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Macrophages Biology and Tissue Inflammation in Health and Disease

Macrophages Biology and Tissue Inflammation in Health and Disease
A Book

by Stuart Goodman,Michiaki Takagi,Jiri Gallo

  • Publisher : Academic Press
  • Release : 2021-11-15
  • Pages : 366
  • ISBN : 9780128217542
  • Language : En, Es, Fr & De
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Macrophages Biology and Tissue Inflammation in Health and Disease, outlines the important role of macrophages, keys cells in the innate immune system, as regulators and orchestrators of inflammation and repair in health and disease. It contains chapters by leading authors on the basic and translational aspects of macrophage biology, in maintaining tissue homeostatis and dealing with internal and external biological threats. Outlines the important role of macrophages, key cells in the innatue immune system, as regulators and orchestrators of inflammation and repair in health and disease Contains chapters by leading authors on the basic and translational aspects of macrophage biology, in maintaining tissue homeostasis Deals with internal and external treats

Macrophages: Biology and Role in the Pathology of Diseases

Macrophages: Biology and Role in the Pathology of Diseases
A Book

by Subhra K. Biswas,Alberto Mantovani

  • Publisher : Springer
  • Release : 2014-11-12
  • Pages : 615
  • ISBN : 1493913115
  • Language : En, Es, Fr & De
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Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
Emerging Roles of Nutraceuticals and Functional Foods in Immune Support

by Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi

  • Publisher : Academic Press
  • Release : 2017-08-31
  • Pages : 476
  • ISBN : 0128054026
  • Language : En, Es, Fr & De
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Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

The Metabolic Challenges of Immune Cells in Health and Disease

The Metabolic Challenges of Immune Cells in Health and Disease

by Claudio Mauro,Christian Frezza

  • Publisher : Unknown Publisher
  • Release : 2015-07-13
  • Pages : 329
  • ISBN : 2889196224
  • Language : En, Es, Fr & De
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Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages to tissue inflammation and insulin resistance, recent studies demonstrate that cells of the adaptive immune compartment, including T and B lymphocytes and dendritic cells also participate in obesity-induced pathogenesis of these conditions. However, the molecular and cellular pathways by which the innate and adaptive branches of immunity control tissue and systemic metabolism remain poorly understood. To engage in growth and activation, cells need to increase their biomass and replicate their genome. This process presents a substantial bioenergetic challenge: growing and activated cells must increase ATP production and acquire or synthesize raw materials, including lipids, proteins and nucleic acids. To do so, they actively reprogram their intracellular metabolism from catabolic mitochondrial oxidative phosphorylation to glycolysis and other anabolic pathways. This metabolic reprogramming is under the control of specific signal transduction pathways whose underlying molecular mechanisms and relevance to physiology and disease are subject of considerable current interest and under intense study. Recent reports have elucidated the physiological role of metabolic reprogramming in macrophage and T cell activation and differentiation, B- and dendritic cell biology, as well as in the crosstalk of immune cells with endothelial and stem cells. It is also becoming increasingly evident that alterations of metabolic pathways play a major role in the pathogenesis of chronic inflammatory disorders. Due to the scientific distance between immunologists and experts in metabolism (e.g., clinicians and biochemists), however, there has been limited cross-talk between these communities. This collection of articles aims at promoting such cross-talk and accelerating discoveries in the emerging field of immunometabolism.

Biology of C Reactive Protein in Health and Disease

Biology of C Reactive Protein in Health and Disease
A Book

by Waliza Ansar,Shyamasree Ghosh

  • Publisher : Springer
  • Release : 2016-03-23
  • Pages : 301
  • ISBN : 8132226801
  • Language : En, Es, Fr & De
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This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution. Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail. The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

Basic Biology and Clinical Aspects of Inflammation

Basic Biology and Clinical Aspects of Inflammation
A Book

by Robert F. Diegelmann,Charles E. Chalfant

  • Publisher : Bentham Science Publishers
  • Release : 2016-03-07
  • Pages : 500
  • ISBN : 1681082276
  • Language : En, Es, Fr & De
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Basic Biology and Clinical Aspects of Inflammation provides information about the critical cells and biochemical mediators involved in the complex process of inflammation. Readers are introduced to the basic scientific background on the subject, after which the book progresses towards translational research in clinical settings. Topics covered in this volume include, the modulation of inflammation during normal and chronic wound healing, altered metabolism during inflammation processes, the effect of ageing on inflammatory processes, as well as details about the underlying molecular processes behind specific clinical pathologies that are driven by excessive inflammation in the body (allergic reactions, type 2 diabetes, cardiac and vascular disease, arthritis, periodontal disease, inflammatory bowel disease and neuroinflammation). The volume also provides the latest information on pharmacotherapy for inflammation and interesting contributions towards the mathematical modeling and network analysis of inflammation. Basic Biology and Clinical Aspects of Inflammation features contributions from by a distinguished group of international researchers and clinicians highly recognized for their specific expertise in the field of inflammation. The information presented in this reference is useful to academics, medical professionals, health care regulators and pharmaceutical scientists.

Macrophages in inflammation and its resolution

Macrophages in inflammation and its resolution
A Book

by Heiko Mühl,Patrizia Rovere-Querini,Amiram Ariel,Jerrold S. Levine,Isabelle Maridonneau-Parini

  • Publisher : Frontiers E-books
  • Release : 2021
  • Pages : 329
  • ISBN : 2889190730
  • Language : En, Es, Fr & De
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Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated macrophages and other macrophage-derived cell types. These processes are affected by the inflammation-resolution axis and can result in health threats, such as atherosclerosis, bone loss, obesity, fibrosis and cancer. This Research Topic issue will cover a wide range of topics in macrophage biology: 1. Macrophages in immune responses to pathogens 2. Macrophages in the termination of acute and acquired immunity. 3. The role of macrophages and their descendents in inflammation-associated pathologies. 4. Macrophage polarization and differentiation. Particular focus will be given to the modulation of macrophage phenotype and function following their encounter with apoptotic cells and the signaling cascades that govern these changes.

Cytokine Frontiers

Cytokine Frontiers
Regulation of Immune Responses in Health and Disease

by Takayuki Yoshimoto,Tomohiro Yoshimoto

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-28
  • Pages : 396
  • ISBN : 4431544429
  • Language : En, Es, Fr & De
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This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.

Lung Macrophages in Health and Disease

Lung Macrophages in Health and Disease
A Book

by Sandra Hodge

  • Publisher : Bentham Science Publishers
  • Release : 2009-09-12
  • Pages : 120
  • ISBN : 1608050203
  • Language : En, Es, Fr & De
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"This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book consists of 8 chapters which provide a full coverage of macrophage function in both healthy and chronically diseased lungs, "

Adipose Tissue and Adipokines in Health and Disease

Adipose Tissue and Adipokines in Health and Disease
A Book

by Giamila Fantuzzi,Carol Braunschweig

  • Publisher : Springer Science & Business
  • Release : 2014-04-25
  • Pages : 372
  • ISBN : 1627037705
  • Language : En, Es, Fr & De
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The field of adipose tissue biology has been expanding at a very rapid pace in the last few years. Numerous advances have been made since publication of the first edition of this book, in terms of basic adipocyte biology, understanding of the determinants of obesity, distribution of body fat and weight loss, as well as the mechanisms linking excess adiposity to various co-morbidities. Adipose Tissue and Adipokines in Health and Disease, Second Edition contains updated chapters from the previous volume but as the field has evolved, some areas covered in the first edition have been refocused to address the new knowledge. The volume is divided in four sections: the first two deal with basic adipose tissue and adipokine biology, while the last two address the problem of obesity and alterations in adipose tissue function from an epidemiological and clinical standpoint. The chapters are written by experts in their fields and include the most up to date scientific information. Adipose Tissue and Adipokines in Health and Disease, Second Edition is a useful resource for physicians interested in adipose tissue biology and basic scientists who want to know more about applied aspects of the field. The book targets endocrinologists, residents and fellows, internists, nutritionists and general practitioners who are exposed to an ever-expanding obese population.

Inflammatory Diseases of Blood Vessels

Inflammatory Diseases of Blood Vessels
A Book

by Gary S. Hoffman,Cornelia M. Weyand,Carol A. Langford,Jorg J. Goronzy

  • Publisher : John Wiley & Sons
  • Release : 2012-07-02
  • Pages : 582
  • ISBN : 1444338226
  • Language : En, Es, Fr & De
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In recent years, considerable progress has been made in understanding the vasculitic diseases, largely due to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in this new edition, which is designed to provide a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.

Myeloid Cells in Health and Disease

Myeloid Cells in Health and Disease
A Synthesis

by Siamon Gordon

  • Publisher : John Wiley & Sons
  • Release : 2020-07-10
  • Pages : 892
  • ISBN : 1555819192
  • Language : En, Es, Fr & De
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The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells. In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including the recruitment of myeloid and other immune cells following microbial infection the role of myeloid cells in the inflammation process and the repair of damaged tissue the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin receptors and downstream signaling pathways that are activated following ligand-receptor binding roles of myeloid cells during microbial and parasite infections contributions of myeloid cells in atherosclerosis myeloid-derived suppressor cells in tumor development and cancer Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies.

Therapeutic Targets in Airway Inflammation

Therapeutic Targets in Airway Inflammation
A Book

by N. Tony Eissa,David P. Huston

  • Publisher : CRC Press
  • Release : 2003-05-13
  • Pages : 1000
  • ISBN : 0203911474
  • Language : En, Es, Fr & De
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This reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction

Immunobiology

Immunobiology
The Immune System in Health and Disease

by Charles Janeway

  • Publisher : Churchill Livingstone
  • Release : 1999-01-01
  • Pages : 635
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cytokines in Animal Health and Disease

Cytokines in Animal Health and Disease
A Book

by Michael J. Myers

  • Publisher : CRC Press
  • Release : 1995-06-09
  • Pages : 480
  • ISBN : 9780824794354
  • Language : En, Es, Fr & De
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This work offers comprehensive, up-to-date coverage of cytokine biology in veterinary and agricultural species, describing the role of cytokines in physiological and pathological processes. It addresses recent advances and new information on the function of cytokines in reproduction, detoxification of xenobiotics, growth modulation and other areas, and discusses the approaches to and pitfalls of studying cytokines in animals.

Lung Inflammation in Health and Disease, Volume I

Lung Inflammation in Health and Disease, Volume I
A Book

by Yong-Xiao Wang

  • Publisher : Springer Nature
  • Release : 2021-05-02
  • Pages : 409
  • ISBN : 3030630463
  • Language : En, Es, Fr & De
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Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Stem Cell Biology in Health and Disease

Stem Cell Biology in Health and Disease
A Book

by Thomas Dittmar,Kurt S. Zänker

  • Publisher : Springer Science & Business Media
  • Release : 2009-10-13
  • Pages : 426
  • ISBN : 9789048130405
  • Language : En, Es, Fr & De
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Stem Cell Biology in Health and Disease presents an up-to-date overview about the dual role of stem cells in health and disease. The Editors have drawn together an international team of experts providing chapters which, in this fully-illustrated volume, discuss: - the controversial debate on the great expectations concerning stem cell based regeneration therapies raised by the pluripotency of various stem cells. - the advantages and concerns about embryonic stem cells (ES cells), induced pluripotent stem cells (iPS cells) and adult stem cells, such as bone marrow-derived stem cells (BMDCs). - the type of stem cells, which has become of interest in the past decade, namely so-called cancer stem cells (CSCs). CSCs are now in the focus of cancer research since the eradication of tumour initiating cells would raise the changes of definitely cure cancer. Professor Dittmar and Professor Zänker have edited a must-read book for researchers and professionals working in the field of regenerative medicine and/or cancer.

Inflammatory Mechanisms in Asthma

Inflammatory Mechanisms in Asthma
A Book

by Stephen Holgate

  • Publisher : Routledge
  • Release : 2018-12-07
  • Pages : 1090
  • ISBN : 1351438492
  • Language : En, Es, Fr & De
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This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

Microglia in Health and Disease: A Unique Immune Cell Population

Microglia in Health and Disease: A Unique Immune Cell Population
A Book

by Alessandro Michelucci,Michel Mittelbronn,Diego Gomez-Nicola

  • Publisher : Frontiers Media SA
  • Release : 2018-10-05
  • Pages : 329
  • ISBN : 2889456013
  • Language : En, Es, Fr & De
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Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.

TAM Receptors in Health and Disease

TAM Receptors in Health and Disease
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-12-01
  • Pages : 176
  • ISBN : 0128218231
  • Language : En, Es, Fr & De
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TAM Receptors in Health and Disease, Volume 357 in the International Review of Cell and Molecular Biology, reviews the role of TAM receptors in health and diseases. Chapters in this new release include TAM receptors and its Role in Efferocytosis: Clearance of Dead Cells, TAM family receptors and their ligands: Role in thrombosis, TAM receptors and its ligand mediated activation: Role in Atherosclerosis, Post-translational modifications of the Ligands: Requirement for TAM receptor activation, Immunogenic role of TAM receptors in the cancer microenvironment: Implications in cancer immunotherapy, TAM receptors: A Phosphatidylserine Receptor family and its implications in Viral infections, and much more. Provides a comprehensive collection of articles on the relatively late evolved and highly conserved TAM receptor tyrosine kinase family Describes TAM receptor biology in great details Presents invited, timely review articles authored by well-established TAM receptor biologists