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Mitochondrial Metabolism

Mitochondrial Metabolism
An Approach to Disease Management

by Jalal Pourahmad,Mohsen Rezaei

  • Publisher : Academic Press
  • Release : 2021-08-09
  • Pages : 316
  • ISBN : 0128224096
  • Language : En, Es, Fr & De
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Mitochondrial Metabolism: An Approach for Disease Management covers mitotherapy from three combined perspectives, Pharmacology, Toxicology and Biochemistry. After an introduction from world-renowned experts, the book's chapters cover the balancing role in reduction/oxidation mitochondria play, mitochondria as targets for therapeutics through its metabolism, mitochondrial contributions to the cell death process, mitochondrial response to environmental toxicants, the mitochondrial role in aging, the impact of calorie restrictive diets, new advances in the identification of altered mitochondria associated signaling pathways in carcinogenesis, and much more. This book provides bioscientists new horizons to realize the importance of mitochondria in present-day research on therapies dealing with mitochondria associated chronic diseases, including diabetes, cancer and neurodegenerative disorders. Details the significant role of mitochondria in chronic diseases Presents new insights on the targeting of mitochondria for therapeutic purposes Includes updated results on mitotherapy and other mitochondria-oriented therapies

Mitochondria in Obesity and Type 2 Diabetes

Mitochondria in Obesity and Type 2 Diabetes
Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases

by Beatrice Morio,Luc Penicaud,Michel Rigoulet

  • Publisher : Academic Press
  • Release : 2019-04-13
  • Pages : 459
  • ISBN : 0128118598
  • Language : En, Es, Fr & De
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Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases synthesizes discoveries from laboratories around the world, enhancing our understanding of the involvement of mitochondria in the etiology of diseases, such as obesity and type 2 diabetes. Chapters illustrate and provide an overview of key concepts on topics such as the role of mitochondria in adipose tissue, cancer, cardiovascular comorbidities, skeletal muscle, the liver, kidney, and more. This book is a must-have reference for students and educational teams in biology, physiology and medicine, and researchers. Synthesizes actual knowledge on mitochondrial function Provides an integrated vision of each tissue in the etiology of obesity and type 2 diabetes Identifies the interactive networks that involve alteration in mitochondrial mass and function in disease progression Highlights the role played by mitochondria in the prevention and treatment of obesity and type 2 diabetes

Cancer as a Metabolic Disease

Cancer as a Metabolic Disease
On the Origin, Management, and Prevention of Cancer

by Thomas Seyfried

  • Publisher : John Wiley & Sons
  • Release : 2012-05-18
  • Pages : 448
  • ISBN : 1118310306
  • Language : En, Es, Fr & De
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The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Oxidative Stress in Lung Diseases

Oxidative Stress in Lung Diseases
A Book

by Sajal Chakraborti,Narasimham L. Parinandi,Rita Ghosh,Nirmal K. Ganguly,Tapati Chakraborti

  • Publisher : Springer Nature
  • Release : 2019-11-23
  • Pages : 488
  • ISBN : 9813293667
  • Language : En, Es, Fr & De
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This is the second volume of the comprehensive, two-volume work on oxidative stress in lung diseases. Adopting a multidisciplinary approach, it demonstrates the cellular and molecular mechanisms associated with ROS (reactive oxygen species)-induced initiation and progression of a variety of lung diseases, such as COPD, emphysema, asthma, cystic fibrosis, occupational pulmonary diseases and pulmonary hypertension and discusses points for therapeutic intervention. The book also covers translational research and the latest research on prevention and therapeutics. Each chapter includes in-depth insights into the mechanisms associated with lung diseases and into identifying targets for drug development. Bridging the gap between fundamental and translational research, and examining applications in the biomedical and pharmaceutical industry, it is a thought- provoking read for basic and applied scientists engaged in biomedical research.

Inborn Errors of Metabolism

Inborn Errors of Metabolism
From Neonatal Screening to Metabolic Pathways

by Brendan Lee MD, PhD,Fernando Scaglia MD

  • Publisher : Oxford University Press
  • Release : 2014-10-01
  • Pages : 400
  • ISBN : 0199797684
  • Language : En, Es, Fr & De
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Texts on inborn errors of metabolism (IEMs) have traditionally focused on classical biochemistry, clinical presentation, and standard treatment approaches. Inborn Errors of Metabolism is an expansion on this model, one that establishes an innovative pathway approach and provides a new authority on this family of disease. Alongside the standard cadre of molecular and clinical underpinnings, this volume includes coverage of newborn screenings and an overarching treatment of IEMs as complex diseases -- how basic alterations can lead to complex secondary and tertiary effects in metabolism that contribute to increasingly recognized natural histories of disease.

Mitochondrial Physiology and Vegetal Molecules

Mitochondrial Physiology and Vegetal Molecules
Therapeutic Potential of Natural Compounds on Mitochondrial Health

by Marcos Roberto de Oliveira

  • Publisher : Academic Press
  • Release : 2021-07-14
  • Pages : 806
  • ISBN : 0128215836
  • Language : En, Es, Fr & De
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Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health provides a comprehensive overview of mitochondrial physiology throughout the human life span, as well as the effect of molecules of vegetal origin on mitochondrial health. The editor has lined up a team of worldwide experts to cover the most exciting and high-impact advancements of research in this area. This book is structured into two parts that provide a balance of both foundational and applied content. Part I provides an overview of mitochondrial physiology including its structure, dynamics, biogenesis, membranes, DNA transcription, and translation in the mitochondria. Part I also covers other themes such as apoptosis. Part II then covers the effect of specific vegetable-derived molecules on mitochondrial health, including anthocyanins, caffeine, cannabinoids, carnosic and rosmarinic acids, citrus flavonoids, polyphenols, pterostilbene, resveratrol, and sulforaphane, among others. Mitochondrial Physiology and Vegetal Molecules: Therapeutic potential of natural compounds on mitochondrial health is a complete resource for researchers in this exciting field. Its comprehensive coverage makes it particularly interesting to bioscience researchers willing to understand the foundations of mitochondrial physiology throughout the human life span. Clinician researchers, MDs, nutritionists, pharmacologists, and sports scientists may be attracted to the detailed information on the health effects of vegetal origin molecules on the organelle. Contains detailed information on plant products and their effect on mitochondria Proposes therapies and reviews mechanisms of absorption at the cellular level Discusses the limited bioavailability of plant molecules/compounds in the human organism Includes coverage of specific conditions such as Sports and affective disorders, among others Presents the protective effects of plant products in mitochondrial health through all stages of life

Inborn Metabolic Diseases

Inborn Metabolic Diseases
Diagnosis and Treatment

by Jean-Marie Saudubray,Matthias R. Baumgartner,John H. Walter

  • Publisher : Springer
  • Release : 2016-11-10
  • Pages : 658
  • ISBN : 3662497719
  • Language : En, Es, Fr & De
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This work is recognised as the standard textbook for professionals involved in the diagnosis and management of inborn errors of metabolism (IEM) and an essential resource in this multidisciplinary field. For the 6th edition all 43 chapters have been newly written or revised by authors with particular expertise in their subject areas. Contents: A clinical and biochemical approach to the recognition and diagnosis of IEM with algorithms to symptoms, signs, and syndromes in patients of all ages; Emergency treatments; Medications – Separate comprehensive sections on IEM of: Carbohydrates; Mitochondrial Energy; Amino and organic acids; Vitamin-responsive defects; Neurotransmitter and Small peptides, Lipid and Bile Acids; Nucleic Acid and Heme; Organelles – Disorders affecting the synthesis and remodelling of complex lipids and fatty acid homeostasis are now included.

Systems Analysis of Energy Metabolism Elucidates the Roles of Mitochondria in Human Health and Disease

Systems Analysis of Energy Metabolism Elucidates the Roles of Mitochondria in Human Health and Disease
A Book

by Thuy D. Vo

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 185
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Beginning as the science of life, biology has been transformed and expanded throughout the years to give rise to fields such as ecology, molecular biology, biophysics, and biochemistry. The distinction among these disciplines is perhaps artificial as the study of any particular biological process or system often spans multiple fields. The research on energy metabolism to follow involves three fields: bioinformatics, bioengineering, and systems biology. The informatics aspect deals with the mining, organization, and management of genomic, proteomic, microarray and biochemical data for reconstructing metabolic networks. The engineering aspect employs the application of mathematics and scientific fundamentals to construct constraint-based models for examination. The systems biology paradigm allows the analysis and interpretation of the models and data from a holistic perspective. Specifically, the findings of this work center on energy metabolism as understood by resource allocation and roles or mitochondria in mammalian cells in health and diseased states. The constraint-based framework provides the facilities for biological discovery using tools from the three mentioned disciplines. This modeling approach describes a biological system as a network of components whose behaviors can be predicted upon the application of constraints. Energy metabolism of four systems - mitochondria, cardiomyocytes, hepatocytes, and fibroblasts - is investigated here. The application of linear constraints on metabolite mass, reaction reversibility and substrate utilization allows an exploration of network capability and topology. The capability and topology of the mitochondrial metabolic network are evaluated based on the theoretical energetic yield of substrates, the number of alternate pathways satisfying the same metabolic objective, and the effects of diabetic and ischemic conditions on feasible steady states. The second part of this dissertation involves the use of stable isotopes to uncover physiological steady states assumed by the cell. Nonlinear constraints are used to balance isotopomers and select for a set of flux distributions that match GC-MS data. Results from studies with cardiomyocytes and hepatocytes elucidate the paths undertaken by substrates as well as effects of media composition on intracellular flux distributions. Most significantly, results from tissue culture study identify complex II as the deficient complex in fibroblasts derived from a patient affected with Leigh's disease.

Nelson Textbook of Pediatrics E-Book

Nelson Textbook of Pediatrics E-Book
A Book

by Robert M. Kliegman,Joseph St. Geme

  • Publisher : Elsevier Health Sciences
  • Release : 2019-04-01
  • Pages : 4264
  • ISBN : 0323568882
  • Language : En, Es, Fr & De
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Welcome to the 21st Edition of Nelson Textbook of Pediatrics – the reference of choice among pediatricians, pediatric residents, and others involved in the care of young patients. This fully revised edition continues to provide the breadth and depth of knowledge you expect from Nelson, while also keeping you up to date with new advances in the science and art of pediatric practice. Authoritative and reader-friendly, it delivers the information you need in a concise, easy-to-use format for everyday reference and study. From rapidly changing diagnostic and treatment protocols to new technologies to the wide range of biologic, psychologic, and social problems faced by children today, this comprehensive reference keeps you on the cutting edge of the very best in pediatric care. Includes more than 70 new chapters, including Postural Orthostatic Tachycardia Syndrome (POTS), Rare and Undiagnosed Diseases, Approach to Mitochondrial Disorders, Electronic Nicotine Delivery Systems, Zika, update on Ebola, Epigenetics, Autoimmune Encephalitis, Global Health, Racism, Media Violence, Strategies for Health Behavior Change, Positive Parenting, and many more. Features hundreds of new figures and tables throughout for visual clarity and quick reference. Offers new and expanded information on CRISPR gene editing; LGBT health care; gun violence; vaccinations; immune treatment with CAR-T cells; new technology in imaging and genomics; new protocols in cancer, genetics, immunology, and pulmonary medicine; and much more. Provides fresh perspectives from four new associate editors: Nathan J. Blum of The Children’s Hospital of Philadelphia; Karen Wilson of Mt. Sinai School of Medicine in New York; Samir S. Shah of Cincinnati Children’s Hospital Medical Center; and Robert C. Tasker of Boston Children’s Hospital. Remains your indispensable source for definitive, evidence-based answers on every aspect of pediatric care.

A Practical Approach to Movement Disorders

A Practical Approach to Movement Disorders
Diagnosis and Medical and Surgical Management

by Dr. Hubert Fernandez, MD,Ramon L. Rodriguez, MD,Frank M. Skidmore, MD,Michael Okun, MD

  • Publisher : Demos Medical Publishing
  • Release : 2007-06-14
  • Pages : 286
  • ISBN : 1933864141
  • Language : En, Es, Fr & De
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"This book provides the busy clinician with a quick, symptom-based guide to the clinical presentation, diagnosis, work-up, and management of the most common types of movement disorders encountered in clinical practice, including Parkinson's disease, chorea, dystonia, myoclonus, and ataxia. Written in expanded outline format, with frequent diagnostic and therapeutic algorithms, tables, and scales, it is an essential guide for clinicians faced with patients with movement disorders. A Practical Approach to Movement Disorders is a welcome departure from the typical lengthy, disease-based hardbound texts ill suited for the busy clinician. Practical yet authoritative, this fit-in-your-coat-pocket guide begins with a comprehensive description of the different presentations of movement disorders. It then details the medical, surgical, and non-pharmacological approaches, including speech and swallowing therapy and physical and occupational therapy. Key features include: Symptom-based, rather than disease-based, chapters A focus on the most common movement disorders A unique section on the neurological aspects of deep brain stimulation (DBS) Dozens of diagnostic and management pearls Suggested readings for each chapter Handy and comprehensive, A Practical Approach to Movement Disorders is the only guide for busy clinicians needing quick information on movement disorders."

Cancer As a Metabolic Disease

Cancer As a Metabolic Disease
A Book

by Applied Research Press

  • Publisher : CreateSpace
  • Release : 2015-07-30
  • Pages : 50
  • ISBN : 9781515293385
  • Language : En, Es, Fr & De
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Emerging evidence indicates that impaired cellular energy metabolism is the defining characteristic of nearly all cancers regardless of cellular or tissue origin. In contrast to normal cells, which derive most of their usable energy from oxidative phosphorylation, most cancer cells become heavily dependent on substrate level phosphorylation to meet energy demands. Evidence is reviewed supporting a general hypothesis that genomic instability and essentially all hallmarks of cancer, including aerobic glycolysis (Warburg effect), can be linked to impaired mitochondrial function and energy metabolism. A view of cancer as primarily a metabolic disease will impact approaches to cancer management and prevention.

Anderson’s Pediatric Cardiology E-Book

Anderson’s Pediatric Cardiology E-Book
A Book

by Robert H. Anderson,Kumar Krishna,Kathleen A. Mussato,Andrew Redington,James S. Tweddell,Justin Tretter

  • Publisher : Elsevier Health Sciences
  • Release : 2019-04-29
  • Pages : 1650
  • ISBN : 0702079243
  • Language : En, Es, Fr & De
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As a leading reference on pediatric cardiology and congenital heart disease, Anderson's Pediatric Cardiology provides exhaustive coverage of potential pediatric cardiovascular anomalies, potential sequelae related to these anomalies, comorbidities and neurodevelopmental problems, and current methods for management and treatment. The fully revised 4th Edition addresses significant and ongoing changes in practice, including recent developments in fetal, neonatal, and adult congenital heart conditions as well as expanded content on intensive care, nursing issues, and societal implications. The outstanding illustration program provides superb visual guidance, and is now supplemented with a remarkable collection of more than 200 professionally curated, author-narrated videos. Offers authoritative, long-term coverage of a broad spectrum of cardiology conditions ranging from fetal development to age 21, including congenital heart disease, adult congenital heart disease (ACHD), acquired heart disease, cardiomyopathies, and rhythm disturbances. Features exceptionally detailed and original drawings by Dr. Robert Anderson and Diane Spicer, including over 850 anatomic, photographic, imaging, and algorithmic figures, and incorporating new images using virtual dissections of 3D datasets obtained in living patients. Contains new chapters on quality improvement in congenital heart disease, models of care delivery, neurocognitive assessment and outcomes, psychosocial issues for patients and families, ethics, nursing implications, acute and chronic renal complications, and telemedicine. Offers a completely new section on fetal imaging and management. Provides a new focus on patient and family-centered care with expert advice on how to communicate difficult diagnoses to patients and families. Features new integration of nursing content into all disease-specific chapters, as well as updated content on genetics, congenital heart disease and follow-up, and new imaging modalities. Contains chapters on new and emerging topics such as MRI and Quantifying the Fetal Circulation in Congenital Cardiac Disease; Congenital Anomalies of the Coronary Arteries; and The Global Burden of Pediatric Heart Disease and Pediatric Cardiac Care in Low- and Middle-Income Countries. Shares the experience and knowledge of an international team of multidisciplinary experts in medicine and advanced practice nursing.

Food and Nutrients in Disease Management

Food and Nutrients in Disease Management
A Book

by Ingrid Kohlstadt

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 740
  • ISBN : 9781420067637
  • Language : En, Es, Fr & De
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Food and nutrients are the original medicine and the shoulders on which modern medicine stands. But in recent decades, food and medicine have taken divergent paths and the natural healing properties of food have been diminished in the wake of modern technical progress. With contributions from highly regarded experts who work on the frontlines of di

Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,

Genetics Diagnosis, Inborn Errors of Metabolism and Newborn Screening: An Update, An Issue of Clinics in Perinatology,
A Book

by Michael J. Gambello

  • Publisher : Elsevier Health Sciences
  • Release : 2015-08-12
  • Pages : 281
  • ISBN : 0323356850
  • Language : En, Es, Fr & De
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Genetic testing and genome sequencing have opened up the possibility to clinicians and families to treat diseases, syndromes, and malformations earlier and provide therapeutic interventions.The guest editors seek to provide a basic overview of the topic for the neonatologist/perinatologist. Articles addres dysmorphology, syndromes in the infant, skeletal dysplasias, limb malformations, craniofacial anomolies, GI/liver disease, disorders of sexual develoment, brain defects, inborn errors of metabolism, and congenital heart disease.

Year Book of Cardiology - 2019

Year Book of Cardiology - 2019
A Book

by Vijay K Chopra

  • Publisher : Jaypee Brothers Medical Publishers
  • Release : 2020-03-31
  • Pages : 140
  • ISBN : 9352708946
  • Language : En, Es, Fr & De
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Salient Features: - The Year Book of Cardiology-2019 Heart Failure brings to you a collection of meticulously chosen articles focusing on the recent advances in the management of Heart Failure. - Articles selected from various peer reviewed journals that were published in the last 12-month period. - Each article has been reviewed by subject reviewers who have written comments on value of the article, previous knowledge on the subject, what the article adds to the prevailing knowledge and practices, strong points and weaknesses of the article and other similar observations. - The book comprises nine major sections highlighting the clinical experience of the reviewers. - This small handbook by the Heart Failure Association of India is an attempt to give a snapshot of the most important developments in this field. - The book is divided into 9 Sections, each containing a brief summary of the best articles in that field followed by comments from an expert.

Disorders of Voluntary Muscle

Disorders of Voluntary Muscle
A Book

by George Karpati

  • Publisher : Cambridge University Press
  • Release : 2010-01-21
  • Pages : 129
  • ISBN : 110737734X
  • Language : En, Es, Fr & De
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This major new edition fulfils the need for a single-volume, up-to-date information resource on the etiology, pathogenesis, diagnosis and treatment of diseases of skeletal muscles, including the muscular dystrophies, mitochondrial myopathies, metabolic myopathies, ion channel disorders, and dysimmune myopathies. As background to the clinical coverage, relevant information on advances in molecular and developmental biology, immunopathology, mitochondrial biology, ion-channel dynamics, cell membrane and signal transduction science, and imaging technology is summarized. Combining essential new knowledge with the fundamentals of history-taking and clinical examination, this extensively illustrated book will continue to be the mainstay for practising physicians and biomedical scientists concerned with muscle disease. Regular updates on the clinical and basic science aspects of muscle disease - written mainly by rising stars of myology - will be published on an accompanying website.

Inherited Metabolic Diseases

Inherited Metabolic Diseases
A Clinical Approach

by Georg F. Hoffmann,Johannes Zschocke,William L. Nyhan

  • Publisher : Springer
  • Release : 2016-09-20
  • Pages : 605
  • ISBN : 3662494108
  • Language : En, Es, Fr & De
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This book focuses on clinical presentations that may be caused by inherited metabolic diseases. Its symptom- and system-based approach will help clinicians with and without detailed knowledge of human biochemistry in all specialties to reach a correct diagnosis and institute the optimal treatment program. The book summarizes the central elements of inherited metabolic diseases and describes clearly how to carry out an efficient yet complete diagnostic work-up, thereby guiding the clinician from the presenting symptoms and signs through to effective initial management. After an introduction to the different disorders, the book explains when to consider an inborn metabolic error and which initial tests to order. Core aspects such as structured communication, guidelines, transition, pregnancy, maternal care and how to respond to various medical emergencies are covered. Therapeutic concepts such as dietary treatment are delineated and practical advice provided on the quite different treatment approaches required for individual diseases. An extensive section structured according to organ systems outlines the correct approach in the context of specific symptoms and signs. The value of each of the potential investigations is explained, with precise advice on the interpretation of results. The inclusion of algorithms, tables, lists, and charts facilitates rapid decision making and information retrieval, and the appendices include a helpful guide to differential diagnosis based on clinical and biochemical phenotypes. This new updated edition of Inherited Metabolic Diseases will be an invaluable aid for the busy clinician and an excellent quick reference for metabolic and genetic specialists.

Plant Disease Management Strategies for Sustainable Agriculture through Traditional and Modern Approaches

Plant Disease Management Strategies for Sustainable Agriculture through Traditional and Modern Approaches
A Book

by Imran Ul Haq,Siddra Ijaz

  • Publisher : Springer Nature
  • Release : 2020-02-12
  • Pages : 339
  • ISBN : 3030359557
  • Language : En, Es, Fr & De
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This book provides an account of the classical and recent trends in plant sciences, which have contributed for disease management strategies in plants for sustainable agriculture. Advancements in the disciplines of biological sciences like biotechnology, microbiology, bioinformatics as well as information and communication technology etc has given the new dimensions for the development of new plant disease management strategies. By keeping this perspective in view, the editors collected and compiled the useful, practical and recent information regarding plant disease management from a diverse group of authors from different countries associated with well-reputed scientific, teaching and research organizations with the objective to update and equip the researchers with comprehensive and latest knowledge of plant disease management. This book is based on the knowledge of traditional and modern approaches for plant disease management. It has 15 chapters, each chapter describing the pillar strategies, which may be the possible way for crop protection from diseases.This effort deals with the history and recent trends in plant disease control, plant genetics and physiology in disease prognosis, conventional plant breeding program for disease resistance, synthetic chemicals: major component of plant disease management, biological antagonism: expected safe and sustainable way to manage plant diseases , soil microbes and plant health, conventional and modern technologies for the management of post-harvest diseases, nanobiotechnology, an innovative plant disease management approach, transgenic approaches in plants: strategic control for disease management, exploiting RNAi mechanism in plants for disease resistance, genome editing technologies for resistance against phytopathogens: principles, applications and future prospects, plant health clinics in Pakistan: operations and prospects, precision agriculture technologies for management of plant disease, quarantine and regulations and development and implementation of IDM program for annual and perennial crops.

Pediatric Primary Care - E-Book

Pediatric Primary Care - E-Book
A Book

by Catherine E. Burns,Ardys M. Dunn,Margaret A. Brady,Nancy Barber Starr,Catherine G. Blosser,Dawn Lee Garzon Maaks

  • Publisher : Elsevier Health Sciences
  • Release : 2012-03-01
  • Pages : 1288
  • ISBN : 1455742171
  • Language : En, Es, Fr & De
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Covering the full spectrum of health conditions seen in the primary care of children, Pediatric Primary Care, 5th Edition emphasizes both prevention and management from the unique perspective of the Nurse Practitioner. Written by an expert editor/contributor team, it provides in-depth, evidence-based guidance for assessing and managing health problems in children from infancy through adolescence. Other key topics include developmental theory, the health status of children today, issues of daily living, and cultural considerations. Four-part organization includes an introductory unit, plus units on child development, the health management of children, and diseases and disorders common to childhood. UNIQUE! Functional health patterns framework in Unit Three provides a lens for discussing health promotion through the various components of healthy living. UNIQUE! ICD framework in Unit Four addresses the classification used to code diseases in both hospital and outpatient settings. UNIQUE! Practice management chapter provides need-to-know information on managing a private healthcare practice, including issues of productivity, compliance with applicable laws, quality-of-care indicators, and successful business practices. UNIQUE! Environmental health chapter offers evidence-based content on the effects of environmental toxicants, such as tobacco smoke, heavy metals, and air pollutants. An 8-page color insert presents over 40 photos that visually demonstrate key assessment findings for ear, skin, and other conditions. NEW! Pediatric Pain Management chapter addresses the increased recognition of pain as the "fifth vital sign" with expanded coverage of acute and chronic pain management in children. Extensively revised and updated genetics chapter presents a new paradigm for addressing genetic considerations in clinical practice, including an introduction to epigenetics. Increased emphasis on health disparities explores the growing health disparities among children in the U.S and worldwide and provides strategies to help patients and parents gain accessibility to health care resources. NEW! Content on implementing a "medical home" explores the trend toward family-centered coordinated health care and fosters appropriate treatment for children with chronic disease. NEW! Updated coverage takes a more global approach, exploring the health status of children outside the U.S. Expanded imaging content offers valuable guidance on using various imaging modalities, including how to prepare the child for diagnostics.