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Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine
A Book

by Zhaohui Wu,Huajun Chen,Xiaohong Jiang

  • Publisher : Elsevier
  • Release : 2012
  • Pages : 233
  • ISBN : 0123985102
  • Language : En, Es, Fr & De
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Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Modern Computational Approaches to Traditional Chinese Medicine

Modern Computational Approaches to Traditional Chinese Medicine
A Book

by Zhaohui Wu,Huajun Chen,Xiaohong Jiang

  • Publisher : Elsevier
  • Release : 2012-10-22
  • Pages : 250
  • ISBN : 0123985196
  • Language : En, Es, Fr & De
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Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM’s independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists Introduces novel network technologies to Traditional Chinese Medicine informatics Provides theory and practical examples and case studies of new techniques

Recent Advances in Theories and Practice of Chinese Medicine

Recent Advances in Theories and Practice of Chinese Medicine
A Book

by Haixue Kuang

  • Publisher : IntechOpen
  • Release : 2012-01-18
  • Pages : 506
  • ISBN : 9789533079035
  • Language : En, Es, Fr & De
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During the recent years, traditional Chinese medicine (TCM) has attracted the attention of researchers all over the world. It is looked upon not only as a bright pearl, but also a treasure house of ancient Chinese culture. Nowadays, TCM has become a subject area with high potential and the possibility for original innovation. This book titled Recent Advances in Theories and Practice of Chinese Medicine provides an authoritative and cutting-edge insight into TCM research, including its basic theories, diagnostic approach, current clinical applications, latest advances, and more. It discusses many often neglected important issues, such as the theory of TCM property, and how to carry out TCM research in the direction of TCM property theory using modern scientific technology. The authors of this book comprise an international group of recognized researchers who possess abundant clinical knowledge and research background due to their years of practicing TCM. Hopefully, this book will help our readers gain a deeper understanding of the unique characteristics of Chinese medicine.

Recent Advances in Theories and Practice of Chinese Medicine

Recent Advances in Theories and Practice of Chinese Medicine
A Book

by Haixue Kuang

  • Publisher : IntechOpen
  • Release : 2012-01-18
  • Pages : 506
  • ISBN : 9789533079035
  • Language : En, Es, Fr & De
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During the recent years, traditional Chinese medicine (TCM) has attracted the attention of researchers all over the world. It is looked upon not only as a bright pearl, but also a treasure house of ancient Chinese culture. Nowadays, TCM has become a subject area with high potential and the possibility for original innovation. This book titled Recent Advances in Theories and Practice of Chinese Medicine provides an authoritative and cutting-edge insight into TCM research, including its basic theories, diagnostic approach, current clinical applications, latest advances, and more. It discusses many often neglected important issues, such as the theory of TCM property, and how to carry out TCM research in the direction of TCM property theory using modern scientific technology. The authors of this book comprise an international group of recognized researchers who possess abundant clinical knowledge and research background due to their years of practicing TCM. Hopefully, this book will help our readers gain a deeper understanding of the unique characteristics of Chinese medicine.

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals

Pharmaceutical Innovation After World War II: From Rational Drug Discovery to Biopharmaceuticals
A Book

by Apostolos Zarros,Tilli Tansey

  • Publisher : Frontiers Media SA
  • Release : 2019-11-27
  • Pages : 137
  • ISBN : 2889632237
  • Language : En, Es, Fr & De
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Traditional Chinese Medicine

Traditional Chinese Medicine
Scientific Basis for Its Use

by James D Adams,Eric J Lien

  • Publisher : Royal Society of Chemistry
  • Release : 2015-10-20
  • Pages : 349
  • ISBN : 1782624937
  • Language : En, Es, Fr & De
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Traditional Chinese medicine has a strong scientific basis, but the science of these important preparations is often rarely discussed. Western approaches often simplify traditional Chinese medicine to drug discovery in Chinese plants, however, the majority of traditional Chinese medications use complex mixtures of plant extracts, rather than single purified drugs. The combination of different extracts is based on yin, yang and chi theories, which are often poorly understood in the West. Yin and yang are known to be the balance of agonists and antagonists, whereas chi derives from signalling processes in the body and regulates bodily functions. Traditional Chinese medical practitioners understand that yin, yang and chi constantly interact in the body to maintain health. Western medical practitioners understand how to use agonists and antagonists and how to modify signalling processes, but generally do not accept the use of complex plant extracts to perform these functions. Aimed at medical scientists, and including detailed explanations of the theories behind the science, this text may help researchers to understand, and communicate more effectively with, Chinese medical practitioners and will lead to greater acceptance of traditional medications in the West. Presenting a clear rationale for the use of traditional Chinese medications in Western medical facilities, it enables scientists to find new directions in experimental design and encourage examination of these useful, but often poorly understood, preparations in clinical trials.

Computational Science - ICCS 2007

Computational Science - ICCS 2007
7th International Conference, Beijing China, May 27-30, 2007, Proceedings

by Yong Shi,Geert Dick van Albada,Jack Dongarra,Peter M.A. Sloot

  • Publisher : Springer Science & Business Media
  • Release : 2007-05-18
  • Pages : 1214
  • ISBN : 354072589X
  • Language : En, Es, Fr & De
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Part of a four-volume set, this book constitutes the refereed proceedings of the 7th International Conference on Computational Science, ICCS 2007, held in Beijing, China in May 2007. The papers cover a large volume of topics in computational science and related areas, from multiscale physics to wireless networks, and from graph theory to tools for program development.

Computational Collective Intelligence. Technologies and Applications

Computational Collective Intelligence. Technologies and Applications
Second International Conference, ICCCI 2010, Kaohsiung, Taiwan, November 10-12, 2010. Proceedings

by Jeng-Shyang Pan,Shyi-Ming Chen,Ngoc Thanh Nguyen

  • Publisher : Springer Science & Business Media
  • Release : 2010-10-21
  • Pages : 514
  • ISBN : 3642167314
  • Language : En, Es, Fr & De
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This volume composes the proceedings of the Second International Conference on Computational Collective Intelligence––Technologies and Applications (ICCCI 2010), which was hosted by National Kaohsiung University of Applied Sciences and Wroclaw University of Technology, and was held in Kaohsiung City on November 10-12, 2010. ICCCI 2010 was technically co-sponsored by Shenzhen Graduate School of Harbin Institute of Technology, the Tainan Chapter of the IEEE Signal Processing Society, the Taiwan Association for Web Intelligence Consortium and the Taiwanese Association for Consumer Electronics. It aimed to bring together researchers, engineers and po- cymakers to discuss the related techniques, to exchange research ideas, and to make friends. ICCCI 2010 focused on the following themes: • Agent Theory and Application • Cognitive Modeling of Agent Systems • Computational Collective Intelligence • Computer Vision • Computational Intelligence • Hybrid Systems • Intelligent Image Processing • Information Hiding • Machine Learning • Social Networks • Web Intelligence and Interaction Around 500 papers were submitted to ICCCI 2010 and each paper was reviewed by at least two referees. The referees were from universities and industrial organizations. 155 papers were accepted for the final technical program. Four plenary talks were kindly offered by: Gary G. Yen (Oklahoma State University, USA), on “Population Control in Evolutionary Multi-objective Optimization Algorithm,” Chin-Chen Chang (Feng Chia University, Taiwan), on “Applying De-clustering Concept to Information Hiding,” Qinyu Zhang (Harbin Institute of Technology, China), on “Cognitive Radio Networks and Its Applications,” and Lakhmi C.

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
A Book

by Rudy J Richardson,Dale E Johnson

  • Publisher : Royal Society of Chemistry
  • Release : 2017-03-01
  • Pages : 332
  • ISBN : 1788011201
  • Language : En, Es, Fr & De
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The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Computational Toxicology

Computational Toxicology
Risk Assessment for Chemicals

by Sean Ekins

  • Publisher : John Wiley & Sons
  • Release : 2018-02-13
  • Pages : 432
  • ISBN : 111928256X
  • Language : En, Es, Fr & De
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A key resource for toxicologists across a broad spectrum of fields, this book offers a comprehensive analysis of molecular modelling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals. • Provides a perspective of what is currently achievable with computational toxicology and a view to future developments • Helps readers overcome questions of data sources, curation, treatment, and how to model / interpret critical endpoints that support 21st century hazard assessment • Assembles cutting-edge concepts and leading authors into a unique and powerful single-source reference • Includes in-depth looks at QSAR models, physicochemical drug properties, structure-based drug targeting, chemical mixture assessments, and environmental modeling • Features coverage about consumer product safety assessment and chemical defense along with chapters on open source toxicology and big data

Kinase Drug Discovery

Kinase Drug Discovery
Modern Approaches

by Richard A Ward,Frederick W Goldberg

  • Publisher : Royal Society of Chemistry
  • Release : 2018-10-31
  • Pages : 413
  • ISBN : 1788015630
  • Language : En, Es, Fr & De
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Kinase inhibition remains an area of significant interest, and growing importance, across academia and the pharmaceutical industry. There are now many marketed drugs that target kinases and a significant number of compounds are currently in various stages of clinical development. This book is a forward-looking analysis of a number of key areas for kinase inhibition in the coming years and builds on the first volume. This includes topics such as screening approaches to target kinases along with different modes of inhibition such as allosteric and covalent. Novel approaches such as macrocyclisation are considered along with how the properties of kinase inhibitors have evolved, including the potential for brain penetration. Recent areas of great importance also covered include cutting edge molecular modelling approaches and the importance of kinase mutations. The evolving biology of kinases has also resulted in increased interest in the immuno-oncology area and also pseudokinases as a target family. As with the first volume the book finishes with a forward looking view of how research against this fascinating target class may evolve.

Computational and Experimental Approaches in Multi-target Pharmacology

Computational and Experimental Approaches in Multi-target Pharmacology

by Thomas J. Anastasio

  • Publisher : Frontiers Media SA
  • Release : 2017-08-24
  • Pages : 129
  • ISBN : 2889452522
  • Language : En, Es, Fr & De
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The next frontier in pharmacology is the development of multi-target strategies in which pathological processes are controlled by pharmacologically manipulating them at many different points at once. Designing multi-target strategies will require deep understanding of the complex physiology that underlies pathological processes. It will also require the development of single drugs with multiple targets, or combinations of drugs with compatible pharmacokinetics that work synergistically to maximize desirable effects while minimizing unwanted side effects. This e-Book contains ten original articles, each addressing a different aspect of this challenge. Together they open new perspectives and show the way forward in the development of multi-target therapeutics.

Medical Biometrics

Medical Biometrics
Computerized TCM Data Analysis

by David Zhang,Wangmeng Zuo,Naimin Li

  • Publisher : World Scientific
  • Release : 2016-02-23
  • Pages : 404
  • ISBN : 9814397261
  • Language : En, Es, Fr & De
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The introduction of traditional Chinese medicine (TCM) through modern information technology will not only achieve the objective progress of the heritage of thousands of years of TCM, but also deliver novel discoveries for modern medicines. This book is an advanced monograph based on a decade's worth of research work by the authors. After a brief introduction on the four diagnosis approaches in TCM, this book delves into the three main TCM data analysis techniques: computerized tongue, pulse and odor analysis. Both graduate students and researchers in computerized TCM data analysis will benefit from the book as it will provide a comprehensive understanding of the state-of-the-art analysis methods, image / signal acquisition devices, and the related feature extraction and classification methods. Contents:Diagnosis Methods in Traditional Chinese Medicine:IntroductionComputerized Tongue Image Analysis:Tongue Image Acquisition and PreprocessingAutomated Tongue SegmentationTongue Image Feature AnalysisComputerized Tongue DiagnosisComputerized Pulse Signal Analysis:Pulse Signal Acquisition and PreprocessingFeature Extraction of Pulse SignalsClassification of Pulse SignalsComputerized Odor Signal Analysis:Breath Analysis System: Design and OptimizationFeature Extraction and Classification of Breath Odor Signals Readership: Students and researchers from both academia and industry: in the field of computerized traditional Chinese medicine data analysis, or in the related fields, e.g., medical image/signal analysis, biometrics, and pattern recognition. Key Features:The first monograph on computerized traditional Chinese medicine data analysis (CTDA)In-depth and self-contained introduction on CTDAComprehensive presentation on three main CTDA technologies

Life Chemistry Research

Life Chemistry Research
Biological Systems

by Roman Joswik,Gennady E. Zaikov,A. K. Haghi

  • Publisher : CRC Press
  • Release : 2015-05-27
  • Pages : 350
  • ISBN : 1498700004
  • Language : En, Es, Fr & De
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This volume contains a collection of topical chapters that promote interdisciplinary approaches to biological systems, focusing on fundamental and relevant connections between chemistry and life. Included are studies and experiments as well as invited lectures and notes by prominent leaders on a wide variety of topics in biology and biochemistry. B

Peptide Therapeutics

Peptide Therapeutics
Strategy and Tactics for Chemistry, Manufacturing, and Controls

by Ved Srivastava

  • Publisher : Royal Society of Chemistry
  • Release : 2019-08-16
  • Pages : 543
  • ISBN : 1788018699
  • Language : En, Es, Fr & De
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Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting step due to lack of knowledge and lack of a formal policy or guidelines on CMC for peptide-based drugs. Regulators use a risk-based approach, reviewing applications on a case-by-case basis. Peptide Therapeutics: Strategy and Tactics for Chemistry, Manufacturing, and Controls covers efficient manufacturing of peptide drug substances, a review of the process for submitting applications to the regulatory authority for drug approval, a holistic approach for quality attributes and quality control from a regulatory perspective, emerging analytical tools for the characterisation of impurities, and the assessment of stability. This book is an essential reference work for students and researchers, in both academia and industry, with an interest in learning about CMC, and facilitating development and manufacture of peptide-based drugs.

Computational Science – ICCS 2008

Computational Science – ICCS 2008
8th International Conference, Kraków, Poland, June 23-25, 2008, Proceedings, Part I

by Marian Bubak,Geert Dick van Albada,Jack Dongarra,Peter M.A. Sloot

  • Publisher : Springer
  • Release : 2008-06-25
  • Pages : 1058
  • ISBN : 354069384X
  • Language : En, Es, Fr & De
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The three-volume set LNCS 5101-5103 constitutes the refereed proceedings of the 8th International Conference on Computational Science, ICCS 2008, held in Krakow, Poland in June 2008. The 167 revised papers of the main conference track presented together with the abstracts of 7 keynote talks and the 100 revised papers from 14 workshops were carefully reviewed and selected for inclusion in the three volumes. The main conference track was divided into approximately 20 parallel sessions addressing topics such as e-science applications and systems, scheduling and load balancing, software services and tools, new hardware and its applications, computer networks, simulation of complex systems, image processing and visualization, optimization techniques, numerical linear algebra, and numerical algorithms. The second volume contains workshop papers related to various computational research areas, e.g.: computer graphics and geometric modeling, simulation of multiphysics multiscale systems, computational chemistry and its applications, computational finance and business intelligence, physical, biological and social networks, geocomputation, and teaching computational science. The third volume is mostly related to computer science topics such as bioinformatics' challenges to computer science, tools for program development and analysis in computational science, software engineering for large-scale computing, collaborative and cooperative environments, applications of workflows in computational science, as well as intelligent agents and evolvable systems.

Model-Based Reasoning in Science, Technology, and Medicine

Model-Based Reasoning in Science, Technology, and Medicine
A Book

by Lorenzo Magnani,Ping Li

  • Publisher : Springer
  • Release : 2007-06-30
  • Pages : 525
  • ISBN : 3540719865
  • Language : En, Es, Fr & De
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The volume is based on papers presented at the international conference on Model-Based Reasoning in Science and Medicine held in China in 2006. The presentations explore how scientific thinking uses models and explanatory reasoning to produce creative changes in theories and concepts. The contributions to the book are written by researchers active in the area of creative reasoning in science and technology. They include the subject area’s most recent results and achievements.

Advances in Near Infrared Spectroscopy and Related Computational Methods

Advances in Near Infrared Spectroscopy and Related Computational Methods
A Book

by Christian Huck,Krzysztof B. Bec

  • Publisher : MDPI
  • Release : 2020-01-03
  • Pages : 496
  • ISBN : 303928052X
  • Language : En, Es, Fr & De
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In the last few decades, near-infrared (NIR) spectroscopy has distinguished itself as one of the most rapidly advancing spectroscopic techniques. Mainly known as an analytical tool useful for sample characterization and content quantification, NIR spectroscopy is essential in various other fields, e.g. NIR imaging techniques in biophotonics, medical applications or used for characterization of food products. Its contribution in basic science and physical chemistry should be noted as well, e.g. in exploration of the nature of molecular vibrations or intermolecular interactions. One of the current development trends involves the miniaturization and simplification of instrumentation, creating prospects for the spread of NIR spectrometers at a consumer level in the form of smartphone attachments—a breakthrough not yet accomplished by any other analytical technique. A growing diversity in the related methods and applications has led to a dispersion of these contributions among disparate scientific communities. The aim of this Special Issue was to bring together the communities that may perceive NIR spectroscopy from different perspectives. It resulted in 30 contributions presenting the latest advances in the methodologies essential in near-infrared spectroscopy in a variety of applications.

Computational Pulse Signal Analysis

Computational Pulse Signal Analysis
A Book

by David Zhang,Wangmeng Zuo,Peng Wang

  • Publisher : Springer
  • Release : 2018-09-14
  • Pages : 328
  • ISBN : 9811040443
  • Language : En, Es, Fr & De
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This book describes the latest advances in pulse signal analysis and their applications in classification and diagnosis. First, it provides a comprehensive introduction to useful techniques for pulse signal acquisition based on different kinds of pulse sensors together with the optimized acquisition scheme. It then presents a number of preprocessing and feature extraction methods, as well as case studies of the classification methods used. Lastly it discusses some promising directions for the future study and clinical applications of pulse signal analysis. The book is a valuable resource for researchers, professionals and postgraduate students working in the field of pulse diagnosis, signal processing, pattern recognition and biometrics. It is also useful for those involved in interdisciplinary research.

Biophysical and Computational Tools in Drug Discovery

Biophysical and Computational Tools in Drug Discovery
A Book

by Anil Kumar Saxena

  • Publisher : Springer Nature
  • Release : 2021-10-18
  • Pages : 402
  • ISBN : 3030852814
  • Language : En, Es, Fr & De
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This book reviews recent physicochemical and biophysical techniques applied in drug discovery research, and it outlines the latest advances in computational drug design. Divided into 10 chapters, the book discusses about the role of structural biology in drug discovery, and offers useful application cases of several biophysical and computational methods, including time-resolved fluorometry (TRF) with Förster resonance energy transfer (FRET), X-Ray crystallography, nuclear magnetic resonance spectroscopy, mass spectroscopy, generative machine learning for inverse molecular design, quantum mechanics/molecular mechanics (QM/MM,ONIOM) and quantum molecular dynamics (QMT) methods. Particular attention is given to computational search techniques applied to peptide vaccines using novel mathematical descriptors and structure and ligand-based virtual screening techniques in drug discovery research. Given its scope, the book is a valuable resource for students, researchers and professionals from pharmaceutical industry interested in drug design and discovery.