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Mesenchymal Stromal Cells

Mesenchymal Stromal Cells
Biology and Clinical Applications

by Peiman Hematti,Armand Keating

  • Publisher : Springer Science & Business Media
  • Release : 2013-01-16
  • Pages : 695
  • ISBN : 1461457114
  • Language : En, Es, Fr & De
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Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues.

Mesenchymal Stromal Cells

Mesenchymal Stromal Cells
Translational Pathways to Clinical Adoption

by Hematti Peiman,Sowmya Viswanathan

  • Publisher : Academic Press
  • Release : 2016-08-11
  • Pages : 362
  • ISBN : 0128028408
  • Language : En, Es, Fr & De
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Mesenchymal Stromal Cells: Translational Pathways to Clinical Adoption provides the latest information on the necessary steps for successful production of stem cells for a clinical trial. Written by professionals with hands-on experience in bringing MSC therapies to the clinic, and building on the biology and mechanisms of action, this unique book covers the development and production of clinical-grade products that are suitable for use in humans. From design of a cell production facility, to obtaining regulatory approval and reimbursement issues, it is a useful guide for researchers and administrators across biomedical research. Provides methodologies for clinical MSC production, from designing a facility, to post-market approval Includes real-life examples of MSC production in academic centers and MSC production for biopharmaceutical clinical trials Offers a unique perspective on the clinical aspects of MSC studies Presents the principles of clinical trials that can be applied to the production of various cell therapies

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal Stromal Cells as Tumor Stromal Modulators
A Book

by Marcela Bolontrade,Mariana García

  • Publisher : Academic Press
  • Release : 2016-10-24
  • Pages : 642
  • ISBN : 0128031034
  • Language : En, Es, Fr & De
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Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Mesenchymal Stromal Cells (MSCs)

Mesenchymal Stromal Cells (MSCs)
Biology, Mechanisms of Action and Clinical Uses

by Randy Morrison

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 97
  • ISBN : 9781634857208
  • Language : En, Es, Fr & De
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Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine.

Current Progress in Mesenchymal Stem/Stromal Cell Research

Current Progress in Mesenchymal Stem/Stromal Cell Research
A Book

by Lindolfo da Silva Meirelles,Karen Bieback,Marcela F. Bolontrade

  • Publisher : Frontiers Media SA
  • Release : 2021-03-24
  • Pages : 329
  • ISBN : 2889666255
  • Language : En, Es, Fr & De
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Mesenchymal Stem Cells - Basics and Clinical Application II

Mesenchymal Stem Cells - Basics and Clinical Application II
A Book

by Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 309
  • ISBN : 3642379443
  • Language : En, Es, Fr & De
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Engineered MSCs from Patient-Specific iPS Cells, by Irina Eberle, Mohsen Moslem, Reinhard Henschler, Tobias Cantz Fate of Intravenously Injected Mesenchymal Stem Cells and Significance for Clinical Application, by Beate Wagner, Reinhard Henschler The Implications of Stem Cell Applications for Diseases of the Respiratory System, by Mei Ling Lim, Philipp Jungebluth, Paolo Macchiarini Potential of Mesenchymal Stem Cell Applications in Plastic and Reconstructive Surgery, by Birgit Weyand, Peter M. Vogt General Principles for the Regeneration of Bone and Cartilage, by Michael Jagodzinski, C. Haasper Adult Mesenchymal Stem Cells Explored in the Dental Field, by K. M. Fawzy El-Sayed, C. Dörfer, F. Fändrich, F. Gieseler, M. H. Moustafa, H. Ungefroren Mesenchymal Stem Cell Therapy and Lung Diseases, by Khondoker M. Akram, Sohel Samad, Monica Spiteri, Nicholas R. Forsyth Mesenchymal Stem Cells as Cellular Immunotherapeutics in Allogeneic Hematopoietic Stem Cell Transplantation, by Claudia Papewalis, Daniela Topolar, Barbara Götz, Stefan Schönberger, Dagmar Dilloo New Cell-Based Therapy Paradigm: Induction of Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells into Pro-Inflammatory MSC1 and Anti-inflammatory MSC2 Phenotypes, by Aline M. Betancourt Interactions Between Mesenchymal Stem Cells and Dendritic Cells, by Grazia Maria Spaggiari, Lorenzo Moretta MSC and Tumors: Homing, Differentiation, and Secretion Influence Therapeutic Potential, by Naomi D’souza, Jorge Sans Burns, Giulia Grisendi, Olivia Candini, Elena Veronesi, Serena Piccinno, Edwin M. Horwitz, Paolo Paolucci, Pierfranco Conte, Massimo Dominici Sources of Mesenchymal Stem Cells: Current and Future Clinical Use, by Michela Pozzobon, Martina Piccoli, Paolo De Coppi Role of the EU Framework in Regulation of Stem Cell-Based Products, by Giovanni Migliaccio, Cristina Pintus

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
A Book

by Lucas G. Chase,Mohan C Vemuri

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-12
  • Pages : 456
  • ISBN : 1627032002
  • Language : En, Es, Fr & De
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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

0498 - Mesenchymal Stromal Cells (MSCs) Isolated from Fat Pad and Femoral Bone Marrow of Elderly Males During Knee Replacement Retain Tri-lineage Potential

0498 - Mesenchymal Stromal Cells (MSCs) Isolated from Fat Pad and Femoral Bone Marrow of Elderly Males During Knee Replacement Retain Tri-lineage Potential
A Book

by Erika Leonardi

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mesenchymal Stromal Cells (MSCs) Isolated from Fat Pad and Femoral Bone Marrow of Elderly Males During Knee Replacement Retain Tri-lineage PotentialEleonora Migliore1, 2, Erika Leonardi1, 2, Pier Francesco Indelli1, 2, Vittorio Sebastiano1 and Constance R. Chu1,21Stanford University, Palo Alto, CA, VA Palo Alto Health Care System, CA2 chucr@stanford.eduDisclosures: Eleonora Migliore (N), Erika Leonardi (N), Pier Francesco Indelli (N), Vittorio Sebastiano (N), Constance R. Chu (N)INTRODUCTION: Osteoarthritis (OA) is a common and chronic degenerative joint disease that is associated with aging. It is a leading cause of disability characterized by pain, stiffness and loss of joint function. There is intense interest in the use of Mesenchymal Stromal Cells (MSCs) for pain relief and, ideally, regenerative effect. Many patients seeking biologic therapies for OA are elderly with advanced OA. Thus, questions related to patient age and OA disease state on MSCs properties remain unanswered. Prior studies suggest differences in MSC chondrogenic potential between males and females, along with a decline in MSC functionality with age, particularly in males [1]. As symptomatic OA is more common in patients over 60 years old than in younger people, examination of MSC performance the characterization in elderly patients with OA has high clinical relevance. This study was performed to evaluate and compare the MSC yield and tri-lineage potential of MSC isolated from bone marrow and fat pad from the same elderly male donors. METHODS: Human Adipose Stromal Cells (hASCs) and Human Bone Marrow Mesenchymal Stromal Cells (hBM-MSCs) were isolated from fat pad and femoral medullary canal tissues obtained at total knee replacement from 5 male patients (60-75 years old) with advanced knee osteoarthritis. The protocols, policies and human samples collection methods were obtained according to Institutional Review Board approved protocols, and informed consent was obtained from all the participants. ASC cells were isolated from fat pad tissue using enzymatic digestion (Collagenase IV 1mg/ml) [2], while the BM-MSC cells were isolated from femoral medullary canal reaming by Ficoll density gradient media protocols [1]. Both cells types were cultured according to established protocols for primary MSC cells. Cells were allowed to adhere for 3-4 days at 37u00b0C and 5% CO2 before the first medium change, which would remove any non-adherent cells, and trypsinized when they reached 70-80% confluence [1,2]. Mesenchymal characterization was performed following the criteria described from the International Society for Cellular Therapy (ISCT): adherence to plastic, specific surface antigen (Ag) expression and multipotent differentiation potential in three different cells lineages (adipocytes, osteoblasts and chondroblasts) [3]. Differentiation procedure was performed using three different culture media with selected growth/differentiation factors in three different 6 well plates at the same cell density (6*10e4 each well). ASCs and BM-MSC cells have been differentiated in adipocytes after 2 weeks and stained with Oil Red O, while the differentiation stages in osteoblasts and chondroblasts were reached after 3 weeks and stained with Alizarin Red and Alcian Blue respectively. Hematoxylin/eosin stain was used to show the different morphology changes before and after the differentiation process. Flow cytometry was performed at passage 2 with the same cell density (1*10e6) for evaluating the mesenchymal surface markers of CD90, CD105, CD44 and CD34, CD45, CD31 as positive and negative markers [3]. RESULTS: Adipose and bone marrow derived cells from the same elderly OA patient adhered to the tissue culture flasks and proliferated from the time of plating (Figure 1). At passage 2 (P2) cells from both tissues plated to the same density demonstrated similar ability to differentiate into the three different cells lineages (Figure 2). ASCs and BM-MSC cells (respectively from the left to the right of Figure 2) accumulated lipid vesicles in the cytosol which confirmed the adipogenesis process after 2 weeks of culture. (Figure 2A1 and 2B1). Furthermore, both ASC and BM-MSC cells showed positive cells for Alizarin Red staining that were widely distributed throughout the tissue culture flask, confirming the osteoblastic differentiation after 3 weeks of culturing (Figure 2A3 and 2B3). MSC cell types stained with Alcian Blue showed the presence of GAG matrix after 21 days of culture in chondrogenic medium, indicating chondrogenic differentiation potential (Figure 2A5 and 2B5). Morphology changes were highlighted using Hematoxylin/eosin staining, confirming the three different differentiation processes (respectively Figure 2A, A2, A4 and A6 for ASC cells and Figure 2B, B2, B4 and B6 for BM-MSC cells). Flow cytometry showed expression of appropriate mesenchymal surface markers, with high expression of CD90, CD105, CD44 along with the lack of CD34, CD45, CD31 (Figure 3).DISCUSSION: These results show MSC features meeting the ISCT criteria in both hASC and hBM-MSC cells from elderly OA patients. The specific surface antigen (Ag) expression was homogeneous in all cells types, showing a well-established mesenchymal phenotype. Based on these preliminary results, both the knee fat pad and the femoral medullary canal bone marrow show potential as alternative sources of MSC despite the older age and advanced OA disease state of the donors. SIGNIFICANCE/CLINICAL RILEVANCE: These in vitro data suggest that MSC isolated from older males with OA can be culture expanded using standard techniques, and that these MSC retain the ability to differentiate into mesenchymal lineages of interest for bone and cartilage regeneration. Further assessment of cellular performance, bioactivity, and senescence are needed to determine therapeutic potential for clinical applications to include treatment of OA.REFERENCES: [1] Payne KA et al, Osteoarthritis Cartilage. 2010 May; 18(5): 705u2013713. [2] Bianchi F et al, Cell Transplant. 2013;22(11):2063-77. [3] Domenici M et al, Cytotherapy. 2006;8(4):315-7.

Mesenchymal Stem Cells - Basics and Clinical Application I

Mesenchymal Stem Cells - Basics and Clinical Application I
A Book

by Birgit Weyand,Massimo Dominici,Ralf Hass,Roland Jacobs,Cornelia Kasper

  • Publisher : Springer
  • Release : 2014-07-08
  • Pages : 194
  • ISBN : 3642356710
  • Language : En, Es, Fr & De
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Prospective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Bühring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schäfer

The Biology and Therapeutic Application of Mesenchymal Cells - Set

The Biology and Therapeutic Application of Mesenchymal Cells - Set
A Book

by Kerry Atkinson

  • Publisher : John Wiley & Sons
  • Release : 2017-01-17
  • Pages : 1048
  • ISBN : 1118907515
  • Language : En, Es, Fr & De
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The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. • Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications • Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models • Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues • Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine. About the Author Kerry Atkinson, MBBS MD DTM&H FRCP FRACP, is an Adjunct Professor at the University of Queensland Centre for Clinical Research in Brisbane, Australia, an Adjunct Professor in the Stem Cell Laboratories, Queensland University of Technology at the Translational Research Institute, Brisbane, Queensland, Australia and a Specialist in Internal Medicine at the Salisbury Medical Centre, Brisbane, Queensland, Australia.

Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies

Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies
A Book

by Guido Moll,Martin Johannes Hoogduijn,James A. Ankrum

  • Publisher : Frontiers Media SA
  • Release : 2020-07-24
  • Pages : 329
  • ISBN : 2889636003
  • Language : En, Es, Fr & De
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Mesenchymal Stromal Cells in Wound Healing

Mesenchymal Stromal Cells in Wound Healing
A Book

by Nina Kosaric

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abnormal wound healing is a significant healthcare problem with rising at-risk patient populations. Despite the multitude of treatment modalities available, few therapies can reverse the deficiencies that contribute to delayed or non-healing wounds. Mesenchymal stromal cells (MSCs) have emerged as a promising next-generation therapy for wound repair due to their ability to secrete trophic factors that modulate inflammation and promote regeneration. This work first provides a comprehensive overview of the intricate process of wound healing and the individual roles of resident cell types to identify potential points of therapeutic intervention at each stage of the wound healing cascade. Secondly, using lineage tracing, multiple models of ischemic injury, and single cell transcriptional analysis, we identify a population of non-hematopoietic, non-endothelial circulating progenitor cells that homes to regions of ischemia and may contribute to tissue repair. We demonstrate that these cells engraft adjacent to endothelial cells, display mesenchymal morphology, and deposit extracellular matrix, suggesting that they may be the in vivo equivalent of MSCs cultured in vitro. Thirdly, we explore the fate of mesenchymal stromal cells following intravenous infusion and their impact on wound healing. Using a mouse excisional wound healing model, we demonstrate that infusion of MSCs leads to pulmonary entrapment followed by rapid clearance from the recipient, but also significantly accelerates wound closure. Using single cell RNA-sequencing of the wound, we show that following MSC delivery, innate immune cells, particularly macrophages, exhibit distinctive transcriptional changes. We identify the appearance of a pro-angiogenic CD9+ macrophage subpopulation, whose induction is mediated by several proteins secreted by MSCs, including COL6A1, PRG4, and TGFB3. These findings suggest that MSCs do not need to act locally to induce broad changes in the immune system and ultimately treat disease. Finally, we investigate the age-related impacts on cellular function of MSCs. We demonstrate that delivery of MSCs from young donors resulted in significantly faster healing compared to delivery of MSCs from older donors. Using single-cell transcriptomic analysis to provide potential molecular insights into these observations, we demonstrate that cells from young donors contain a higher proportion of cells characterized by a higher expression of genes involved in tissue regeneration. In addition, we identify a unique, quiescent subpopulation that is exclusively present in young donor cells. These findings may explain a novel mechanism for the enhanced healing capacity of young stem cells and may have implications for autologous cell therapy in the extremes of age.

Genetic Engineering of Mesenchymal Stem Cells

Genetic Engineering of Mesenchymal Stem Cells
A Book

by Jan A. Nolta

  • Publisher : Springer Science & Business Media
  • Release : 2006-08-29
  • Pages : 170
  • ISBN : 140203959X
  • Language : En, Es, Fr & De
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MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Mesenchymal Stem Cells

Mesenchymal Stem Cells
Isolation, Characterization and Applications

by Phuc Van Pham

  • Publisher : BoD – Books on Demand
  • Release : 2017-11-29
  • Pages : 300
  • ISBN : 9535136151
  • Language : En, Es, Fr & De
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Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.

Mesenchymal Stem Cells in Human Health and Diseases

Mesenchymal Stem Cells in Human Health and Diseases
A Book

by Ahmed El-Hashash

  • Publisher : Academic Press
  • Release : 2020-01-06
  • Pages : 228
  • ISBN : 0128197137
  • Language : En, Es, Fr & De
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Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

Mesenchymal Stromal Cells for Graft-versus-host Disease

Mesenchymal Stromal Cells for Graft-versus-host Disease
A Book

by Antonio Galleu

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Adult and Embryonic Stem Cells

Adult and Embryonic Stem Cells
A Book

by Kursad Turksen

  • Publisher : Springer Science & Business Media
  • Release : 2012-02-03
  • Pages : 262
  • ISBN : 1617796301
  • Language : En, Es, Fr & De
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This volume will cover a series of reviews on stem cells including adult and embryonic stem cells. Speakers were invited to present these talks during the Stem Cell Symposia in fall of 2010, in Samsun, Turkey. Unique aspect of this volume is that it brings a multidisciplinary aspect of stem cells extracted from a symposium.

Stromal Cells

Stromal Cells
Structure, Function, and Therapeutic Implications

by Mani T. Valarmathi

  • Publisher : BoD – Books on Demand
  • Release : 2019-01-23
  • Pages : 260
  • ISBN : 1789849845
  • Language : En, Es, Fr & De
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Stromal cells are connective tissue cells of any organ, and they support the function of the parenchymal cells of that particular organ. Stromal/stromal stem cells are fundamentally a heterogeneous population of cells with contradictory differentiation potential depending upon their environmental niche. Stromal cell biology is not only intriguing, but equally stromal cell ontogeny in vivo remains challenging. In recent years there has been substantial advances in our understanding of stromal cell biology, especially stromal cell isolation, characterization, differentiation, and interactions in physiological (epithelial-stromal interactions) as well as pathophysiological (stromal-cancer interactions) contexts. In addition, stromal cells are also utilized more and more as a therapeutic tool not only in the field of gene therapy but also in the translational field of tissue engineering and regenerative medicine. Therefore, the goal of this book is to consolidate the recent advances in the area of stromal/stromal stem cell biology covering a broad range of interrelated topics in a timely fashion and to disseminate that knowledge in a lucid way to a greater scientific audience. This book will prove highly useful for students, researchers, and clinicians in stem cell biology, developmental biology, cancer biology, pathology, oncology, as well as tissue engineering and regenerative medicine. This quick reference will benefit anyone desiring a thorough overview of stromal cell structure, function, and its therapeutic implications.

Bioreactor Systems for Tissue Engineering II

Bioreactor Systems for Tissue Engineering II
Strategies for the Expansion and Directed Differentiation of Stem Cells

by Cornelia Kasper,Martijn van Griensven,Ralf Pörtner

  • Publisher : Springer
  • Release : 2010-10-17
  • Pages : 322
  • ISBN : 3642160514
  • Language : En, Es, Fr & De
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Alternative Sources of Adult Stem Cells: Human Amniotic Membrane, by S. Wolbank, M. van Griensven, R. Grillari-Voglauer, and A. Peterbauer-Scherb; * Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications, by P. Moretti, T. Hatlapatka, D. Marten, A. Lavrentieva, I. Majore, R. Hass and C. Kasper; * Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells, by J. W. Kuhbier, B. Weyand, C. Radtke, P. M. Vogt, C. Kasper and K. Reimers; * Induced Pluripotent Stem Cells: Characteristics and Perspectives, by T. Cantz and U. Martin; * Induced Pluripotent Stem Cell Technology in Regenerative Medicine and Biology, by D. Pei, J. Xu, Q. Zhuang, H.-F. Tse and M. A. Esteban; * Production Process for Stem Cell Based Therapeutic Implants: Expansion of the Production Cell Line and Cultivation of Encapsulated Cells, by C. Weber, S. Pohl, R. Poertner, P. Pino-Grace, D. Freimark, C. Wallrapp, P. Geigle and P. Czermak; * Cartilage Engineering from Mesenchymal Stem Cells, by C. Goepfert, A. Slobodianski, A.F. Schilling, P. Adamietz and R. Poertner; * Outgrowth Endothelial Cells: Sources, Characteristics and Potential Applications in Tissue Engineering and Regenerative Medicine, by S. Fuchs, E. Dohle, M. Kolbe, C. J. Kirkpatrick; * Basic Science and Clinical Application of Stem Cells in Veterinary Medicine, by I. Ribitsch, J. Burk, U. Delling, C. Geißler, C. Gittel, H. Jülke, W. Brehm; * Bone Marrow Stem Cells in Clinical Application: Harnessing Paracrine Roles and Niche Mechanisms, by R. M. El Backly, R. Cancedda; * Clinical Application of Stem Cells in the Cardiovascular System, C. Stamm, K. Klose, Y.-H. Choi

Mesenchymal Stromal Cells Immunobiology and Therapeutic Implications

Mesenchymal Stromal Cells Immunobiology and Therapeutic Implications
A Book

by Chiara Giacomini

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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