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Metabolic Phenotyping in Personalized and Public Healthcare

Metabolic Phenotyping in Personalized and Public Healthcare
A Book

by Jeremy Nicholson,Ara Darzi,Elaine Holmes,John C. Lindon

  • Publisher : Academic Press
  • Release : 2016-02-11
  • Pages : 428
  • ISBN : 0128004142
  • Language : En, Es, Fr & De
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Metabolic Phenotyping in Personalized and Public Healthcare provides information on the widespread recognition that a personalized or stratified approach to patient treatment may offer a more efficient and effective healthcare solution than phenotype-led approaches. In order to achieve that objective, a deep personal description is required at the level of the genome, proteome, metabolome, or preferably a combination of these aided by technology. This book, edited and written by the outstanding luminaries of this evolving field, evaluates metabolic profiling and its uses across personalized and population healthcare, while also covering the advent of new technology fields, such as surgical metabonomics. In addition, the text presents specific examples of where this technology has been used clinically and with efficacy, pointing towards a framework and protocol for usage as it hits the clinical mainstream. Translates the conjunction of new surgical tools for intraoperative, real-time, metabolite evaluation and direct analysis of biofluid samples into novel options for augmented clinical decision-making Discusses longitudinal sampling from individual patients for stratified medicine Covers high resolution analytical spectroscopy and sophisticated computational modelling for prediction of adverse reactions in critical care scenarios, prognostic evaluation of cancer from biofluidism, and prognostic prediction of metabolism or response of patients to pharmaceutical interventions Encapsulates recent technology options for broader population profiling considerations, in particular, the metabolome-wide association studies (MWAS) that aid the translational researcher in identifying metabolic patterns associated with disease Foreword written by Professor Dame Sally Davies who is the Chief Medical Officer for England

The Handbook of Metabolic Phenotyping

The Handbook of Metabolic Phenotyping
A Book

by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes

  • Publisher : Elsevier
  • Release : 2018-10-04
  • Pages : 619
  • ISBN : 0128122943
  • Language : En, Es, Fr & De
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The Handbook of Metabolic Phenotyping is the definitive work on the rapidly developing subject of metabolic phenotyping. It explores in detail the wide array of analytical chemistry and statistical modeling techniques used in the field, coupled with surveys of the various application areas in human development, nutrition, disease, therapy, and epidemiology to create a comprehensive exploration of the area of study. It covers recent studies that integrate the various -omics data sets to derive a systems biology view. It also addresses current issues on standardization, assay and statistics validation, and data storage and sharing. Written by experts with many years of practice in the field who pioneered many of the approaches widely used today, The Handbook of Metabolic Phenotyping is a valuable resource for postgrads and research scientists studying and furthering the field of metabolomics. Contains theoretical and practical explanations of all the main analytical chemistry techniques used in metabolic phenotyping Explores, in detail, the many diverse statistical approaches used in the field Offers practical tips for successfully conducting metabolic phenotyping studies Features reviews of all of the various fields of activity relating to human studies

Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology
100 Years of the Handbook of Experimental Pharmacology

by James E. Barrett,Clive P. Page,Martin C. Michel

  • Publisher : Springer Nature
  • Release : 2019-12-24
  • Pages : 466
  • ISBN : 3030353621
  • Language : En, Es, Fr & De
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Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Encyclopedia of Analytical Science

Encyclopedia of Analytical Science
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2019-04-02
  • Pages : 5109
  • ISBN : 008101984X
  • Language : En, Es, Fr & De
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The third edition of the Encyclopedia of Analytical Science is a definitive collection of articles covering the latest technologies in application areas such as medicine, environmental science, food science and geology. Meticulously organized, clearly written and fully interdisciplinary, the Encyclopedia of Analytical Science provides foundational knowledge across the scope of modern analytical chemistry, linking fundamental topics with the latest methodologies. Articles will cover three broad areas: analytical techniques (e.g., mass spectrometry, liquid chromatography, atomic spectrometry); areas of application (e.g., forensic, environmental and clinical); and analytes (e.g., arsenic, nucleic acids and polycyclic aromatic hydrocarbons), providing a one-stop resource for analytical scientists. Offers readers a one-stop resource with access to information across the entire scope of modern analytical science Presents articles split into three broad areas: analytical techniques, areas of application and and analytes, creating an ideal resource for students, researchers and professionals Provides concise and accessible information that is ideal for non-specialists and readers from undergraduate levels and higher

Liquid Chromatography

Liquid Chromatography
Applications

by Salvatore Fanali,Paul R. Haddad,Colin Poole,Marja-Liisa Riekkola

  • Publisher : Elsevier
  • Release : 2017-06-23
  • Pages : 838
  • ISBN : 0128093447
  • Language : En, Es, Fr & De
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Liquid Chromatography: Applications, Second Edition,is a single source of authoritative information on all aspects of the practice of modern liquid chromatography. It gives those working in both academia and industry the opportunity to learn, refresh, and deepen their knowledge of the wide variety of applications in the field. In the years since the first edition was published, thousands of papers have been released on new achievements in liquid chromatography, including the development of new stationary phases, improvement of instrumentation, development of theory, and new applications in biomedicine, metabolomics, proteomics, foodomics, pharmaceuticals, and more. This second edition addresses these new developments with updated chapters from the most expert researchers in the field. Emphasizes the integration of chromatographic methods and sample preparation Explains how liquid chromatography is used in different industrial sectors Covers the most interesting and valuable applications in different fields, e.g., proteomic, metabolomics, foodomics, pollutants and contaminants, and drug analysis (forensic, toxicological, pharmaceutical, biomedical) Includes references and tables with commonly used data to facilitate research, practical work, comparison of results, and decision-making

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
A Book

by Yvonne Will,James A. Dykens

  • Publisher : John Wiley & Sons
  • Release : 2018-03-23
  • Pages : 816
  • ISBN : 1119329744
  • Language : En, Es, Fr & De
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Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. • Covers both basic science and applied technology / methods • Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects • Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development • Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria

Data Mining and Big Data

Data Mining and Big Data
4th International Conference, DMBD 2019, Chiang Mai, Thailand, July 26–30, 2019, Proceedings

by Ying Tan,Yuhui Shi

  • Publisher : Springer
  • Release : 2019-07-25
  • Pages : 340
  • ISBN : 9813295635
  • Language : En, Es, Fr & De
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This book constitutes the refereed proceedings of the 4th International Conference on Data Mining and Big Data, DMBD 2019, held in Chiang Mai, Thailand, in July 2019. The 26 full papers and 8 short papers presented in this volume were carefully reviewed and selected from 79 submissions. They are organized in topical sections named: data analysis; prediction; clustering; classification; mining pattern; mining tasks.

10 Years of Pharmacogenetics and Pharmacogenomics

10 Years of Pharmacogenetics and Pharmacogenomics
A Book

by Jose Agundez

  • Publisher : Frontiers Media SA
  • Release : 2020-07-08
  • Pages : 281
  • ISBN : 2889638286
  • Language : En, Es, Fr & De
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The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board is composed of 34 Associate Editors which, together with the Guest Associate Editors and the Reviewer Editors, constitute a team of nearly 340 leading experts in the field of Pharmacogenetics and Pharmacogenomics. This guarantees high quality in the reviewing process as well as short review times. A look back: 10 years of Frontiers in Pharmacogenetics & Pharmacogenomics (Continued in eBook)

Precision Medicine for Investigators, Practitioners and Providers

Precision Medicine for Investigators, Practitioners and Providers
A Book

by Joel Faintuch,Salomao Faintuch

  • Publisher : Academic Press
  • Release : 2019-11-16
  • Pages : 640
  • ISBN : 0128191791
  • Language : En, Es, Fr & De
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Precision Medicine for Investigators, Practitioners and Providers addresses the needs of investigators by covering the topic as an umbrella concept, from new drug trials to wearable diagnostic devices, and from pediatrics to psychiatry in a manner that is up-to-date and authoritative. Sections include broad coverage of concerning disease groups and ancillary information about techniques, resources and consequences. Moreover, each chapter follows a structured blueprint, so that multiple, essential items are not overlooked. Instead of simply concentrating on a limited number of extensive and pedantic coverages, scholarly diagrams are also included. Provides a three-pronged approach to precision medicine that is focused on investigators, practitioners and healthcare providers Covers disease groups and ancillary information about techniques, resources and consequences Follows a structured blueprint, ensuring essential chapters items are not overlooked

Emerging Technologies and the Digital Transformation of Museums and Heritage Sites

Emerging Technologies and the Digital Transformation of Museums and Heritage Sites
First International Conference, RISE IMET 2021, Nicosia, Cyprus, June 2–4, 2021, Proceedings

by Maria Shehade

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 3030836479
  • Language : En, Es, Fr & De
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Surgical Metabolism

Surgical Metabolism
The Metabolic Care of the Surgical Patient

by Kimberly A. Davis,Stanley H. Rosenbaum

  • Publisher : Springer Nature
  • Release : 2020-04-15
  • Pages : 373
  • ISBN : 3030397815
  • Language : En, Es, Fr & De
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The goal of this book is not to follow a traditional systems or organ-based approach but rather to encourage our readers to think of the patients as complex biochemical systems. The book provides information that supplements the more traditional approaches and provides a detailed overview of the metabolic knowledge needed for surgical practice. The text reviews normal physiology, the pathophysiology of starvation and surgical stressors. It also focuses on appropriate nutritional repletion for various common disease states. Specifically, chapters address the severe metabolic demands created by systemic inflammation, infection, and major insults such as trauma and burns. All chapters are written by experts in their fields and include the most up-to-date scientific and clinical information. As biochemical aspects of modern medicine are advancing rapidly, chapters have been updated and several new chapters have been added in order to help readers keep pace in this race for state-of-the-art knowledge. Surgical Metabolism: The Metabolic Care of the Surgical Patient 2nd Edition is designed for clinicians across levels of training and provides clear and concise evidence based guidelines for the metabolic management and nutritional support of the surgical patient.

Biomarkers of Kidney Disease

Biomarkers of Kidney Disease
A Book

by Charles L. Edelstein

  • Publisher : Academic Press
  • Release : 2016-11-08
  • Pages : 632
  • ISBN : 0128030356
  • Language : En, Es, Fr & De
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Biomarkers of Kidney Disease, Second Edition, focuses on the basic and clinical research of biomarkers in common kidney diseases, detailing the characteristics of an ideal biomarker. The latest techniques for biomarker detection, including metabolomics and proteomics are covered in the book. This comprehensive book details the latest advances made in the field of biomarker research and development in kidney diseases. The book is an ideal companion for those interested in biomarker research and development, proteomics and metabolomics, kidney diseases, statistical analysis, transplantation, and preeclampsia. New chapters include biomarkers of cardiovascular disease in patients with CKD, biomarkers of Polycystic Kidney Disease, and biomarkers and the role of nanomedicine. Explores both the practical and conceptual steps performed in the discovery of biomarkers in kidney disease Presents a comprehensive account of newer biomarker discover strategies, such as metabolomics and proteomics, all illustrated by clear examples Offers clear translational presentations by the top basic and clinical researchers in each specific renal disease, including AKI, transplantation, cancer, CKD, PKD, diabetic nephropathy, preeclampsia, and glomerular disease

Experimental Museology

Experimental Museology
Institutions, Representations, Users

by Marianne Achiam,Michael Haldrup,Kirsten Drotner

  • Publisher : Routledge
  • Release : 2021-06-29
  • Pages : 240
  • ISBN : 1000405567
  • Language : En, Es, Fr & De
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Experimental Museology scrutinizes innovative endeavours to transform museum interactions with the world. Analysing cutting-edge cases from around the globe, the volume demonstrates how museums can design, apply and assess new modes of audience engagement and participation. Written by an interdisciplinary group of researchers and research-led professionals, the book argues that museum transformations must be focused on conceptualizing and documenting the everyday challenges and choices facing museums, especially in relation to wider social, political and economic ramifications. In order to illuminate the complexity of these challenges, the volume is structured into three related key dimensions of museum practice - namely institutions, representations and users. Each chapter is based on a curatorial design proposed and performed in collaboration between university-based academics and a museum. Taken together, the chapters provide insights into a diversity of geographical contexts, fields and museums, thus building a comprehensive and reflexive repository of design practices and formative experiments that can help strengthen future museum research and design. Experimental Museology will be of great value to academics and students in the fields of museum, gallery and heritage studies, as well as architecture, design, communication and cultural studies. It will also be of interest to museum professionals and anyone else who is interested in learning more about experimentation and design as resources in museums.

Textbook of Personalized Medicine

Textbook of Personalized Medicine
A Book

by Kewal K. Jain

  • Publisher : Springer Nature
  • Release : 2020-12-05
  • Pages : 744
  • ISBN : 3030620808
  • Language : En, Es, Fr & De
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This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considers genetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various players in it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

In Silico Drug Design

In Silico Drug Design
Repurposing Techniques and Methodologies

by Kunal Roy

  • Publisher : Academic Press
  • Release : 2019-02-12
  • Pages : 886
  • ISBN : 0128163771
  • Language : En, Es, Fr & De
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In Silico Drug Design: Repurposing Techniques and Methodologies explores the application of computational tools that can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, this book gives scientists, researchers and R&D professionals in the pharmaceutical industry valuable insights into drug design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies relating to the in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents, and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition

Nutrigenomics and Nutrigenetics in Functional Foods and Personalized Nutrition
A Book

by Lynnette R. Ferguson

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 451
  • ISBN : 1439876819
  • Language : En, Es, Fr & De
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While functional foods have become a reasonably well-established concept, personalized nutrition is still treated with skepticism by many. The recognition that people would have different nutrient requirements, or perceive foods in different ways, raises several concerns-some real, some not so real. Nutrigenomics and Nutrigenetics in Functional Foo

Personalized Nutrition

Personalized Nutrition
Principles and Applications

by Frans Kok,Laura Bouwman,Frank Desiere

  • Publisher : CRC Press
  • Release : 2007-08-24
  • Pages : 304
  • ISBN : 9781420009170
  • Language : En, Es, Fr & De
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From one person to the next, optimal health is governed by a huge array of minor genetic differences. When modulated by a variety of food bioiactives, these differences result in changes in gene expression and subsequent phenotypic expression. Combining biomedical and social science with contributions from leaders in both fields, Personalized Nutrition: Principles and Applications illustrates molecular, physiological, epidemiological, and public health aspects with examples from major diseases and discusses the behavioral, ethical, and consumer perspectives that will influence a successful introduction of personalized nutrition. Divided into three sections, the book answers pertinent questions crucial to the mainstream acceptance of personalized nutrition: to what extent is this personal diet-and-health relationship practically valid? how can nutrition science demonstrate this? And what is the proposition of stakeholders in society, including the consumer? The book begins with an overview of the state-of-the-science in nutrigenomic technologies including transcriptomics, proteomics, and metabolomics. It covers the use of genomics technology for a better understanding of the molecular mechanisms involved in major diet-related chronic disorders such as chronic inflammation, cardiovascular disease, diabetes, cancer, and obesity. Section two compares the practices and opinions of scientists, food companies, consumers, competitive athletes, and health care providers on the subject of personalized nutrition. It reviews marketing potential, consumer attitudes, and the ethical issues surrounding personalized advice. The final section focuses on humanitarian concerns related to developing countries and calls for international efforts to develop best practices, collaboration, and dataset sharing. The authors also consider ongoing innovations in food technology, nutrigenomics, and food delivery systems.

Chocolate in Health and Nutrition

Chocolate in Health and Nutrition
A Book

by Ronald Ross Watson,Victor R. Preedy,Sherma Zibadi

  • Publisher : Springer Science & Business Media
  • Release : 2012-08-04
  • Pages : 553
  • ISBN : 1617798037
  • Language : En, Es, Fr & De
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Chocolate in Health and Nutrition represents the first comprehensive compilation of the newest data on the actions of the flavonoids and microorganisms associated with the beneficial effects of chocolate. This unique text provides practical, data-driven resources based upon the totality of the evidence to help the reader understand the basics, treatments and preventive strategies that are involved in the understanding of the role chocolate may play in healthy individuals as well as those with cardiovascular disease, diabetes or neurocognitive declines. Of equal importance, critical issues that involve patient concerns, such as dental caries and food preferences in children, potential effects on weight gain, addiction and withdrawal are included in well-referenced, informative chapters. The latest research on the role of chocolate in normal health areas including mood, pain and weight management, cardiovascular disease and related conditions are presented. Chocolate in Health and Nutrition provides health professionals in many areas of research and practice with the most up-to-date, well referenced and comprehensive volume on the current state of the science and medical uses of chocolate.

Personalized Nutrition as Medical Therapy for High-Risk Diseases

Personalized Nutrition as Medical Therapy for High-Risk Diseases
A Book

by Nilanjana Maulik

  • Publisher : CRC Press
  • Release : 2020-04-18
  • Pages : 348
  • ISBN : 1351621831
  • Language : En, Es, Fr & De
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Personalized nutrition involves the formulation of individualized nutritional recommendations to promote and maintain health based on an individual's genetic makeup and other unique intrinsic and extrinsic factors. Implementing personalized nutrition plans for individuals with certain diseases or who are in danger of developing health conditions could help control the onset and severity of symptoms. Personalized Nutrition as Medical Therapy for High-Risk Diseases offers a practical guide for physicians seeking to provide tailored dietary recommendations to their patients with disease treatment, modulation and prevention in mind. The book focuses on the biological mechanisms of specific diseases and provides evidence for how personalized nutrition positively impacts them. It explores conditions including cardiovascular diseases, hypertension, hypercholesteromia, diabetes, obesity, Crohn's disease, as well as multiple pediatric, renal and psychological disorders. Features: · Includes case studies that document how people respond differently towards food depending on their genetic structure and other factors. · Discusses genome wide association studies (GWIMS) to understand the interplay between genetic susceptibility and dietary interactions. · Provides users information to effectively implement personalized nutrition into practice. · Identifies possible challenges to the implementation of personalized nutritional interventions in a clinical setting. This book is for medical practitioners and will also appeal to researchers and students.

Personalized Medicine in Healthcare Systems

Personalized Medicine in Healthcare Systems
Legal, Medical and Economic Implications

by Nada Bodiroga-Vukobrat,Daniel Rukavina,Krešimir Pavelić,Gerald G. Sander

  • Publisher : Springer
  • Release : 2019-08-02
  • Pages : 411
  • ISBN : 3030164659
  • Language : En, Es, Fr & De
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This book gathers scientific contributions on comprehensive approaches to personalized medicine. In a systematic and clear manner, it provides extensive information on the methodological, technological, and clinical aspects of high-throughput analytics, nanotechnology approaches, microbiota/human interactions, in-vitro fertilization and preimplantation, and various diseases like cancer.Moreover, the book analyzes the social and legal aspects of social security systems, healthcare systems and EU law – e.g. the role of solidarity, regulatory possibilities and obstacles, justice and equality, privacy/disclosure of data, and the right to know – from an interdisciplinary perspective. Lastly, it explores the economical and ethical context in the fields of business models, intellectual property issues, the patient/physician relationship, and price discrimination.