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Laboratory Methods in Microfluidics

Laboratory Methods in Microfluidics
A Book

by Basant Giri

  • Publisher : Elsevier
  • Release : 2017-06-01
  • Pages : 200
  • ISBN : 9780128132357
  • Language : En, Es, Fr & De
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Laboratory Methods in Microfluidics features a range of lab methods and techniques necessary to fully understanding microfluidic technology applications. Microfluidics deals with the manipulation of small volume of fluids at sub-millimeter scale domain channels. This exciting new field is becoming an increasingly popular subject both for research and education in various disciplines of science, including chemistry, chemical engineering, and environmental science. The unique properties of microfluidic technologies, such as rapid sample processing and precise control of fluids in assay, have made them attractive candidates to replace traditional experimental approaches. Practical for students, instructors, and researchers, Laboratory Methods in Microfluidics provides a much-needed, comprehensive new laboratory reference in this rapidly growing and exciting new field of research. Provides a number of detailed methods and instructions for experiments in microfluidics Features an appendix that highlights several standard laboratory techniques, including reagent preparation plus a list of materials vendors for quick reference Authored by a microfluidics expert with nearly a decade of research on the subject

Laboratory Methods in Microfluidics

Laboratory Methods in Microfluidics
A Book

by Basant Giri

  • Publisher : Elsevier
  • Release : 2017-05-15
  • Pages : 178
  • ISBN : 0128132361
  • Language : En, Es, Fr & De
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Laboratory Methods in Microfluidics features a range of lab methods and techniques necessary to fully understand microfluidic technology applications. Microfluidics deals with the manipulation of small volumes of fluids at sub-millimeter scale domain channels. This exciting new field is becoming an increasingly popular subject both for research and education in various disciplines of science, including chemistry, chemical engineering and environmental science. The unique properties of microfluidic technologies, such as rapid sample processing and precise control of fluids in assay have made them attractive candidates to replace traditional experimental approaches. Practical for students, instructors, and researchers, this book provides a much-needed, comprehensive new laboratory reference in this rapidly growing and exciting new field of research. Provides a number of detailed methods and instructions for experiments in microfluidics Features an appendix that highlights several standard laboratory techniques, including reagent preparation plus a list of materials vendors for quick reference Authored by a microfluidics expert with nearly a decade of research on the subject

Microfluidics and Lab-on-a-Chip

Microfluidics and Lab-on-a-Chip
A Book

by Andreas Manz,Giuseppina Simone,Jonathan S. O'Connor,Pavel Neuzil

  • Publisher : Royal Society of Chemistry
  • Release : 2020-09-24
  • Pages : 280
  • ISBN : 1782628339
  • Language : En, Es, Fr & De
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Responding to the need for an affordable, easy-to-read textbook that introduces microfluidics to undergraduate and postgraduate students, this concise book will provide a broad overview of the important theoretical and practical aspects of microfluidics and lab-on-a-chip, as well as its applications.

Laboratory Methods in Dynamic Electroanalysis

Laboratory Methods in Dynamic Electroanalysis
A Book

by M. Teresa Fernández Abedul

  • Publisher : Elsevier
  • Release : 2019-10-13
  • Pages : 408
  • ISBN : 0128159332
  • Language : En, Es, Fr & De
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Laboratory Methods in Dynamic Electroanalysis is a useful guide to introduce analytical chemists and scientists of related disciplines to the world of dynamic electroanalysis using simple and low-cost methods. The trend toward decentralization of analysis has made this fascinating field one of the fastest-growing branches of analytical chemistry. As electroanalytical devices have moved from conventional electrochemical cells (10-20 mL) to current cells (e.g. 5-50 mL) based on different materials such as paper or polymers that integrate thick- or thin-film electrodes, interesting strategies have emerged, such as the combination of microfluidic cells and biosensing or nanostructuration of electrodes. This book provides detailed, easy procedures for dynamic electroanalysis and covers the main trends in electrochemical cells and electrodes, including microfluidic electrodes, electrochemical detection in microchip electrophoresis, nanostructuration of electrodes, development of bio (enzymatic, immuno, and DNA) assays, paper-based electrodes, interdigitated array electrodes, multiplexed analysis, and combination with optics. Different strategies and techniques (amperometric, voltammetric, and impedimetric) are presented in a didactic, practice-based way, and a bibliography provides readers with additional sources of information. Provides easy-to-implement experiments using low-cost, simple equipment Includes laboratory methodologies that utilize both conventional designs and the latest trends in dynamic electroanalysis Goes beyond the fundamentals covered in other books, focusing instead on practical applications of electroanalysis

Diagnostic Devices with Microfluidics

Diagnostic Devices with Microfluidics
A Book

by Francesco Piraino,Šeila Selimović

  • Publisher : CRC Press
  • Release : 2017-06-26
  • Pages : 279
  • ISBN : 1498772943
  • Language : En, Es, Fr & De
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This book provides a current view of the research and commercial landscape of diagnostics devices, particularly those that utilize microscale technologies, intended for both patient and laboratory use. Common diagnostic devices that are based on microfluidic principles include glucose sensors for diabetic patients and over-the-counter pregnancy tests. Other diagnostic devices are being developed to quickly test a patient for bacterial and viral infections, and other diseases. The chapters, written by experts from around the world, discuss how to fabricate, apply, and market microfluidic diagnostic chips – for lab and at-home use. Most importantly, the book also contains a discussion of topics relevant to the private sector, including patient-focused, market-oriented development of diagnostics devices. Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498772938_oachapter9.pdf

Design Automation Methods and Tools for Microfluidics-Based Biochips

Design Automation Methods and Tools for Microfluidics-Based Biochips
A Book

by Jun Zeng

  • Publisher : Springer Science & Business Media
  • Release : 2006-11-08
  • Pages : 403
  • ISBN : 1402051239
  • Language : En, Es, Fr & De
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Design Automation Methods and Tools for Microfluidics-Based Biochips deals with all aspects of design automation for microfluidics-based biochips. Experts have contributed chapters on many aspects of biochip design automation. Topics covered include: device modeling; adaptation of bioassays for on-chip implementations; numerical methods and simulation tools; architectural synthesis, scheduling and binding of assay operations; physical design and module placement; fault modeling and testing; and reconfiguration methods.

Microfluidics and Nanofluidics

Microfluidics and Nanofluidics
A Book

by Mohsen Sheikholeslami Kandelousi

  • Publisher : BoD – Books on Demand
  • Release : 2018-08-22
  • Pages : 318
  • ISBN : 1789235405
  • Language : En, Es, Fr & De
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In the present book, various applications of microfluidics and nanofluidics are introduced. Microfluidics and nanofluidics span a broad array of disciplines including mechanical, materials, and electrical engineering, surface science, chemistry, physics and biology. Also, this book deals with transport and interactions of colloidal particles and biomolecules in microchannels, which have great importance to many microfluidic applications, such as drug delivery in life science, microchannel heat exchangers in electronic cooling, and food processing industry. Furthermore, this book focuses on a detailed description of the thermal transport behavior, challenges and implications that involve the development and use of HTFs under the influence of atomistic-scale structures and industrial applications.

Microfluidic Techniques

Microfluidic Techniques
Reviews and Protocols

by Shelley D. Minteer

  • Publisher : Springer Science & Business Media
  • Release : 2006
  • Pages : 247
  • ISBN : 1592599974
  • Language : En, Es, Fr & De
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This volume highlights recent important advances in microfluidic techniques for biological applications. Opening chapters focus on the most popular techniques for fabrication of microchips (photolithography, laser ablation, and soft lithography), while further sections focus on microfluidic techniques for bioanalytical assays and bioprocesses, such as DNA analysis, PCR, immunoassays, and cell reactors. Microfluidic Techniques will provide molecular biologists and biochemists with the state-of-the-art technical information required to perform microscale bioassays and bioprocessing in the laboratory.

Henry's Clinical Diagnosis and Management by Laboratory Methods: First South Asia Edition_e-Book

Henry's Clinical Diagnosis and Management by Laboratory Methods: First South Asia Edition_e-Book
A Book

by Richard A. McPherson

  • Publisher : Elsevier India
  • Release : 2016-08-31
  • Pages : 1581
  • ISBN : 8131246779
  • Language : En, Es, Fr & De
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To interpret the laboratory results. To distinguish the normal from the abnormal and to understand the merits and demerits of the assays under study. The book attempts to train a laboratory medicine student to achieve sound knowledge of analytical methods and quality control practices, to interpret the laboratory results, to distinguish the normal from the abnormal and to understand the merits and demerits of the assays under study.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
A Book

by Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao

  • Publisher : William Andrew
  • Release : 2012-12-31
  • Pages : 452
  • ISBN : 143773460X
  • Language : En, Es, Fr & De
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The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery

Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery
A Book

by Paul C.H. Li

  • Publisher : CRC Press
  • Release : 2010-02-24
  • Pages : 418
  • ISBN : 1439882177
  • Language : En, Es, Fr & De
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Lab-on-a-chip technology permits us to make many important discoveries that can only be observed at the microscale or the nanoscale. Using this technology, biological and biochemical analyses translate into greater sensitivity, more accurate results, and more valuable findings. Authored by one of the field’s pioneering researchers, Fundamentals of Microfluidics and Lab on a Chip for Biological Analysis and Discovery focuses on all key aspects of microfluidic lab-on-a-chip technologies to offer an exceptionally cohesive overview of the science, its limitations, breakthroughs made over the years, and currently emerging advances. The book emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays, and enzymatic assays. The book includes more than 300 figures that depict novel chip functions and breakthroughs and 16 tables summarize materials and refer readers to additional resources. An appendix compiles extensive analytical applications from emerging and established research groups. Beginners in the field will find the book useful for navigating the vast literature related to the technology, while experienced researchers will rely on the compiled information for easy comparison and references for further study. Derived from the highly popular Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery (2006), this volume is also readily adaptable for classroom use. Problem sets in each chapter help students test their assimilation of the material and clarify challenging concepts. The book contains a comprehensive glossary, a complete index, and extensive references. A solutions manual is available with qualifying course adoption.

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip

Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip
Principles and Applications

by Xiujun James Li,Chaoyong Yang,Paul C. H. Li

  • Publisher : Newnes
  • Release : 2021-09-19
  • Pages : 484
  • ISBN : 0444594612
  • Language : En, Es, Fr & De
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Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery. Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring. Provides calculations, solved problems, data tables and design rules to help understand microfluidic basic theory and principles Gives an applied understanding of the principles behind the design, manufacture, and testing of microfluidic systems Emphasizes on quickly developing and emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology

Digital Microfluidic Biochips

Digital Microfluidic Biochips
Synthesis, Testing, and Reconfiguration Techniques

by Krishnendu Chakrabarty,Fei Su

  • Publisher : CRC Press
  • Release : 2018-10-03
  • Pages : 228
  • ISBN : 1351837532
  • Language : En, Es, Fr & De
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Digital Microfluidic Biochips focuses on the automated design and production of microfluidic-based biochips for large-scale bioassays and safety-critical applications. Bridging areas of electronic design automation with microfluidic biochip research, the authors present a system-level design automation framework that addresses key issues in the design, analysis, and testing of digital microfluidic biochips. The book describes a new generation of microfluidic biochips with more complex designs that offer dynamic reconfigurability, system scalability, system integration, and defect tolerance. Part I describes a unified design methodology that targets design optimization under resource constraints. Part II investigates cost-effective testing techniques for digital microfluidic biochips that include test resource optimization and fault detection while running normal bioassays. Part III focuses on different reconfiguration-based defect tolerance techniques designed to increase the yield and dependability of digital microfluidic biochips. Expanding upon results from ongoing research on CAD for biochips at Duke University, this book presents new design methodologies that address some of the limitations in current full-custom design techniques. Digital Microfluidic Biochips is an essential resource for achieving the integration of microfluidic components in the next generation of system-on-chip and system-in-package designs.

Microfluidics for Cells and Other Organisms

Microfluidics for Cells and Other Organisms
A Book

by Danny van Noort

  • Publisher : MDPI
  • Release : 2019-10-23
  • Pages : 200
  • ISBN : 3039215620
  • Language : En, Es, Fr & De
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Microfluidics-based devices play an important role in creating realistic microenvironments in which cell cultures can thrive. They can, for example, be used to monitor drug toxicity and perform medical diagnostics, and be in a static-, perfusion- or droplet-based device. They can also be used to study cell-cell, cell-matrix or cell-surface interactions. Cells can be either single cells, 3D cell cultures or co-cultures. Other organisms could include bacteria, zebra fish embryo, C. elegans, to name a few.

Advances in Microfluidics Technology for Diagnostics and Detection

Advances in Microfluidics Technology for Diagnostics and Detection
A Book

by David Kinahan,Dario Mager ,Elizaveta Vereshchagina,Celina Miyazaki

  • Publisher : MDPI
  • Release : 2021-09-06
  • Pages : 124
  • ISBN : 3036513663
  • Language : En, Es, Fr & De
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Microfluidics and lab-on-a-chip have, in recent years, come to the forefront in diagnostics and detection. At point-of-care, in the emergency room, and at the hospital bed or GP clinic, lab-on-a-chip offers the potential to rapidly detect time-critical and life-threatening diseases such as sepsis and bacterial meningitis. Furthermore, portable and user-friendly diagnostic platforms can enable disease diagnostics and detection in resource-poor settings where centralised laboratory facilities may not be available. At point-of-use, microfluidics and lab-on-chip can be applied in the field to rapidly identify plant pathogens, thus reducing the need for damaging broad spectrum pesticides while also reducing food losses. Microfluidics can also be applied to the continuous monitoring of water quality and can support policy-makers and protection agencies in protecting the environment. Perhaps most excitingly, microfluidics also offers the potential to enable entirely new diagnostic tests that cannot be implemented using conventional laboratory tools. Examples of microfluidics at the frontier of new medical diagnostic tests include early detection of cancers through circulating tumour cells (CTCs) and highly sensitive genetic tests using droplet-based digital PCR. This Special Issue on “Advances in Microfluidics Technology for Diagnostics and Detection” aims to gather outstanding research and to carry out comprehensive coverage of all aspects related to microfluidics in diagnostics and detection.

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery

Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery
A Book

by Paul C.H. Li

  • Publisher : CRC Press
  • Release : 2005-11-01
  • Pages : 528
  • ISBN : 142002745X
  • Language : En, Es, Fr & De
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The microfluidic lab-on-a-chip allows scientists to conduct chemical and biochemical analysis in a miniaturized format so small that properties and effects are successfully enhanced, and processes seamlessly integrated. This microscale advantage translates into greater sensitivity, more accurate results, and better information. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery focuses on all aspects of the microfluidic lab-on-a-chip technologies and offers an overview of the available technology, its limitations, and its breakthroughs over the years. It emphasizes analytical applications of microfluidic technology and offers in-depth coverage of micromachining methods, microfluidic operations, chemical separations, sample preparation and injection methods, detection technology, and various chemical and biological analyses. Other topics of interest include the use of polymeric chips, fluid flow valve and control, single-cell analysis, DNA and RNA amplification techniques, DNA hybridization, immunoassays and enzymatic assays. Originally conceived as a single chapter published in Ewing's Analytical Instrumentation, this book is a gateway to the vast literature and conference proceedings on the topic. Microfluidic Lab-on-a-Chip for Chemical and Biological Analysis and Discovery expands upon its roots to present a comprehensive treatment of microfluidic lab-on-a-chip methods and applications for novices and advanced researchers alike.

Highly Integrated Microfluidics Design

Highly Integrated Microfluidics Design
A Book

by Dan E. Angelescu

  • Publisher : Artech House
  • Release : 2011
  • Pages : 255
  • ISBN : 159693980X
  • Language : En, Es, Fr & De
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The recent development of microfluidics has lead to the concept of lab-on-a-chip, where several functional blocks are combined into a single device that can perform complex manipulations and characterizations on the microscopic fluid sample. However, integration of multiple functionalities on a single device can be complicated. This a cutting-edge resource focuses on the crucial aspects of integration in microfluidic systems. It serves as a one-stop guide to designing microfluidic systems that are highly integrated and scalable. This practical book covers a wide range of critical topics, from fabrication techniques and simulation tools, to actuation and sensing functional blocks and their inter-compatibility. This unique reference outlines the benefits and drawbacks of different approaches to microfluidic integration and provides a number of clear examples of highly integrated microfluidic systems.

Microfluidic Devices for Biomedical Applications

Microfluidic Devices for Biomedical Applications
A Book

by Xiujun James Li,Yu Zhou

  • Publisher : Woodhead Publishing
  • Release : 2021-08-09
  • Pages : 722
  • ISBN : 0128227559
  • Language : En, Es, Fr & De
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Microfluidic Devices for Biomedical Applications, Second Edition provides updated coverage on the fundamentals of microfluidics, while also exploring a wide range of medical applications. Chapters review materials and methods, microfluidic actuation mechanisms, recent research on droplet microfluidics, applications in drug discovery and controlled-delivery, including micro needles, consider applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and their role in developing tissue scaffolds, and cover the applications of microfluidic devices in diagnostic sensing, including genetic analysis, low-cost bioassays, viral detection, and radio chemical synthesis. This book is an essential reference for medical device manufacturers, scientists and researchers concerned with microfluidics in the field of biomedical applications and life-science industries. Discusses the fundamentals of microfluidics or lab-on-a-chip (LOC) and explores a wide range of medical applications Considers materials and methods for microfabrication, microfluidic actuation mechanisms and digital microfluidic technologies Details applications of microfluidic devices in cellular analysis and manipulation, tissue engineering and its role in developing tissue scaffolds, and stem cell engineering

Molecular Diagnostics

Molecular Diagnostics
A Book

by George P. Patrinos,Wilhelm Ansorge,Phillip B. Danielson

  • Publisher : Academic Press
  • Release : 2016-10-27
  • Pages : 520
  • ISBN : 0128029889
  • Language : En, Es, Fr & De
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Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management. Presents a comprehensive account of all new technologies and applications used in clinical diagnostic laboratories Explores a wide range of molecular-based tests that are available to assess DNA variation and changes in gene expression Offers clear translational presentations by the top molecular pathologists, clinical chemists, and molecular geneticists in the field

Microfluidics in Detection Science

Microfluidics in Detection Science
Lab-on-a-chip Technologies

by Fatima H Labeed,Henry O Fatoyinbo

  • Publisher : Royal Society of Chemistry
  • Release : 2014-10-24
  • Pages : 281
  • ISBN : 1849737606
  • Language : En, Es, Fr & De
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The concept of a miniaturised laboratory on a disposable chip is now a reality, and in everyday use in industry, medicine and defence. New devices are launched all the time, prompting the need for a straightforward guide to the design and manufacture of lab-on-a-chip (LOC) devices. This book presents a modular approach to the construction and integration of LOC components in detection science. The editors have brought together some of the leading experts from academia and industry to present an accessible guide to the technology available and its potential. Several chapters are devoted to applications, presenting both the sampling regime and detection methods needed. Further chapters describe the integration of LOC devices, not only with each other but also into existing technologies. With insights into LOC applications, from biosensing to molecular and chemical analysis, and presenting scaled-down versions of existing technology alongside unique approaches that exploit the physics of the micro and nano-scale, this book will appeal to newcomers to the field and practitioners requiring a convenient reference.