Download Mesenchymal Stem Cells in Human Health and Diseases Ebook PDF

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
A Book

by Ahmed H.K. El-Hashash

  • Publisher : Academic Press
  • Release : 2020-01-07
  • Pages : 228
  • ISBN : 0128205334
  • Language : En, Es, Fr & De
GET BOOK

Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Developmental and Stem Cell Biology in Health and Disease

Developmental and Stem Cell Biology in Health and Disease
A Book

by Ahmed El-Hashash

  • Publisher : Bentham Science Publishers
  • Release : 2016-07-14
  • Pages : 260
  • ISBN : 1681082195
  • Language : En, Es, Fr & De
GET BOOK

Research into stem cells started in the 1960s with experiments on spleen cultures. Evans and Kaufman made a breakthrough in mouse embryo culturing and embryonic stem cell extraction in 1981, followed by the work of Thomson in 1998 on the technique for extracting human embryonic stem cells. Since then, stem cell research has rapidly expanded as a therapeutic avenue for different diseases in humans. This book explains the basic developmental biology of stem cells including the development of stem cells during the implantation stage in utero to the regulation of stem cell division. Medical applications of stem cells in the therapy of diseases such as cancer, neurodegenerative diseases, and bone diseases are also explained in subsequent chapters. The book also explains the effect of parasitic cells on stem cell growth. Concepts in the book are explained in a simple clear manner, making this book an informative reference for non-experts, students and professionals in the field of biology and medicine.

T Regulatory Cells in Human Health and Diseases

T Regulatory Cells in Human Health and Diseases
A Book

by Song-Guo Zheng

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 9811564078
  • Language : En, Es, Fr & De
GET BOOK

Stem Cells and Human Diseases

Stem Cells and Human Diseases
A Book

by Rakesh K. Srivastava,Sharmila Shankar

  • Publisher : Springer Science & Business Media
  • Release : 2012-01-31
  • Pages : 630
  • ISBN : 9400728018
  • Language : En, Es, Fr & De
GET BOOK

The main objective of this book is to provide a comprehensive review on stem cells and their role in tissue regeneration, homeostasis and therapy. In addition, the role of cancer stem cells in cancer initiation, progression and drug resistance are discussed. The cell signaling pathways and microRNA regulating stem cell self-renewal, tissue homeostasis and drug resistance are also mentioned. Overall, these reviews will provide a new understanding of the influence of stem cells in tissue regeneration, disease regulation, therapy and drug resistance in several human diseases.

Autophagy in Health and Disease

Autophagy in Health and Disease
Potential Therapeutic Approaches

by Kursad Turksen

  • Publisher : Springer
  • Release : 2018-10-06
  • Pages : 177
  • ISBN : 3319981463
  • Language : En, Es, Fr & De
GET BOOK

This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing clinicians and advanced graduate students.

Microfluidic Technologies for Human Health

Microfluidic Technologies for Human Health
A Book

by Ali Khademhosseini,Utkan Demirci,Robert Langer

  • Publisher : World Scientific
  • Release : 2012
  • Pages : 478
  • ISBN : 9814405515
  • Language : En, Es, Fr & De
GET BOOK

Ch. 1. A microscale bioinspired cochlear-like sensor / Robert D. White, Robert Littrell, and Karl Grosh -- ch. 2. Systematic evaluation of the efficiencies of proteins and chemicals in pharmaceutical applications / Morgan Hamon and Jong Wook Hong -- ch. 3. Microfluidic glucose sensors / Jithesh V. Veetil ... [et al.] -- ch. 4. Applications of microfabrication and microfluidic techniques in mesenchymal stem cell research / Abhijit Majumder ... [et al.] -- ch. 5. Patient-specific modeling of low-density lipoprotein transport in coronary arteries / Ufuk Olgac -- ch. 6. Point-of-care microdevices for global health diagnostics of infectious diseases / Sau Yin Chin ... [et al.] -- ch. 7. Integrated microfluidic sample preparation for chip-based molecular diagnostics / Jane Y. Zhang ... [et al.] -- ch. 8. Microfluidic devices for cellular proteomic studies / Yihong Zhan and Chang Lu -- ch. 9. Microfluidics for neuroscience: novel tools and future implications / Vivian M. Hernandez and P. Hande Ozdinler -- ch. 10. Microfluidics: on-chip platforms as in vitro disease models / Shan Gao, Erkin Seker, and Martin L. Yarmush -- ch. 11. Application of microfluidics in stem cell and tissue engineering / Sasha H. Bakhru, Christopher Highley, and Stefan Zappe -- ch. 12. Microfluidic "on-the-fly" fabrication of microstructures for biomedical applications / Edward Kang, Sau Fung Wong, and Sang-Hoon Lee -- ch. 13. Microfluidics as a promising tool toward distributed viral detection / Elodie Sollier and Dino Di Carlo -- ch. 14. Electrophoresis and dielectrophoresis for lab-on-a-chip (LOC) analyses / Yagmur Demircan, Gurkan Yilmaz, and Haluk Kulah -- ch. 15. Ultrasonic embossing of carbon nanotubes for the fabrication of polymer microfluidic chips for DNA sample purification / Puttachat Khuntontong, Min Gong, and Zhiping Wang -- ch. 16. Ferrofluidics / A. Rezzan Kose and Hur Koser -- ch. 17. Antibody-based blood bioparticle capture and separation using microfluidics for global health / ZhengYuan Luo ... [et al.] -- ch. 18. Applications of quantum dots for fluorescence imaging in biomedical research / ShuQi Wang ... [et al.]

Stem Cell Innovation in Health & Disease: The Lung, Volume 2

Stem Cell Innovation in Health & Disease: The Lung, Volume 2
A Book

by Ahmed El-Hashash

  • Publisher : Academic Press
  • Release : 2021-06-10
  • Pages : 174
  • ISBN : 0128212071
  • Language : En, Es, Fr & De
GET BOOK

In the lung, more recent data have been accumulated on lung stem cell biology/function and the potential applications of stem cells in pulmonary diseases that are facilitated by the recent development of a broad range of cutting edge in vitro and in vivo research tools and approaches, including mouse and human organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 2: The Lung, contains two major sections describing cutting edge research for understanding stem cell functions in the lung and respiratory system, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model lung diseases, through the cutting-edge research aiming to bring stem cells from bench to bedside, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of lung diseases/disorders. This book, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the lung in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand respiratory stem cell functions and develop methods to bring stem cells from bench to bedside for different lung diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and iPSC-derived alveolar epithelia cell therapy in the lung Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the lung

Guidelines for Stem Cell Research and Therapy

Guidelines for Stem Cell Research and Therapy
A Book

by India. Department of Biotechnology,Indian Council of Medical Research

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 66
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Stem cell research holds great promise for improving human health by control of degenerative diseases and restoration of damage to organs by various injuries; but at the same time it also raises several ethical and social issues such as destruction of human embryos to create human embryonic stem (hES) cell lines, potential for introducing commodification in human tissues and organs with inherent barriers of access to socioeconomically deprived and possible use of technology for germ-line engineering and reproductive cloning. The research in this field, therefore, needs to be regulated to strike a balance. Of utmost importance is assurance of safety, and rights of those donating gametes/ blastocysts/ somatic cells for derivation of stem cells; or fetal tissues/umbilical cord cells/ adult tissue (or cells) for use as stem cells. Safeguards have also to be in place to protect research participants receiving stem cell transplants, and patients at large from unproven therapies/remedies. With success of growing human embryonic stem cells without feeder layer, derivation of histocompatible hES from embryos created by Somatic Cell Nuclear Transfer (SCNT) and tissue specific differentiation of umbilical cord/bone marrow derived mesenchymal and haematopoeitic stem cells, there is a need to generate public confidence in potential benefit of stem cell research to human health and disease. As stem cell therapy is poised to enter into clinical practice, there is an urgent need to formulate guidelines for Stem cell Research and Therapy (SCRT). The aims and scope of this document are to lay down general principles for stem cell research and therapy keeping in view the ethical issues. To formulate specific guidelines for derivation, propagation, differentiation, characterization, banking, and use of human stem cells for research and therapy. These guidelines provide a mechanism to ensure that research with human stem cells is conducted in a responsible and ethically sensitive manner and complies with all regulatory requirements pertaining to biomedical research in general and stem cell research in particular.

Neural Stem Cells in Health and Disease

Neural Stem Cells in Health and Disease
A Book

by Ashok K Shetty

  • Publisher : World Scientific Publishing Company
  • Release : 2015-08-28
  • Pages : 572
  • ISBN : 9814623199
  • Language : En, Es, Fr & De
GET BOOK

This book is a comprehensive guide on neural stem cell behavior in health and disease. The book confers the altered behavior of endogenous neural stem cells in neurodegenerative disease conditions and the prospects of neural stem cell therapy for alleviating brain dysfunction in a variety of neurodegenerative disorders. Neural stem cell activity and neurogenesis in the adult brain is now confirmed in virtually all mammalian species including humans. Hence, a series of chapters in the first half of the book discusses the current knowledge on mechanisms of neural stem cell activity, the extent and functional significance of neurogenesis in the adult brain under normal, aged and disease environments, the susceptibility of neural stem cells and the plasticity of neurogenesis to alcohol, drugs of abuse and anesthetic agents, and advanced techniques that trigger neurogenesis in non-neurogenic regions. A second series of chapters in this book are focused on discussing the promise and efficacy of grafting of neural stem cells and/or other stem cells for treating neurological disorders such as Parkinson's disease, stroke, temporal lobe epilepsy, Alzheimer's disease and spinal cord injury. The final chapter confers on advances that are made in manufacturing a variety of neural cell types from human pluripotent stem cells that can be used as donor cells for cell transplantation.

Stem Cells from Culture Dish to Clinic

Stem Cells from Culture Dish to Clinic
A Book

by Vinod Verma,M. P. Singh,Manoj Kumar

  • Publisher : Unknown Publisher
  • Release : 2017-12
  • Pages : 327
  • ISBN : 9781536127324
  • Language : En, Es, Fr & De
GET BOOK

Despite extensive research and medical advancements in the prevention, diagnosis and treatment of dreaded diseases like Diabetes, Cancer, Neurodegenerative and Heart diseases, continue to impose a great threat to human life. Research in human developmental biology has led to the discovery of stem cells which has the potential to cure wide range of dreaded diseases. Stem cells are the unicellular equivalent to the entire animal. In optimum culture milieu they can be differentiated into all cell types of an adult animal. The capability of potency and the relative ease to isolate and expand these cells are invaluable properties for regenerative medicine. Stem cells hold tremendous promise to unravel the key developmental pathways involved in organogenesis and may serve as an essential tissue source for regenerative therapy. Stem cell biology is a fast growing field that is providing new insights into the molecular mechanisms that control developmental processes. At the same time, stem cells may have potential uses in the treatment of devastating diseases such as cardiovascular disease, neurodegenerative disease, musculoskeletal disease, diabetes and cancer. The enormous clinical potential of cardiac regeneration has generated great expectations in both clinicians and patients. Regenerative medicine in the field of skin, cartilage, bone, adipose tissue, and cornea is already well established and is used clinically. Stem cell research harbours potential to have a significant impact on human health. The book will help to increase the awareness vis-�-vis stem cell research in developing countries in particular India. The book pronounces the ways which may help us to extract maximum benefits from state of the art technology. The thrust areas of the proposed book are induced pluripotent stem cells, cord blood stem cells, mesenchymal stem cells, livestock stem cells, amniotic fluid stem cells, role of epigenetics in stem cells, tissue engineering, cancer stem cells, bioinformatics strategies for stem cell research, Protocols for iPS generation and so on. These areas have been identified keeping in mind the current and future alighted issues that have a direct impact on the health sector of the world in general.

The Intestine

The Intestine
A Book

by Ahmed El-Hashash,Eiman Abdel Meguid

  • Publisher : Academic Press
  • Release : 2021-06-15
  • Pages : 204
  • ISBN : 0128212713
  • Language : En, Es, Fr & De
GET BOOK

The intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world. Provides intensive scientific background and most recent information on cutting edge research to understand intestinal stem cell functions and develop methods to bring stem cells from bench to bedside for different intestinal diseases Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and the CRISPR gene editing system in the intestine Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the intestine

Microbiome in Human Health and Disease

Microbiome in Human Health and Disease
A Book

by Pallaval Veera Bramhachari

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 9811631565
  • Language : En, Es, Fr & De
GET BOOK

Lung Stem Cells in Development, Health and Disease

Lung Stem Cells in Development, Health and Disease
A Book

by Nikolic, Marko Z.,Hogan, Brigid L.M.

  • Publisher : European Respiratory Society
  • Release : 2021-04-01
  • Pages : 392
  • ISBN : 1849841349
  • Language : En, Es, Fr & De
GET BOOK

Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease
A Book

by Stefaan Verbruggen

  • Publisher : Academic Press
  • Release : 2018-08-09
  • Pages : 527
  • ISBN : 0128129530
  • Language : En, Es, Fr & De
GET BOOK

Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature
A Book

by Amy Firth,Jason X.-J. Yuan

  • Publisher : Springer
  • Release : 2015-05-23
  • Pages : 345
  • ISBN : 3319162322
  • Language : En, Es, Fr & De
GET BOOK

This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Bone Marrow Adipose Tissue: Formation, Function, and Impact on Health and Disease

Bone Marrow Adipose Tissue: Formation, Function, and Impact on Health and Disease

by William P. Cawthorn,Erica L. Scheller

  • Publisher : Frontiers Media SA
  • Release : 2017-08-15
  • Pages : 129
  • ISBN : 288945245X
  • Language : En, Es, Fr & De
GET BOOK

Adipocytes are a major component of the bone marrow, accounting for up to 70% of total bone marrow volume in healthy humans. Indeed, this bone marrow adipose tissue (often referred to as ‘MAT’ or ‘BMAT’) accounts for at least 5% of total adipose tissue mass in lean, healthy humans, suggesting a role in normal physiology and development. Bone marrow adiposity further increases with ageing and in diverse clinical conditions, including major public health challenges such as osteoporosis. Yet despite this abundance and compelling clinical potential, bone marrow adipocytes have received surprisingly little attention from the biomedical research community. Thankfully, this is now beginning to change. Research over the past decade has begun to increase our knowledge of BMAT, including the conditions associated with altered bone marrow adiposity and the potential physiological and pathological functions of bone marrow adipocytes. The articles within this e-Book highlight many of these recent developments, underscoring our increasing knowledge of BMAT formation and function; showcasing emerging techniques for basic and clinical BMAT analysis; and highlighting key questions and future directions for this burgeoning and increasingly diverse field. The editors would like to express their thanks to the authors for contributing the articles within this e-Book; to the senior editors at Frontiers in Endocrinology for their guidance; and to the staff at Frontiers for their helpful input throughout.

CCN proteins in health and disease

CCN proteins in health and disease
An overview of the Fifth International Workshop on the CCN family of genes

by Annick Perbal,Masaharu Takigawa,Bernard Perbal

  • Publisher : Springer Science & Business Media
  • Release : 2010-04-26
  • Pages : 338
  • ISBN : 9789048137794
  • Language : En, Es, Fr & De
GET BOOK

The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th international workshop on the CCN family of genes, that was held in Toronto in 2008 brought together scientists from around the world who have an interest in the biological roles of this emerging family of proteins. On an educational point of view, the workshop was a unique place for an efficient diffusion of scientific information. The present book comprises a series of selected manuscripts that are based on the original communications that were presented at the meeting by worldwide leaders in the field of CCN biology. All major aspects of CCN proteins biology in both normal and pathological conditions are covered in this volume, from structure-functions analysis up to the involvement of CCN proteins in complex physiological functions. In addition to reports that support the Yin-Yang concept of CCN proteins driving opposite effects on the same biological process, this book also comprises several contributions that point to CCN proteins as amenable targets for therapeutic manipulation of disease processes. Together with the special issue of Journal of Cell Communication and Signaling in which authors have extended on the original data presented at the meeting, the present Proceedings provide an instant picture and unique update of the state of the art in the CCN field.

RNA-Based Regulation in Human Health and Disease

RNA-Based Regulation in Human Health and Disease
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-08-15
  • Pages : 444
  • ISBN : 0128171944
  • Language : En, Es, Fr & De
GET BOOK

RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics. Comprehensive information of non-canonical RNA-based genome regulation modulating human health and disease Defines RNA classes with special emphasis on unexplored world of noncoding RNA at different hierarchies Disease specific role of RNA - causal, prognostic, diagnostic and therapeutic Features contributions from leading experts in the field

Genetic Engineering of Mesenchymal Stem Cells

Genetic Engineering of Mesenchymal Stem Cells
A Book

by Jan A. Nolta

  • Publisher : Springer Science & Business Media
  • Release : 2006-08-29
  • Pages : 170
  • ISBN : 140203959X
  • Language : En, Es, Fr & De
GET BOOK

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Nanoparticles in Polymer Systems for Biomedical Applications

Nanoparticles in Polymer Systems for Biomedical Applications
A Book

by Jince Thomas,Sabu Thomas,Nandakumar Kalarikkal,Jiya Jose

  • Publisher : CRC Press
  • Release : 2018-12-12
  • Pages : 342
  • ISBN : 1351047876
  • Language : En, Es, Fr & De
GET BOOK

The volume includes presentations of technological and research accomplishments along with novel approaches in nanomedicine and nanotechnology. It explores the different types of nanomedicinal drugs with their production and commercial significance. Other topics discussed are the use of natural and synthetic nanoparticles for the production of drugs, different types of nanoparticles systems, drug carriers, wound-healing antimicrobial activity, effects of natural materials in nanomedicine, and toxicity of nanoparticles. The valuable information presented in this volume will help to keep those in this field up to date on the key findings, observations, and fabrication of drugs related to nanomedicine and nanotechnology. With chapters written by prominent researchers from academia, industry, and government and private research laboratories across the world, the book will prove to be a rich resource.