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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics
A Book

by Georg Hempel

  • Publisher : Elsevier
  • Release : 2019-10-17
  • Pages : 380
  • ISBN : 0444640673
  • Language : En, Es, Fr & De
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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Therapeutic Drug Monitoring

Therapeutic Drug Monitoring
Newer Drugs and Biomarkers

by Amitava Dasgupta

  • Publisher : Academic Press
  • Release : 2012
  • Pages : 459
  • ISBN : 0123854679
  • Language : En, Es, Fr & De
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Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring. Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants. Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques.

Pharmacogenomics in Clinical Therapeutics

Pharmacogenomics in Clinical Therapeutics
A Book

by Loralie J. Langman,Amitava Dasgupta

  • Publisher : John Wiley & Sons
  • Release : 2012-01-09
  • Pages : 400
  • ISBN : 1119959586
  • Language : En, Es, Fr & De
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Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.

Personalized Immunosuppression in Transplantation

Personalized Immunosuppression in Transplantation
Role of Biomarker Monitoring and Therapeutic Drug Monitoring

by Michael Oellerich,Amitava Dasgupta

  • Publisher : Elsevier
  • Release : 2015-08-08
  • Pages : 316
  • ISBN : 0128011335
  • Language : En, Es, Fr & De
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Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Applied Pharmacokinetics

Applied Pharmacokinetics
Principles of Therapeutic Drug Monitoring

by William E. Evans,Jerome J. Schentag,William J. Jusko

  • Publisher : Applied Therapeutics, Incorporated
  • Release : 1992
  • Pages : 1202
  • ISBN : 9780915486151
  • Language : En, Es, Fr & De
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The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods
Therapeutics and Drugs of Abuse

by Amitava Dasgupta

  • Publisher : Springer Science & Business Media
  • Release : 2007-10-05
  • Pages : 446
  • ISBN : 1597450316
  • Language : En, Es, Fr & De
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Written in a handbook style with specific methods and tips on eliminating false positive and false negative results, this book is a practical guide to the detailed mechanisms of such occurrences.

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring

Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring
A Comprehensive Guide

by Amitava Dasgupta

  • Publisher : John Wiley & Sons
  • Release : 2012-07-31
  • Pages : 457
  • ISBN : 1118149653
  • Language : En, Es, Fr & De
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The tools for detecting false positives, false negatives, and interference in interactions when testing and monitoring therapeutic drug use For physicians monitoring a patient's progress, efficacy of treatment is often linked to a patient's response to medication. Determining whether a patient is taking the prescribed amount, the drug or dosage is effective, or the prescribed medication is interacting with other drugs can be determined through drug testing. Written as a guide for toxicologists, chemists, and health professionals involved in patient care, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring provides an up-to-date introduction to the tests and methodologies used in a toxicology lab as well as the sources of testing error that can lead to false positives, false negatives, and unreliable conclusions of drug abuse or under use. Covering a host of common therapeutic drugs as well as specific types of interference in immunoassays used in drug testing, the book details a number of possible testing scenarios and problems as well as solutions: False positive results in immunoassays for drugs in abuse testing Interferences in immunoassays used for monitoring anticonvulsants, tricyclic antidepressants, and digoxin False positive alcohol tests using breath analyzers and automated analyzers When a toxicology report is negative in a suspected overdose patient: the world of designer drugs Effects of drug-herb interactions on therapeutic drug monitoring Pharmacogenomics and the general principles of genetic analysis Approaches for eliminating interference/discordant specimen in therapeutic drug monitoring and drugs in abuse testing What to do in case there is no readily available method for testing Complete with easy-to-read tables and flowcharts, this book helps toxicologists, clinical chemists, clinical pathologists, and forensic pathologists develop accurate, unbiased drug monitoring and toxicology reports. Health care professionals involved in patient care, especially of critically ill patients, will find this guide indispensable in making sure lab tests are reliable enough to provide high-quality care. An indispensable handbook to the entire suite of toxicology lab tests, as well as all the possible sources of testing error, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring offers clear remedies for eliminating and preventing testing error.

Molecular Investigation of Metabolism and Transport of Drugs

Molecular Investigation of Metabolism and Transport of Drugs
From Animal to Human Tissue : European Symposium of the European Society of Biochemical Pharmacology, the Friedrich Schiller University Jena, and the Deutsche Akademie Der Naturforscher Leopoldina, Halle (Saale), September 27 to 29, 2001

by Johannes Doehmer

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 377
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles of Drug Therapy in Neurology

Principles of Drug Therapy in Neurology
A Book

by Michael V. Johnston,Robert Gross

  • Publisher : Oxford University Press
  • Release : 2008-05
  • Pages : 558
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Since the first edition of this book was published in 1992, the number of pharmacological therapies available for treating neurological disorders has grown exponentialy. This new edition brings the book fully up-to-date, and features PET scans to illustrate brain action, and new chapters on practical therapeutics and clinical trials.

Veterinary and Human Toxicology

Veterinary and Human Toxicology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Journal of the Association of Physicians of India

The Journal of the Association of Physicians of India
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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International Research Centers Directory

International Research Centers Directory
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Archives of Pathology & Laboratory Medicine

Archives of Pathology & Laboratory Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Acta Physiologica Scandinavica

Acta Physiologica Scandinavica
Supplementum

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts from XX Nordic Congress of Physiology & Pharmacology, the Panum Institute, University of Copenhagen, August 16-19, 1992

Abstracts from XX Nordic Congress of Physiology & Pharmacology, the Panum Institute, University of Copenhagen, August 16-19, 1992
A Book

by Sten Christensen,Hans Hultborn,Henrik Jahnsen

  • Publisher : Unknown Publisher
  • Release : 1992
  • Pages : 224
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Principles of Medical Pharmacology

Principles of Medical Pharmacology
A Book

by Harold Kalant,Denis Michael Grant,Jane Mitchell

  • Publisher : W B Saunders Company Canada Limited
  • Release : 2007
  • Pages : 1022
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This edition includes new case studies, overview chapters on second messenger systems and the nervous and cardiovascular systems, and sections on topics such as drug-resistant TB and pharmacogenetics.

Periodicum Biologorum

Periodicum Biologorum
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Canadian Journal of Physiology and Pharmacology

Canadian Journal of Physiology and Pharmacology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics

Proceedings of the Second World Conference on Clinical Pharmacology and Therapeutics
Washington, D.C., July 31-August 5, 1983

by Louis Lemberger,Marcus M. Reidenberg

  • Publisher : American Society for Pharmacology & Experimental Therapeutic
  • Release : 1984
  • Pages : 996
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pharmacoepidemiology

Pharmacoepidemiology
A Book

by Brian L. Strom

  • Publisher : John Wiley & Sons Incorporated
  • Release : 2000-10-11
  • Pages : 874
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Third Edition of this successful book has been revised and updated to include the latest advances in the field. It incorporates new topics such as prescription event monitoring, general practice research database, and drug utilization review. * Provides an American and European perspective. * The authors are renowned in the field.