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Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
Systems and Network Biology Approaches

by Asfar Azmi

  • Publisher : Elsevier
  • Release : 2014-04-14
  • Pages : 458
  • ISBN : 0124079466
  • Language : En, Es, Fr & De
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Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Molecular Diagnostics in Cancer Patients

Molecular Diagnostics in Cancer Patients
A Book

by Kamla Kant Shukla,Praveen Sharma,Sanjeev Misra

  • Publisher : Springer
  • Release : 2019-03-15
  • Pages : 341
  • ISBN : 981135877X
  • Language : En, Es, Fr & De
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This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
A Book

by Dongfeng Tan,Henry T. Lynch

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2012-12-07
  • Pages : 992
  • ISBN : 1469820641
  • Language : En, Es, Fr & De
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The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Pancreatic Cancer

Pancreatic Cancer
A Book

by Daniel D. Von Hoff,Douglas Brian Evans,Ralph H. Hruban

  • Publisher : Jones & Bartlett Learning
  • Release : 2005
  • Pages : 832
  • ISBN : 9780763721787
  • Language : En, Es, Fr & De
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Pancreatic cancer is the fourth leading cause of cancer death in the United States and has the worst mortality rate of any cancer. It is very likely that the number of deaths from pancreatic cancer each year will surpass the number of deaths from other more common cancers, such as breast cancer. This volume is dedicated to helping curb these daunting statistics by providing a knowledge base for clinicians and scientists who want to make a difference for patients both now and in the future. Edited by an eminent team consisting of a medical oncologist, a cancer surgeon and a pathologist, with contributions from over 100 world-class experts in the field, the book includes 54 state of the art chapters -- all with full color illustrations. Special "Commentaries," written by world authorities on the subject, provide expert analysis and counterpoint to selected topics.

Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy

Molecular Diagnosis and Targeting for Thoracic and Gastrointestinal Malignancy
A Book

by Yutaka Shimada,Katsuhiko Yanaga

  • Publisher : Springer
  • Release : 2017-11-29
  • Pages : 156
  • ISBN : 9811064695
  • Language : En, Es, Fr & De
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This volume focuses on the clinical applications of molecular diagnosis and targeted therapy from the viewpoint of oncologists specializing in specific organs. In addition, it discusses the role of molecular diagnosis and targeted therapy in the course of surgical treatment. Recent, rapid advances in molecular biology have shed new light on the mechanisms of cancer progression, and molecularly targeted drugs have been used to treat a variety of malignant diseases. For the diagnosis and precise treatment of cancer, analysis of the molecular background of the tumor is indispensable. However, there are both tumor-specific and comprehensive mechanisms involved in these processes. Accordingly, a firm grasp of molecular diagnosis and targeted therapies for different tumors is vital for clinicians and basic researchers alike. This book provides essential information and the latest findings on molecular diagnosis and targeted therapy for thoracic and gastrointestinal malignancies. Though primarily intended for clinical and basic oncologists, it also offers a useful guide for clinicians who are interested in this field and are considering getting started in molecular diagnosis and targeted therapy.

Gastrointestinal Cancers

Gastrointestinal Cancers
Biology, Diagnosis, and Therapy

by Anil K. Rustgi

  • Publisher : Lippincott Williams & Wilkins
  • Release : 1995
  • Pages : 663
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The newest title in the Sleisenger and Fordtran family provides the field with comprehensive and practical coverage of all gastrointestinal cancers from significant advances in understanding to its clinical manifestations, diagnosis, and treatment. A multidisciplinary team of experts explores all of the significant new advances in our understanding of cancer and details the clinical manifestations, diagnosis, and treatment of each type.

Lawyers' Medical Cyclopedia of Personal Injuries and Allied Specialties

Lawyers' Medical Cyclopedia of Personal Injuries and Allied Specialties
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Diagnostics of Human Cancer

Molecular Diagnostics of Human Cancer
A Book

by Mark Furth,Melvyn F. Greaves,Melvyn Greaves

  • Publisher : Cold Spring Harbor Laboratory Press
  • Release : 1989
  • Pages : 414
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Scientists and physicians share overlapping interests in fundamental cancer biology and in the potential clinical ramifications of specific mutations in cancer cells. In this volume, they present their ideas on the role of oncogenes and their protein products in human tumors, with emphasis on diagnostic applications. They also review the medical implications of discoveries concerning the genetic basis of neoplastic disease. Topics include nuclear oncogene proteins; growth factors and their receptors; activation of ras, src, and raf oncogenes; chromosomal rearrangements associated with oncogene activation; gene loss in human cancers; the identification and potential function of anti-oncogenes ; the genetic basis for the resistance of tumor cells to chemotherapeutic drugs; and DNA tumor virus oncogenes in some human cancers. Molecular Diagnosis of Human Cancer also includes technical advances, as well as data on the diagnostic and prognostic implications of particular oncogene alterations in a number of cancers, notably pediatric neuroblastoma, the myelogenous leukemias, and carcinomas of the colon, bladder, pancreas, and breast.

Hepato-gastroenterology

Hepato-gastroenterology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Research Report

Research Report
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Diagnostic Procedures in Pancreatic Disease

Diagnostic Procedures in Pancreatic Disease
A Book

by P. Malfertheiner,J.E. Dominguez-Munoz,H.-U. Schulz,Hans Lippert

  • Publisher : Springer
  • Release : 1997-04-16
  • Pages : 446
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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These proceedings of an international meeting held as recently as December 1996 cover diagnostic procedures in pancreatic disease, together with the progress made over the last 10 years in treating acute and chronic pancreatitis as well as pancreatic cancer. The meeting also covered standards in medical and surgical treatment.

Gastrointestinal Oncology

Gastrointestinal Oncology
Evidence and Analysis

by Peter McCulloch

  • Publisher : CRC Press
  • Release : 2007-06-06
  • Pages : 383
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This reference discusses best practices for the management of patients with cancers of the esophagus, stomach, colon, liver, and pancreas. Focusing on a wide variety of GI carcinomas by organ and tumor type, this source provides expert coverage of diagnostic, staging, and treatment procedures by seasoned oncologists and radiologists, and offers in-depth discussions of current research regarding tumor markers, molecular biology, and clinical presentation. A must for the busy clinician, this source: spans the existing evidence from experienced opinion leaders in the field of gastrointestinal oncology pairs organ-based chapters so that surgical and non-surgical oncologists provide perspectives on the same condition...supplies an up-to-date and relevant summary of the key topics in gastrointestinal oncology, supported by clear scientific evidence combines surgical and medical approaches to cancers in specific organs, supplying a rigorous evidence-based approach to the evaluation of various treatments addresses critical topics in the area including the management and prevention of cancers around the gastroesophageal junction, rectal cancer, and gastrointestinal stromal tumors considers the latest developments in surgical, radiation, and chemotherapeutic management

The Metabolic & Molecular Bases of Inherited Disease

The Metabolic & Molecular Bases of Inherited Disease
A Book

by Charles R. Scriver

  • Publisher : New York ; Montreal : McGraw-Hill
  • Release : 2001
  • Pages : 6338
  • ISBN : 9780071363228
  • Language : En, Es, Fr & De
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Presents clinical, biochemical, and genetic information concerning those metabolic anomalies grouped under inborn errors of metabolism.

Cancer Research

Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genetic Disorders and the Fetus

Genetic Disorders and the Fetus
Diagnosis, Prevention, and Treatment

by Aubrey Milunsky

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 1074
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Be cool in Italian! Perfect for kids eight- to fourteen-years old, Way-Cool Italian covers the latest in kid language as it is spoken in the Italian-speaking world. Inside you will find out how kids in another country talk about their computers, how they text each other, and how they speak about their favorite music on their iPods. Includes words and phrases on topics such as numbers, greetings, weather, time, as well as the cool language you really want to know like the words for mobile phones, computers, music, comics, clothes, sports--even the Wii and avatars!

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors

Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors
Diagnosis and Management

by Hans G. Beger,Akimasa Nakao,John P. Neoptolemos,Shu You Peng,Michael G. Sarr

  • Publisher : John Wiley & Sons
  • Release : 2015-04-27
  • Pages : 456
  • ISBN : 0470673184
  • Language : En, Es, Fr & De
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Pancreatic Cancer, Cystic Neoplasms and Endocrine Tumors: Diagnosis and Management is a modern, expertly crafted and clinically focused guide to the diagnosis, management and best-practice care of patients suffering from pancreatic cancer, cystic neoplasms and endocrine tumours. Packed with outstanding figures and with reference to the leading society guidelines, its main focus is on the many endoscopic and radiologic diagnostic techniques, medical and surgical management of both full-blown cancer and other tumors, and the risks of each form of treatment. Also covered in detail are issues of tumor recurrence and long-term outcome of treatment. Brought to you by highly skilled national and international leaders in the specialty and an experienced editor team, this is an invaluable guide to practicing gastroenterologists and surgeons in the hospital and clinical environment, as well as oncologists and endocrinologists managing patients with pancreatic tumorous lesions.

Kyoto University Bulletin

Kyoto University Bulletin
A Book

by Kyōto Daigaku

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Therapy of Digestive Disorders

Therapy of Digestive Disorders
A Companion to Sleisenger and Fordtran's Gastrointestinal and Liver Disease

by M. Michael Wolfe

  • Publisher : W B Saunders Company
  • Release : 2000
  • Pages : 882
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New edition publishing November 2005. Provides diagnostic guidance and therapeutic recommendations from over 80 world-renowned experts. Covers disorders of the esophagus, stomach, duodenum, pancreas, liver, small and large intestine. Summarises therapies into concise, quick-access tables. Includes over 200 detailed illustrations and algorithms. Features plentiful references that enable readers to further investigate therapeutic options

Pathology and Epidemiology of Cancer

Pathology and Epidemiology of Cancer
A Book

by Massimo Loda,Lorelei A. Mucci,Megan L. Mittelstadt,Mieke Van Hemelrijck,Maura Bríd Cotter

  • Publisher : Springer
  • Release : 2016-09-01
  • Pages : 670
  • ISBN : 3319351532
  • Language : En, Es, Fr & De
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This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.

Cystic Tumors of the Pancreas

Cystic Tumors of the Pancreas
Diagnosis and Treatment

by Marco Del Chiaro,Stephan L. Haas,Richard D. Schulick

  • Publisher : Springer
  • Release : 2016-07-14
  • Pages : 181
  • ISBN : 3319318829
  • Language : En, Es, Fr & De
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This book provides a detailed, up-to-date overview of cystic tumors of the pancreas, with coverage of all aspects of diagnosis and treatment (medical, endoscopic, and surgical). After opening chapters on pathology and classification, cytology, molecular biology, and epidemiology, the role of each of the relevant diagnostic methods is carefully examined. The treatment-related chapters describe surgical approaches, including minimally invasive surgery, as well as ablation modalities and chemo-radiotherapy. Thorough guidance is also provided specifically on the management of cystic tumors in high-risk cases and on follow-up. The authors are global opinion leaders in their field who have contributed cutting-edge chapters, with emphasis on clear diagnostic and therapeutic algorithms and with numerous supporting tables and illustrations. Owing to the widespread use of imaging modalities, clinicians are being confronted by an increasing number of patients with cystic tumors of the pancreas, ranging from benign cysts to metastasized malignancies. The widening spectrum of available diagnostic measures has resulted in controversy over the choice of further means of investigation when cystic changes are encountered, and the growth in therapeutic options has similarly been accompanied by considerable debate over their use. Against this background, Cystic Tumors of the Pancreas will be a valuable source of relevant information for both clinicians and surgeons and will also be of interest to radiologists, pathologists, and basic scientists.