacturing in Medical Applications

Virtual Prototyping & Bio Manufacturing in Medical Applications
A Book

by Bopaya Bidanda,Paulo Jorge Bártolo

  • Publisher : Springer Nature
  • Release : 2020-10-21
  • Pages : 293
  • ISBN : 3030358801
  • Language : En, Es, Fr & De
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The original role of RP was to confirm the shape and feel of concept design, but innovations in RP now allow for the development of sophisticated medical devices such as catheters, stents, drug delivery systems, syringes and cardio-vascular devices, and more. RP has moved beyond medical devices, as surgeons now regularly use RP models to brainstorm strategies for surgeries. This book presents new uses for rapid prototyping in state-of-the-art medical applications.

Brenner and Rector's The Kidney E-Book

Brenner and Rector's The Kidney E-Book
A Book

by Karl Skorecki,Glenn M. Chertow,Philip A. Marsden,Maarten W. Taal,Alan S. L. Yu,Valerie Luyckx

  • Publisher : Elsevier Health Sciences
  • Release : 2019-09-25
  • Pages : 2748
  • ISBN : 0323550851
  • Language : En, Es, Fr & De
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Put the world’s most well-known kidney reference to work in your practice with the 11th Edition of Brenner & Rector’s The Kidney. This two-volume masterwork provides expert, well-illustrated information on everything from basic science and pathophysiology to clinical best practices. Addressing current issues such as new therapies for cardiorenal syndrome, the increased importance of supportive or palliative care in advanced chronic kidney disease, increasing live kidney donation in transplants, and emerging discoveries in stem cell and kidney regeneration, this revised edition prepares you for any clinical challenge you may encounter. Extensively updated chapters throughout, providing the latest scientific and clinical information from authorities in their respective fields. Lifespan coverage of kidney health and disease from pre-conception through fetal and infant health, childhood, adulthood, and old age. Discussions of today’s hot topics, including the global increase in acute kidney injury, chronic kidney disease of unknown etiology, cardiovascular disease and renal disease, and global initiatives for alternatives in areas with limited facilities for dialysis or transplant. New Key Points that represent either new findings or "pearls" of information that are not widely known or understood. New Clinical Relevance boxes that highlight the information you must know during a patient visit, such as pertinent physiology or pathophysiology. Hundreds of full-color, high-quality photographs as well as carefully chosen figures, algorithms, and tables that illustrate essential concepts, nuances of clinical presentation and technique, and clinical decision making. A new editor who is a world-renowned expert in global health and nephrology care in underserved populations, Dr. Valerie A. Luyckx from University of Zürich. Board review-style questions to help you prepare for certification or recertification.

Kidney Transplantation, Bioengineering, and Regeneration

Kidney Transplantation, Bioengineering, and Regeneration
Kidney Transplantation in the Regenerative Medicine Era

by Giuseppe Orlando,Giuseppe Remuzzi,David F. Williams

  • Publisher : Academic Press
  • Release : 2017-06-08
  • Pages : 1252
  • ISBN : 0128018364
  • Language : En, Es, Fr & De
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Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Zebrafish at the Interface of Development and Disease Research

Zebrafish at the Interface of Development and Disease Research
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2017-03-21
  • Pages : 384
  • ISBN : 0128033436
  • Language : En, Es, Fr & De
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There are many shared pathways that govern development and also can contribute to disease. Zebrafish have traditionally been used to study vertebrate development, and from decades of work in this system, we have learned details about developmental processes, genes and pathways that are implicated in disease. In each chapter of this book, we interweave how studying zebrafish development has informed our understanding of diseases from the immune system, to the kidney, liver, heart and others. The subject matter is unique - no single volume has pulled together the theme of development and disease with zebrafish as a centerpiece Leading experts in the field - all of them running zebrafish focused labs for each chapter

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life

Factors Influencing Mammalian Kidney Development: Implications for Health in Adult Life
A Book

by Karen Moritz,E. Marelyn Wintour-Coghlan,M. Jane Black,John F. Bertram,Georgina Caruana

  • Publisher : Springer Science & Business Media
  • Release : 2008-05-11
  • Pages : 79
  • ISBN : 3540777687
  • Language : En, Es, Fr & De
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In this monograph the authors have emphasized a number of important concepts in mammalian kidney development. Emphasis has been put on methodology so that the reader can understand how certain results or conclusions were reached and what the optimal methods for reliable results to be obtained are. In addition, as well as descriptions of the morphology there is information on the genetic basis of the structural development. In addition much attention has been paid to how nephron number may be altered by changes in the environment of the developing kidney and to the consequences for the remaining nephron gene expression and kidney function when total nephron number is altered. The consequences for the health of the adult, upon the formation of an adult kidney with altered nephron number and (potentially) gene expression, can be quite serious. The epigenetic mechanisms by which such changes can occur are introduced as a very fertile field for future investigation.

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
A Book

by P. Michael Conn

  • Publisher : Academic Press
  • Release : 2017-06-20
  • Pages : 1198
  • ISBN : 0128096993
  • Language : En, Es, Fr & De
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Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Renal Ontogeny and Evaluation of Decellularized Kidney Scaffolds for Tissue Engineering in a Rhesus Monkey Model

Renal Ontogeny and Evaluation of Decellularized Kidney Scaffolds for Tissue Engineering in a Rhesus Monkey Model
A Book

by Jennifer Leigh Keyser,California State University, Sacramento

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 64
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The prevalence of end stage renal disease (ESRD) is dramatically increasing. It is estimated that the number of people in the United States undergoing treatment for chronic kidney disease will rise from 500,000 to two million by the year 2030. In infants and children, ESRD is commonly caused by developmental abnormalities including obstruction of the fetal urinary tract. Characterization of developing glomerular precursors including renal vesicles, C- and S-shaped bodies, and podocytes is necessary in order to determine effective ways to recapitulate ontogeny with the goal of repair. New strategies to repair damaged organs using decellularized biological scaffolds are being developed, with the hope of using cell therapy for tissue regeneration within a natural framework. Decellularized scaffolds must serve as a support for cellular interactions and not result in an immune response. This study characterizes fetal kidney development in a clinically relevant rhesus monkey model and assesses whether MHC Class I or Class II proteins remain in a decellularized kidney scaffold. This was addressed by staining fetal kidneys across gestation with hematoxylin and eosin (H&E), v and performing immunohistochemistry (IHC) and enzyme-linked immunosorbant assay (ELISA) on fresh kidneys and kidneys decellularized in 1% sodium dodecyl sulfate (SDS). Results show that renal development in the rhesus monkey mimics that in the human. Glomerular precursors are abundant in the cortex during the first and second trimesters, and by the third trimester, nearly all precursors have differentiated to mature glomeruli. Near term kidneys from the fetal rhesus monkey model of obstructive renal dysplasia show cystic glomeruli with cystic dilatation of Bowman0́9s space, and abnormal glomerular tuft development when compared with unobstructed kidneys. The podocyte marker, WT-1, is strongly expressed in the condensed mesenchyme and nephrogenic zone at the cortical border during the first and second trimesters. By the third trimester, WT-1 expression is confined to mature glomeruli. IHC and ELISA revealed that HLA-E and HLA-DR were removed from the scaffolds during decellularization, while modest amounts of HLA-DQ remained in juvenile decellularized kidney scaffolds. The results from this study add to the growing base of research concerning the use of decellularized scaffolds and will contribute to the ability to repair or replace damaged kidneys in vivo.

Clinical Regenerative Medicine in Urology

Clinical Regenerative Medicine in Urology
A Book

by Bup Wan Kim

  • Publisher : Springer
  • Release : 2017-09-14
  • Pages : 285
  • ISBN : 9811027234
  • Language : En, Es, Fr & De
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This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.

Combating Diabetes and Diabetic Kidney Disease

Combating Diabetes and Diabetic Kidney Disease
A Book

by Swayam Prakash Srivastava,Julie Goodwin,Keizo Kanasaki

  • Publisher : Frontiers Media SA
  • Release : 2021-09-10
  • Pages : 129
  • ISBN : 2889712834
  • Language : En, Es, Fr & De
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The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation, Development, Disease and Repair After Injury

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation, Development, Disease and Repair After Injury
A Book

by Zhouguang Wang,Xiaokun Li,Li Lin,Saverio Bellusci,Jin-San Zhang

  • Publisher : Frontiers Media SA
  • Release : 2020-11-19
  • Pages : 129
  • ISBN : 2889661288
  • Language : En, Es, Fr & De
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Chronic Renal Disease

Chronic Renal Disease
A Book

by Paul L. Kimmel,Mark E. Rosenberg

  • Publisher : Academic Press
  • Release : 2019-08-28
  • Pages : 1390
  • ISBN : 0128158778
  • Language : En, Es, Fr & De
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Chronic Renal Disease, Second Edition, comprehensively investigates the physiology, pathophysiology, treatment and management of chronic kidney disease (CKD). This translational reference takes an in-depth look at CKD with no coverage of dialysis or transplantation. Chapters are devoted to the scientific investigation of chronic kidney disease, the most common problems faced by nephrologists in the management of chronic kidney disease, specific illnesses in the CKD framework, and how the management of CKD in a polycystic kidney disease patient differs from other CKD patients. This award-winning reference features a series of case studies, covering both clinical aspects and pathophysiology. Questions are open ended, progressively more difficult, and repetitive across different patient clinical problems and different chapters. The cases and questions included will be useful for medical students, residency board reviews, and clinician teaching or conference preparation. Includes case studies and questions which can be used as a teaching tool for medical students and resident Provides coverage of classification and measurement, epidemiology, pathophysiology, complications of CKD, fluid/electrolyte disorders in CKD, CKD and systemic illnesses, clinical considerations, therapeutic considerations, and special considerations

Podocytopathy

Podocytopathy
A Book

by Z.-H. Liui,J.C. He

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2014-05-16
  • Pages : 277
  • ISBN : 3318026514
  • Language : En, Es, Fr & De
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The podocyte is a key cell that forms the last barrier of the kidney filtration unit. One of the most exciting developments in the field of nephrology in the last decade has been the elucidation of its biology and its role in the pathophysiology of inherited and acquired glomerular disease, termed podocytopathy. In this publication, world-renowned experts summarize the most recent findings and advances in the field: they describe the unique biological features and injury mechanisms of the podocyte, novel techniques used in their study, and diagnosis and potential therapeutic approaches to glomerular diseases. Due to its broad scope, this publication is of great value not only for clinical nephrologists and researchers, but also for students, residents, fellows, and postdocs.

Organ Development

Organ Development
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-02-21
  • Pages : 502
  • ISBN : 0128104902
  • Language : En, Es, Fr & De
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Organ Development, Volume 132, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapter written by an international board of authors. This volume highlights cogent reviews of the development, maintenance and regeneration/repair of several organ systems, from eye to kidney, to the musculoskeletal system. Many reviews highlight new techniques or technologies that are currently pushing the field. The role of both embryonic and adult stem cells are highlighted and senior authors are all women scientists. Provides the authority and expertise of leading contributors from an international board of author Presents the latest release in this series Updated release includes the latest information on organ development

Regenerative Medicine - from Protocol to Patient

Regenerative Medicine - from Protocol to Patient
5. Regenerative Therapies II

by Gustav Steinhoff

  • Publisher : Springer
  • Release : 2016-06-14
  • Pages : 396
  • ISBN : 3319283863
  • Language : En, Es, Fr & De
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​Regenerative medicine is the main field of groundbreaking medical development and therapy using knowledge from developmental and stem cell biology as well as advanced molecular and cellular techniques. This collection of volumes on Regenerative Medicine: From Protocol to Patient, aims to explain the scientific knowledge and emerging technology as well as the clinical application in different organ systems and diseases. International leading experts from all over the world describe the latest scientific and clinical knowledge of the field of regenerative medicine. The process of translating science of laboratory protocols into therapies is explained in sections on regulatory, ethical and industrial issues. This collection is organized into five volumes: (1) Biology of Tissue Regeneration, (2) Stem Cell Science and Technology, (3) Tissue Engineering, Biomaterials and Nanotechnology, (4) Regenerative Therapies I, and (5) Regenerative Therapies II. The textbook gives the student, the researcher, the health care professional, the physician and the patient a complete survey on the current scientific basis, therapeutical protocols, clinical translation and practiced therapies in regenerative medicine. Volume 5 contains clinical science and translation surveys on the circulatory system, visceral, musculoskeletal and skin. The state-of-the-art descriptions involve concepts for clinical diagnosis, stem cell and gene therapy, biomaterials for tissue replacement and pharmacological/biomolecule treatment strategies.