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Lipid Signaling and Metabolism

Lipid Signaling and Metabolism
A Book

by James M. Ntambi

  • Publisher : Academic Press
  • Release : 2020-08-09
  • Pages : 566
  • ISBN : 0128194057
  • Language : En, Es, Fr & De
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Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics. Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine. Provides a clear, up-to-date understanding of lipid signaling and metabolism and the impact of recent technologies critical to advancing new studies Empowers researchers to examine bioactive lipid signaling and metabolism, supporting translation to clinical care and precision medicine Discusses the role of lipid signaling and metabolism in obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders, among others

Lipid Signaling Protocols

Lipid Signaling Protocols
A Book

by Banafshé Larijani,Rudiger Woscholski,Colin A. Rosser

  • Publisher : Humana Press
  • Release : 2008-11-11
  • Pages : 429
  • ISBN : 9781588297273
  • Language : En, Es, Fr & De
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Lipid Signaling Protocols assembles in a single volume the various tools and methodologies needed by the interested investigator to unravel lipid dependent signaling and cell function. Divided into two convenient sections, the volume begins by summarizing the physical properties of hydrophobic metabolites as well as the physical methodologies used for their analysis, which leads to the second section and its selection of biological methods, focused around the most relevant lipids, their corresponding metabolizing enzymes and the recognition proteins. Following the highly successful Methods in Molecular BiologyTM series format, the chapters provide readily reproducible laboratory protocols, lists of necessary materials and reagents, and the tips on troubleshooting and avoiding known pitfalls. Contributed to by top researchers in the field, Lipid Signaling Protocols is an essential resource for both experienced and novice researchers who desire a better understanding of the application of physical methodologies in the context of lipid signaling and lipid metabolism in cell biology.

Druggable Lipid Signaling Pathways

Druggable Lipid Signaling Pathways
A Book

by Yasuyuki Kihara

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030506215
  • Language : En, Es, Fr & De
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Lipid Metabolism in Signaling Systems

Lipid Metabolism in Signaling Systems
A Book

by John N. Fain

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 357
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Major topics covered include: * Techniques for examining the role of phosphoinositides in signal transduction * Techniques related to protein kinase C * Analysis of inositol phosphates * Techniques to analyze phospholipid turnover in the brain

Membrane Lipid Signaling in Aging and Age-Related Disease

Membrane Lipid Signaling in Aging and Age-Related Disease
A Book

by M.P. Mattson

  • Publisher : Elsevier
  • Release : 2003-05-06
  • Pages : 236
  • ISBN : 9780080522500
  • Language : En, Es, Fr & De
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The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators has been linked to the pathogenesis of age-related diseases. This book provides a comprehensive review of specific membrane lipid mediators and their roles in aging and age-related disease.

Lipid Signaling in Human Diseases

Lipid Signaling in Human Diseases
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 329
  • ISBN : 9783030336691
  • Language : En, Es, Fr & De
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Lipids are an integral part of cell membrane architecture, are intermediaries in cell metabolism, and are involved in transmitting cell signals from hormones, growth factors and nutrients. A number of lipases and phospholipases, lipid kinases, lipid phosphatases, sphingosine kinases, and their reaction products have been implicated in fundamental cellular processes including cell proliferation, division and migration. These enzymes and their products underlie the molecular mechanisms of numerous human diseases, in particular metabolic disease (diabetes), cancer, neurodegenerative disease and cardiovascular disease. Over the last decade, studies have advanced to the point that a number of inhibitors for these enzymes have been developed to attempt to ameliorate these conditions; some of the inhibitors are currently in human clinical trial. The need for this book is to review the current status of this field and the prospect for the inhibitors to be clinically important. .

Model Organisms in Drug Discovery

Model Organisms in Drug Discovery
A Book

by Pamela M. Carroll,Kevin Fitzgerald

  • Publisher : John Wiley & Sons
  • Release : 2004-04-21
  • Pages : 302
  • ISBN : 047087130X
  • Language : En, Es, Fr & De
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Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Advances in Lipid Research

Advances in Lipid Research
Skin Lipids

by Peter M. Elias

  • Publisher : Elsevier
  • Release : 2016-01-21
  • Pages : 366
  • ISBN : 1483215458
  • Language : En, Es, Fr & De
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Advances in Lipid Research, Volume 24 provides information pertinent to the fundamental aspects of skin lipids. This book discusses the importance of epidermal lipids for cutaneous barrier function. Organized into 11 chapters, this volume begins with an overview of the biochemical, metabolic, and structural aspects of the role of lipids in permeability barrier formation and maintenance. This text then examines the lipid biophysics of the intercellular lipid domains in the stratum corneum, and the regulation of percutaneous absorption by these domains. Other chapters consider the lipid content and metabolism of cultured keratinocytes, which are grown under standard conditions and in various in vitro systems that attempt to produce an epidermal equivalent. This book discusses as well the important field of lipid signaling mechanisms in the epidermis. The final chapter deals with the clinical, pathophysiological, and therapeutic applications of vitamin D. This book is a valuable resource for chemist, cytochemists, and clinicians.

Intersection of Lipid Metabolism and the Innate Immune Response to Mycobacterial Infection

Intersection of Lipid Metabolism and the Innate Immune Response to Mycobacterial Infection
A Book

by Dennis Jay Montoya

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 226
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Elucidating the Role of SOX6 in Cardiac Muscle Development

Elucidating the Role of SOX6 in Cardiac Muscle Development
A Book

by An Dang Do

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 58
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Metabolic Profiling of Biologically Active Conjugated Dienes Using Diels-Alder Derivatization and Electrospray Ionization/tandem Mass Spectrometry

Metabolic Profiling of Biologically Active Conjugated Dienes Using Diels-Alder Derivatization and Electrospray Ionization/tandem Mass Spectrometry
A Book

by Pavel Andreevich Aronov

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 218
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Membrane Microdomain Signaling

Membrane Microdomain Signaling
Lipid Rafts in Biology and Medicine

by Mark P. Mattson

  • Publisher : Springer Science & Business Media
  • Release : 2007-10-27
  • Pages : 214
  • ISBN : 159259803X
  • Language : En, Es, Fr & De
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Cutting-edge articles review our current understanding of lipid microdomain signaling mechanisms and their physiological and pathological importance. The book describes the role of lipid rafts in learning, memory, and cancer, presents the emerging evidence that lipid rafts play critical roles in signaling pathways and the regulation of synaptic function in the nervous system, and shows how alterations in lipid raft metabolism are implicated in the pathogenesis of neurodegenerative disorders. Techniques are also described for the isolation of lipid rafts, the analysis of the lipid and protein components of lipid rafts, the imaging of lipid rafts in living cells, and the analysis of signal transduction in lipid rafts.

Lipids and Insulin Resistance

Lipids and Insulin Resistance
The Role of Fatty Acid Metabolism and Fuel Partitioning

by Iwar Klimes

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 583
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Insulin resistance is central to the development of a cluster of prevalent conditions including Type 2 diabetes, dyslipidemias, hypertension and cardiovascular disease. Scientists' current understanding of the etiology of insulin resistance is limited and few therapies are available. However, it is clear that the understanding of lipid metabolism and of lipids in their many forms and functions provides the keys to unlocking the mysteries of insulin resistance. In this volume, an international group of investigators from a range of lipid-related disciplines explores new ideas for therapeutic targets.

The Regulation of Membrane Lipid Metabolism, Second Edition

The Regulation of Membrane Lipid Metabolism, Second Edition
A Book

by Guy A. Thompson, Jr.

  • Publisher : CRC Press
  • Release : 1992-03-10
  • Pages : 240
  • ISBN : 9780849345616
  • Language : En, Es, Fr & De
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This book provides a concise description of the metabolic pathways by which lipids of animal and plant membranes are formed. The book emphasizes modulation of these pathways by hormones, diet, environmental stress, and other factors. This new edition is extensively revised, containing new material on topics such as lipid-mediated signal transduction and lipid-induced protein translocation. The new edition also features an entirely new chapter on lipids covalently bound to proteins. The book is excellent for all researchers and students interested in membrane lipid metabolism.

International Journal of Oncology

International Journal of Oncology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997-07
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biochemistry and Cell Biology

Biochemistry and Cell Biology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Lipid-mediated Protein Signaling

Lipid-mediated Protein Signaling
A Book

by Daniel G.S. Capelluto

  • Publisher : Springer Science & Business Media
  • Release : 2013-06-17
  • Pages : 219
  • ISBN : 940076331X
  • Language : En, Es, Fr & De
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This book provides the most updated information of how membrane lipids mediate protein signaling from studies carried out in animal and plant cells. Also, there are some chapters that go beyond and expand these studies of protein-lipid interactions at the structural level. The book begins with a literature review from investigations associated to sphingolipids, followed by studies that describe the role of phosphoinositides in signaling and closing with the function of other key lipids in signaling at the plasma membrane and intracellular organelles.

Lipid Mediators and Their Metabolism in the Brain

Lipid Mediators and Their Metabolism in the Brain
A Book

by Akhlaq A. Farooqui

  • Publisher : Springer Science & Business Media
  • Release : 2011-08-12
  • Pages : 327
  • ISBN : 9781441999405
  • Language : En, Es, Fr & De
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Lipid Mediators and Their Metabolism in the Brain presents readers with cutting edge and comprehensive information not only on the synthesis and degradation of glycerophospholipid-, sphingolipid-, and cholesterol-derived lipid mediators, but also their involvement in neurological disorders. It is hoped that this monograph will be useful not only to postgraduate student and their teachers, but also to research scientists and physicians, who are curious about the generation and roles of lipid mediators in the brain.

Development of Metabolic Health Assessment

Development of Metabolic Health Assessment
Paving the Way to Disease Prevention Through Personalized Nutrition

by Angela M. Zivkovic

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 390
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Stearoyl-CoA Desaturase Genes in Lipid Metabolism

Stearoyl-CoA Desaturase Genes in Lipid Metabolism
A Book

by James M. Ntambi, Ph.D.

  • Publisher : Springer Science & Business Media
  • Release : 2013-08-15
  • Pages : 239
  • ISBN : 146147969X
  • Language : En, Es, Fr & De
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Obesity and diabetes develop as a complex result of genetic, metabolic and environmental factors and are characterized by increased lipogenesis and lipid accumulation in many tissues. Stearoyl-CoA desaturase (SCD) genes are a critical regulator of lipogenesis and catalyzes the synthesis of monounsaturated fatty acids (MUFA), mainly oleoyl- (18:1n9) and palmitoleoyl-CoA (16:1n7). These MUFAs are the major fatty acid substrates for the synthesis of triglycerides, cholesterol esters, wax esters and membrane phospholipids. There are 4 SCD isoforms (SCD1-4) in mice and two (hSCD1 and hSCD5) expressed in humans. At first glance, stearoyl-CoA desaturase enzyme would be considered a housekeeping enzyme because it synthesizes oleate a well-known fatty acid that is abundant in many dietary sources. However numerous studies have shown that SCD is a very highly regulated enzyme that features in so many physiological processes ranging from fat differentiation, carbohydrate and fat metabolism, inflammation and cancer. The editor’s studies using stearoyl-CoA desaturase knockout (SCD1-/-) mice and studies of other investigators using pharmacological approaches to reduce SCD1 expression in mouse tissues have all established that the expression of SCD1 gene isoform represents a key step in partitioning of lipids between storage and oxidation. High SCD expression favors fat storage leading to obesity while reduced SCD expression favors fat burning and leanness. Although these studies clearly illustrated that SCD1 expression is involved in the development of obesity and insulin resistance, questions remain in the elucidation of the mechanisms involved and role of SCD1. This book includes chapters by leading researchers on SCD Genes in the brain, heart, muscle, liver metabolism, Colitis, and more. ​