Download Mitochondrial Metabolism: An approach for disease management Ebook PDF

Mitochondrial Metabolism

Mitochondrial Metabolism
An Approach for Disease Management

by Jalal Pourahmad,Mohsen Rezaei

  • Publisher : Academic Press
  • Release : 2021-07-15
  • Pages : 416
  • ISBN : 9780128224168
  • Language : En, Es, Fr & De
GET BOOK

With the increasing evidence that mitochondria play an essential role in the pathogenesis of diseases, targeting them for the treatment of diseases has become a significant therapeutic pathway. Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology, and Biochemistry. The editors have recruited researchers from around the world to write chapters on their specialties. After an introduction from the Editors, the first chapter covers the balancing role in reduction/oxidation mitochondria play. The next chapter discusses mitochondria as targets for therapeutics through its metabolism. Chapter three covers mitochondrial contributions to the cell death process while chapter 4 focuses on mitochondrial response to environmental toxicants. Chapter five provides an overview of the mitochondrial role in aging and the impact of calories restrictive diets. Chapter 6 covers the new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis. The next chapter is devoted to mitochondria and cancer therapy. Chapters eight and nine cover diabetes, and neurological disorders. Chapter ten discusses mitochondrial abnormalities in psychological disorders. The book ends with a final chapter by the editors on the prospect of mitotherapy. Mitochondrial Metabolism: An Approach for Disease Management provides bioscientists new horizons to realize the importance of mitochondria in the present-day researches on therapies dealing with mitochondria associated chronic diseases including diabetes, cancer and neurodegenerative disorders. Physician-scientist may also be interested in the contents associated with the conditions aligned with their specialties and the potential therapies presented in this book. Detailed significant role of mitochondria in the chronic diseases New insights in targeting of mitochondria for therapeutic purposes Updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondrial Medicine

Mitochondrial Medicine
A Book

by Salvatore DiMauro,Michio Hirano,Eric A. Schon

  • Publisher : CRC Press
  • Release : 2019-11-29
  • Pages : 16
  • ISBN : 9780367446369
  • Language : En, Es, Fr & De
GET BOOK

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology.

A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease - E-Book

A Practical Approach to the Spectrum of Alcoholic Liver Disease, An Issue of Clinics in Liver Disease - E-Book
A Book

by David Bernstein

  • Publisher : Elsevier Health Sciences
  • Release : 2012-11-14
  • Pages : 240
  • ISBN : 1455747378
  • Language : En, Es, Fr & De
GET BOOK

The Guest Editor has organized this issue to focus on the clinical management of alcoholic liver disease. Authors have written state-of-the-art reviews on the following topics: Prevalence and Natural History of ALD; Alcohol Metabolism; Immunology in ALD; Histological Findings in ALD; Diagnosis and Management of Alcoholic Hepatitis; Management of Alcohol Abuse; Long Term Management of Alcoholic Liver Disease; Infections in ALD; Nutrition in ALD; Alcohol’s Effect on Other Chronic Liver Diseases; Liver Cancer and Alcohol; Evaluation and Selection of Candidates for Liver Transplantation; and ALD and Specific Transplant-Related Issues.

Inborn Errors of Metabolism

Inborn Errors of Metabolism
From Neonatal Screening to Metabolic Pathways

by Brendan Lee MD, PhD,Fernando Scaglia MD

  • Publisher : Oxford University Press
  • Release : 2014-10-01
  • Pages : 400
  • ISBN : 0199797684
  • Language : En, Es, Fr & De
GET BOOK

Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases -- how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

Mitochondria in Health and in Sickness

Mitochondria in Health and in Sickness
A Book

by Andrea Urbani,Mohan Babu

  • Publisher : Springer Nature
  • Release : 2019-08-26
  • Pages : 277
  • ISBN : 9811383677
  • Language : En, Es, Fr & De
GET BOOK

Besides bringing together researchers and clinicians from various disciplines to share their scope of research on the seminal role of mitochondria in human disease, this original volume of the book has a broader appeal by exploring the health and disease of mitochondria, with specific emphasis on how mitochondrial dysfunction contributes to the development of various neurodegeneration, cancer, and metabolic disorders. The book also provides a foundational overview of the mitochondrial pathogenic or genetic variants and highlights various analytical tools used in the field of mitochondrial genetics; mitochondrial replacement therapy and strategies geared towards shifting heteroplasmy in individuals with mitochondrial disease; how state-of-the-art omics technologies (proteomics, functional genomics) have been employed to study mitochondrial biology in healthy and disease states; post-translational modifications in the regulation of mitochondrial proteins; and the role of mitochondria in host-pathogen interactions. Current approaches taken to study steady-state characteristics of mitochondrial structure and function in live mammalian cells in the contexts of normal and diseased states, and most recent research efforts to develop compounds with anti-cancer potential by targeting mitochondrial proteases or advances in therapeutic approaches towards mitochondrial disease were also explored. By covering this broad range of topics, our hope is to disseminate a wealth of knowledge on the critical role of mitochondria, and how to probe its function in health and in sickness.

A Practical Approach to Movement Disorders

A Practical Approach to Movement Disorders
Diagnosis and Medical and Surgical Management

by Michael S. Okun, MD,Ramon L. Rodriguez, MD,Frank M. Skidmore, MD

  • Publisher : Demos Medical Publishing
  • Release : 2007-06-14
  • Pages : 274
  • ISBN : 1935281887
  • Language : En, Es, Fr & De
GET BOOK

This book provides the busy clinician with a quick, symptom-based guide to the clinical presentation, diagnosis, work-up, and management of the most common types of movement disorders encountered in clinical practice, including Parkinson's disease, chorea, dystonia, myoclonus, and ataxia. Written in expanded outline format, with frequent diagnostic and therapeutic algorithms, tables, and scales, it is an essential guide for clinicians faced with patients with movement disorders. A Practical Approach to Movement Disorders is a welcome departure from the typical lengthy, disease-based hardbound texts ill suited for the busy clinician. Practical yet authoritative, this fit-in-your-coat-pocket guide begins with a comprehensive description of the different presentations of movement disorders. It then details the medical, surgical, and non-pharmacological approaches, including speech and swallowing therapy and physical and occupational therapy. Key features include: Symptom-based, rather than disease-based, chapters A focus on the most common movement disorders A unique section on the neurological aspects of deep brain stimulation (DBS) Dozens of diagnostic and management pearls Suggested readings for each chapter Handy and comprehensive, A Practical Approach to Movement Disorders is the only guide for busy clinicians needing quick information on movement disorders.

Mitochondrial Medicine

Mitochondrial Medicine
Mitochondrial Metabolism, Diseases, Diagnosis and Therapy

by Anna Gvozdjáková

  • Publisher : Springer Science & Business Media
  • Release : 2008-02-01
  • Pages : 409
  • ISBN : 9781402067143
  • Language : En, Es, Fr & De
GET BOOK

Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. This book is based on extensive data gathered over 30 years of clinical and experimental research. In it, internationally recognized authors share their experience in various fields of their expertise and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Update on Dementia

Update on Dementia
A Book

by Davide Moretti

  • Publisher : BoD – Books on Demand
  • Release : 2016-09-28
  • Pages : 558
  • ISBN : 9535126547
  • Language : En, Es, Fr & De
GET BOOK

The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,
A Book

by Michael J. Gambello

  • Publisher : Elsevier Health Sciences
  • Release : 2015-08-12
  • Pages : 281
  • ISBN : 0323356850
  • Language : En, Es, Fr & De
GET BOOK

Genetic testing and genome sequencing have opened up the possibility to clinicians and families to treat diseases, syndromes, and malformations earlier and provide therapeutic interventions.The guest editors seek to provide a basic overview of the topic for the neonatologist/perinatologist. Articles addres dysmorphology, syndromes in the infant, skeletal dysplasias, limb malformations, craniofacial anomolies, GI/liver disease, disorders of sexual develoment, brain defects, inborn errors of metabolism, and congenital heart disease.

Pediatric Primary Care - E-Book

Pediatric Primary Care - E-Book
A Book

by Catherine E. Burns,Ardys M. Dunn,Margaret A. Brady,Nancy Barber Starr,Catherine G. Blosser,Dawn Lee Garzon Maaks

  • Publisher : Elsevier Health Sciences
  • Release : 2012-03-01
  • Pages : 1288
  • ISBN : 1455742171
  • Language : En, Es, Fr & De
GET BOOK

Covering the full spectrum of health conditions seen in the primary care of children, Pediatric Primary Care, 5th Edition emphasizes both prevention and management from the unique perspective of the Nurse Practitioner. Written by an expert editor/contributor team, it provides in-depth, evidence-based guidance for assessing and managing health problems in children from infancy through adolescence. Other key topics include developmental theory, the health status of children today, issues of daily living, and cultural considerations. Four-part organization includes an introductory unit, plus units on child development, the health management of children, and diseases and disorders common to childhood. UNIQUE! Functional health patterns framework in Unit Three provides a lens for discussing health promotion through the various components of healthy living. UNIQUE! ICD framework in Unit Four addresses the classification used to code diseases in both hospital and outpatient settings. UNIQUE! Practice management chapter provides need-to-know information on managing a private healthcare practice, including issues of productivity, compliance with applicable laws, quality-of-care indicators, and successful business practices. UNIQUE! Environmental health chapter offers evidence-based content on the effects of environmental toxicants, such as tobacco smoke, heavy metals, and air pollutants. An 8-page color insert presents over 40 photos that visually demonstrate key assessment findings for ear, skin, and other conditions. NEW! Pediatric Pain Management chapter addresses the increased recognition of pain as the "fifth vital sign" with expanded coverage of acute and chronic pain management in children. Extensively revised and updated genetics chapter presents a new paradigm for addressing genetic considerations in clinical practice, including an introduction to epigenetics. Increased emphasis on health disparities explores the growing health disparities among children in the U.S and worldwide and provides strategies to help patients and parents gain accessibility to health care resources. NEW! Content on implementing a "medical home" explores the trend toward family-centered coordinated health care and fosters appropriate treatment for children with chronic disease. NEW! Updated coverage takes a more global approach, exploring the health status of children outside the U.S. Expanded imaging content offers valuable guidance on using various imaging modalities, including how to prepare the child for diagnostics.

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease
On the Origin, Management, and Prevention of Cancer

by Thomas Seyfried

  • Publisher : John Wiley & Sons
  • Release : 2012-05-18
  • Pages : 438
  • ISBN : 1118310306
  • Language : En, Es, Fr & De
GET BOOK

The book addresses controversies related to the origins of cancerand provides solutions to cancer management and prevention. Itexpands upon Otto Warburg's well-known theory that all cancer is adisease of energy metabolism. However, Warburg did not linkhis theory to the "hallmarks of cancer" and thus his theory wasdiscredited. This book aims to provide evidence, throughcase studies, that cancer is primarily a metabolic diseaserequring metabolic solutions for its management andprevention. Support for this position is derived fromcritical assessment of current cancer theories. Brain cancercase studies are presented as a proof of principle for metabolicsolutions to disease management, but similarities are drawn toother types of cancer, including breast and colon, due tothe same cellular mutations that they demonstrate.

Mitochondrial Diseases

Mitochondrial Diseases
A Book

by Eylem Taskin,Celal Guven,Yusuf Sevgiler

  • Publisher : BoD – Books on Demand
  • Release : 2018-08-29
  • Pages : 496
  • ISBN : 1789236746
  • Language : En, Es, Fr & De
GET BOOK

Mitochondria are crucial organelles for any cell type. Mitochondria take responsibility for not only energy production but also regulation of cell death, also called apoptosis; calcium storage; and heat production. Therefore, mitochondrial disease is implicated in the mode of action of many harmful factors for cells such as drugs and environmental contaminants, dysfunction of the oxygen transport system, malnutrition, intense exercise, and genetic variations. This book presents up-to-date knowledge about mitochondrial disease and its complex relation to some diseases such as cardiac failure, cancer, and Alzheimer's and Parkinson's diseases. This book will, therefore, be essential for readers who are interested in life sciences, especially in medicine.

Mitochondria in Liver Disease

Mitochondria in Liver Disease
A Book

by Derick Han,Neil Kaplowitz

  • Publisher : CRC Press
  • Release : 2015-10-28
  • Pages : 485
  • ISBN : 1482236982
  • Language : En, Es, Fr & De
GET BOOK

"...excellent, well-organized, and timely." —Lester Packer and Enrique Cardenas, University of Southern California, Los Angeles, from the Series Preface The liver is a vital organ that is responsible for a wide range of functions, most of which are essential for survival. The multitude of functions the liver performs makes it vulnerable to a wide range of diseases. Mitochondrial dysfunction plays an important role in many liver diseases including drug-induced liver injury, alcoholic liver disease, and nonalcoholic fatty liver disease. Mitochondria in Liver Disease gathers the most current research regarding the role of mitochondria in the liver and various diseases to which it is susceptible. The book is separated into two sections, the first of which highlights the latest developments in mitochondrial research. It includes cutting-edge topics such as the regulation of mitochondrial respiration using hydrogen sulfide and the regulation of mitochondrial fusion–fission via the endoplasmic reticulum. The second section reviews the most current research on the role of mitochondria in a wide range of liver diseases. It also addresses novel topics such as the importance of liver mitochondrial constituents as biomarkers of liver injury in plasma and as regulators of the immune system. Mitochondria in Liver Disease represents the current state of knowledge and research on mitochondrial roles in liver diseases. Written by a group of global experts, it provides an authoritative and comprehensive overview of the latest advances and methods that mark key starting points for future research.

Practical Hepatic Pathology: A Diagnostic Approach E-Book

Practical Hepatic Pathology: A Diagnostic Approach E-Book
A Volume in the Pattern Recognition Series

by Romil Saxena

  • Publisher : Elsevier Health Sciences
  • Release : 2011-02-11
  • Pages : 728
  • ISBN : 1455711969
  • Language : En, Es, Fr & De
GET BOOK

Practical Hepatic Pathology—a new volume in the new Pattern Recognition series—offers you a practical guide to diagnosing every challenging liver biopsy that you encounter in your daily practice. Dr. Romil Saxena presents diagnoses according to a pattern-based organization that guides you from a histological pattern of injury, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish, full-color images capture key hepatic pathology patterns of injury, pathognomonic features and common variations of all major liver diseases and hepatic neoplasms. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in liver biopsies. Recognize the basic patterns of liver injury through an algorithmic approach and establish diagnosis by a pattern-based visual index present at the beginning of the book. Evaluate and interpret biopsy samples using superb, high-quality, full-color images that illustrate pathognomonic features and common variations. Get comprehensive information on major adult and childhood liver diseases, hepatic neoplasms and pre-neoplastic nodules including clinical features, laboratory tests, imaging findings and differential diagnosis. Understand the pathology and practice of liver transplantation with coverage of the clinical aspects of this procedure.

Neuromuscular Diseases

Neuromuscular Diseases
A Practical Approach to Diagnosis and Management

by Michael Swash,Martin S. Schwartz

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-14
  • Pages : 541
  • ISBN : 1447138341
  • Language : En, Es, Fr & De
GET BOOK

Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological characteristics, however, remain as important as ever, since they constitute the clinical problem itself and, indeed, the database from which all other concepts emerge. Knowledge of the pathogenesis, genetics, and molecular biology of neuromuscular disorders is essential both in developing and applying new therapies and preventive measures, and in formulating genetic and prognostic advice. However, this informa tion does not necessarily always define clinically useful syndromes. Myotonia, for example, is an electrophysiological finding in some syndromes in which it is un detectable by clinical examination, although the phenomenon itself was originally defined as a clinical entity. The limb girdle muscular dystrophy syndromes can be defined by severity, distribution of weakness, age of onset, sex distribution and other characteristics and many of these can be better understood by study of the under lying defect in cell structural proteins.

Parkinson's Disease

Parkinson's Disease
Diagnosis & Clinical Management : Second Edition

by Dr. Stewart A. Factor, DO,Dr. William Weiner, MD

  • Publisher : Demos Medical Publishing
  • Release : 2007-12-15
  • Pages : 1024
  • ISBN : 9781934559871
  • Language : En, Es, Fr & De
GET BOOK

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Still the only major text on the subject, the completely revised and updated second edition of Parkinson's Disease: Diagnosis and Clinical Management comes at a time when specialists have made important advances in our understanding of the etiology, pathogenesis, investigation, and management of Parkinson's disease. The book includes 23 completely new chapters, and has updated information on: Genetics Pathology Biomarkers Pathogenesis Impulse control disorders in Parkinson's disease Updated outcome measures Complementary and alternative medicine for the treatment of Parkinson's disease Together the chapters form a comprehensive review of the many issues facing PD physicians today. Lucid and easily readable from beginning to end, each chapter may also stand on its own as a scholarly review of the individual subject. Each one is concisely written and heavily referenced for this purpose. The second edition of Parkinson's Disease: Diagnosis and Clinical Management provides a state-of-the-art review of where we've been, where we are now, and where we are going in treating this disease.

Neuromuscular Disorders: Management and Treatment E-Book

Neuromuscular Disorders: Management and Treatment E-Book
A Book

by Tulio E. Bertorini

  • Publisher : Elsevier Health Sciences
  • Release : 2010-09-08
  • Pages : 472
  • ISBN : 1437736408
  • Language : En, Es, Fr & De
GET BOOK

Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life. Effectively treat your patients using the latest management tools and targeted therapeutic strategies. Manage all neuromuscular disorders as well as resulting complications through comprehensive coverage of diagnosis and evaluations, treatments, and outcomes. Apply the multi-disciplinary approach of an expert in clinical neuromuscular care and a team of world-renown contributors. Easily refer to tools for diagnosis, treatment algorithms, and drug tables included throughout the text.

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson's Disease
A Book

by Lori M. Buhlman

  • Publisher : Springer
  • Release : 2016-09-13
  • Pages : 275
  • ISBN : 3319421395
  • Language : En, Es, Fr & De
GET BOOK

This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

New Approaches to the Treatment of Early Parkinson's Disease

New Approaches to the Treatment of Early Parkinson's Disease
A Book

by Urpo K. Rinne

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 98
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Heart Failure: A Companion to Braunwald's Heart Disease E-book

Heart Failure: A Companion to Braunwald's Heart Disease E-book
A Book

by Douglas L. Mann

  • Publisher : Elsevier Health Sciences
  • Release : 2010-11-11
  • Pages : 928
  • ISBN : 1437703631
  • Language : En, Es, Fr & De
GET BOOK

Dr. Douglas L. Mann, one of the foremost experts in the field, presents the 2nd Edition of Heart Failure: A Companion to Braunwald’s Heart Disease. This completely reworked edition covers the scientific and clinical guidance you need to effectively manage your patients and captures the dramatic advances made in the field over the last five years. Now in full color, this edition features eleven new chapters, including advanced cardiac imaging techniques, use of biomarkers, cell-based therapies and tissue engineering, device therapies, and much more. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Use this Braunwald’s companion as the definitive source to prepare for the ABIM’s new Heart Failure board exam. Access the fully searchable contents of the book online at Expert Consult. This edition includes 67 new authors, who are experts in the field of heart failure Stay on the cutting edge with new chapters on: The latest practice guidelines for medical and device therapy Hemodynamic assessment of heart failure Contemporary medical therapy for heart failure patients with reduced and preserved ejection fraction Biomarkers in heart failure Pulmonary hypertension Management of co-morbidities in heart failure Mechanical cardiac support devices Get up to speed with the latest clinical trials, as well as how they have influenced current practice guidelines Explore what’s changing in key areas such as basic mechanisms of heart failure, genetic screening, cell and gene therapies, pulmonary hypertension, heart failure prevention, co-morbid conditions, telemedicine/remote monitoring, and palliative care