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Kidney Transplantation, Bioengineering, and Regeneration

Kidney Transplantation, Bioengineering, and Regeneration
Kidney Transplantation in the Regenerative Medicine Era

by Giuseppe Orlando,Giuseppe Remuzzi,David F. Williams

  • Publisher : Academic Press
  • Release : 2017-06-08
  • Pages : 1252
  • ISBN : 0128018364
  • Language : En, Es, Fr & De
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Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
Volume 1

by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Robert J. Stratta,Rainer W.G. Gruessner

  • Publisher : Academic Press
  • Release : 2019-11-09
  • Pages : 890
  • ISBN : 0128148349
  • Language : En, Es, Fr & De
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Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas, Volume 1, sets a new standard in transplant and regenerative medicine. The book details the-state-of-the-art in modern whole pancreas and islet transplantation, including donor selection, immunosuppression, complications, allograft pathology, and more. As regenerative medicine is changing the premise of solid organ transplantation, this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Edited and authored by unparalleled leaders in the field, this new volume argues for a much needed synergy between organ transplantation and regenerative medicine. Provides comprehensive and cutting-edge knowledge of whole pancreas and islet transplantation Includes sections that address donor selection, immunosuppression, complications, allograft pathology, and more Offers an update on the progress of regenerative medicine research aimed at beta cells replacement in the treatment of diabetes

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation
A Book

by Giuseppe Orlando

  • Publisher : Academic Press
  • Release : 2013-10-11
  • Pages : 1050
  • ISBN : 012398520X
  • Language : En, Es, Fr & De
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Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Organ Repair and Regeneration

Organ Repair and Regeneration
Preserving Organs in the Regenerative Medicine Era

by Giuseppe Orlando,Shaf Keshavjee

  • Publisher : Academic Press
  • Release : 2021-01-25
  • Pages : 304
  • ISBN : 0128194529
  • Language : En, Es, Fr & De
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Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation. Covers all aspects of organ preservation, repair and regeneration Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas

Transplantation, Bioengineering, and Regeneration of the Endocrine Pancreas
A Book

by Giuseppe Orlando,Lorenzo Piemonti,Camillo Ricordi,Rainer W. G. Gruessner,Robert Stratta

  • Publisher : Academic Press
  • Release : 2019-11
  • Pages : 700
  • ISBN : 9780128148310
  • Language : En, Es, Fr & De
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Islet Auto-Transplantation and Regenerative Medicine of the Pancreas, Volume 2 sets a new standard in transplant and regenerative medicine. The state of the art of modern islet auto- transplantation is detailed, as is the current progress of regenerative medicine research as it is applied to diabetes medicine. Regenerative medicine is changing the premise of solid organ transplantation, and this volume catalogs the technologies being developed and the methods being implemented to bioengineer or regenerate the endocrine pancreas in order to more effectively treat diabetes. Bioengineering and regenerating beta cells, clinical pancreas and islet transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology are all addressed and applied directly to diabetes medicine. Edited and authored by unparalleled leaders in the field, the volume argues for a much needed synergy between organ transplantation and regenerative medicine.

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
New Technologies and Future Prospects

by Nihal Vrana,Helena Knopf-Marques,Julien Barthes

  • Publisher : Woodhead Publishing
  • Release : 2020-03-20
  • Pages : 846
  • ISBN : 0081029071
  • Language : En, Es, Fr & De
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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Translating Regenerative Medicine to the Clinic

Translating Regenerative Medicine to the Clinic
A Book

by Jeffrey Laurence,Pedro Baptista,Anthony Atala

  • Publisher : Academic Press
  • Release : 2015-11-18
  • Pages : 354
  • ISBN : 0128005521
  • Language : En, Es, Fr & De
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Translating Regenerative Medicine to the Clinic reviews the current methodological tools and experimental approaches used by leading translational researchers, discussing the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration, and regeneration of the bone and skin. Pedagogically, the book concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasizing recent innovations, critical barriers to progress, the new tools that are being used to overcome them, and specific areas of research that require additional study to advance the field as a whole. Volumes in the series include Translating Gene Therapy to the Clinic, Translating Regenerative Medicine to the Clinic, Translating MicroRNAs to the Clinic, Translating Biomarkers to the Clinic, and Translating Epigenetics to the Clinic. Encompasses the latest innovations and tools being used to develop regenerative medicine in the lab and clinic Covers the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field Contains extensive pedagogical updates aiming to improve the education of translational researchers in this field Provides a transdisciplinary approach that supports cross-fertilization between different sub-specialties of medicine

Regenerative Biology and Medicine

Regenerative Biology and Medicine
A Book

by David L. Stocum

  • Publisher : Academic Press
  • Release : 2012-06-07
  • Pages : 474
  • ISBN : 012384861X
  • Language : En, Es, Fr & De
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Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. Highly Commended 2013 BMA Medical Book Award for Medicine Includes coverage of skin, hair, teeth, cornea, and central neural tissues Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals

Principles of Regenerative Medicine

Principles of Regenerative Medicine
A Book

by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem

  • Publisher : Academic Press
  • Release : 2010-12-16
  • Pages : 1202
  • ISBN : 9780123814234
  • Language : En, Es, Fr & De
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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

Principles of Tissue Engineering

Principles of Tissue Engineering
A Book

by Robert Lanza,Robert Langer,Joseph P. Vacanti

  • Publisher : Elsevier
  • Release : 2000-05-16
  • Pages : 995
  • ISBN : 008053967X
  • Language : En, Es, Fr & De
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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features * Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves * Essential to anyone working in the field * Educates and directs both the novice and advanced researcher * Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves * Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell * Considered the definitive reference in the field * List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

Translational Regenerative Medicine

Translational Regenerative Medicine
A Book

by Anthony Atala,Julie Allickson

  • Publisher : Academic Press
  • Release : 2014-12-01
  • Pages : 606
  • ISBN : 0124104576
  • Language : En, Es, Fr & De
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Translational Regenerative Medicine is a reference book that outlines the life cycle for effective implementation of discoveries in the dynamic field of regenerative medicine. By addressing science, technology, development, regulatory, manufacturing, intellectual property, investment, financial, and clinical aspects of the field, this work takes a holistic look at the translation of science and disseminates knowledge for practical use of regenerative medicine tools, therapeutics, and diagnostics. Incorporating contributions from leaders in the fields of translational science across academia, industry, and government, this book establishes a more fluid transition for rapid translation of research to enhance human health and well-being. Provides formulaic coverage of the landscape, process development, manufacturing, challenges, evaluation, and regulatory aspects of the most promising regenerative medicine clinical applications Covers clinical aspects of regenerative medicine related to skin, cartilage, tendons, ligaments, joints, bone, fat, muscle, vascular system, hematopoietic /immune system, peripheral nerve, central nervous system, endocrine system, ophthalmic system, auditory system, oral system, respiratory system, cardiac system, renal system, hepatic system, gastrointestinal system, genitourinary system Identifies effective, proven tools and metrics to identify and pursue clinical and commercial regenerative medicine

Technological Advances in Organ Transplantation

Technological Advances in Organ Transplantation
A Book

by Satish N. Nadig,Jason A. Wertheim

  • Publisher : Springer
  • Release : 2018-05-23
  • Pages : 313
  • ISBN : 3319621424
  • Language : En, Es, Fr & De
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This book provides an expert view into the current technologies that are revolutionizing the field of solid organ transplantation. This unique book provides insight into progress made in areas spanning robotic surgery to tissue engineering and also gives a glimpse into what may lie ahead for this innovative specialty. Topics covered include nanotherapy, machine perfusion, artificial organ development, robotics in transplant surgery, mobile health technology, stem cell therapy, and ex vivo repair of organs. This is an ideal book for biomedical engineers, physicians and surgeons, general and transplant surgeons, medical students, medical and surgical trainees, and transplant procurement technicians.

Handbook of Tissue Engineering Scaffolds: Volume Two

Handbook of Tissue Engineering Scaffolds: Volume Two
A Book

by Masoud Mozafari,Farshid Sefat,Anthony Atala

  • Publisher : Woodhead Publishing
  • Release : 2019-06-15
  • Pages : 874
  • ISBN : 0081025629
  • Language : En, Es, Fr & De
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Handbook of Tissue Engineering Scaffolds: Volume Two provides a comprehensive and authoritative review on recent advancements in the application and use of composite scaffolds in tissue engineering. Chapters focus on specific tissue/organ (mostly on the structure and anatomy), the materials used for treatment, natural composite scaffolds, synthetic composite scaffolds, fabrication techniques, innovative materials and approaches for scaffolds preparation, host response to the scaffolds, challenges and future perspectives, and more. Bringing all the information together in one major reference, the authors systematically review and summarize recent research findings, thus providing an in-depth understanding of scaffold use in different body systems. Dedicated to the specialist topic of composite scaffolds, featuring all human body systems Covers basic fundamentals and advanced clinical applications Includes up-to-date information on preparation methodology and characterization techniques Highlights clinical data and case studies

Kidney Inflammation, Injury and Regeneration

Kidney Inflammation, Injury and Regeneration
A Book

by Patrick C. Baer,Benjamin Koch,Helmut Geiger

  • Publisher : MDPI
  • Release : 2020-04-03
  • Pages : 496
  • ISBN : 3039285386
  • Language : En, Es, Fr & De
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Acute kidney injury (AKI) is still associated with high morbidity and mortality incidence rates, and also bears an elevated risk of subsequent chronic kidney disease. Although the kidney has a remarkable capacity for regeneration after injury and may recover completely depending on the type of renal lesions, the options for clinical intervention are restricted to fluid management and extracorporeal kidney support. The development of novel therapies to prevent AKI, to improve renal regeneration capacity after AKI, and to preserve renal function is urgently needed. The Special Issue covers research articles that investigated the molecular mechanisms of inflammation and injury during different renal pathologies, renal regeneration, diagnostics using new biomarkers, and the effects of different stimuli like medication or bacterial components on isolated renal cells or in vivo models. The Special Issue contains important reviews that consider the current knowledge of cell death and regeneration, inflammation, and the molecular mechanisms of kidney diseases. In addition, the potential of cell-based therapy approaches that use mesenchymal stromal/stem cells or their derivates is summarized. This edition is complemented by reviews that deal with the current data situation on other specific topics like diabetes and diabetic nephropathy or new therapeutic targets.

Foundations of Regenerative Medicine

Foundations of Regenerative Medicine
Clinical and Therapeutic Applications

by Anthony Atala

  • Publisher : Academic Press
  • Release : 2009-09-04
  • Pages : 824
  • ISBN : 9780123785626
  • Language : En, Es, Fr & De
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The interdisciplinary field of regenerative medicine holds the promise of repairing and replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Derived from the fields of tissue engineering, cell and developmental biology, biomaterials science, nanotechnology, physics, chemistry, physiology, molecular biology, biochemistry, bioengineering, and surgery, regenerative medicine is one of the most influential topics of biological research today. Derived from the successful Principles of Regenerative Medicine, this volume brings together the latest information on the advances in technology and medicine and the replacement of tissues and organs damaged by disease. Chapters focus on the fundamental principles of regenerative therapies that have crossover with a broad range of disciplines. From the molecular basis to therapeutic applications, this volume is an essential source for students, researchers, and technicians in tissue engineering, stem cells, nuclear transfer (therapeutic cloning), cell, tissue, and organ transplantation, nanotechnology, bioengineering, and medicine to gain a comprehensive understanding of the nature and prospects for this important field. Highlights the fundamentals of regenerative medicine to relate to a variety of related science and technology fields Introductory chapter directly addresses why regenerative medicine is important to a variety of researchers by providing practical examples and references to primary literature Includes new discoveries from leading researchers on restoration of diseased tissues and organs

Stem Cells in Craniofacial Development and Regeneration

Stem Cells in Craniofacial Development and Regeneration
A Book

by George T.J. Huang,Irma Thesleff

  • Publisher : John Wiley & Sons
  • Release : 2013-02-15
  • Pages : 584
  • ISBN : 1118498119
  • Language : En, Es, Fr & De
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Stem Cells, Craniofacial Development and Regeneration is anintroduction to stem cells with an emphasis on their role incraniofacial development. Divided into five sections, chaptersbuild from basic introductory information on the definition andcharacteristics of stem cells to more indepth explorations oftheir role in craniofacial development. Section I covers embryonicand adult stem cells with a focus on the craniofacial region, whilesections II-IV cover the development and regeneration ofcraniofacial bone, tooth, temporomandibular joint, salivary glandsand muscle. Concluding chapters describe the current, cutting-edgeresearch utilizing stem cells for craniofacial tissuebioengineering to treat lost or damaged tissue. The authoritative resource for dentistry students as well ascraniofacial researchers at the graduate and post-graduate level,Stem Cells, Craniofacial Development and Regenerationexplores the rapidly expanding field of stem cells and regenerationfrom the perspective of the dentistry and craniofacial community,and points the way forward in areas of tissue bioengineering andcraniofacial stem cell therapies.

Scaffolds in Tissue EngineeringMaterials, Technologies and Clinical Applications

Scaffolds in Tissue EngineeringMaterials, Technologies and Clinical Applications
A Book

by Francesco Baino

  • Publisher : BoD – Books on Demand
  • Release : 2017-12-13
  • Pages : 332
  • ISBN : 9535136410
  • Language : En, Es, Fr & De
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Biomaterials are often designed to act as scaffolds, i.e., 3D porous templates that support and stimulate the growth of healthy tissue and then safely dissolve once they have performed their functions. This book provides a picture of the current state of the art in the field of scaffolds for tissue engineering, highlighting the potential associated to the latest scientific and technological advancements. The former part of the book focuses on the repair of "hard" tissues (primarily bone) by means of bioceramic/glass scaffolds, and the latter deals with the applications of polymeric scaffolds for regenerating "soft" tissues and structures including the peripheral nerve, heart, gastric mucosa and pancreas. Special emphasis is given to the challenges associated to scaffold manufacturing, biomimetic properties and cell-scaffold interactions.

Bio-inspired Materials for Biomedical Engineering

Bio-inspired Materials for Biomedical Engineering
A Book

by Anthony B. Brennan,Chelsea M. Kirschner

  • Publisher : John Wiley & Sons
  • Release : 2014-04-14
  • Pages : 400
  • ISBN : 111836936X
  • Language : En, Es, Fr & De
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This book covers the latest bio-inspired materials synthesis techniques and biomedical applications that are advancing the field of tissue engineering. Bio-inspired concepts for biomedical engineering are at the forefront of tissue engineering and regenerative medicine. Scientists, engineers and physicians are working together to replicate the sophisticated hierarchical organization and adaptability found in nature and selected by evolution to recapitulate the cellular microenvironment. This book demonstrates the dramatic clinical breakthroughs that have been made in engineering all four of the major tissue types and modulating the immune system. Part I (Engineering Bio-inspired Material Microenvironments) covers Bio-inspired Presentation of Chemical Cues, Bio-inspired Presentation of Physical Cues, and Bio-inspired Integration of Natural Materials. Part II (Bio-inspired Tissue Engineering) addresses tissue engineering in epithelial tissue, muscle tissue, connective tissue, and the immune system.

Organ Donation and Transplantation

Organ Donation and Transplantation
Current Status and Future Challenges

by Georgios Tsoulfas

  • Publisher : BoD – Books on Demand
  • Release : 2018-07-25
  • Pages : 452
  • ISBN : 1789233402
  • Language : En, Es, Fr & De
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One of the most interesting and at the same time most challenging fields of medicine and surgery has been that of organ donation and transplantation. It is a field that has made tremendous strides during the last few decades through the combined input and efforts of scientists from various specialties. What started as a dream of pioneers has become a reality for the thousands of our patients whose lives can now be saved and improved. However, at the same time, the challenges remain significant and so do the expectations. This book will be a collection of chapters describing these same challenges involved including the ethical, legal, and medical issues in organ donation and the technical and immunological problems the experts are facing involved in the care of these patients.The authors of this book represent a team of true global experts on the topic. In addition to the knowledge shared, the authors provide their personal clinical experience on a variety of different aspects of organ donation and transplantation.

Fundamentals of Tissue Engineering and Regenerative Medicine

Fundamentals of Tissue Engineering and Regenerative Medicine
A Book

by Ulrich Meyer,Thomas Meyer,Jörg Handschel,Hans Peter Wiesmann

  • Publisher : Springer Science & Business Media
  • Release : 2009-02-11
  • Pages : 1049
  • ISBN : 3540777555
  • Language : En, Es, Fr & De
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"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.